当前位置： SCI文献检索 > JOURNAL OF BONE AND MINERAL METABOLISM期刊下所有文献 > Effectiveness of monthly intravenous ibandronate on the low responders to oral bisphosphonate: the MOVEMENT study.

Effectiveness of monthly intravenous ibandronate on the low responders to oral bisphosphonate: the MOVEMENT study.

Abstract：

:The MOVEMENT study was designed to assess the effectiveness of monthly intravenous ibandronate on bone mineral density (BMD) in daily clinical practice in Japanese patients with primary osteoporosis whose lumbar spine BMD did not increase despite oral bisphosphonate therapy. This study was a multicenter, prospective, interventional study (52 sites; August 2015 to March 2018). Patients aged ≥ 50 years with primary osteoporosis, evaluated as low responders to oral bisphosphonate treatment for 1-3 years, continued on their existing oral bisphosphonate or switched to monthly intravenous ibandronate (1 mg) for 12 months. The primary endpoint was change in lumbar spine BMD from baseline to 12 months in the intravenous ibandronate group (IV IBN). A total of 240 and 141 patients were enrolled in the IV IBN and oral bisphosphonate groups (OBP), respectively. At 12 months, a significant increase in mean percent change from baseline in lumbar spine BMD was observed in the IV IBN (2.70%). This change was also significant at 6 months (1.92%). Similarly, the change in total hip BMD showed a significant increase at 12 months (0.78%). In the IV IBN, the responder rate, percentage of patient whose change from baseline of lumbar spine BMD has greater than 0%, for lumbar spine BMD was high at both 6 (72.3%, 141/195 patients) and 12 (78.0%, 145/186 patients) months. No new safety concerns were observed in either treatment group. Treatment with intravenous ibandronate significantly increased lumbar spine BMD without any new safety concerns in Japanese patients with osteoporosis who showed low response to existing oral bisphosphonates.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Hagino H,Sakai A,Ikeda S,Imanishi Y,Tsurukami H,Nakajo S,Miyakoshi N

doi

10.1007/s00774-019-01005-z

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

1013-1023

issue

6

eissn

0914-8779

issn

1435-5604

pii

10.1007/s00774-019-01005-z

journal_volume

37

pub_type

临床试验,杂志文章,多中心研究

相关文献

JOURNAL OF BONE AND MINERAL METABOLISM文献大全
  • Effects of sciatic neurectomy on the femur in growing rats: application of peripheral quantitative computed tomography and Fourier transform infrared spectroscopy.

    abstract：:The effects of unilateral sciatic neurectomy (USN) on the development of the femur were studied in 15 growing Wistar-derived rats (age, 5 weeks). The rats were divided into four groups: USN-operated group (right femur), USN-nonoperated group (left femur), sham-operated group (right femur), and sham-nonoperated group (...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740050093

    authors： Yonezu H,Ikata T,Takata S,Shibata A

    更新日期：1999-01-01 00:00:00

  • Association of objectively measured physical activity and sedentary behavior with bone stiffness in peripubertal children.

    abstract：INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01021-z

    authors： Yamakita M,Ando D,Akiyama Y,Sato M,Suzuki K,Yamagata Z

    更新日期：2019-11-01 00:00:00

  • Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study.

    abstract：:The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00774-013-0529-7

    authors： Vasic J,Petranova T,Povoroznyuk V,Barbu CG,Karadzic M,Gojkovic F,Elez J,Winzenrieth R,Hans D,CulaficVojinovic V,Poiana C,Dzerovych N,Rashkov R,Dimic A

    更新日期：2014-09-01 00:00:00

  • Zinc signal: a new player in osteobiology.

    abstract：:Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies ha...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-012-0409-6

    authors： Fukada T,Hojyo S,Furuichi T

    更新日期：2013-03-01 00:00:00

  • CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations.

    abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0659-7

    authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

    更新日期：2006-01-01 00:00:00

  • The prevalence of Apo E4 genotype and its relationship to bone mineral density in Hong Kong Chinese.

    abstract：:Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 6...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0593-0

    authors： Wong SY,Lau EM,Li M,Chung T,Sham A,Woo J

    更新日期：2005-01-01 00:00:00

  • Serum homocysteine, folate and vitamin B12 in patients with Paget's disease of bone: the effect of zoledronic acid.

    abstract：:High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B(12) stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B(12) in patients with Paget's disease of bone (PDB) and the effect of zoledr...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0131-1

    authors： Polyzos SA,Anastasilakis AD,Efstathiadou Z,Litsas I,Kita M,Panagiotou A,Papatheodorou A,Arsos G,Moralidis E,Barmpalios G,Zafeiriadou E,Triantafillidou E,Makrigiannaki E,Terpos E

    更新日期：2010-05-01 00:00:00

  • Lactoferrin immuno-expression in human normal and neoplastic bone tissue.

    abstract：:Lactoferrin (Lf) expression was investigated by using a Lf monoclonal antibody in 50 formalin-fixed and paraffin-embedded human bone tumours [10 giant cell tumours (GCTs), 7 osteoid osteomas, 6 ossifying fibromas, 19 enchondromas, 2 chondroblastomas, 2 chondrosarcomas, 2 chondroblastic osteosarcomas, 1 myeloma and 1 a...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0044-z

    authors： Ieni A,Barresi V,Grosso M,Rosa MA,Tuccari G

    更新日期：2009-01-01 00:00:00

  • Peripheral computed tomography (pQCT) detected short-term effect of AAACa (heated oyster shell with heated algal ingredient HAI): a double-blind comparison with CaCO3 and placebo.

    abstract：:Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated under reduced pressure with addition of heated algal ingredient (HAI) (group A); AACa, the same preparation wit...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s007740070022

    authors： Fujita T,Fujii Y,Goto B,Miyauchi A,Takagi Y

    更新日期：2000-01-01 00:00:00

  • Alfacalcidol treatment increases bone mass from anticatabolic and anabolic effects on cancellous and cortical bone in intact female rats.

    abstract：:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without ex...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-008-0854-4

    authors： Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

    更新日期：2008-01-01 00:00:00

  • Bone metabolism and the muscle-bone relationship in children, adolescents and young adults with phenylketonuria.

    abstract：:The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0216-x

    authors： Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

    更新日期：2011-03-01 00:00:00

  • Low calcium intake is associated with decreased adrenal androgens and reduced bone age in premenarcheal girls in the last pubertal stages.

    abstract：:In 50 premenarcheal girls selected from the lowest and highest end of the calcium-intake distribution of a large population sample, we evaluated bone mineral density (BMD), together with the following hormonal-metabolic parameters: androstenedione (ASD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (D...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0451-5

    authors： Bonofiglio D,Garofalo C,Catalano S,Marsico S,Aquila S,Andò S

    更新日期：2004-01-01 00:00:00

  • The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients.

    abstract：:It has been suggested that there are several possible linkages between vascular calcification and osteoporosis. In addition, the processes of vascular calcification may have a common etiology with bone formation. Thus, we hypothesized that the serum levels of bone metabolic markers would be different between osteoporo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0528-9

    authors： Iba K,Takada J,Yamashita T

    更新日期：2004-01-01 00:00:00

  • Adequate vitamin D status and adiposity contribute to bone health in peripubertal nonobese children.

    abstract：:The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-012-0419-4

    authors： Lee YA,Kim JY,Kang MJ,Chung SJ,Shin CH,Yang SW

    更新日期：2013-05-01 00:00:00

  • Effect of periosteal reaction in medication-related osteonecrosis of the jaw on treatment outcome after surgery.

    abstract：INTRODUCTION:Surgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01154-6

    authors： Soutome S,Yanamoto S,Sumi M,Hayashida S,Kojima Y,Sawada S,Rokutanda S,Iwai H,Saito T,Umeda M

    更新日期：2020-10-12 00:00:00

  • Interindividual and intraspecimen variability of 3-D bone microarchitectural parameters in iliac crest biopsies imaged by conventional micro-computed tomography.

    abstract：:Bone microarchitecture of the iliac bone is used to characterize the properties of bone tissue in osteoporosis, particularly in pharmacological studies. Trabecular bone is known to be heterogeneous media. For a few years, the analysis of three-dimensional (3-D) bone microarchitecture has been based on micro-computed t...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-008-0856-2

    authors： Chappard C,Marchadier A,Benhamou L

    更新日期：2008-01-01 00:00:00

  • Etelcalcetide decreases the PTH-calcium setpoint without changing maximum and minimum PTH secretion in mice with primary hyperparathyroidism.

    abstract：INTRODUCTION:Etelcalcetide binds to the extracellular domain of the calcium-sensing receptor (CaSR), while cinacalcet binds to the 7-transmembrane domain of the CaSR; however, it is unknown, whether etelcalcetide has similar effects to cinacalcet on parathyroid hormone (PTH) secretion. MATERIALS AND METHODS:The PTH-ca...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01169-z

    authors： Hayashi N,Imanishi Y,Hirakawa T,Kobayashi I,Tateishi T,Miyaoka D,Nagata Y,Mori K,Morioka T,Inoue A,Harada K,Inaba M,Emoto M

    更新日期：2020-11-16 00:00:00

  • Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.

    abstract：:Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-006-0723-y

    authors： Sato T,Watanabe K,Masuhara M,Hada N,Hakeda Y

    更新日期：2007-01-01 00:00:00

  • Aromatase inhibitors attenuate the effect of alendronate in women with breast cancer.

    abstract：INTRODUCTION:Aromatase inhibitors are known to accelerate bone loss in patients with breast cancer. However, how much AIs affect the efficacy of antiresorptive agents has not been studied. The study aimed to compare the effect of alendronate on bone mineral density (BMD) between patients with and without AI treatment. ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01111-3

    authors： Kong SH,Kim JH,Kim SW,Shin CS

    更新日期：2020-09-01 00:00:00

  • Effects of interleukin-11 on the expression of human bone sialoprotein gene.

    abstract：:Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0576-8

    authors： Matsumura H,Nakayama Y,Takai H,Ogata Y

    更新日期：2015-03-01 00:00:00

  • Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis.

    abstract：:The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 6...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00774-017-0861-4

    authors： Ebina K,Hirao M,Hashimoto J,Hagihara K,Kashii M,Kitaguchi K,Matsuoka H,Iwahashi T,Chijimatsu R,Yoshikawa H

    更新日期：2018-07-01 00:00:00

  • Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia.

    abstract：:Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect o...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00774-015-0728-5

    authors： Siviero-Miachon AA,Spinola-Castro AM,de Martino Lee ML,Calixto AR,Geloneze B,Lazaretti-Castro M,Guerra-Junior G

    更新日期：2017-01-01 00:00:00

  • Structuring of parameters for assessing vertebral bone strength by star volume analysis using a morphological filter.

    abstract：:Based on the relationship between bone strength, trabecular skeletal structure, and bone mineral density (BMD), structure parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra of elderly persons. The trabecular bone pattern of each bone block was b...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170035

    authors： Tanaka T,Sakurai T,Kashima I

    更新日期：2001-01-01 00:00:00

  • Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women.

    abstract：:In Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindI...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0478-7

    authors： Mo XY,Cao CK,Xu FH,Liu MY,Li MX,Qin YJ,Zhou Q,Zhang YY,Deng HW

    更新日期：2004-01-01 00:00:00

  • Genetic factors influencing bone mineral content in a black South African population.

    abstract：:Bone mass differs according to ethnic classification, with individuals of African ancestry attaining the highest measurements across numerous skeletal sites. Elevated bone mass is even maintained in those individuals exposed to adverse environmental factors, suggesting a prominent genetic effect that may have clinical...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0431-3

    authors： May A,Pettifor JM,Norris SA,Ramsay M,Lombard Z

    更新日期：2013-11-01 00:00:00

  • Incidence of osteonecrosis of the jaw in Japanese osteoporosis patients taking minodronic acid.

    abstract：:Osteonecrosis of the jaw (ONJ) associated with bisphosphonate therapy is a rare but severe side effect in osteoporosis patients. Recently, the number of osteoporosis patients with ONJ has dramatically increased in Japan. This has contributed to an increase in the number of patients avoiding extractions. However, there...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00774-019-00990-5

    authors： Taguchi A,Uemura Y,Imai T,Tanaka S,Ohta H,Nakamura T,Orimo H,Sugimoto T,Soen S,Shiraki M,Adequate Treatment of Osteoporosis (A-TOP) research group.

    更新日期：2019-09-01 00:00:00

  • Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.

    abstract：:Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major differences t...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-016-0753-z

    authors： Pérez-Campo FM,May T,Zauers J,Sañudo C,Delgado-Calle J,Arozamena J,Berciano MT,Lafarga M,Riancho JA

    更新日期：2017-03-01 00:00:00

  • Tracking of appendicular bone mineral density for 6 years including the pubertal growth spurt: Japanese Population-based Osteoporosis kids cohort study.

    abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0213-0

    authors： Fujita Y,Iki M,Ikeda Y,Morita A,Matsukura T,Nishino H,Yamagami T,Kagamimori S,Kagawa Y,Yoneshima H

    更新日期：2011-03-01 00:00:00

  • A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident.

    abstract：:Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0482-5

    authors： Ishii T,Ito K,Kato S,Tsubokura M,Ochi S,Iwamoto Y,Saito Y

    更新日期：2013-11-01 00:00:00

  • Biochemical bone turnover markers are useful tools to assess changes in bone metabolism in marmosets.

    abstract：:This study was designed to investigate whether biochemical markers of bone resorption and formation could be determined in the serum and urine of marmosets (Callithrix jacchus), using standard laboratory chemistry methods and commercially available human kits. Consequently, the findings from this study will indicate w...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0469-8

    authors： Angeliewa A,Budde M,Schlachter M,Hoyle NR,Bauss F

    更新日期：2004-01-01 00:00:00