Abstract:
:The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary metanephrine (UM), and urinary normetanephrine (UNM) were measured in 16 patients with pheochromocytoma and 224 patients with nonfunctioning adrenal incidentaloma (NFAI), we compared skeletal muscle mass and fat mass (FM) between the two groups. After adjustments for confounders, UM (β = - 0.171, P = 0.006) and UNM (β = - 0.249, P < 0.001) levels were correlated inversely with skeletal muscle mass index (SMI), but not FM or percentage FM (pFM), in all subjects. Patients with pheochromocytoma had lower ASM by 7.7% (P = 0.022) and SMI by 6.6% (P = 0.001) than patients with NFAI. Conversely, FM and pFM were not statistically different between the two groups. The odds ratio for low skeletal muscle mass in the presence of pheochromocytoma was 10.33 (95% confidence interval, 2.65-40.22). Our results indicate that patients with pheochromocytoma have a reduced skeletal muscle mass and suggest that catecholamine excess has adverse effects on skeletal muscle metabolism.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Lee SH,Kwak MK,Ahn SH,Kim H,Cho YY,Suh S,Song KH,Koh JM,Kim JH,Kim BJdoi
10.1007/s00774-018-0959-3subject
Has Abstractpub_date
2019-07-01 00:00:00pages
694-702issue
4eissn
0914-8779issn
1435-5604pii
10.1007/s00774-018-0959-3journal_volume
37pub_type
杂志文章,多中心研究,随机对照试验abstract:INTRODUCTION:Cold intolerance is defined as abnormal pain resulting from exposure to cold stimulation after trauma. However, the pathophysiology remains unclear. We recently demonstrated that regional osteoporotic changes accompanied by high bone turnover were involved in causing pain-like behaviors in the unloaded hin...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-020-01086-1
更新日期:2020-07-01 00:00:00
abstract::Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0213-0
更新日期:2011-03-01 00:00:00
abstract::The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0216-x
更新日期:2011-03-01 00:00:00
abstract::Lactoferrin (Lf) expression was investigated by using a Lf monoclonal antibody in 50 formalin-fixed and paraffin-embedded human bone tumours [10 giant cell tumours (GCTs), 7 osteoid osteomas, 6 ossifying fibromas, 19 enchondromas, 2 chondroblastomas, 2 chondrosarcomas, 2 chondroblastic osteosarcomas, 1 myeloma and 1 a...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-009-0044-z
更新日期:2009-01-01 00:00:00
abstract::Abeta-2M-amyloidosis is a type of systemic amyloidosis that is specifically seen in patients with chronic kidney diseases. The precursor protein of Abeta-2M-amyloid fibril is beta2-microglobulin, and its elevated serum level is the main cause of Abeta-2M-amyloidosis in patients with kidney failure. However, the precis...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,评审
doi:10.1007/s00774-005-0669-5
更新日期:2006-01-01 00:00:00
abstract::Chronic liver disease in adults is a risk factor of osteoporosis, but little is known about risk of fractures in children with non-cholestatic liver disease. The aim of this study was to investigate associations among the severity of liver fibrosis, bone mass and low-energy fractures in children. History of fractures,...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0219-7
更新日期:2011-05-01 00:00:00
abstract::In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, pr...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-013-0447-8
更新日期:2013-05-01 00:00:00
abstract::In order to explore the effects of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) from ovariectomized (OVX) rats, an OVX rat model was used. An ELISA was performed to examine the changes in CGRP level in the plasma and skeleton. The BMSCs from the sham rats were designated group A. The B...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-016-0780-9
更新日期:2017-09-01 00:00:00
abstract::Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00774-012-0397-6
更新日期:2013-03-01 00:00:00
abstract::Stimulation of osteoblast proliferation and differentiation is important for the in vivo bone-bonding ability of biomaterials. Previous in vitro studies have used biochemical assays to analyze osteoblast-specific gene expression in cultured osteoblasts. In this study, we generated transgenic mice harboring a monomeric...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-013-0544-8
更新日期:2014-11-01 00:00:00
abstract::The purpose of this study was to investigate the association of the Singh index, cortical thickness index (CTI) and calcar-to-canal (CC) ratio with bone mineral density (BMD) as well as their relationship with physical parameters [age, gender, height, and body mass index (BMI)] in order to assess their potential as an...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-012-0348-2
更新日期:2012-09-01 00:00:00
abstract::Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies ha...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,评审
doi:10.1007/s00774-012-0409-6
更新日期:2013-03-01 00:00:00
abstract::Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0723-y
更新日期:2007-01-01 00:00:00
abstract::Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,评审
doi:10.1007/s00774-004-0517-z
更新日期:2004-01-01 00:00:00
abstract::Digital X-ray radiogrammetry (DXR) is a computer-assisted diagnosis technique for quantifying cortical hand bone mineral density (BMD) as well as the metacarpal index (MCI) in the metacarpal bones from radiographs. The objective was to compare DXR-BMD and DXR-MCI between healthy individuals and patients with rheumatoi...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-016-0741-3
更新日期:2017-03-01 00:00:00
abstract::We previously reported that simvastatin induces estrogen receptor-alpha (ERα) in murine bone marrow stromal cells in vitro. In this study, we investigated the effect of simvastatin on ERα expression in bone and uterus in ovariectomized (OVX) rats and evaluated bone mass, bone strength, and uterine wet weight. Three-mo...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0231-y
更新日期:2011-07-01 00:00:00
abstract::In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femo...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-019-00988-z
更新日期:2019-09-01 00:00:00
abstract::Osteocytes form a three-dimensional (3D) cellular network within the mineralized bone matrix. The cellular network has important roles in mechanosensation and mechanotransduction related to bone homeostasis. We visualized the embedded osteocyte network in chick calvariae and observed the flow-induced Ca2+ signaling in...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-017-0868-x
更新日期:2018-09-01 00:00:00
abstract::Osteopathic changes sometimes occur in patients with complex regional pain syndrome (reflex sympathetic dystrophy and causalgia). We aimed to investigate whether such osteopathic changes occurred in rats with chronic constriction injury (CCI) of the sciatic nerve. A CCI of the sciatic nerve was established in a unilat...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740200012
更新日期:2002-01-01 00:00:00
abstract::Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-013-0482-5
更新日期:2013-11-01 00:00:00
abstract::The objective of this study was to record the clinical course of osteoporosis over time in Japanese women. We hypothesized that successful control of acute pain associated with osteoporosis will allow better treatment for health-related problems. To confirm this working hypothesis, we developed the Japan Questionnaire...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-013-0458-5
更新日期:2013-11-01 00:00:00
abstract::McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia. However, it remains unclear whether a humoral factor is associated with the cause of hypophosphatemia. We isolated cells with mutations of the Gsalpha gene from fibrous bone dysplasia tissues of two MAS patients (MAS cells). Severe combined i...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740170012
更新日期:2001-01-01 00:00:00
abstract::High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B(12) stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B(12) in patients with Paget's disease of bone (PDB) and the effect of zoledr...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-009-0131-1
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Aromatase inhibitors are known to accelerate bone loss in patients with breast cancer. However, how much AIs affect the efficacy of antiresorptive agents has not been studied. The study aimed to compare the effect of alendronate on bone mineral density (BMD) between patients with and without AI treatment. ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-020-01111-3
更新日期:2020-09-01 00:00:00
abstract::Recent studies have showed a significant correlation between vascular calcification and bone mineral density (BMD). Therefore, an investigation was carried out on the association between arterial stiffness, lumbar BMD and bone metabolic markers in Japanese postmenopausal women. Brachial-ankle PWV (baPWV) and BMD of th...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-008-0014-x
更新日期:2009-01-01 00:00:00
abstract::Lipid rafts are membrane platforms for signaling molecules that regulate various cellular functions. During osteoclastogenesis, lipid rafts also have been shown to play a crucial role for cell fusion upon RANK/RANKL interaction and further activation of osteoclasts, resulting in bone resorption. To investigate protein...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-009-0150-y
更新日期:2010-07-01 00:00:00
abstract::In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this s...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-018-0976-2
更新日期:2019-07-01 00:00:00
abstract::The purpose of this study was to investigate the relationship between intervertebral disk degeneration and bone mass. Magnetic resonance imaging was performed to evaluate lumbar disk degeneration according to Thompson's classification (grades 1 and 2, normal disk; grades 3, 4, and 5, degenerated disk), and bone minera...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740300004
更新日期:2003-01-01 00:00:00
abstract::We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-016-0736-0
更新日期:2017-01-01 00:00:00
abstract::Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference. Sixty female monke...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-015-0658-2
更新日期:2016-03-01 00:00:00