The signals that drive kidney development: a view from the fly eye.

abstract：:The vasculature wall is an active, integrated organ composed of endothelial cells and vascular smooth muscle cells, as well as other cell types depending on the specific vascular segment (e.g. fibroblasts in many vascular regions). The vascular wall is not static; the vascular components (cells and extracellular matri...

journal_title：Current opinion in nephrology and hypertension

authors： Dubey RK,Jackson EK,Rupprecht HD,Sterzel RB

更新日期：1997-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The review describes studies investigating the role of microRNAs in the signaling pathway of the mineralocorticoid hormone, aldosterone. RECENT FINDINGS:Emerging evidence indicates that aldosterone alters the expression of microRNAs in target tissues thereby modulating the expression of key regulator...

journal_title：Current opinion in nephrology and hypertension

authors： Butterworth MB

更新日期：2018-09-01 00:00:00

abstract：:Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Trad...

journal_title：Current opinion in nephrology and hypertension

authors： Yu AS

更新日期：2001-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The current article reviews the available literature on the incidence, complications, outcomes, and management of pregnancies in kidney transplant recipients. RECENT FINDINGS:Pregnancy can be a reasonable option for women with a kidney transplant. More than 4700 successful pregnancies have been repor...

journal_title：Current opinion in nephrology and hypertension

authors： Vijayan M,Pavlakis M

更新日期：2017-11-01 00:00:00

abstract：:Recent investigations cast some doubts on the status of insulin resistance as a trigger in hyperinsulinemia-associated hypertension or obesity-related hypertension, or both. Major epidemiological studies have shown that central adiposity is a powerful risk factor for stroke or coronary artery disease when accompanied ...

journal_title：Current opinion in nephrology and hypertension

authors： Reisin E,Messerli FH

更新日期：1995-01-01 00:00:00

abstract：:Tests have become available that not only give an index of iron stores and availability but also provide an integrated assessment of the efficacy of its utilization. This has allowed the revision of previously accepted criteria of iron deficiency as well as the most appropriate strategies for iron administration. By o...

journal_title：Current opinion in nephrology and hypertension

authors： van Zyl-Smit R

更新日期：2000-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Hypertension is an important risk factor for adverse cardiovascular and renal outcomes particularly in patients with chronic kidney disease. This review compares blood pressure measurements obtained in the clinic with those obtained outside the clinic to predict cardiovascular and renal injury and out...

journal_title：Current opinion in nephrology and hypertension

authors： Agarwal R

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now a...

journal_title：Current opinion in nephrology and hypertension

authors： Nguyen Dinh Cat A,Jaisser F

更新日期：2012-03-01 00:00:00

abstract：:The possible association between low-level lead exposure and blood pressure and the causal nature of any such relationship continue to be debated. A recent meta-analysis of the human model data showed that on average a doubling of blood lead was associated with a rise in blood pressure averaging 1 mm Hg systolic and 0...

journal_title：Current opinion in nephrology and hypertension

authors： Staessen JA,Lauwerys RR,Bulpitt CJ,Fagard R,Lijnen P,Roels H,Thijs L,Amery A

更新日期：1994-05-01 00:00:00

abstract：:Crystals of calcium oxalate and calcium phosphate bind to anionic molecules on the apical surface of renal collecting duct cells. Atomic arrays on crystal faces interact stereospecifically with cell-surface anions to bind crystals that nucleate in tubular fluid, or those that nucleate directly on the plasma membrane. ...

journal_title：Current opinion in nephrology and hypertension

authors： Lieske JC,Toback FG

更新日期：2000-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Calcium is an essential ion for the maintenance of normal bone health and physiologic functions. The extracellular and intracellular levels of calcium are maintained through hormonal regulation called homeostasis. Balance, the net intake minus excretion of calcium, is maintained by hormonal regulation...

journal_title：Current opinion in nephrology and hypertension

authors： Moe SM

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular endothelial growth factors (VEGFs) influence renal function through angiogenesis, with VEGF-A being the most potent inducer of vascular formation. In the normal glomerulus, tight homeostatic balance is maintained between the levels of VEGF-A isoforms produced by podocyte cells, and the VEGF r...

journal_title：Current opinion in nephrology and hypertension

authors： Logue OC,McGowan JW,George EM,Bidwell GL 3rd

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Sodium-glucose cotransporter 2 (SGLT2) inhibitors are antihyperglycemic drugs that act by inhibiting renal sodium-glucose cotransport. Here we present new insights into 'off target', or indirect, effects of SGLT2 inhibitors. RECENT FINDINGS:SGLT2 inhibition causes an acute increase in urinary glucose...

journal_title：Current opinion in nephrology and hypertension

authors： Dominguez Rieg JA,Xue J,Rieg T

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Connective tissue growth factor (CCN2) has recently received much attention as a possible key determinant of progressive renal fibrosis. However, the mechanism(s) by which this growth factor functions is not known. The purpose of this review is to summarize and discuss the recent findings regarding th...

journal_title：Current opinion in nephrology and hypertension

authors： Abdel Wahab N,Mason RM

更新日期：2004-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Simultaneous liver kidney transplantation (SLK) has taken center stage since the initiation of the new kidney allocation system (KAS). This review places SLK in the context of the changing landscape of organ allocation. RECENT FINDINGS:The introduction of the Mayo End-Stage Liver Disease score into l...

journal_title：Current opinion in nephrology and hypertension

authors： Formica RN Jr

更新日期：2016-11-01 00:00:00

abstract：:There is ample evidence to support the recommendation of renin-angiotensin system blockade therapy as the standard of care for strategies aimed at preserving renal function in chronic renal disease. Nevertheless, despite the well established antihypertensive effects of these drugs, the use of renin-angiotensin system ...

journal_title：Current opinion in nephrology and hypertension

authors： Remuzzi G,Perico N

更新日期：2002-01-01 00:00:00

abstract：:It is well known that hyperparathyroidism begins early in renal failure and progresses, probably not linearly, throughout the natural course of renal diseases and dialysis therapy. Recent progress in basic medical science has improved our understanding of the mechanisms by which the classically known stimuli for parat...

journal_title：Current opinion in nephrology and hypertension

authors： Argilés A,Mourad G,Mion C

更新日期：1996-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the increasing incidence and prevalence of ESRD in the elderly, we are now transplanting more elderly patients. Although we know from previous reports that transplantation provides increased survival advantage and/or quality of life when compared to being on dialysis, we also know that transplant...

journal_title：Current opinion in nephrology and hypertension

authors： Kodali L,Turner A

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current understanding of hemodialysis-mediated clearance of commonly used cardiovascular medications. RECENT FINDINGS:Although cardiovascular drug dialyzability is poorly understood, many drug classes appear to include agents with substantially different degrees of dialyzability. Recent...

journal_title：Current opinion in nephrology and hypertension

authors： Tieu A,Leither M,Urquhart BL,Weir MA

更新日期：2016-05-01 00:00:00

abstract：:Data suggest that ischemic renal disease secondary to atherosclerotic renal artery stenosis is a prevalent health problem. Atherosclerotic renal artery stenosis is a rapidly progressive process that can result in end-stage renal disease. Renal arteriography is the current diagnostic method of choice for the demonstrat...

journal_title：Current opinion in nephrology and hypertension

authors： Breyer JA,Jacobson HR

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to provide an update on the current knowledge regarding the role of the intrarenal rennin-angiotensin system (RAS) in the regulation of glomerular function including glomerular dynamics and filtration rate, glomerular permeability and structural alterations during chronic...

journal_title：Current opinion in nephrology and hypertension

authors： Navar LG

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Thrombotic microangiopathies (TMAs) manifest as a spectrum of related disorders in the form of thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). New data on both diseases support more and more the relatedness of the disorders and reveal related pathomechanisms, which, however, manife...

journal_title：Current opinion in nephrology and hypertension

authors： Zipfel PF,Heinen S,Skerka C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:MRI can noninvasively assess the structure and function of the kidney in a single MRI scan session. This review summarizes recent advancements in functional renal MRI techniques, with a particular focus on clinical applications. RECENT FINDINGS:A number of MRI techniques now provide measures of relev...

journal_title：Current opinion in nephrology and hypertension

authors： Mahmoud H,Buchanan C,Francis ST,Selby NM

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Defective transduction of the dopamine receptor signal in the kidney has been shown to be important in the pathogenesis of hypertension This review will discuss the genetic mechanism for the defective renal dopaminergic function and the interaction with other gene variant products in the pathogenesis ...

journal_title：Current opinion in nephrology and hypertension

authors： Jose PA,Eisner GM,Felder RA

更新日期：2003-03-01 00:00:00

abstract：:The immunosuppressants cyclosporine and FK506 (tacrolimus) are extremely potent inhibitors of T-lymphocyte activation. Recent studies have shown that these agents are actually prodrugs that become active only when bound to specific members of the cyclophilin or FK506 binding protein receptor gene families. The cyclosp...

journal_title：Current opinion in nephrology and hypertension

authors： Tocci MJ,Sigal NH

更新日期：1992-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To characterize the mechanism and clinical impact of the angiotensin-receptor blocker losartan on both renal uric acid handling and thereby serum uric acid. RECENT FINDINGS:Losartan effect on serum uric acid has been demonstrated at various stages of renal failure including most recently observations...

journal_title：Current opinion in nephrology and hypertension

authors： Sica DA,Schoolwerth AC

更新日期：2002-09-01 00:00:00

abstract：:Vascular endothelial growth factor is a diffusible endothelial cell-specific mitogen and angiogenic factor that can also increase vascular permeability. The vascular endothelial growth factor receptors are specifically expressed on the cell surface of vascular endothelial cells. Recent studies point to vascular endoth...

journal_title：Current opinion in nephrology and hypertension

authors： Ferrara N,Bunting S

更新日期：1996-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Both cognitive and physical function are commonly impaired in individuals with chronic kidney disease (CKD), resulting in important impacts on their quality of life and overall health. This review summarizes the burden of cognitive and physical impairment in CKD, focusing on recent research that highl...

journal_title：Current opinion in nephrology and hypertension

authors： Weiner DE,Seliger SL

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite advances in hemodialysis technology, a stable and well functioning vascular access remains the bane of every hemodialysis patient. It is recognized that vascular access contributes to cardiovascular disease mortality through a number of mechanisms. This review describes the relationship betwee...

journal_title：Current opinion in nephrology and hypertension

authors： MacRae JM

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate lowering toward the normal range is advocated and widely practiced in patients with end-stage renal disease receiving dialysis. This approach is guided by basic science data and large observational studies that have demonstrated a consistent association between hyperphosphatemia and adverse ...

journal_title：Current opinion in nephrology and hypertension

authors： Wald R,Thorpe KE,Walsh MW

更新日期：2019-01-01 00:00:00