Simvastatin induces estrogen receptor-alpha (ER-alpha) in murine bone marrow stromal cells.

abstract：:Expression of the genes encoding bone morphogenetic proteins (BMPs), BMP type IA receptor (BMPR-1A), and rat distal-less homolog (rDlx) was studied in bone, callus, and the surrounding soft tissue following rat femoral closed fracture, using RT-PCR-based techniques. Before fracture, the genes encoding BMP-5, BMP-6, an...

journal_title：Journal of bone and mineral metabolism

authors： Yaoita H,Orimo H,Shirai Y,Shimada T

更新日期：2000-01-01 00:00:00

abstract：:Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodi...

journal_title：Journal of bone and mineral metabolism

authors： Carbone LD,Barrow KD,Bush AJ,Boatright MD,Michelson JA,Pitts KA,Pintea VN,Kang AH,Watsky MA

更新日期：2005-01-01 00:00:00

abstract：:Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major differences t...

journal_title：Journal of bone and mineral metabolism

authors： Pérez-Campo FM,May T,Zauers J,Sañudo C,Delgado-Calle J,Arozamena J,Berciano MT,Lafarga M,Riancho JA

更新日期：2017-03-01 00:00:00

abstract：:The present study aimed to evaluate the prevalence and clinical presentation of Paget's disease of bone (PDB) in Japan. As PDB is a very rare disease in Japan, a nationwide mail survey was conducted targeting doctors in the specialty most frequently diagnosing and treating PDB patients in Japan. First, the literature ...

journal_title：Journal of bone and mineral metabolism

authors： Hashimoto J,Ohno I,Nakatsuka K,Yoshimura N,Takata S,Zamma M,Yabe H,Abe S,Terada M,Yoh K,Fukunaga M,Cooper C,Morii H,Yoshikawa H,Japanese Committee on Clinical Guidelines of Diagnosis and Treatment of Paget's Disease of Bone o

更新日期：2006-01-01 00:00:00

abstract：:Digital X-ray radiogrammetry (DXR) is a computer-assisted diagnosis technique for quantifying cortical hand bone mineral density (BMD) as well as the metacarpal index (MCI) in the metacarpal bones from radiographs. The objective was to compare DXR-BMD and DXR-MCI between healthy individuals and patients with rheumatoi...

journal_title：Journal of bone and mineral metabolism

authors： Pfeil A,Haugeberg G,Renz DM,Reinhardt L,Jung C,Franz M,Wolf G,Böttcher J

更新日期：2017-03-01 00:00:00

abstract：:The purpose of this study was to investigate the relationship between intervertebral disk degeneration and bone mass. Magnetic resonance imaging was performed to evaluate lumbar disk degeneration according to Thompson's classification (grades 1 and 2, normal disk; grades 3, 4, and 5, degenerated disk), and bone minera...

journal_title：Journal of bone and mineral metabolism

authors： Nanjo Y,Morio Y,Nagashima H,Hagino H,Teshima R

更新日期：2003-01-01 00:00:00

abstract：:We investigated the combinatorial effects of whole-body vertical vibration (WBVV) with the primarily osteoanabolic parathyroid hormone (PTH) and the mainly antiresorptive strontium ranelate (SR) in a rat model of osteoporosis. Ovariectomies were performed on 76 three-month-old Sprague-Dawley rats (OVX, n = 76; NON-OVX...

journal_title：Journal of bone and mineral metabolism

authors： Hoffmann DB,Sehmisch S,Hofmann AM,Eimer C,Komrakova M,Saul D,Wassmann M,Stürmer KM,Tezval M

更新日期：2017-01-01 00:00:00

abstract：:Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect o...

journal_title：Journal of bone and mineral metabolism

authors： Siviero-Miachon AA,Spinola-Castro AM,de Martino Lee ML,Calixto AR,Geloneze B,Lazaretti-Castro M,Guerra-Junior G

更新日期：2017-01-01 00:00:00

abstract：:A cell line of murine osteogenic progenitor cells, Kusa, was established from femoral bone marrow stromal cells with other types of mesenchymal progenitor cells. We characterized two sublines of Kusa (Kusa-A1 and Kusa-O) from several aspects, including the use of an expression profiling system, a cDNA microarray. The ...

journal_title：Journal of bone and mineral metabolism

authors： Kawashima N,Shindo K,Sakamoto K,Kondo H,Umezawa A,Kasugai S,Perbal B,Suda H,Takagi M,Katsube K

更新日期：2005-01-01 00:00:00

abstract：:A T869-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene is reported to be associated with genetic susceptibility to both osteoporosis and vertebral fractures. A low serum 25-hydroxyvitamin D [25(OH)D] level is known to be associated with a higher risk for hip fracture. This study aimed to asse...

journal_title：Journal of bone and mineral metabolism

authors： Mori S,Fuku N,Chiba Y,Tokimura F,Hosoi T,Kimbara Y,Tamura Y,Araki A,Tanaka M,Ito H

更新日期：2010-07-01 00:00:00

abstract：:We designed a randomized, double-blind, controlled clinical trial to compare the effect of two regimens for administering cholecalciferol on the serum 25-hydroxycholecalciferol [25(OH)D] levels and in the reversion of secondary hyperparathyroidism in the elderly living in a low-income housing unit in the city of Porto...

journal_title：Journal of bone and mineral metabolism

authors： Premaor MO,Scalco R,da Silva MJ,Froehlich PE,Furlanetto TW

更新日期：2008-01-01 00:00:00

abstract：:We previously reported that simvastatin induces estrogen receptor-alpha (ERα) in murine bone marrow stromal cells in vitro. In this study, we investigated the effect of simvastatin on ERα expression in bone and uterus in ovariectomized (OVX) rats and evaluated bone mass, bone strength, and uterine wet weight. Three-mo...

journal_title：Journal of bone and mineral metabolism

authors： Li X,Song QS,Wang JY,Leng HJ,Chen ZQ,Liu ZJ,Dang GT,Song CL

更新日期：2011-07-01 00:00:00

abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....

journal_title：Journal of bone and mineral metabolism

authors： Lopez Franco GE,Blank RD,Akhter MP

更新日期：2011-01-01 00:00:00

abstract：:Osteocytes form a three-dimensional (3D) cellular network within the mineralized bone matrix. The cellular network has important roles in mechanosensation and mechanotransduction related to bone homeostasis. We visualized the embedded osteocyte network in chick calvariae and observed the flow-induced Ca2+ signaling in...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka T,Hoshijima M,Sunaga J,Nishida T,Hashimoto M,Odagaki N,Osumi R,Aadachi T,Kamioka H

更新日期：2018-09-01 00:00:00

abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...

journal_title：Journal of bone and mineral metabolism

authors： Fujita Y,Iki M,Ikeda Y,Morita A,Matsukura T,Nishino H,Yamagami T,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2011-03-01 00:00:00

abstract：:Recent studies have suggested that a high level of recent physical activity increases the risk of a wrist fracture in postmenopausal women. The relationship of more distant past physical activity to wrist fracture is less clear, and most studies have relied on recall of physical activity much earlier in life. The aim ...

journal_title：Journal of bone and mineral metabolism

authors： Thorpe DL,Knutsen SF,Beeson WL,Fraser GE

更新日期：2006-01-01 00:00:00

abstract：:The impact of smoking on peak bone density has not been conclusively established. We examined how smoking exposure influences bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative sample of Japanese women in 1996. The effect of current an...

journal_title：Journal of bone and mineral metabolism

authors： Tamaki J,Iki M,Sato Y,Kajita E,Kagamimori S,Kagawa Y,Yoneshima H

更新日期：2010-05-01 00:00:00

abstract：:We evaluated adherence with raloxifene therapy compared with daily bisphosphonate in Asian postmenopausal women at increased risk of osteoporotic fractures. In this 12-month observational study conducted in Asia (Hong Kong, Malaysia, Pakistan, Philippines, Singapore, Taiwan), 984 postmenopausal women (aged 55 years or...

journal_title：Journal of bone and mineral metabolism

authors： Pasion EG,Sivananthan SK,Kung AW,Chen SH,Chen YJ,Mirasol R,Tay BK,Shah GA,Khan MA,Tam F,Hall BJ,Thiebaud D

更新日期：2007-01-01 00:00:00

abstract：:The activation sequence of clasts (the designation clast was used because ultrastructurally in this tissue, it is not always possible to differentiate between chondroclasts sitting on cartilage and osteoclasts sitting on bone matrix) was studied in vivo using the healing of low-phosphate, vitamin D-deficiency rickets ...

journal_title：Journal of bone and mineral metabolism

authors： Hollberg K,Nordahl J,Hultenby K,Mengarelli-Widholm S,Andersson G,Reinholt FP

更新日期：2005-01-01 00:00:00

abstract：:The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...

journal_title：Journal of bone and mineral metabolism

authors： Lee YA,Kim JY,Kang MJ,Chung SJ,Shin CH,Yang SW

更新日期：2013-05-01 00:00:00

abstract：:Cleidocranial dysplasia (CCD) is an autosomal dominant disorder due to mutations in runt-related gene 2 (RUNX2)/polyomavirus enhancer-binding protein 2alphaA (PEBP2alphaA)/core-binding factor A1 (CBFA1)/acute myeloid leukemia 3 (AML3). To investigate the RUNX2 mutations in a Japanese patient with classic CCD, we analy...

journal_title：Journal of bone and mineral metabolism

authors： Goseki-Sone M,Orimo H,Watanabe A,Hamatani R,Yokozeki M,Ohyama K,Kuroda T,Watanabe H,Miyazaki H,Shimada T,Oida S

更新日期：2001-01-01 00:00:00

abstract：:The effects of unilateral sciatic neurectomy (USN) on the development of the femur were studied in 15 growing Wistar-derived rats (age, 5 weeks). The rats were divided into four groups: USN-operated group (right femur), USN-nonoperated group (left femur), sham-operated group (right femur), and sham-nonoperated group (...

journal_title：Journal of bone and mineral metabolism

authors： Yonezu H,Ikata T,Takata S,Shibata A

更新日期：1999-01-01 00:00:00

abstract：:Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the stren...

journal_title：Journal of bone and mineral metabolism

authors： Yakabe M,Hosoi T,Akishita M,Ogawa S

更新日期：2020-01-01 00:00:00

abstract：:In this study, we focused on collagen metabolism as a factor involved in menatetrenone (MK-4)-related improvement in bone quality. Using rats with a congenital ascorbic acid (AA) deficiency, osteogenic disorder Shionogi (ODS) rats, we established a model in which abnormal collagen metabolism reduced bone mechanical pr...

journal_title：Journal of bone and mineral metabolism

authors： Hara K,Akiyama Y

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Very few studies have been performed to evaluate both the severity and site of aortic calcification (AC) in both end-stage kidney disease (ESKD) and diabetes mellitus (DM). The purpose of our study was to examine the utility of a newly developed three-dimensional (3D) visualization and quantification metho...

journal_title：Journal of bone and mineral metabolism

authors： Fujii H,Kono K,Watanabe K,Goto S,Nishii T,Kono A,Nishi S

更新日期：2020-11-03 00:00:00

abstract：INTRODUCTION:Physical activity (PA) is a key factor of bone mass acquisition in peripubertal children. Sedentary behavior (SB) has been shown to influence bone outcomes. This study aimed to examine the association between objectively measured PA and SB and bone stiffness in Japanese children. MATERIALS AND METHODS:Par...

journal_title：Journal of bone and mineral metabolism

authors： Yamakita M,Ando D,Akiyama Y,Sato M,Suzuki K,Yamagata Z

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:Surgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze ...

journal_title：Journal of bone and mineral metabolism

authors： Soutome S,Yanamoto S,Sumi M,Hayashida S,Kojima Y,Sawada S,Rokutanda S,Iwai H,Saito T,Umeda M

更新日期：2020-10-12 00:00:00

abstract：:Osteonecrosis of the jaw (ONJ) associated with bisphosphonate therapy is a rare but severe side effect in osteoporosis patients. Recently, the number of osteoporosis patients with ONJ has dramatically increased in Japan. This has contributed to an increase in the number of patients avoiding extractions. However, there...

journal_title：Journal of bone and mineral metabolism

authors： Taguchi A,Uemura Y,Imai T,Tanaka S,Ohta H,Nakamura T,Orimo H,Sugimoto T,Soen S,Shiraki M,Adequate Treatment of Osteoporosis (A-TOP) research group.

更新日期：2019-09-01 00:00:00

abstract：:Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

journal_title：Journal of bone and mineral metabolism

authors： Matsumura H,Nakayama Y,Takai H,Ogata Y

更新日期：2015-03-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk o...

journal_title：Journal of bone and mineral metabolism

authors： Nakatsukasa K,Koyama H,Ouchi Y,Sakaguchi K,Fujita Y,Matsuda T,Kato M,Konishi E,Taguchi T

更新日期：2019-09-01 00:00:00