Aromatase inhibitors attenuate the effect of alendronate in women with breast cancer.

abstract：:A T869-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene is reported to be associated with genetic susceptibility to both osteoporosis and vertebral fractures. A low serum 25-hydroxyvitamin D [25(OH)D] level is known to be associated with a higher risk for hip fracture. This study aimed to asse...

journal_title：Journal of bone and mineral metabolism

authors： Mori S,Fuku N,Chiba Y,Tokimura F,Hosoi T,Kimbara Y,Tamura Y,Araki A,Tanaka M,Ito H

更新日期：2010-07-01 00:00:00

abstract：:We have been using hormone replacement therapy (HRT) as the treatment of choice for menopausal symptoms and osteoporosis. Estrogen increases bone mineral density (BMD) for 2 or 3 years, and only maintains BMD thereafter. In the present study, we investigated whether BMD improved with HRT in combination with vitamin K(...

journal_title：Journal of bone and mineral metabolism

authors： Hidaka T,Hasegawa T,Fujimura M,Sakai M,Saito S

更新日期：2002-01-01 00:00:00

abstract：:Low levels of vitamin D nutrition (i.e., vitamin D insufficiency), which potentially cause osteoporosis, have been recognized as a common health problem for elderly people in European and North American countries, but there have been no studies on the prevalence of vitamin D insufficiency in Japan until recently. The ...

journal_title：Journal of bone and mineral metabolism

authors： Nakamura K

更新日期：2006-01-01 00:00:00

abstract：:Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference. Sixty female monke...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka M,Matsugaki A,Ishimoto T,Nakano T

更新日期：2016-03-01 00:00:00

abstract：:This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 yea...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Iidaka T,Oka H,Horii C,Kawaguchi H,Akune T,Nakamura K,Tanaka S

更新日期：2019-11-01 00:00:00

abstract：:In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, pr...

journal_title：Journal of bone and mineral metabolism

authors： Soen S,Fukunaga M,Sugimoto T,Sone T,Fujiwara S,Endo N,Gorai I,Shiraki M,Hagino H,Hosoi T,Ohta H,Yoneda T,Tomomitsu T,Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the R

更新日期：2013-05-01 00:00:00

abstract：:We have previously demonstrated the efficacy of therapeutic exercise for osteoarthritis (OA) of the knee. This study was performed to examine the additive effects of glucosamine or risedronate on the exercise therapy. In this study, 142 female patients with moderate OA of the knee, who had been recommended to undergo ...

journal_title：Journal of bone and mineral metabolism

authors： Kawasaki T,Kurosawa H,Ikeda H,Kim SG,Osawa A,Takazawa Y,Kubota M,Ishijima M

更新日期：2008-01-01 00:00:00

abstract：:There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...

journal_title：Journal of bone and mineral metabolism

authors： Kanaji A,Higashi M,Namisato M,Ando K,Nakagawa M,Yato Y,Ichinose H,Sakamaki T,Yamada H

更新日期：2005-01-01 00:00:00

abstract：:Measurements of bone biochemical markers are increasingly being used to evaluate the state of bone turnover in the management of bone metabolic diseases, especially osteoporosis. However, changes in the bone turnover rate vary with age. The aim of this study was to establish the laboratory reference range of serum bon...

journal_title：Journal of bone and mineral metabolism

authors： Pi YZ,Wu XP,Liu SP,Luo XH,Cao XZ,Xie H,Liao EY

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:This study aimed to examine long-term persistence in new users of oral bisphosphonates in a population-wide cohort in Manitoba, Canada. MATERIALS AND METHODS:A longitudinal observational study was conducted using administrative health data characterizing long-term bisphosphonate persistence in those who s...

journal_title：Journal of bone and mineral metabolism

authors： Friesen KJ,Bugden S,Falk J

更新日期：2020-05-01 00:00:00

abstract：:In Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindI...

journal_title：Journal of bone and mineral metabolism

authors： Mo XY,Cao CK,Xu FH,Liu MY,Li MX,Qin YJ,Zhou Q,Zhang YY,Deng HW

更新日期：2004-01-01 00:00:00

abstract：:The purpose of this study was to investigate the relationship between intervertebral disk degeneration and bone mass. Magnetic resonance imaging was performed to evaluate lumbar disk degeneration according to Thompson's classification (grades 1 and 2, normal disk; grades 3, 4, and 5, degenerated disk), and bone minera...

journal_title：Journal of bone and mineral metabolism

authors： Nanjo Y,Morio Y,Nagashima H,Hagino H,Teshima R

更新日期：2003-01-01 00:00:00

abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...

journal_title：Journal of bone and mineral metabolism

authors： Zanatta M,Valenti MT,Donatelli L,Zucal C,Dalle Carbonare L

更新日期：2012-11-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk o...

journal_title：Journal of bone and mineral metabolism

authors： Nakatsukasa K,Koyama H,Ouchi Y,Sakaguchi K,Fujita Y,Matsuda T,Kato M,Konishi E,Taguchi T

更新日期：2019-09-01 00:00:00

abstract：:In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-...

journal_title：Journal of bone and mineral metabolism

authors： Zhaojun W,Lin W,Zhenyong W,Jian W,Ran L

更新日期：2013-05-01 00:00:00

abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....

journal_title：Journal of bone and mineral metabolism

authors： Lopez Franco GE,Blank RD,Akhter MP

更新日期：2011-01-01 00:00:00

abstract：:Based on the relationship between bone strength, trabecular skeletal structure, and bone mineral density (BMD), structure parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra of elderly persons. The trabecular bone pattern of each bone block was b...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka T,Sakurai T,Kashima I

更新日期：2001-01-01 00:00:00

abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...

journal_title：Journal of bone and mineral metabolism

authors： Fujita Y,Iki M,Ikeda Y,Morita A,Matsukura T,Nishino H,Yamagami T,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2011-03-01 00:00:00

abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

journal_title：Journal of bone and mineral metabolism

authors： Yao GQ,Wu JJ,Troiano N,Insogna K

更新日期：2011-03-01 00:00:00

abstract：:We examined response to bone mineral density (BMD) gains in the MOVER study following treatment with intravenous (IV) ibandronate 1 mg/month, and investigated the characteristics of a non-responder group. At 1 year, responder rates for patients with BMD increases >0 % were similar with IV ibandronate 0.5 or 1 mg/month...

journal_title：Journal of bone and mineral metabolism

authors： Nakano T,Yamamoto M,Hashimoto J,Tobinai M,Yoshida S,Nakamura T

更新日期：2016-11-01 00:00:00

abstract：:Patients with MRI-proved acute painful vertebral fractures in whom conservative pain management fails are frequently referred for vertebroplasty. This study investigated the effects of treating osteoporosis on the mortality rate of patients with MRI-proved acute osteoporosis-related vertebral fractures who had undergo...

journal_title：Journal of bone and mineral metabolism

authors： Chen YC,Su FM,Cheng TT,Lin WC,Lui CC

更新日期：2016-05-01 00:00:00

abstract：:Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use ...

journal_title：Journal of bone and mineral metabolism

authors： Dai L,Xu M,Wu H,Xue L,Yuan D,Wang Y,Shen Z,Zhao H,Hu M

更新日期：2016-01-01 00:00:00

abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...

journal_title：Journal of bone and mineral metabolism

authors： Hishiya A,Watanabe K

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Etelcalcetide binds to the extracellular domain of the calcium-sensing receptor (CaSR), while cinacalcet binds to the 7-transmembrane domain of the CaSR; however, it is unknown, whether etelcalcetide has similar effects to cinacalcet on parathyroid hormone (PTH) secretion. MATERIALS AND METHODS:The PTH-ca...

journal_title：Journal of bone and mineral metabolism

authors： Hayashi N,Imanishi Y,Hirakawa T,Kobayashi I,Tateishi T,Miyaoka D,Nagata Y,Mori K,Morioka T,Inoue A,Harada K,Inaba M,Emoto M

更新日期：2020-11-16 00:00:00

abstract：:We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...

journal_title：Journal of bone and mineral metabolism

authors： Hoffmann DB,Sehmisch S,Hofmann AM,Eimer C,Komrakova M,Saul D,Wassmann M,Stürmer KM,Tezval M

更新日期：2017-01-01 00:00:00

abstract：:Rodent hindlimb unloading (HU) by tail-suspension is a model to investigate disuse-induced bone loss in vivo. Previously, we have shown that osteopontin (OPN, also known as Spp1) is required for unloading-induced bone loss. However, how unloading affects OPN expression in the body is not fully understood. Here, we exa...

journal_title：Journal of bone and mineral metabolism

authors： Ezura Y,Nagata J,Nagao M,Hemmi H,Hayata T,Rittling S,Denhardt DT,Noda M

更新日期：2015-01-01 00:00:00

abstract：:Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...

journal_title：Journal of bone and mineral metabolism

authors： Miki T,Nakatsuka K,Naka H,Kitatani K,Saito S,Masaki H,Tomiyoshi Y,Morii H,Nishizawa Y

更新日期：2003-01-01 00:00:00

abstract：:This study was carried out to evaluate the clinical validity and usefulness of serum tartrate-resistant fluoride-sensitive acid phosphatase (TrFsACP) activity using 2,6-dichloro-4-acetylphenyl phosphate as substrate at pH 6.2 in metabolic bone diseases. The mean Z-scores of TrFsACP activity in patients on hemodialysis...

journal_title：Journal of bone and mineral metabolism

authors： Nakanishi M,Yoh K,Uchida K,Maruo S,Rai SK,Matsuoka A

更新日期：1999-01-01 00:00:00

abstract：:Expression of the genes encoding bone morphogenetic proteins (BMPs), BMP type IA receptor (BMPR-1A), and rat distal-less homolog (rDlx) was studied in bone, callus, and the surrounding soft tissue following rat femoral closed fracture, using RT-PCR-based techniques. Before fracture, the genes encoding BMP-5, BMP-6, an...

journal_title：Journal of bone and mineral metabolism

authors： Yaoita H,Orimo H,Shirai Y,Shimada T

更新日期：2000-01-01 00:00:00

abstract：INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...

journal_title：Journal of bone and mineral metabolism

authors： Yamakita M,Ando D,Akiyama Y,Sato M,Suzuki K,Yamagata Z

更新日期：2019-11-01 00:00:00