Association of frailty with mortality in older inpatients with Covid-19: a cohort study.

Abstract:

BACKGROUND:COVID-19 has disproportionately affected older people. OBJECTIVE:The objective of this paper to investigate whether frailty is associated with all-cause mortality in older hospital inpatients, with COVID-19. DESIGN:Cohort study. SETTING:Secondary care acute hospital. PARTICIPANTS:Participants included are 677 consecutive inpatients aged 65 years and over. METHODS:Cox proportional hazards models were used to examine the association of frailty with mortality. Frailty was assessed at baseline, according to the Clinical Frailty Scale (CFS), where higher categories indicate worse frailty. Analyses were adjusted for age, sex, deprivation, ethnicity, previous admissions and acute illness severity. RESULTS:Six hundred and sixty-four patients were classified according to CFS. Two hundred and seventy-one died, during a mean follow-up of 34.3 days. Worse frailty at baseline was associated with increased mortality risk, even after full adjustment (P = 0.004). Patients with CFS 4 and CFS 5 had non-significant increased mortality risks, compared to those with CFS 1-3. Patients with CFS 6 had a 2.13-fold (95% CI 1.34-3.38) and those with CFS 7-9 had a 1.79-fold (95% CI 1.12-2.88) increased mortality risk, compared to those with CFS 1-3 (P = 0.001 and 0.016, respectively). Older age, male sex and acute illness severity were also associated with increased mortality risk. CONCLUSIONS:Frailty is associated with all-cause mortality risk in older inpatients with COVID-19.

journal_name

Age Ageing

journal_title

Age and ageing

authors

Aw D,Woodrow L,Ogliari G,Harwood R

doi

10.1093/ageing/afaa184

subject

Has Abstract

pub_date

2020-10-23 00:00:00

pages

915-922

issue

6

eissn

0002-0729

issn

1468-2834

pii

5890511

journal_volume

49

pub_type

杂志文章
  • Confidentiality and cognitive impairment: professional and philosophical ethics.

    abstract::In the UK, the General Medical Council's new guidance on confidentiality restates the professional duty for doctors to regard personal information revealed to them as confidential. Such information can be shared only with the patient's explicit consent--the exceptions to this are narrowly defined. We believe the guida...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/31.2.147

    authors: Hughes JC,Louw SJ

    更新日期:2002-03-01 00:00:00

  • Investigation of ward fidelity to a multicomponent delirium prevention intervention during a multicentre, pragmatic, cluster randomised, controlled feasibility trial.

    abstract:BACKGROUND:delirium is a frequent complication of hospital admission for older people and can be reduced by multicomponent interventions, but implementation and delivery of such interventions is challenging. OBJECTIVE:to investigate fidelity to the prevention of delirium system of care within a multicentre, pragmatic,...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa042

    authors: Smith J,Green J,Siddiqi N,Inouye SK,Collinson M,Farrin A,Young J

    更新日期:2020-07-01 00:00:00

  • Severity of age-related hearing loss is associated with impaired activities of daily living.

    abstract:BACKGROUND:age-related hearing loss is a common chronic condition; hence, it is important to understand its influence on the functional status of older adults. We assessed the association between hearing impairment with activity limitations as assessed by the activities of daily living (ADL) scale. METHODS:a total of ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afr155

    authors: Gopinath B,Schneider J,McMahon CM,Teber E,Leeder SR,Mitchell P

    更新日期:2012-03-01 00:00:00

  • Evidence for the validity of the Short-form 36 Questionnaire (SF-36) in an elderly population.

    abstract::The objective of this study was to determine whether the Short-form 36 Health Status Questionnaire (SF-36) is suitable for use in an elderly population. The SF-36 was administered by interview to a random sample of 827 adults from West Glamorgan. Among the 216 adults aged 65 and over the data were 98.8% complete. Evid...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/23.3.182

    authors: Lyons RA,Perry HM,Littlepage BN

    更新日期:1994-05-01 00:00:00

  • Temporal trends in impairments of physical function among older adults during 2001-16 in Sweden: towards a healthier ageing.

    abstract:Background:a trend towards decline in disability has been reported in older adults, but less is known about corresponding temporal trends in measured physical functions. Objective:to verify these trends during 2001-16 in an older Swedish population. Methods:functional status was assessed at three occasions: 2001-04 (...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afy085

    authors: Santoni G,Angleman SB,Ek S,Heiland EG,Lagergren M,Fratiglioni L,Welmer AK

    更新日期:2018-09-01 00:00:00

  • An unusual presentation of sporadic Creutzfeldt-Jakob disease.

    abstract::Sporadic Creutzfeld-Jakob disease (CJD) is a rare neurodegenerative disorder. It is uniformly fatal. Clinical signs include myoclonus, visual disturbances, cerebellar ataxia, akinetic mutism and pyramidal/extrapyramidal signs in addition to a rapidly progressive dementia. Premortem diagnosis is challenging due to the ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa013

    authors: Podger H,Ipe A

    更新日期:2020-04-27 00:00:00

  • Circulating oxidised LDL lipids, when proportioned to HDL-c, emerged as a risk factor of all-cause mortality in a population-based survival study.

    abstract:BACKGROUND AND OBJECTIVE:the data concerning the predictive role of oxidised LDL (ox-LDL) in all-cause mortality are scarce. We investigated whether circulating ox-LDL would stand out as a risk factor of total mortality in the elderly. Study subjects, design and methods: a total of 1,260 elderly inhabitants (533 men, 7...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afs074

    authors: Linna M,Ahotupa M,Löppönen MK,Irjala K,Vasankari T

    更新日期:2013-01-01 00:00:00

  • Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial.

    abstract:BACKGROUND:cranberry juice is often given to older people in hospital to prevent urinary tract infection (UTI), although there is little evidence to support its use. OBJECTIVE:to assess whether cranberry juice ingestion is effective in reducing UTIs in older people in hospital. DESIGN:randomised, placebo-controlled, ...

    journal_title:Age and ageing

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ageing/afi101

    authors: McMurdo ME,Bissett LY,Price RJ,Phillips G,Crombie IK

    更新日期:2005-05-01 00:00:00

  • Changing attitudes to cardiopulmonary resuscitation in older people: a 15-year follow-up study.

    abstract:BACKGROUND:while it is well established that individual patient preferences regarding cardiopulmonary resuscitation (CPR) may change with time, the stability of population preferences, especially during periods of social and economic change, has received little attention. OBJECTIVE:to elicit the resuscitation preferen...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afn291

    authors: Cotter PE,Simon M,Quinn C,O'Keeffe ST

    更新日期:2009-03-01 00:00:00

  • Dysphagia treatment post stroke: a systematic review of randomised controlled trials.

    abstract:BACKGROUND:dysphagia is common following stroke and is associated with the development of pneumonia. Many dysphagia treatment options are available, some still experimental and others already rooted in common practice. Previous reviews of these treatments were limited due to a dearth of available studies. Recently, mor...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afn064

    authors: Foley N,Teasell R,Salter K,Kruger E,Martino R

    更新日期:2008-05-01 00:00:00

  • Dementia in resuscitation policy: a prospective study of a psychogeriatric ward in a Dutch general teaching hospital.

    abstract::Resuscitation decisions during the first 6 weeks were analysed for 97 admissions to a psychogeriatric ward of a general teaching hospital. Seventy-seven patients (79%) had a written 'do not resuscitate' (DNR) order on admission and 74 patients (875) had a written DNR order after 6 weeks. Morbidity was assessed with a ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/25.3.234

    authors: Dautzenberg PL,Hooyer C,Schonwetter RS,Dermout KM,vd Veer JK,Duursma SA

    更新日期:1996-05-01 00:00:00

  • Impairments in hearing and vision impact on mortality in older people: the AGES-Reykjavik Study.

    abstract:OBJECTIVE:to examine the relationships between impairments in hearing and vision and mortality from all-causes and cardiovascular disease (CVD) among older people. DESIGN:population-based cohort study. PARTICIPANTS:the study population included 4,926 Icelandic individuals, aged ≥67 years, 43.4% male, who completed vi...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft122

    authors: Fisher D,Li CM,Chiu MS,Themann CL,Petersen H,Jónasson F,Jónsson PV,Sverrisdottir JE,Garcia M,Harris TB,Launer LJ,Eiriksdottir G,Gudnason V,Hoffman HJ,Cotch MF

    更新日期:2014-01-01 00:00:00

  • The Short FES-I: a shortened version of the falls efficacy scale-international to assess fear of falling.

    abstract:BACKGROUND:the 16-item Falls Efficacy Scale-International (FES-I) has been shown to have excellent reliability and construct validity. However, for practical and clinical purposes, a shortened version of the FES-I would be useful. OBJECTIVE:to develop and validate a shortened version of FES-I while preserving good psy...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afm157

    authors: Kempen GI,Yardley L,van Haastregt JC,Zijlstra GA,Beyer N,Hauer K,Todd C

    更新日期:2008-01-01 00:00:00

  • Experiences of Japanese aged care: the pursuit of optimal health and cultural engagement.

    abstract::Japan is a super-ageing society that faces pressures on its aged care system from a growing population of older adults. Naturalistic observations were undertaken at eight aged care facilities in central and northern Japan to explore how aged care is configured. Four aspects of contemporary provision were identified th...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afw144

    authors: Annear MJ,Otani J,Sun J

    更新日期:2016-11-01 00:00:00

  • Myocardial contractility in aged rats.

    abstract::The elastic and mechanical behaviour of isolated papillar muscle was studied in aged and in young rats. The spontaneous fall in tension (stress relaxation phenomenon) and the duration of the active state of the contractile element during the isometric and isotonic contraction were greater in aged than in young rats. T...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/5.2.71

    authors: Minelli R,Reggiani C,De Nicola P

    更新日期:1976-05-01 00:00:00

  • Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia.

    abstract:BACKGROUND:Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dementia including diabetes, stroke, heart diseases and hypertension. The ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa111

    authors: Zheng L,Matthews FE,Anstey KJ

    更新日期:2021-01-08 00:00:00

  • A systematic review of outcomes following emergency transfer to hospital for residents of aged care facilities.

    abstract:BACKGROUND:residential aged care facility (RACF) resident numbers are increasing. Residents are frequently frail with substantial co-morbidity, functional and cognitive impairment with high susceptibility to acute illness. Despite living in facilities staffed by health professionals, a considerable proportion of reside...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/afu117

    authors: Dwyer R,Gabbe B,Stoelwinder JU,Lowthian J

    更新日期:2014-11-01 00:00:00

  • Health-related quality of life and antihypertensive medication adherence among older adults.

    abstract:PURPOSE:health-related quality of life (HRQOL) is an important psycho-social characteristic which may impact an individual's ability to manage their chronic disease. We examined the association between HRQOL and antihypertensive medication adherence in older adults. METHODS:participants were part of a cohort study of ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afq040

    authors: Holt EW,Muntner P,Joyce CJ,Webber L,Krousel-Wood MA

    更新日期:2010-07-01 00:00:00

  • Age-associated change in pain threshold measured by transcutaneous neuronal electrical stimulation.

    abstract::The measurement of cutaneous pain threshold using the Neuromod Selectra Model 7750 Transcutaneous Neuronal Electrical Stimulator is described. Pain threshold, measured in 520 healthy volunteers aged 5-105 years, increased with age. Consistent values were obtained in 22 healthy volunteers on three successive days. Pain...

    journal_title:Age and ageing

    pub_type: 杂志文章,评审

    doi:10.1093/ageing/18.4.241

    authors: Tucker MA,Andrew MF,Ogle SJ,Davison JG

    更新日期:1989-07-01 00:00:00

  • Smoking cessation in late life is associated with increased risk of all-cause mortality amongst oldest old people: a community-based prospective cohort study.

    abstract:OBJECTIVE:we aimed to investigate the association of smoking cessation with risk of all-cause mortality amongst oldest old people (aged ≥ 80 years). DESIGN:this was a prospective cohort study. SETTING:the Chinese Longitudinal Healthy Longevity Survey, implemented in 23 provinces of China. PARTICIPANTS:a total of 28,...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afaa280

    authors: Wei Y,Lv Y,Zhou J,Gao X,Duan J,Zhao C,Yin Z,Kang Q,Wu B,Chen C,Mao C,Li J,Shi X

    更新日期:2021-01-23 00:00:00

  • Factors associated with self- and informant ratings of quality of life, well-being and life satisfaction in people with mild-to-moderate dementia: results from the Improving the experience of Dementia and Enhancing Active Life programme.

    abstract:BACKGROUND:a large number of studies have explored factors related to self- and informant ratings of quality of life in people with dementia, but many studies have had relatively small sample sizes and mainly focused on health conditions and dementia symptoms. The aim of this study is to compare self- and informant-rat...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afz177

    authors: Wu YT,Nelis SM,Quinn C,Martyr A,Jones IR,Victor CR,Knapp M,Henderson C,Hindle JV,Jones RW,Kopelman MD,Morris RG,Pickett JA,Rusted JM,Thom JM,Litherland R,Matthews FE,Clare L,IDEAL Programme team.

    更新日期:2020-04-27 00:00:00

  • Slicing the health service cake: the Islington study.

    abstract:BACKGROUND:Little is known about the factors that are associated with receipt of care in older people. This study aims to describe the pattern and predictors of service usage, by a representative sample of people aged 65 and over. METHOD:We assessed psychiatric and physical morbidity, formal and informal care and pres...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/31.6.445

    authors: Nelson T,Livingston G,Knapp M,Manela M,Kitchen G,Katona C

    更新日期:2002-11-01 00:00:00

  • Bridging the gap: the effectiveness of teaming a stroke coordinator with patient's personal physician on the outcome of stroke.

    abstract:OBJECTIVES:to test the hypothesis as to whether persons newly discharged into the community following an acute stroke and assigned a stroke case manager would experience, compared to usual post-hospital care, better health-related quality of life (HRQL), fewer emergency room visits and less non-elective hospitalisation...

    journal_title:Age and ageing

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/ageing/afm133

    authors: Mayo NE,Nadeau L,Ahmed S,White C,Grad R,Huang A,Yaffe MJ,Wood-Dauphinee S

    更新日期:2008-01-01 00:00:00

  • The prevalence of faecal incontinence in older people living at home.

    abstract:BACKGROUND:faecal incontinence affects quality of life and causes caregiver strain. Patients are often reluctant to seek help because of embarrassment and perceived lack of effective treatment. Persisting faecal soiling may lead to unwanted and premature institutionalization. OBJECTIVE:to ascertain the prevalence of f...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/30.6.503

    authors: Edwards NI,Jones D

    更新日期:2001-11-01 00:00:00

  • Electrocardiographic abnormalities in the sick elderly.

    abstract::From a study of routine electrocardiography on 300 ill elderly patients in an acute geriatric unit, it is evident that the incidence of atrial fibrillation, ventricular extrasystoles, myocardial ischaemia and myocardial infarction is much higher than in the general population of similar age group. In females, the inci...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/6.3.163

    authors: Patel KP

    更新日期:1977-08-01 00:00:00

  • Bacterial surveillance cultures in a geriatric ward.

    abstract::A study was carried out to examine the prevalence of oropharyngeal and urinary tract colonization and to compare the colonizing bacteria with the strains causing nosocomial infections during patients' stays in a geriatric ward. Colonization with Gram-negative rods was not uncommon. Nosocomial infections frequently occ...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/22.3.221

    authors: Michielsen W,Vandevondele D,Verschraegen G,Claeys G,Afschrift M

    更新日期:1993-05-01 00:00:00

  • Inhaled therapy in elderly COPD patients; time for re-evaluation?

    abstract:OBJECTIVE:chronic obstructive pulmonary disease (COPD) prevalence steadily increases with age. However, the effectiveness of inhaled therapy in the elderly COPD population has rarely been formally evaluated. We studied a group of elderly patients with COPD with a range of severity, selected from one General Practice re...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/afl174

    authors: Jarvis S,Ind PW,Shiner RJ

    更新日期:2007-03-01 00:00:00

  • Alcohol and age.

    abstract::Alcohol consumption constitutes a substantial burden of disease. Older people are being admitted to hospital for alcohol problems in increasing numbers. A recent systematic review reports cautious supportive evidence for primary prevention interventions in reducing excessive alcohol consumption in older drinkers, but ...

    journal_title:Age and ageing

    pub_type: 评论,杂志文章

    doi:10.1093/ageing/afx191

    authors: Crome IB,Crome P

    更新日期:2018-03-01 00:00:00

  • Preparation to care for confused older patients in general hospitals: a study of UK health professionals.

    abstract:BACKGROUND AND OBJECTIVE:in the UK, two-thirds of patients in general hospitals are older than 70, of whom half have dementia or delirium or both. Our objective was to explore doctors, nurses and allied health professionals' perceptions of their preparation to care for confused older patients on general hospital wards....

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/aft171

    authors: Griffiths A,Knight A,Harwood R,Gladman JR

    更新日期:2014-07-01 00:00:00

  • Aged men and ischaemic heart disease: serum cholesterol and triglyceride levels.

    abstract::Fasting serum cholesterol and triglyceride levels, and lipoprotein electrophoretic patterns have been investigated in 42 men aged 67-92 years (mean 79 years). Although all the cholesterol and the majority of the triglyceride levels were within the normal range for younger people, both were significantly greater (P < 0...

    journal_title:Age and ageing

    pub_type: 杂志文章

    doi:10.1093/ageing/9.3.154

    authors: Horsey J,Livesley B,Dickerson JW

    更新日期:1980-08-01 00:00:00