MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis.

abstract：:Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlo...

journal_title：Journal of bone and mineral metabolism

authors： Daghma DES,Malhan D,Simon P,Stötzel S,Kern S,Hassan F,Lips KS,Heiss C,El Khassawna T

更新日期：2018-05-01 00:00:00

abstract：:Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifesty...

journal_title：Journal of bone and mineral metabolism

authors： Kanazawa I,Inaba M,Inoue D,Uenishi K,Saito M,Shiraki M,Suzuki A,Takeuchi Y,Hagino H,Fujiwara S,Sugimoto T,from the Japan Osteoporosis Society Lifestyle diseases-related Fracture Risk Investigation Committee.

更新日期：2020-11-01 00:00:00

abstract：:In order to investigate the effect of manganese (Mn) deficiency on bone metabolism in chicks, ninety 1-day-old male Arbor Acre chicks were randomly divided into 3 groups and each group were given a diet having a different concentration of Mn (60 mg kg(-1), control group; 40 mg kg(-1), Mn-deficient group I; 8.7 mg kg(-...

journal_title：Journal of bone and mineral metabolism

authors： Zhaojun W,Lin W,Zhenyong W,Jian W,Ran L

更新日期：2013-05-01 00:00:00

abstract：:Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcem...

journal_title：Journal of bone and mineral metabolism

authors： Lee IT,Sheu WH,Tu ST,Kuo SW,Pei D

更新日期：2006-01-01 00:00:00

abstract：:We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered resid...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Oka H,Kawaguchi H,Nakamura K,Akune T

更新日期：2011-11-01 00:00:00

abstract：:Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect o...

journal_title：Journal of bone and mineral metabolism

authors： Siviero-Miachon AA,Spinola-Castro AM,de Martino Lee ML,Calixto AR,Geloneze B,Lazaretti-Castro M,Guerra-Junior G

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:This study aimed to examine long-term persistence in new users of oral bisphosphonates in a population-wide cohort in Manitoba, Canada. MATERIALS AND METHODS:A longitudinal observational study was conducted using administrative health data characterizing long-term bisphosphonate persistence in those who s...

journal_title：Journal of bone and mineral metabolism

authors： Friesen KJ,Bugden S,Falk J

更新日期：2020-05-01 00:00:00

abstract：:The MOVEMENT study was designed to assess the effectiveness of monthly intravenous ibandronate on bone mineral density (BMD) in daily clinical practice in Japanese patients with primary osteoporosis whose lumbar spine BMD did not increase despite oral bisphosphonate therapy. This study was a multicenter, prospective, ...

journal_title：Journal of bone and mineral metabolism

authors： Hagino H,Sakai A,Ikeda S,Imanishi Y,Tsurukami H,Nakajo S,Miyakoshi N

更新日期：2019-11-01 00:00:00

abstract：:Skull changes are poorly described in vitamin D insufficiency [serum 25-hydroxyvitamin D (s-25(OH)D) 25-50 nmol/L]. We aimed to investigate factors associated with cranial anthropometrics in infants, especially s-25(OH)D. In infants 2.5-6 months old from the Odense Child Cohort, associations between cord and pregnancy...

journal_title：Journal of bone and mineral metabolism

authors： Egge S,Christensen N,Lykkedegn S,Jensen TK,Christesen HT

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Cold intolerance is defined as abnormal pain resulting from exposure to cold stimulation after trauma. However, the pathophysiology remains unclear. We recently demonstrated that regional osteoporotic changes accompanied by high bone turnover were involved in causing pain-like behaviors in the unloaded hin...

journal_title：Journal of bone and mineral metabolism

authors： Ibe K,Iba K,Hanaka M,Kiyomoto K,Hayakawa H,Teramoto A,Emori M,Yamashita T

更新日期：2020-07-01 00:00:00

abstract：:The impact of smoking on peak bone density has not been conclusively established. We examined how smoking exposure influences bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative sample of Japanese women in 1996. The effect of current an...

journal_title：Journal of bone and mineral metabolism

authors： Tamaki J,Iki M,Sato Y,Kajita E,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2010-05-01 00:00:00

abstract：:Recent studies have showed a significant correlation between vascular calcification and bone mineral density (BMD). Therefore, an investigation was carried out on the association between arterial stiffness, lumbar BMD and bone metabolic markers in Japanese postmenopausal women. Brachial-ankle PWV (baPWV) and BMD of th...

journal_title：Journal of bone and mineral metabolism

authors： Mikumo M,Okano H,Yoshikata R,Ishitani K,Ohta H

更新日期：2009-01-01 00:00:00

abstract：:Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 6...

journal_title：Journal of bone and mineral metabolism

authors： Wong SY,Lau EM,Li M,Chung T,Sham A,Woo J

更新日期：2005-01-01 00:00:00

abstract：:The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before star...

journal_title：Journal of bone and mineral metabolism

authors： Bramati A,Girelli S,Farina G,Dazzani MC,Torri V,Moretti A,Piva S,Dimaiuta M,La Verde N

更新日期：2015-01-01 00:00:00

abstract：:Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density...

journal_title：Journal of bone and mineral metabolism

authors： Ishii T,Ito K,Kato S,Tsubokura M,Ochi S,Iwamoto Y,Saito Y

更新日期：2013-11-01 00:00:00

abstract：:We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...

journal_title：Journal of bone and mineral metabolism

authors： Hoffmann DB,Sehmisch S,Hofmann AM,Eimer C,Komrakova M,Saul D,Wassmann M,Stürmer KM,Tezval M

更新日期：2017-01-01 00:00:00

abstract：:Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodi...

journal_title：Journal of bone and mineral metabolism

authors： Carbone LD,Barrow KD,Bush AJ,Boatright MD,Michelson JA,Pitts KA,Pintea VN,Kang AH,Watsky MA

更新日期：2005-01-01 00:00:00

abstract：:Bone microarchitecture of the iliac bone is used to characterize the properties of bone tissue in osteoporosis, particularly in pharmacological studies. Trabecular bone is known to be heterogeneous media. For a few years, the analysis of three-dimensional (3-D) bone microarchitecture has been based on micro-computed t...

journal_title：Journal of bone and mineral metabolism

authors： Chappard C,Marchadier A,Benhamou L

更新日期：2008-01-01 00:00:00

abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...

journal_title：Journal of bone and mineral metabolism

authors： Balsa JA,Lafuente C,Gómez-Martín JM,Galindo J,Peromingo R,García-Moreno F,Rodriguez-Velasco G,Martínez-Botas J,Gómez-Coronado D,Escobar-Morreale HF,Botella-Carretero JI

更新日期：2016-11-01 00:00:00

abstract：:This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...

journal_title：Journal of bone and mineral metabolism

authors： Zhang T,Gao J,Fang J,Gong H

更新日期：2018-03-01 00:00:00

abstract：:Gastrectomy-evoked osteopenia in the femoral metaphysis of rats can be prevented by the consumption of fructooligosaccharides (FOS). We examined the effect of FOS on the femoral neck. Twenty-eight 5-week-old male Sprague-Dawley rats were divided into two groups, sham-operated (SH) and gastrectomized (GX). One week aft...

journal_title：Journal of bone and mineral metabolism

authors： Hirama Y,Morohashi T,Sano T,Maki K,Ohta A,Sakai N,Yamada S,Sasa R

更新日期：2003-01-01 00:00:00

abstract：:We have been using hormone replacement therapy (HRT) as the treatment of choice for menopausal symptoms and osteoporosis. Estrogen increases bone mineral density (BMD) for 2 or 3 years, and only maintains BMD thereafter. In the present study, we investigated whether BMD improved with HRT in combination with vitamin K(...

journal_title：Journal of bone and mineral metabolism

authors： Hidaka T,Hasegawa T,Fujimura M,Sakai M,Saito S

更新日期：2002-01-01 00:00:00

abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....

journal_title：Journal of bone and mineral metabolism

authors： Lopez Franco GE,Blank RD,Akhter MP

更新日期：2011-01-01 00:00:00

abstract：:Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...

journal_title：Journal of bone and mineral metabolism

authors： Sato T,Watanabe K,Masuhara M,Hada N,Hakeda Y

更新日期：2007-01-01 00:00:00

abstract：:Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use ...

journal_title：Journal of bone and mineral metabolism

authors： Dai L,Xu M,Wu H,Xue L,Yuan D,Wang Y,Shen Z,Zhao H,Hu M

更新日期：2016-01-01 00:00:00

abstract：:The present study aimed to evaluate the prevalence and clinical presentation of Paget's disease of bone (PDB) in Japan. As PDB is a very rare disease in Japan, a nationwide mail survey was conducted targeting doctors in the specialty most frequently diagnosing and treating PDB patients in Japan. First, the literature ...

journal_title：Journal of bone and mineral metabolism

authors： Hashimoto J,Ohno I,Nakatsuka K,Yoshimura N,Takata S,Zamma M,Yabe H,Abe S,Terada M,Yoh K,Fukunaga M,Cooper C,Morii H,Yoshikawa H,Japanese Committee on Clinical Guidelines of Diagnosis and Treatment of Paget's Disease of Bone o

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Aromatase inhibitors are known to accelerate bone loss in patients with breast cancer. However, how much AIs affect the efficacy of antiresorptive agents has not been studied. The study aimed to compare the effect of alendronate on bone mineral density (BMD) between patients with and without AI treatment. ...

journal_title：Journal of bone and mineral metabolism

authors： Kong SH,Kim JH,Kim SW,Shin CS

更新日期：2020-09-01 00:00:00

abstract：:Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...

journal_title：Journal of bone and mineral metabolism

authors： Miki T,Nakatsuka K,Naka H,Kitatani K,Saito S,Masaki H,Tomiyoshi Y,Morii H,Nishizawa Y

更新日期：2003-01-01 00:00:00

abstract：:Inactivating mutations and/or deletions of PHEX ( Phosphate-regulating gene with Homologies to Endopeptidase on the X chromosome) are responsible for X-linked hypophosphatemic rickets in humans. In the present study, three Drosophila PHEX homologues (dPHEX-1, -2, -3) were isolated by the screening of a Drosophila cDNA...

journal_title：Journal of bone and mineral metabolism

authors： Ito M,Akai E,Izuka M,Segawa H,Kuwahata M,Miyamoto K

更新日期：2004-01-01 00:00:00

abstract：:The activation sequence of clasts (the designation clast was used because ultrastructurally in this tissue, it is not always possible to differentiate between chondroclasts sitting on cartilage and osteoclasts sitting on bone matrix) was studied in vivo using the healing of low-phosphate, vitamin D-deficiency rickets ...

journal_title：Journal of bone and mineral metabolism

authors： Hollberg K,Nordahl J,Hultenby K,Mengarelli-Widholm S,Andersson G,Reinholt FP

更新日期：2005-01-01 00:00:00