当前位置： SCI文献检索 > JOURNAL OF BONE AND MINERAL METABOLISM期刊下所有文献 > Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis.

Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis.

Abstract：

:The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 65.9 years, lumbar spine (LS) T score -1.8, femoral neck (FN) T score -2.3, dose and rate of taking oral prednisolone (3.6 mg/day) 75.8%, and prior BP treatment duration 40.0 months. The patients were allocated to (1) the BP-continue group (n = 80), (2) the switch-to-DMAb group (n = 74), or (3) the switch-to-TPTD group (n = 40). After 18 months, the increase in bone mineral density (BMD) was significantly greater in the switch-to-DMAb group than in the BP-continue group (LS 5.2 vs 2.3%, P < 0.01; FN 3.8 vs 0.0%, P < 0.01) and in the switch-to-TPTD group than in the BP-continue group (LS 9.0 vs 2.3%, P < 0.001; FN 4.9 vs 0.0%, P < 0.01). Moreover, the switch-to-TPTD group showed a higher LS BMD (P < 0.05) and trabecular bone score (TBS) (2.1 vs -0.7%; P < 0.05) increase than the switch-to-DMAb group. Clinical fracture incidence during this period was 8.8% in the BP-continue group, 4.1% in the switch-to-DMAb group, and 2.5% in the switch-to-TPTD group. Both the switch-to-DMAb group and the switch-to-TPTD group showed significant increases in LS and FN BMD, and the switch-to-TPTD group showed a higher increase in TBS compared to the BP-continue group at 18 months. Switching BPs to DMAb or TPTD in female RA may provide some useful osteoporosis treatment options.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Ebina K,Hirao M,Hashimoto J,Hagihara K,Kashii M,Kitaguchi K,Matsuoka H,Iwahashi T,Chijimatsu R,Yoshikawa H

doi

10.1007/s00774-017-0861-4

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

478-487

issue

4

eissn

0914-8779

issn

1435-5604

pii

10.1007/s00774-017-0861-4

journal_volume

36

pub_type

杂志文章,多中心研究

相关文献

JOURNAL OF BONE AND MINERAL METABOLISM文献大全
  • Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain.

    abstract：:The present study examined the early effects of prostaglandin (PG)E2 on proximal tibial metaphyses of 20-month-old Wistar male rats. PGE, was given to intact rats for 10 and 30 days at 3mg/kg/day. After multiple in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170057

    authors： Cui L,Ma YF,Yao W,Zhou H,Setterberg RB,Liang TC,Jee WS

    更新日期：2001-01-01 00:00:00

  • High prevalence of spine–femur bone mineral density discordance and comparison of vertebral fracture risk assessment using femoral neck and lumbar spine bone density in Korean patients.

    abstract：:The aim of this study was to evaluate the prevalence of spine–femur discordance, and to compare the effectiveness of femoral neck (FN) and lumbar spine (LS) bone mineral density (BMD) for estimation of the risk of vertebral fractures. Women who were evaluated with dual energy X-ray absorptiometry between January 2001 ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0512-3

    authors： Seok H,Kim KJ,Kim KM,Rhee Y,Cha BS,Lim SK

    更新日期：2014-07-01 00:00:00

  • Identification of the CLCN7 gene mutations in two Chinese families with autosomal dominant osteopetrosis (type II).

    abstract：:Here we report the identification of two different mutations in chloride channel 7 gene in two unrelated patients with autosomal dominant osteopetrosis type II. We determined that one patient (a 32-year-old woman) carried a heterozygous gene for a R767W mutation in exon 24, and another patient (a 17-year-old boy) carr...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0051-0

    authors： Zhang ZL,He JW,Zhang H,Hu WW,Fu WZ,Gu JM,Yu JB,Gao G,Hu YQ,Li M,Liu YJ

    更新日期：2009-01-01 00:00:00

  • Updated concept of sarcopenia based on muscle-bone relationship.

    abstract：:Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the stren...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-019-01048-2

    authors： Yakabe M,Hosoi T,Akishita M,Ogawa S

    更新日期：2020-01-01 00:00:00

  • Eldecalcitol reduces the risk of severe vertebral fractures and improves the health-related quality of life in patients with osteoporosis.

    abstract：:Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-012-0397-6

    authors： Hagino H,Takano T,Fukunaga M,Shiraki M,Nakamura T,Matsumoto T

    更新日期：2013-03-01 00:00:00

  • A significant induction of neutrophilic chemoattractants but not RANKL in synoviocytes stimulated with interleukin 17.

    abstract：:Interleukin 17 (IL-17) is a cytokine implicated in the promotion of osteoclastogenesis. Its effect has been believed not to be directly exerted on osteoclast precursors, but rather indirectly carried out via an induction of receptor activator of NF-κB ligand (RANKL), the osteoclast differentiation factor, on osteoclas...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0565-y

    authors： Ota M,Yanagisawa M,Tachibana H,Yokota K,Araki Y,Sato K,Mimura T

    更新日期：2015-01-01 00:00:00

  • Post-surgery cholecystectomy, hepatectomy, and pancreatectomy patients increase the risk of osteoporotic vertebral fracture.

    abstract：INTRODUCTION:Data is currently lacking regarding association between the cholecystectomy/hepatectomy/pancreatectomy and the development of osteoporotic fracture. A retrospective cohort study was conducted to investigate the relationship between cholecystectomy/hepatectomy/pancreatectomy and the subsequent risk of devel...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01129-7

    authors： Cheng WZ,Lin YL,Su YC,Lin MC,Tseng CH,Lin RM,Huang ST

    更新日期：2020-08-05 00:00:00

  • Number and severity of prevalent vertebral fractures and the risk of subsequent vertebral fractures in Japanese women with osteoporosis: results from the minodronate trial.

    abstract：:The aim was to evaluate the risk of new vertebral fractures with the increasing number and severity of prevalent vertebral fractures in women who received placebo or minodronate in a post hoc analysis of a 2-year randomized, double-blind, placebo-controlled study. The subjects were women aged 55-80 years old with 1-5 ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-013-0439-8

    authors： Hagino H,Shiraki M,Fukunaga M,Nakano T,Takaoka K,Ohashi Y,Nakamura T,Matsumoto T

    更新日期：2013-09-01 00:00:00

  • Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study.

    abstract：:This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 yea...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01012-0

    authors： Yoshimura N,Muraki S,Iidaka T,Oka H,Horii C,Kawaguchi H,Akune T,Nakamura K,Tanaka S

    更新日期：2019-11-01 00:00:00

  • Effects of interleukin-11 on the expression of human bone sialoprotein gene.

    abstract：:Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0576-8

    authors： Matsumura H,Nakayama Y,Takai H,Ogata Y

    更新日期：2015-03-01 00:00:00

  • High calcium, phosphate and calcitriol supplementation leads to an osteocyte-like phenotype in calcified vessels and bone mineralisation defect in uremic rats.

    abstract：:A link between vascular calcification and bone anomalies has been suggested in chronic kidney disease (CKD) patients with low bone turnover disease. We investigated the vascular expression of osteocyte markers in relation to bone microarchitecture and mineralization defects in a model of low bone turnover CKD rats wit...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-018-0919-y

    authors： Bisson SK,Ung RV,Picard S,Valade D,Agharazii M,Larivière R,Mac-Way F

    更新日期：2019-03-01 00:00:00

  • Abeta-2M-amyloidosis and related bone diseases.

    abstract：:Abeta-2M-amyloidosis is a type of systemic amyloidosis that is specifically seen in patients with chronic kidney diseases. The precursor protein of Abeta-2M-amyloid fibril is beta2-microglobulin, and its elevated serum level is the main cause of Abeta-2M-amyloidosis in patients with kidney failure. However, the precis...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-005-0669-5

    authors： Kazama JJ,Yamamoto S,Takahashi N,Ito Y,Maruyama H,Narita I,Gejyo F

    更新日期：2006-01-01 00:00:00

  • Expression of bone morphogenetic proteins and rat distal-less homolog genes following rat femoral fracture.

    abstract：:Expression of the genes encoding bone morphogenetic proteins (BMPs), BMP type IA receptor (BMPR-1A), and rat distal-less homolog (rDlx) was studied in bone, callus, and the surrounding soft tissue following rat femoral closed fracture, using RT-PCR-based techniques. Before fracture, the genes encoding BMP-5, BMP-6, an...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740050013

    authors： Yaoita H,Orimo H,Shirai Y,Shimada T

    更新日期：2000-01-01 00:00:00

  • CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations.

    abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0659-7

    authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

    更新日期：2006-01-01 00:00:00

  • High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery.

    abstract：:Serum 25-hydroxyvitamin D (25-OHD) concentrations are thought to accurately reflect vitamin D stores, and vitamin D deficiency causes secondary hyperparathyroidism, irreversible bone loss, and increased risk of fracture. Recent studies suggest that decrease of serum 25-OHD level in mothers could increase the risk of p...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-011-0264-x

    authors： Shibata M,Suzuki A,Sekiya T,Sekiguchi S,Asano S,Udagawa Y,Itoh M

    更新日期：2011-09-01 00:00:00

  • Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.

    abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0202-3

    authors： Yao GQ,Wu JJ,Troiano N,Insogna K

    更新日期：2011-03-01 00:00:00

  • Menin and bone metabolism.

    abstract：:Menin, a product of the MEN1 gene, is related to the ontogeny of several cancers such as MEN1 and sporadic endocrine tumors, although it is considered to be a tumor suppressor. Many proteins interact with menin, and it is involved in various biological functions in several tissues. Menin plays some physiological and p...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-012-0355-3

    authors： Kaji H

    更新日期：2012-07-01 00:00:00

  • Should COPD patients be routinely evaluated for bone mineral density?

    abstract：:There are many factors that increase the risk of osteoporosis, including smoking, malnutrition, vitamin D deficiency, hypogonadism, limited physical activity due to chronic disease, and corticosteroid therapy in chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate bone mineral density...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-002-0416-0

    authors： Karadag F,Cildag O,Yurekli Y,Gurgey O

    更新日期：2003-01-01 00:00:00

  • Causes of secondary hyperparathyroidism in a healthy population: the Tromsø study.

    abstract：:Secondary hyperparathyroidism (SHPT) develops as a compensatory mechanism when the body is in calcium deficit. SHPT may be harmful and has been associated with elevated blood pressure. The cause of SHPT could be low calcium intake, reduced intestinal calcium absorption, or increased excretion. However, the relative im...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0647-y

    authors： Saleh F,Jorde R,Sundsfjord J,Haug E,Figenschau Y

    更新日期：2006-01-01 00:00:00

  • Genetic factors influencing bone mineral content in a black South African population.

    abstract：:Bone mass differs according to ethnic classification, with individuals of African ancestry attaining the highest measurements across numerous skeletal sites. Elevated bone mass is even maintained in those individuals exposed to adverse environmental factors, suggesting a prominent genetic effect that may have clinical...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0431-3

    authors： May A,Pettifor JM,Norris SA,Ramsay M,Lombard Z

    更新日期：2013-11-01 00:00:00

  • Progeroid syndrome as a model for impaired bone formation in senile osteoporosis.

    abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-004-0517-z

    authors： Hishiya A,Watanabe K

    更新日期：2004-01-01 00:00:00

  • Prevalence and clinical features of Paget's disease of bone in Japan.

    abstract：:The present study aimed to evaluate the prevalence and clinical presentation of Paget's disease of bone (PDB) in Japan. As PDB is a very rare disease in Japan, a nationwide mail survey was conducted targeting doctors in the specialty most frequently diagnosing and treating PDB patients in Japan. First, the literature ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0670-z

    authors： Hashimoto J,Ohno I,Nakatsuka K,Yoshimura N,Takata S,Zamma M,Yabe H,Abe S,Terada M,Yoh K,Fukunaga M,Cooper C,Morii H,Yoshikawa H,Japanese Committee on Clinical Guidelines of Diagnosis and Treatment of Paget's Disease of Bone o

    更新日期：2006-01-01 00:00:00

  • Association of objectively measured physical activity and sedentary behavior with bone stiffness in peripubertal children.

    abstract：INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01021-z

    authors： Yamakita M,Ando D,Akiyama Y,Sato M,Suzuki K,Yamagata Z

    更新日期：2019-11-01 00:00:00

  • The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients.

    abstract：:It has been suggested that there are several possible linkages between vascular calcification and osteoporosis. In addition, the processes of vascular calcification may have a common etiology with bone formation. Thus, we hypothesized that the serum levels of bone metabolic markers would be different between osteoporo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-004-0528-9

    authors： Iba K,Takada J,Yamashita T

    更新日期：2004-01-01 00:00:00

  • Persistence with osteoporosis medication among newly-treated osteoporotic patients.

    abstract：:Low persistence with osteoporosis medication is associated with higher fracture risk. Previous studies estimated that 1-year persistence with osteoporosis medication is low. Our aim was to study persistence with osteoporosis medication among patients with long-term follow-up (to 5 years). The InterAction Database (IAD...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0440-2

    authors： van Boven JF,de Boer PT,Postma MJ,Vegter S

    更新日期：2013-09-01 00:00:00

  • MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis.

    abstract：:Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarth...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-014-0628-0

    authors： Jingsheng S,Yibing W,Jun X,Siqun W,Jianguo W,Feiyan C,Gangyong H,Jie C

    更新日期：2015-01-01 00:00:00

  • Osteoporosis following chronic constriction injury of sciatic nerve in rats.

    abstract：:Osteopathic changes sometimes occur in patients with complex regional pain syndrome (reflex sympathetic dystrophy and causalgia). We aimed to investigate whether such osteopathic changes occurred in rats with chronic constriction injury (CCI) of the sciatic nerve. A CCI of the sciatic nerve was established in a unilat...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740200012

    authors： Suyama H,Moriwaki K,Niida S,Maehara Y,Kawamoto M,Yuge O

    更新日期：2002-01-01 00:00:00

  • Bone mineral density and bone microarchitecture after long-term suppressive levothyroxine treatment of differentiated thyroid carcinoma in young adult patients.

    abstract：:Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or ad...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00774-015-0680-4

    authors： Mendonça Monteiro de Barros G,Madeira M,Vieira Neto L,de Paula Paranhos Neto F,Carvalho Mendonça LM,Corrêa Barbosa Lima I,Corbo R,Fleiuss Farias ML

    更新日期：2016-07-01 00:00:00

  • Multiscale investigation on the effects of additional weight bearing in combination with low-magnitude high-frequency vibration on bone quality of growing female rats.

    abstract：:This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-017-0827-6

    authors： Zhang T,Gao J,Fang J,Gong H

    更新日期：2018-03-01 00:00:00

  • Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.

    abstract：:Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhanc...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0513-2

    authors： Li X,Liu C,Liang W,Ye H,Chen W,Lin R,Li Z,Liu X,Wu M

    更新日期：2014-07-01 00:00:00