当前位置： SCI文献检索 > JOURNAL OF BONE AND MINERAL METABOLISM期刊下所有文献 > Prospective, mono-institutional study of the impact of a systematic prevention program on incidence and outcome of osteonecrosis of the jaw in patients treated with bisphosphonates for bone metastases.

Prospective, mono-institutional study of the impact of a systematic prevention program on incidence and outcome of osteonecrosis of the jaw in patients treated with bisphosphonates for bone metastases.

Abstract：

:The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before starting BPs, each patient underwent a strict dental preventive program with a specialized odontoiatric team. The odontoiatric evaluation identified patients with oral pathologies or inadequate oral hygiene and provided a dental preventive treatment. From April 2007 to April 2012, 254 patients were enrolled. After excluding patients due to previous BPs treatment, 212 patients with a mean age of 74 years (range 37-95) were included. On average, patients received 9.7 treatment cycles (range 1-48). No ONJ was recorded (0.0 %; 95 % confidence interval [CI] 0.0-1.4). Comparing this risk with that observed in a previous cohort who did not receive dental prevention (16/186, 8.6 %; 95 % CI 4.2-15.3 %), we observed clear efficacy in preventing ONJ (relative risk reduction: 100 %, 95 % CI 86-100 %, P < 0.0001). We developed a strict three-step prevention program that is able to decrease ONJ incidence and the need for destructive surgery with permanent sequelae. We demonstrated that ONJ could be effectively prevented. We recommend a mandatory preventive program involving a multidisciplinary team for all patients starting BPs.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Bramati A,Girelli S,Farina G,Dazzani MC,Torri V,Moretti A,Piva S,Dimaiuta M,La Verde N

doi

10.1007/s00774-014-0566-x

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

119-24

issue

1

eissn

0914-8779

issn

1435-5604

journal_volume

33

pub_type

杂志文章

相关文献

JOURNAL OF BONE AND MINERAL METABOLISM文献大全
  • Bisphosphonate pretreatment attenuates hungry bone syndrome postoperatively in subjects with primary hyperparathyroidism.

    abstract：:Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcem...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0680-x

    authors： Lee IT,Sheu WH,Tu ST,Kuo SW,Pei D

    更新日期：2006-01-01 00:00:00

  • Number and severity of prevalent vertebral fractures and the risk of subsequent vertebral fractures in Japanese women with osteoporosis: results from the minodronate trial.

    abstract：:The aim was to evaluate the risk of new vertebral fractures with the increasing number and severity of prevalent vertebral fractures in women who received placebo or minodronate in a post hoc analysis of a 2-year randomized, double-blind, placebo-controlled study. The subjects were women aged 55-80 years old with 1-5 ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-013-0439-8

    authors： Hagino H,Shiraki M,Fukunaga M,Nakano T,Takaoka K,Ohashi Y,Nakamura T,Matsumoto T

    更新日期：2013-09-01 00:00:00

  • Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.

    abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0202-3

    authors： Yao GQ,Wu JJ,Troiano N,Insogna K

    更新日期：2011-03-01 00:00:00

  • Identification of a progenitor cell population destined to form fracture fibrocartilage callus in Dickkopf-related protein 3-green fluorescent protein reporter mice.

    abstract：:Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic, and angiogenic differentiation. The mechanisms underlying the proliferation and differentiation of mesenchymal progenitor cells remain unclear. Here, we demonstrate Dickkopf-relat...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-015-0711-1

    authors： Mori Y,Adams D,Hagiwara Y,Yoshida R,Kamimura M,Itoi E,Rowe DW

    更新日期：2016-11-01 00:00:00

  • Incidence of four major types of osteoporotic fragility fractures among elderly individuals in Sado, Japan, in 2015.

    abstract：:The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-018-0937-9

    authors： Imai N,Endo N,Shobugawa Y,Oinuma T,Takahashi Y,Suzuki K,Ishikawa Y,Makino T,Suzuki H,Miyasaka D,Sakuma M

    更新日期：2019-05-01 00:00:00

  • Involvement of endoplasmic reticulum stress in homocysteine-induced apoptosis of osteoblastic cells.

    abstract：:Hyperhomocysteinemia has been shown to increase the incidence of osteoporosis and osteoporotic fractures. Endoplasmic reticulum (ER) stress was recently shown to be associated with apoptosis in several types of cells. In this study, we determined the effect of homocysteine (Hcy) on the apoptosis of osteoblastic cells ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-011-0346-9

    authors： Park SJ,Kim KJ,Kim WU,Oh IH,Cho CS

    更新日期：2012-07-01 00:00:00

  • Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial.

    abstract：:We have previously demonstrated the efficacy of therapeutic exercise for osteoarthritis (OA) of the knee. This study was performed to examine the additive effects of glucosamine or risedronate on the exercise therapy. In this study, 142 female patients with moderate OA of the knee, who had been recommended to undergo ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-007-0813-5

    authors： Kawasaki T,Kurosawa H,Ikeda H,Kim SG,Osawa A,Takazawa Y,Kubota M,Ishijima M

    更新日期：2008-01-01 00:00:00

  • Effects of genistein on vertebral trabecular bone microstructure, bone mineral density, microcracks, osteocyte density, and bone strength in ovariectomized rats.

    abstract：:Until now, the effects of phytoestrogen on bone in both women and ovarian hormone-deficient animal models of osteoporosis have remained uncertain. We have aimed here to investigate the effect of genistein (GEN) on trabecular bone quality in ovariectomized (OVX) rats. Forty 7-month-old female Sprague-Dawley rats were r...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-007-0830-4

    authors： Dai R,Ma Y,Sheng Z,Jin Y,Zhang Y,Fang L,Fan H,Liao E

    更新日期：2008-01-01 00:00:00

  • Cord serum 25-hydroxyvitamin D is not associated with cranial anthropometrics in infants up to 6 months of age. An Odense Child Cohort study.

    abstract：:Skull changes are poorly described in vitamin D insufficiency [serum 25-hydroxyvitamin D (s-25(OH)D) 25-50 nmol/L]. We aimed to investigate factors associated with cranial anthropometrics in infants, especially s-25(OH)D. In infants 2.5-6 months old from the Odense Child Cohort, associations between cord and pregnancy...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-017-0881-0

    authors： Egge S,Christensen N,Lykkedegn S,Jensen TK,Christesen HT

    更新日期：2018-11-01 00:00:00

  • Simvastatin induces estrogen receptor-alpha (ER-alpha) in murine bone marrow stromal cells.

    abstract：:Simvastatin has been shown to stimulate osteogenesis both in vitro and in vivo. However, the mechanism by which simvastatin exerts its effects is still unclear. We previously reported that simvastatin promotes bone morphogenetic protein 2 (BMP-2) expression, induces osteoblastic differentiation, and inhibits adipocyti...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-007-0820-6

    authors： Song C,Wang J,Song Q,Li X,Chen Z,Ma Q,Liu Z,Jia H,Dang G

    更新日期：2008-01-01 00:00:00

  • Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain.

    abstract：:The present study examined the early effects of prostaglandin (PG)E2 on proximal tibial metaphyses of 20-month-old Wistar male rats. PGE, was given to intact rats for 10 and 30 days at 3mg/kg/day. After multiple in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170057

    authors： Cui L,Ma YF,Yao W,Zhou H,Setterberg RB,Liang TC,Jee WS

    更新日期：2001-01-01 00:00:00

  • The effects of α-zearalanol on the proliferation of bone-marrow-derived mesenchymal stem cells and their differentiation into osteoblasts.

    abstract：:The aim of this study was to explore the effects of α-zearalanol (α-ZAL) on the proliferation of mouse bone-marrow-derived mesenchymal stem cells (BMSCs) and their differentiation into osteoblasts. Six- to eight-week-old BALB/C mice were used either as recipients or as bone marrow donors. BMSCs were isolated and colle...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-015-0659-1

    authors： Zong S,Zeng G,Fang Y,Peng J,Zou B,Gao T,Zhao J

    更新日期：2016-03-01 00:00:00

  • Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population.

    abstract：:Positive associations between vitamin D levels and hand grip strength have been reported worldwide, but the results are not consistent and few studies on East Asian populations have been published. The aim of this study was to determine whether such an association is present in a community-dwelling Japanese population...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01040-w

    authors： Kitsu T,Kabasawa K,Ito Y,Kitamura K,Watanabe Y,Tanaka J,Nakamura K,Narita I

    更新日期：2020-03-01 00:00:00

  • A fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta.

    abstract：:Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous stu...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/pl00010645

    authors： Cassella JP,Barrie PJ,Garrington N,Ali SY

    更新日期：2000-01-01 00:00:00

  • Selective cyclooxygenase-2 inhibitor prevents reduction of trabecular bone mass in collagen-induced arthritic mice in association with suppression of RANKL/OPG ratio and IL-6 mRNA expression in synovial tissues but not in bone marrow cells.

    abstract：:We performed this study to clarify whether celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, prevents trabecular bone mass reduction by suppressing arthritis-related increase of bone resorption, and to discriminate differences in actions on bone among celecoxib, SC-58560 (a selective COX-1 inhibitor), and ind...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-007-0808-2

    authors： Taketa T,Sakai A,Tanaka S,Nakai K,Menuki K,Yamane H,Tanaka K,Nakamura T

    更新日期：2008-01-01 00:00:00

  • Detective value of historical height loss and current height/knee height ratio for prevalent vertebral fracture in Japanese postmenopausal women.

    abstract：:Vertebral fracture (VFx) is associated with various co-morbidities and increased mortality. In this paper, we have studied the detective value of height loss for VFx using two indices; historical height loss (HHL) which is the difference between the maximal height, and the current height (CH), and CH/knee height (KH) ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0525-y

    authors： Yoh K,Kuwabara A,Tanaka K

    更新日期：2014-09-01 00:00:00

  • Repetition of continuous PTH treatments followed by periodic withdrawals exerts anabolic effects on rat bone.

    abstract：:Various animal experiments and human studies have shown that intermittent injections of parathyroid hormone (PTH) exert anabolic effects on bone, whereas continuous PTH treatment decreases the bone mass and causes hypercalcemia in animals. However, limited data are available with regard to the effects of a repetitive ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0181-4

    authors： Etoh M,Yamaguchi A

    更新日期：2010-11-01 00:00:00

  • A possible role for leptin in normo- or hypoparathyroid uremic bone in postmenopausal dialysis women.

    abstract：:Leptin has been proposed to be a key molecule involved in energy regulation. Based on the generally acknowledged concept that a heavier person has a higher bone density, leptin is thought to be potentially involved in bone metabolism. Serum leptin, various bone markers, and bone mineral density (BMD) were studied in 5...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170050

    authors： Yoneda T,Maruyama Y,Uji Y,Motomiya Y,Hashiguchi Y,Miura M,Kitajima I,Maruyama I

    更新日期：2001-01-01 00:00:00

  • Polarization and secretion of cathepsin K precede tartrate-resistant acid phosphatase secretion to the ruffled border area during the activation of matrix-resorbing clasts.

    abstract：:The activation sequence of clasts (the designation clast was used because ultrastructurally in this tissue, it is not always possible to differentiate between chondroclasts sitting on cartilage and osteoclasts sitting on bone matrix) was studied in vivo using the healing of low-phosphate, vitamin D-deficiency rickets ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0626-3

    authors： Hollberg K,Nordahl J,Hultenby K,Mengarelli-Widholm S,Andersson G,Reinholt FP

    更新日期：2005-01-01 00:00:00

  • Higher response with bone mineral density increase with monthly injectable ibandronate 1 mg compared with oral risedronate in the MOVER study.

    abstract：:We examined response to bone mineral density (BMD) gains in the MOVER study following treatment with intravenous (IV) ibandronate 1 mg/month, and investigated the characteristics of a non-responder group. At 1 year, responder rates for patients with BMD increases >0 % were similar with IV ibandronate 0.5 or 1 mg/month...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-015-0717-8

    authors： Nakano T,Yamamoto M,Hashimoto J,Tobinai M,Yoshida S,Nakamura T

    更新日期：2016-11-01 00:00:00

  • Proteomic analysis of osteoclast lipid rafts: the role of the integrity of lipid rafts on V-ATPase activity in osteoclasts.

    abstract：:Lipid rafts are membrane platforms for signaling molecules that regulate various cellular functions. During osteoclastogenesis, lipid rafts also have been shown to play a crucial role for cell fusion upon RANK/RANKL interaction and further activation of osteoclasts, resulting in bone resorption. To investigate protein...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0150-y

    authors： Ryu J,Kim H,Chang EJ,Kim HJ,Lee Y,Kim HH

    更新日期：2010-07-01 00:00:00

  • Alfacalcidol treatment increases bone mass from anticatabolic and anabolic effects on cancellous and cortical bone in intact female rats.

    abstract：:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without ex...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-008-0854-4

    authors： Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

    更新日期：2008-01-01 00:00:00

  • Adult hypophosphatasia with painful periarticular calcification treated with surgical resection.

    abstract：:Hypophosphatasia is a rare inherited disorder characterized by a low serum alkaline phosphatase (ALP) activity and defective bone mineralization. Adult hypophosphatasia typically manifests in middle-age as a result of osteomalacia with recurrent stress fractures of the lower limb. However, considerable variation occur...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-011-0338-9

    authors： Iida K,Fukushi J,Fujiwara T,Oda Y,Iwamoto Y

    更新日期：2012-11-01 00:00:00

  • Diagnostic criteria for primary osteoporosis: year 2012 revision.

    abstract：:In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, pr...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0447-8

    authors： Soen S,Fukunaga M,Sugimoto T,Sone T,Fujiwara S,Endo N,Gorai I,Shiraki M,Hagino H,Hosoi T,Ohta H,Yoneda T,Tomomitsu T,Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the R

    更新日期：2013-05-01 00:00:00

  • Progeroid syndrome as a model for impaired bone formation in senile osteoporosis.

    abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-004-0517-z

    authors： Hishiya A,Watanabe K

    更新日期：2004-01-01 00:00:00

  • Change of skeletal muscle mass in patients with pheochromocytoma.

    abstract：:The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary met...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00774-018-0959-3

    authors： Lee SH,Kwak MK,Ahn SH,Kim H,Cho YY,Suh S,Song KH,Koh JM,Kim JH,Kim BJ

    更新日期：2019-07-01 00:00:00

  • Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies.

    abstract：:Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major differences t...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-016-0753-z

    authors： Pérez-Campo FM,May T,Zauers J,Sañudo C,Delgado-Calle J,Arozamena J,Berciano MT,Lafarga M,Riancho JA

    更新日期：2017-03-01 00:00:00

  • Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine.

    abstract：:Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and resorption activity have been shown to be enhanced in the presence of hypoxia. In the present study we examined the effects of the hypoxia mimetics dimethyloxallyl glyci...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0171-6

    authors： Leger AJ,Altobelli A,Mosquea LM,Belanger AJ,Song A,Cheng SH,Jiang C,Yew NS

    更新日期：2010-09-01 00:00:00

  • Effect of periosteal reaction in medication-related osteonecrosis of the jaw on treatment outcome after surgery.

    abstract：INTRODUCTION:Surgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01154-6

    authors： Soutome S,Yanamoto S,Sumi M,Hayashida S,Kojima Y,Sawada S,Rokutanda S,Iwai H,Saito T,Umeda M

    更新日期：2020-10-12 00:00:00

  • Zoledronic acid administration failed to prevent bone loss at the knee in persons with acute spinal cord injury: an observational cohort study.

    abstract：:After acute spinal cord injury (SCI), rapid depletion of the sublesional skeleton occurs, particularly at the distal femur and proximal tibia. Subsequently, fragility fractures of the knee may occur. We determined the efficacy of zoledronic acid to prevent sublesional bone mineral density (BMD) loss at 6 and 12 months...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-014-0602-x

    authors： Bauman WA,Cirnigliaro CM,La Fountaine MF,Martinez L,Kirshblum SC,Spungen AM

    更新日期：2015-07-01 00:00:00