Alfacalcidol treatment increases bone mass from anticatabolic and anabolic effects on cancellous and cortical bone in intact female rats.

Abstract:

:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without exercise. Seventy-four, 8.5-month-old, intact female rats were orally treated with 0, 0.005, 0.025, 0.05, or 0.1 microg/kg alfacalcidol alone or in combination with raised cage (RC) exercise for 3 months. In vivo peripheral quantitative computerized tomography (pQCT) of the proximal tibial metaphyses (PTM) and ex vivo histomorphometric analyses of the PTM and tibial shaft (TX) were performed. Only the 0.1 microg alfacalcidol/kg dose proved to be anabolic. pQCT analysis showed that this dose increased total and cortical bone mineral content and density and trabecular bone mineral density. Histomorphometrically, it induced an anabolic response by increased trabecular mass and microarchitecture from stimulated cancellous bone and bone bouton formations, and suppressed bone resorption more than bone formation on the trabecular and endocortical surfaces, to produce a positive bone balance. A positive correlation between trabecular connectivity and bone bouton numbers occurred. These findings suggest alfacalcidol treatment augments bone mass by increased cancellous bone mass and improved trabecular architecture through its anticatabolic and anabolic properties in the intact adult female rat. Last, raised cage exercise alone or the combination of raised cage and alfacalcidol was no more effective than alfacalcidol alone.

journal_name

J Bone Miner Metab

authors

Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

doi

10.1007/s00774-008-0854-4

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

425-35

issue

5

eissn

0914-8779

issn

1435-5604

journal_volume

26

pub_type

杂志文章
  • Effects of basic fibroblast growth factor on osteoblast-related gene expression in the process of medullary bone formation induced in rat femur.

    abstract::The effects of basic fibroblast growth factor (bFGF) on osteogenic differentiation in-vivo were investigated using a rat bone marrow ablation model. bFGF was infused directly into rat femora for 6 days after bone marrow ablation. The contralateral femur was infused with vehicle only and used as control. Bone formation...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s007740300012

    authors: Tanaka H,Wakisaka A,Ogasa H,Kawai S,Liang CT

    更新日期:2003-01-01 00:00:00

  • Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain.

    abstract::The present study examined the early effects of prostaglandin (PG)E2 on proximal tibial metaphyses of 20-month-old Wistar male rats. PGE, was given to intact rats for 10 and 30 days at 3mg/kg/day. After multiple in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histo...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s007740170057

    authors: Cui L,Ma YF,Yao W,Zhou H,Setterberg RB,Liang TC,Jee WS

    更新日期:2001-01-01 00:00:00

  • The influence of the sensory neurotransmitter calcitonin gene-related peptide on bone marrow mesenchymal stem cells from ovariectomized rats.

    abstract::In order to explore the effects of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) from ovariectomized (OVX) rats, an OVX rat model was used. An ELISA was performed to examine the changes in CGRP level in the plasma and skeleton. The BMSCs from the sham rats were designated group A. The B...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-016-0780-9

    authors: Chen J,Ma G,Liu W,Liu Y,Ding Y

    更新日期:2017-09-01 00:00:00

  • Texture analysis of X-ray radiographs is correlated with bone histomorphometry.

    abstract::Three-dimensional (3D) alteration of trabecular microarchitecture is a risk factor for vertebral fractures. Histomorphometry allows microarchitectural analysis of bone, but the necessity to perform a transiliac bone biopsy limits its use in large series of patients. X-Ray films are commonly used in routine practice an...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-004-0536-9

    authors: Chappard D,Guggenbuhl P,Legrand E,Baslé MF,Audran M

    更新日期:2005-01-01 00:00:00

  • Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats.

    abstract::There are safety concerns regarding administration of bisphosphonates to children. Little is known about the effects of bisphosphonates on bone matrix organization during bone modeling. The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicul...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-007-0782-8

    authors: Kashii M,Hashimoto J,Nakano T,Umakoshi Y,Yoshikawa H

    更新日期:2008-01-01 00:00:00

  • Age, body mass index, current smoking history, and serum insulin-like growth factor-I levels associated with bone mineral density in middle-aged Korean men.

    abstract::Osteoporosis is a growing health problem in women and in men. This cross-sectional study examined the association of anthropometric, lifestyle, and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men. Smoking habits and alcohol consumption were assessed by interview. Serum testostero...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-003-0500-0

    authors: Rhee EJ,Oh KW,Lee WY,Kim SW,Oh ES,Baek KH,Kang MI,Park CY,Choi MG,Yoo HJ,Park SW

    更新日期:2004-01-01 00:00:00

  • Bone metabolism and the muscle-bone relationship in children, adolescents and young adults with phenylketonuria.

    abstract::The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-010-0216-x

    authors: Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

    更新日期:2011-03-01 00:00:00

  • Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population.

    abstract::Positive associations between vitamin D levels and hand grip strength have been reported worldwide, but the results are not consistent and few studies on East Asian populations have been published. The aim of this study was to determine whether such an association is present in a community-dwelling Japanese population...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-019-01040-w

    authors: Kitsu T,Kabasawa K,Ito Y,Kitamura K,Watanabe Y,Tanaka J,Nakamura K,Narita I

    更新日期:2020-03-01 00:00:00

  • Association between lumbar bone mineral density and vascular stiffness as assessed by pulse wave velocity in postmenopausal women.

    abstract::Recent studies have showed a significant correlation between vascular calcification and bone mineral density (BMD). Therefore, an investigation was carried out on the association between arterial stiffness, lumbar BMD and bone metabolic markers in Japanese postmenopausal women. Brachial-ankle PWV (baPWV) and BMD of th...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-008-0014-x

    authors: Mikumo M,Okano H,Yoshikata R,Ishitani K,Ohta H

    更新日期:2009-01-01 00:00:00

  • Impact of bisphosphonate wash-out prior to teriparatide therapy in clinical practice.

    abstract::Concurrent use of bisphosphonate therapy reduces the anabolic effect of teriparatide. Consequently, in clinical practice bisphosphonates are discontinued and teriparatide therapy held for a few months to allow bone turnover to increase. We aimed to evaluate the effect of prior bisphosphonate exposure and the effect of...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00774-009-0101-7

    authors: Keel C,Kraenzlin ME,Kraenzlin CA,Müller B,Meier C

    更新日期:2010-01-01 00:00:00

  • Zinc signal: a new player in osteobiology.

    abstract::Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies ha...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章,评审

    doi:10.1007/s00774-012-0409-6

    authors: Fukada T,Hojyo S,Furuichi T

    更新日期:2013-03-01 00:00:00

  • Effects of interleukin-11 on the expression of human bone sialoprotein gene.

    abstract::Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-014-0576-8

    authors: Matsumura H,Nakayama Y,Takai H,Ogata Y

    更新日期:2015-03-01 00:00:00

  • Age-related changes in bone biochemical markers and their relationship with bone mineral density in normal Chinese women.

    abstract::Measurements of bone biochemical markers are increasingly being used to evaluate the state of bone turnover in the management of bone metabolic diseases, especially osteoporosis. However, changes in the bone turnover rate vary with age. The aim of this study was to establish the laboratory reference range of serum bon...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-006-0703-2

    authors: Pi YZ,Wu XP,Liu SP,Luo XH,Cao XZ,Xie H,Liao EY

    更新日期:2006-01-01 00:00:00

  • Effect of alendronate on bone mineral density and bone turnover in Thai postmenopausal osteoporosis.

    abstract::Alendronate has recently been approved for the prevention and treatment of postmenopausal osteoporosis, and its efficacy has been demonstrated in many Western countries. Our present study was performed to evaluate the effect of alendronate on bone mineral density (BMD) and its tolerability in Thais. Eighty postmenopau...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00774-003-0438-2

    authors: Chailurkit LO,Jongjaroenprasert W,Rungbunnapun S,Ongphiphadhanakul B,Sae-tung S,Rajatanavin R

    更新日期:2003-01-01 00:00:00

  • Detective value of historical height loss and current height/knee height ratio for prevalent vertebral fracture in Japanese postmenopausal women.

    abstract::Vertebral fracture (VFx) is associated with various co-morbidities and increased mortality. In this paper, we have studied the detective value of height loss for VFx using two indices; historical height loss (HHL) which is the difference between the maximal height, and the current height (CH), and CH/knee height (KH) ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-013-0525-y

    authors: Yoh K,Kuwabara A,Tanaka K

    更新日期:2014-09-01 00:00:00

  • Etelcalcetide decreases the PTH-calcium setpoint without changing maximum and minimum PTH secretion in mice with primary hyperparathyroidism.

    abstract:INTRODUCTION:Etelcalcetide binds to the extracellular domain of the calcium-sensing receptor (CaSR), while cinacalcet binds to the 7-transmembrane domain of the CaSR; however, it is unknown, whether etelcalcetide has similar effects to cinacalcet on parathyroid hormone (PTH) secretion. MATERIALS AND METHODS:The PTH-ca...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-020-01169-z

    authors: Hayashi N,Imanishi Y,Hirakawa T,Kobayashi I,Tateishi T,Miyaoka D,Nagata Y,Mori K,Morioka T,Inoue A,Harada K,Inaba M,Emoto M

    更新日期:2020-11-16 00:00:00

  • Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells.

    abstract::Rodent hindlimb unloading (HU) by tail-suspension is a model to investigate disuse-induced bone loss in vivo. Previously, we have shown that osteopontin (OPN, also known as Spp1) is required for unloading-induced bone loss. However, how unloading affects OPN expression in the body is not fully understood. Here, we exa...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-014-0568-8

    authors: Ezura Y,Nagata J,Nagao M,Hemmi H,Hayata T,Rittling S,Denhardt DT,Noda M

    更新日期:2015-01-01 00:00:00

  • Trochanteric hip fracture in an elderly patient with leprosy during osteoporosis treatment with risedronate and alfacalcidol.

    abstract::There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-004-0546-7

    authors: Kanaji A,Higashi M,Namisato M,Ando K,Nakagawa M,Yato Y,Ichinose H,Sakamaki T,Yamada H

    更新日期:2005-01-01 00:00:00

  • Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study.

    abstract::This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 yea...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-019-01012-0

    authors: Yoshimura N,Muraki S,Iidaka T,Oka H,Horii C,Kawaguchi H,Akune T,Nakamura K,Tanaka S

    更新日期:2019-11-01 00:00:00

  • Should COPD patients be routinely evaluated for bone mineral density?

    abstract::There are many factors that increase the risk of osteoporosis, including smoking, malnutrition, vitamin D deficiency, hypogonadism, limited physical activity due to chronic disease, and corticosteroid therapy in chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate bone mineral density...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-002-0416-0

    authors: Karadag F,Cildag O,Yurekli Y,Gurgey O

    更新日期:2003-01-01 00:00:00

  • Can antiosteoporotic therapy reduce mortality in MRI-proved acute osteoporotic vertebral fractures?

    abstract::Patients with MRI-proved acute painful vertebral fractures in whom conservative pain management fails are frequently referred for vertebroplasty. This study investigated the effects of treating osteoporosis on the mortality rate of patients with MRI-proved acute osteoporosis-related vertebral fractures who had undergo...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-015-0672-4

    authors: Chen YC,Su FM,Cheng TT,Lin WC,Lui CC

    更新日期:2016-05-01 00:00:00

  • Biochemical bone turnover markers are useful tools to assess changes in bone metabolism in marmosets.

    abstract::This study was designed to investigate whether biochemical markers of bone resorption and formation could be determined in the serum and urine of marmosets (Callithrix jacchus), using standard laboratory chemistry methods and commercially available human kits. Consequently, the findings from this study will indicate w...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-003-0469-8

    authors: Angeliewa A,Budde M,Schlachter M,Hoyle NR,Bauss F

    更新日期:2004-01-01 00:00:00

  • Executive summary of clinical practice guide on fracture risk in lifestyle diseases.

    abstract::Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifesty...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-020-01149-3

    authors: Kanazawa I,Inaba M,Inoue D,Uenishi K,Saito M,Shiraki M,Suzuki A,Takeuchi Y,Hagino H,Fujiwara S,Sugimoto T,from the Japan Osteoporosis Society Lifestyle diseases-related Fracture Risk Investigation Committee.

    更新日期:2020-11-01 00:00:00

  • MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis.

    abstract::Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarth...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章,评审

    doi:10.1007/s00774-014-0628-0

    authors: Jingsheng S,Yibing W,Jun X,Siqun W,Jianguo W,Feiyan C,Gangyong H,Jie C

    更新日期:2015-01-01 00:00:00

  • Bone mineral density of extremities is associated with coronary calcification and biopsy-verified vascular calcification in living-donor renal transplant recipients.

    abstract::Chronic kidney disease (CKD) mineral and bone disorders (CKD-MBD) may lead to low bone mineral density (BMD) and vascular calcification (VC), but links to the latter are unclear. Here we investigated associations between BMD, coronary artery calcium (CAC) scores, and histological signs of VC in end-stage renal disease...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-016-0788-1

    authors: Chen Z,Sun J,Haarhaus M,Barany P,Wennberg L,Ripsweden J,Brismar TB,Lindholm B,Wernerson A,Söderberg M,Stenvinkel P,Qureshi AR

    更新日期:2017-09-01 00:00:00

  • Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures.

    abstract::Advanced glycation end products (AGE) in collagen have been reported to decrease the mechanical property of bone. However, there are no available data on the relation between fracture risk and levels of glycoxidative (nonenzymatic) cross-links of collagen in clinical samples. A total of 432 Japanese elderly women who ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-007-0784-6

    authors: Shiraki M,Kuroda T,Tanaka S,Saito M,Fukunaga M,Nakamura T

    更新日期:2008-01-01 00:00:00

  • A fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta.

    abstract::Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous stu...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/pl00010645

    authors: Cassella JP,Barrie PJ,Garrington N,Ali SY

    更新日期:2000-01-01 00:00:00

  • Adequate vitamin D status and adiposity contribute to bone health in peripubertal nonobese children.

    abstract::The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-012-0419-4

    authors: Lee YA,Kim JY,Kang MJ,Chung SJ,Shin CH,Yang SW

    更新日期:2013-05-01 00:00:00

  • Association of objectively measured physical activity and sedentary behavior with bone stiffness in peripubertal children.

    abstract:INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s00774-019-01021-z

    authors: Yamakita M,Ando D,Akiyama Y,Sato M,Suzuki K,Yamagata Z

    更新日期:2019-11-01 00:00:00

  • The visualization and evaluation of bone architecture in the rat using three-dimensional X-ray microcomputed tomography.

    abstract::Microcomputed tomography allows the true three-dimensional structure of bone to be assessed by a nondestructive analysis. This article describes how this technique has for the first time been applied to rat bone to determine the effects of aging, ovariectomy, and antiresorptive drugs on bone structure and how these re...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章

    doi:10.1007/s007740050061

    authors: Barbier A,Martel C,de Vernejoul MC,Tirode F,Nys M,Mocaer G,Morieux C,Murakami H,Lacheretz F

    更新日期:1999-01-01 00:00:00