Abstract:
:In Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindIII polymorphism and bone mineral density (BMD) in 388 premenopausal (31.18 +/- 5.92 years) and 169 postmenopausal (58.90 +/- 6.27 years) Chinese women. The BMD of spine and hip was measured by dual-energy X-ray absorptiometry (DEXA). All the study subjects were genotyped at the HindIII site of the BGP gene by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) detecting methods. The BGP alleles were designated according to the absence ( H) or presence ( h) of the HindIII restriction site. We did not find any significant difference in spine and hip BMD across BGP genotypes in either pre- or postmenopausal women or the combined group. Our result is not consistent with recent reports that the HindIII marker of the BGP gene is associated with osteoporosis. The different findings may reflect inter-population differences in the association (i.e., linkage disequilibrium) of molecular markers with BMD, and indicate the limit of using the HindIII marker of the BGP gene as a genetic marker to discern women susceptible to low BMD and thus osteoporosis in Chinese.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Mo XY,Cao CK,Xu FH,Liu MY,Li MX,Qin YJ,Zhou Q,Zhang YY,Deng HWdoi
10.1007/s00774-003-0478-7subject
Has Abstractpub_date
2004-01-01 00:00:00pages
264-9issue
3eissn
0914-8779issn
1435-5604journal_volume
22pub_type
杂志文章abstract::To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 sy...
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
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更新日期:2008-01-01 00:00:00
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
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journal_title:Journal of bone and mineral metabolism
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更新日期:2013-11-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 临床试验,杂志文章
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