Dopamine action and metabolism in the kidney.

abstract：:The cellular and molecular mechanisms whereby hypertension causes vascular and cardiac disease are beginning to be understood. Angiotensin II, perhaps because so many probes to explore its action are available, is emerging as a central pathogenetic factor in the development of both vascular and cardiac hypertrophy. It...

journal_title：Current opinion in nephrology and hypertension

authors： Oliver JA

更新日期：1993-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Epithelial sodium channels mediate Na+ transport across high resistance, Na+-transporting epithelia. This review describes recent findings that indicate that epithelial sodium channels are activated by the proteolytic release of inhibitory peptides from the alpha and gamma subunits. RECENT FINDINGS:N...

journal_title：Current opinion in nephrology and hypertension

authors： Hughey RP,Carattino MD,Kleyman TR

更新日期：2007-09-01 00:00:00

abstract：:Ischemic nephropathy is a major cause of chronic renal failure in people over 50 years of age. In addition, renal artery stenosis is associated with increased mortality, particularly if renal or cardiac function is compromised. The diagnosis is made both by clinical characteristics and imaging studies. At present, dup...

journal_title：Current opinion in nephrology and hypertension

authors： Tuttle KR

更新日期：2001-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Disturbances in mineral metabolism are common among individuals with chronic kidney disease and have consistently been associated with cardiovascular and bone disease. The current review aims to describe the current knowledge of the genetic aspects of mineral metabolism disturbances and to suggest dir...

journal_title：Current opinion in nephrology and hypertension

authors： Robinson-Cohen C

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Over the past decade post-hoc analyses of clinical trials and observational studies have tended to show that participants treated with thiazide diuretics are at greater risk for newly diagnosed diabetes mellitus than those treated with other medication classes. We review the results of several recent ...

journal_title：Current opinion in nephrology and hypertension

authors： Barzilay JI,Cutler JA,Davis BR

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will critically highlight the role of leukotrienes as mediators of renal diseases and drug nephrotoxicity. It will also discuss the recently identified mechanism of cysteinyl leukotrienes induction and action, and will propose clinical implementation of these findings. RECENT FINDINGS:Sin...

journal_title：Current opinion in nephrology and hypertension

authors： Rubinstein M,Dvash E

更新日期：2018-01-01 00:00:00

abstract：:Experimental animal models and cell culture techniques, highlighting the central role of glucose metabolism, have provided important insight into the pathogenesis of diabetic nephropathy. Microalbuminuria and other candidate phenotypic or genotypic markers for the early onset of disease are discussed. Management recom...

journal_title：Current opinion in nephrology and hypertension

authors： Mogyorósi A,Ziyadeh FN

更新日期：1996-05-01 00:00:00

abstract：:The cardinal feature of systemic lupus erythematosus is the formation of anti-nuclear antibodies. In recent years, it has become clear that the nucleosome is a major autoantigen that drives this T cell-dependent autoimmune response, as exemplified by the presence of nucleosome-specific T helper cells and the high prev...

journal_title：Current opinion in nephrology and hypertension

authors： Berden JH,Licht R,van Bruggen MC,Tax WJ

更新日期：1999-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Incretin mimetics, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as dipeptidyl peptidase-IV (DPP-IV) inhibitors, are used in the treatment of type 2 diabetes mellitus (T2DM). In addition to stimulating insulin secretion from pancreatic β cells,...

journal_title：Current opinion in nephrology and hypertension

authors： Tanaka T,Nangaku M,Nishiyama A

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate homeostasis is tightly controlled by the coordinated activity of bone, kidney, intestine, and parathyroid gland. The renal phosphate transporters have emerged as key regulators of both total body phosphate homeostasis and serum phosphate concentration. This review focuses on the latest updat...

journal_title：Current opinion in nephrology and hypertension

authors： Lederer E

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:There is currently a major debate on the mechanisms of albuminuria, and this review appraises recent studies in this area. RECENT FINDINGS:The traditional view of albuminuria is that it is the result of damage to an essentially impermeable glomerular barrier. However, over the years, critical evidenc...

journal_title：Current opinion in nephrology and hypertension

authors： Comper WD,Russo LM

更新日期：2009-07-01 00:00:00

abstract：:Recent insights into the etiopathogenesis of nephritogenic immune responses are derived primarily from experimental models of systemic and organ-specific autoimmunity. Genetic analyses and immune-related gene ablation studies indicate that multiple independent mechanisms determine disease susceptibility. However, full...

journal_title：Current opinion in nephrology and hypertension

authors： Fitzsimons MM,Foster MH

更新日期：1997-05-01 00:00:00

abstract：:There has been an increasing focus on renovascular disease, particularly in renal failure, and on the role of renal angioplasty and stenting. Significant improvements have occurred in non-invasive imaging techniques. This review concentrates on the recent developments in imaging that specifically targets the renal art...

journal_title：Current opinion in nephrology and hypertension

authors： Reidy JF

更新日期：2002-11-01 00:00:00

abstract：:Growth hormone and a number of polypeptide growth factors exert actions on renal development, growth, and metabolism and on repair processes following renal injury. There is increasing evidence that under selected circumstances, these agents play roles in the pathogenesis of kidney disease and that under others, they ...

journal_title：Current opinion in nephrology and hypertension

authors： O'Shea M,Miller SB,Finkel K,Hammerman MR

更新日期：1993-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The review will examine clinically relevant advances in the area of polycystic kidney disease (PKD), mainly focusing on autosomal dominant polycystic kidney disease (ADPKD). Discussion will focus on predicting the course of ADPKD, clinical trials and new research endeavors. RECENT FINDINGS:During the...

journal_title：Current opinion in nephrology and hypertension

authors： Steinman TI

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of 'cumulative metabolic stress'. This article discusses mechanisms of AGE formation and reviews published literature on SAF as a biomarker and risk factor across the spec...

journal_title：Current opinion in nephrology and hypertension

authors： Viramontes Hörner D,Taal MW

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Neutrophil gelatinase-associated lipocalin (NGAL) is a member of the lipocalin superfamily of carrier proteins. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. Here, we review the expression, siderophore-...

journal_title：Current opinion in nephrology and hypertension

authors： Schmidt-Ott KM,Mori K,Kalandadze A,Li JY,Paragas N,Nicholas T,Devarajan P,Barasch J

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear transcription factor that regulates many important physiological processes including glucose and lipid metabolism, energy homeostasis, cell proliferation, inflammation, immunity and reproduction. The current review ...

journal_title：Current opinion in nephrology and hypertension

authors： Yang J,Zhou Y,Guan Y

更新日期：2012-01-01 00:00:00

abstract：:An increasing number of population-based studies and clinical trials have examined the role of blood pressure in renal disease. Recent reports indicate that elevations of blood pressure, even within the normotensive range, may result in renal damage. The available evidence suggests that blood pressure reduction dimini...

journal_title：Current opinion in nephrology and hypertension

authors： Perneger TV,Whelton PK

更新日期：1993-05-01 00:00:00

abstract：PURPOSE OF THIS REVIEW:The purpose of this review is to explain the rationale and limitations for use of mineralocorticoid receptor blockers (MRBs) for the treatment of chronic kidney disease (CKD) and its complications. RECENT FINDINGS:Recent studies in animal models of CKD demonstrate that blockade of the mineraloco...

journal_title：Current opinion in nephrology and hypertension

authors： Toto RD

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies of patients with tumors associated with osteomalacia (tumor-induced osteomalacia), X-linked hypophosphatemia (XLH) and autosomal-dominant hypophosphatemic rickets have provided important new insights into the identity and mechanisms of action of factors that play a role in controlling renal ph...

journal_title：Current opinion in nephrology and hypertension

authors： Kumar R

更新日期：2002-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Arterial calcification in chronic kidney disease (CKD) is associated with increased cardiovascular risk. The mechanisms responsible for arterial calcification include alterations of mineral metabolism and expression of mineral-regulating proteins. RECENT FINDINGS:Arterial calcification is similar to ...

journal_title：Current opinion in nephrology and hypertension

authors： London GM,Marchais SJ,Guérin AP,Métivier F

更新日期：2005-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Dialysis has been the prevailing treatment paradigm in advanced chronic kidney disease (CKD) for patients ineligible for or unlikely to receive kidney transplantation. As dialysis may neither offer survival benefit nor improved quality of life in certain groups, there has been increasing interest in c...

journal_title：Current opinion in nephrology and hypertension

authors： Rhee CM,Nguyen DV,Nyamathi A,Kalantar-Zadeh K

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Phosphate lowering toward the normal range is advocated and widely practiced in patients with end-stage renal disease receiving dialysis. This approach is guided by basic science data and large observational studies that have demonstrated a consistent association between hyperphosphatemia and adverse ...

journal_title：Current opinion in nephrology and hypertension

authors： Wald R,Thorpe KE,Walsh MW

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Klotho is a transmembrane protein that acts as a co-receptor for fibroblast growth factor 23 (FGF23). Recent investigations have discovered the presence of Klotho in bone-forming osteoblasts and osteocytes. This review summarizes emerging literature on the roles of bone Klotho in mineral and bone meta...

journal_title：Current opinion in nephrology and hypertension

authors： Komaba H,Lanske B

更新日期：2018-07-01 00:00:00

abstract：:Secondary hyperparathyroidism remains the predominant histologic lesion in pediatric patients undergoing regular dialysis, but recent evidence indicates that the regulation of parathyroid hormone secretion by calcium does not differ substantially between patients with osteitis fibrosa and subjects with normal renal fu...

journal_title：Current opinion in nephrology and hypertension

authors： Salusky IB,Ramirez JA,Goodman WG

更新日期：1993-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although glomerular cell apoptosis may be detrimental in acute and chronic inflammation, it is also a key component of the reparative glomerular remodelling that can follow injury. All glomerular cells are vulnerable to apoptosis although there are often differences in the nature of the initiating sti...

journal_title：Current opinion in nephrology and hypertension

authors： Hughes J,Savill JS

更新日期：2005-07-01 00:00:00

abstract：:Our basic understanding of sodium mechanisms provides unique insights into epithelial transport processes, and unusual clinical syndromes can arise from mutations of these ion transporters. These genetic disorders affect sodium balance, with both sodium-retaining and sodium-wasting conditions being the consequence. A ...

journal_title：Current opinion in nephrology and hypertension

authors： Warnock DG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The calcium-sensing receptor gene (CaSR, chr. 3q13.3-21) is a candidate to explain nephrolithiasis. This review analyzes the potential role of CaSR in lithogenesis according to findings of functional and genetic studies. RECENT FINDINGS:CaSR is a cation receptor located in the tubular cell plasma mem...

journal_title：Current opinion in nephrology and hypertension

authors： Vezzoli G,Terranegra A,Soldati L

更新日期：2012-07-01 00:00:00

abstract：:It has been 6 years since the first reports of the use of recombinant human erythropoietin for the treatment of renal anemia appeared in the medical literature. During this period, erythropoietin has become established as a safe and highly effective therapy, and it is currently being evaluated for other nonrenal types...

journal_title：Current opinion in nephrology and hypertension

authors： Macdougall IC

更新日期：1992-12-01 00:00:00