The effect of a single dose versus a daily dose of cholecalciferol on the serum 25-hydroxycholecalciferol and parathyroid hormone levels in the elderly with secondary hyperparathyroidism living in a low-income housing unit.


:We designed a randomized, double-blind, controlled clinical trial to compare the effect of two regimens for administering cholecalciferol on the serum 25-hydroxycholecalciferol [25(OH)D] levels and in the reversion of secondary hyperparathyroidism in the elderly living in a low-income housing unit in the city of Porto Alegre, southern Brazil. We studied 28 individuals ranging in age from 65 to 102 years with serum parathyroid hormone (PTH) levels greater than 48 pg/ml and normal or reduced serum calcium levels. Subjects were randomized to receive oral cholecalciferol, as a single dose of 300 000 IU (group 1) or 800 IU (group 2) daily for 9 months. Both groups received 1250 mg calcium carbonate per day. Serum 25(OH)D and PTH levels were measured at baseline and after 1, 2, 3, 6, and 9 months. Serum 25(OH)D levels in group 1 were significantly higher than in group 2 during the study (P < 0.001). After 1 (P < 0.001) and 2 (P < 0.04) months of treatment, mean serum 25(OH)D levels were higher in group 1. The number of subjects who reached serum 25(OH)D levels >/=20 ng/dl was higher in group 1, after the first (P < 0.001) and third (P = 0.008) months. In the short term, a single 300 000 IU oral dose of vitamin D(3) was more effective than 800 IU per day to increase serum 25(OH)D levels in elderly persons, living in a low-income housing unit, who were taking 500 mg elementary calcium supplement per day.


J Bone Miner Metab


Premaor MO,Scalco R,da Silva MJ,Froehlich PE,Furlanetto TW




Has Abstract


2008-01-01 00:00:00












  • Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.

    abstract::Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Yao GQ,Wu JJ,Troiano N,Insogna K

    更新日期:2011-03-01 00:00:00

  • Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.

    abstract::Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Sato T,Watanabe K,Masuhara M,Hada N,Hakeda Y

    更新日期:2007-01-01 00:00:00

  • Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip.

    abstract::In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femo...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Shimamura M,Iwata K,Mashiba T,Miki T,Yamamoto T

    更新日期:2019-09-01 00:00:00

  • Identification of the CLCN7 gene mutations in two Chinese families with autosomal dominant osteopetrosis (type II).

    abstract::Here we report the identification of two different mutations in chloride channel 7 gene in two unrelated patients with autosomal dominant osteopetrosis type II. We determined that one patient (a 32-year-old woman) carried a heterozygous gene for a R767W mutation in exon 24, and another patient (a 17-year-old boy) carr...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Zhang ZL,He JW,Zhang H,Hu WW,Fu WZ,Gu JM,Yu JB,Gao G,Hu YQ,Li M,Liu YJ

    更新日期:2009-01-01 00:00:00

  • Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.

    abstract::To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 sy...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Hojo H,Yano F,Ohba S,Igawa K,Nakajima K,Komiyama Y,Kan A,Ikeda T,Yonezawa T,Woo JT,Takato T,Nakamura K,Kawaguchi H,Chung UI

    更新日期:2010-11-01 00:00:00

  • Low calcium intake is associated with decreased adrenal androgens and reduced bone age in premenarcheal girls in the last pubertal stages.

    abstract::In 50 premenarcheal girls selected from the lowest and highest end of the calcium-intake distribution of a large population sample, we evaluated bone mineral density (BMD), together with the following hormonal-metabolic parameters: androstenedione (ASD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (D...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Bonofiglio D,Garofalo C,Catalano S,Marsico S,Aquila S,Andò S

    更新日期:2004-01-01 00:00:00

  • Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis.

    abstract::Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miki T,Nakatsuka K,Naka H,Kitatani K,Saito S,Masaki H,Tomiyoshi Y,Morii H,Nishizawa Y

    更新日期:2003-01-01 00:00:00

  • Activation of focal adhesion kinase induces extracellular signal-regulated kinase-mediated osteogenesis in tensile force-subjected periodontal ligament fibroblasts but not in osteoblasts.

    abstract::The exact mechanism by which focal adhesion kinase (FAK) translates mechanical signals into osteogenesis differentiation in force-subjected cells has not been elucidated. The responses to different forces differ according to the origin of cells and the type of stress applied. Therefore, the recruitment of osteoclast a...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Chen YJ,Shie MY,Hung CJ,Wu BC,Liu SL,Huang TH,Kao CT

    更新日期:2014-11-01 00:00:00

  • Impact of bisphosphonate wash-out prior to teriparatide therapy in clinical practice.

    abstract::Concurrent use of bisphosphonate therapy reduces the anabolic effect of teriparatide. Consequently, in clinical practice bisphosphonates are discontinued and teriparatide therapy held for a few months to allow bone turnover to increase. We aimed to evaluate the effect of prior bisphosphonate exposure and the effect of...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 临床试验,杂志文章


    authors: Keel C,Kraenzlin ME,Kraenzlin CA,Müller B,Meier C

    更新日期:2010-01-01 00:00:00

  • Multiscale investigation on the effects of additional weight bearing in combination with low-magnitude high-frequency vibration on bone quality of growing female rats.

    abstract::This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Zhang T,Gao J,Fang J,Gong H

    更新日期:2018-03-01 00:00:00

  • Aromatase inhibitors attenuate the effect of alendronate in women with breast cancer.

    abstract:INTRODUCTION:Aromatase inhibitors are known to accelerate bone loss in patients with breast cancer. However, how much AIs affect the efficacy of antiresorptive agents has not been studied. The study aimed to compare the effect of alendronate on bone mineral density (BMD) between patients with and without AI treatment. ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Kong SH,Kim JH,Kim SW,Shin CS

    更新日期:2020-09-01 00:00:00

  • Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice.

    abstract::Endoplasmic reticulum (ER) stress has been reported to be linked to various diseases such as diabetes, neurodegenerative diseases, and osteogenesis imperfecta (OI). Old astrocyte specifically induced substance (OASIS), a novel type of ER stress transducer, is a basic leucine zipper transcription factor belonging to th...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Sekiya H,Murakami T,Saito A,Hino S,Tsumagari K,Ochiai K,Imaizumi K

    更新日期:2010-07-01 00:00:00

  • Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis.

    abstract::The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 6...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章,多中心研究


    authors: Ebina K,Hirao M,Hashimoto J,Hagihara K,Kashii M,Kitaguchi K,Matsuoka H,Iwahashi T,Chijimatsu R,Yoshikawa H

    更新日期:2018-07-01 00:00:00

  • Role of stromal cells in osteoclast differentiation in bone marrow.

    abstract::Bone marrow stromal cells have been considered to play an important role in osteoclast differentiation. However, the interaction of these cells in vivo has not been clearly demonstrated. To clarify this, we examined the distribution of alkaline phosphatase (ALPase) and tartrate-resistant acid phosphatase (TRAPase) act...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Kondo Y,Irie K,Ikegame M,Ejiri S,Hanada K,Ozawa H

    更新日期:2001-01-01 00:00:00

  • Texture analysis of X-ray radiographs is correlated with bone histomorphometry.

    abstract::Three-dimensional (3D) alteration of trabecular microarchitecture is a risk factor for vertebral fractures. Histomorphometry allows microarchitectural analysis of bone, but the necessity to perform a transiliac bone biopsy limits its use in large series of patients. X-Ray films are commonly used in routine practice an...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Chappard D,Guggenbuhl P,Legrand E,Baslé MF,Audran M

    更新日期:2005-01-01 00:00:00

  • Eldecalcitol reduces the risk of severe vertebral fractures and improves the health-related quality of life in patients with osteoporosis.

    abstract::Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章,随机对照试验


    authors: Hagino H,Takano T,Fukunaga M,Shiraki M,Nakamura T,Matsumoto T

    更新日期:2013-03-01 00:00:00

  • Age-related changes in bone biochemical markers and their relationship with bone mineral density in normal Chinese women.

    abstract::Measurements of bone biochemical markers are increasingly being used to evaluate the state of bone turnover in the management of bone metabolic diseases, especially osteoporosis. However, changes in the bone turnover rate vary with age. The aim of this study was to establish the laboratory reference range of serum bon...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Pi YZ,Wu XP,Liu SP,Luo XH,Cao XZ,Xie H,Liao EY

    更新日期:2006-01-01 00:00:00

  • Lack of association between the HindIII RFLP of the osteocalcin (BGP) gene and bone mineral density (BMD) in healthy pre- and postmenopausal Chinese women.

    abstract::In Caucasian populations, the polymorphic restriction endonuclease HindIII marker of the osteocalcin (also known as BGP, for bone Gla protein) gene has recently been reported to be associated with bone mass, a major risk determinant of osteoporosis. In this study, we investigated the relationship between the BGP HindI...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Mo XY,Cao CK,Xu FH,Liu MY,Li MX,Qin YJ,Zhou Q,Zhang YY,Deng HW

    更新日期:2004-01-01 00:00:00

  • Menin and bone metabolism.

    abstract::Menin, a product of the MEN1 gene, is related to the ontogeny of several cancers such as MEN1 and sporadic endocrine tumors, although it is considered to be a tumor suppressor. Many proteins interact with menin, and it is involved in various biological functions in several tissues. Menin plays some physiological and p...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章,评审


    authors: Kaji H

    更新日期:2012-07-01 00:00:00

  • Absolute height reduction and percent height ratio of the vertebral body in incident fracture in Japanese women.

    abstract::Vertebral fractures are the most common complication associated with osteoporosis. The definition of prevalent or incident vertebral fractures is important in epidemiological evaluation and in clinical trials of osteoporosis treatment. There have been few reports regarding the morphometric cutoff criteria for incident...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Fukunaga M,Nakamura T,Shiraki M,Kuroda T,Ohta H,Hosoi T,Orimo H

    更新日期:2004-01-01 00:00:00

  • Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats.

    abstract::Bone is a specialized connective tissue that functions as the load-bearing structure of the body. Free radicals may affect bone remodeling by regulating osteoclast activity in either the physiological or pathological condition. Vitamin E, a lipid-soluble antioxidant, has been demonstrated to offer protection against o...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Mehat MZ,Shuid AN,Mohamed N,Muhammad N,Soelaiman IN

    更新日期:2010-09-01 00:00:00

  • Bone metabolism and the muscle-bone relationship in children, adolescents and young adults with phenylketonuria.

    abstract::The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

    更新日期:2011-03-01 00:00:00

  • The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients.

    abstract::It has been suggested that there are several possible linkages between vascular calcification and osteoporosis. In addition, the processes of vascular calcification may have a common etiology with bone formation. Thus, we hypothesized that the serum levels of bone metabolic markers would be different between osteoporo...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Iba K,Takada J,Yamashita T

    更新日期:2004-01-01 00:00:00

  • Trochanteric hip fracture in an elderly patient with leprosy during osteoporosis treatment with risedronate and alfacalcidol.

    abstract::There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Kanaji A,Higashi M,Namisato M,Ando K,Nakagawa M,Yato Y,Ichinose H,Sakamaki T,Yamada H

    更新日期:2005-01-01 00:00:00

  • Updated concept of sarcopenia based on muscle-bone relationship.

    abstract::Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the stren...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章,评审


    authors: Yakabe M,Hosoi T,Akishita M,Ogawa S

    更新日期:2020-01-01 00:00:00

  • Effectiveness of monthly intravenous ibandronate on the low responders to oral bisphosphonate: the MOVEMENT study.

    abstract::The MOVEMENT study was designed to assess the effectiveness of monthly intravenous ibandronate on bone mineral density (BMD) in daily clinical practice in Japanese patients with primary osteoporosis whose lumbar spine BMD did not increase despite oral bisphosphonate therapy. This study was a multicenter, prospective, ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Hagino H,Sakai A,Ikeda S,Imanishi Y,Tsurukami H,Nakajo S,Miyakoshi N

    更新日期:2019-11-01 00:00:00

  • Growth pattern of lumbar bone mineral content and trunk muscles in adolescent male soccer players.

    abstract:INTRODUCTION:Previous studies have reported that the peak in lean body mass (LBM) precedes the peak in bone mineral content (BMC). However, it is unknown whether the trunk region growth is similar. MATERIALS AND METHODS:We investigated the difference between pubertal peak age in the increase of LBM in the trunk (trunk...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Takei S,Taketomi S,Tanaka S,Torii S

    更新日期:2020-05-01 00:00:00

  • Densitometric and geometric measurement of the proximal femur in elderly women with and without osteoporotic vertebral fractures by volumetric quantitative multi-slice CT.

    abstract::There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral ne...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Wu SY,Qi J,Lu Y,Lan J,Yu JC,Wen LQ,Zhang ZL

    更新日期:2010-11-01 00:00:00

  • Sclerostin, preadipocyte factor-1 and bone mineral values in eumenorrheic adolescent athletes with different training patterns.

    abstract:INTRODUCTION:The specific aims of the study were to compare possible differences in sclerostin and preadipocyte factor-1 (Pref-1) between rhythmic gymnasts (RG), swimmers (SW) and untrained controls (UC), and to investigate the relationships of sclerostin and Pref-1 with bone mineral characteristics in studied groups. ...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Jürimäe J,Karvelyte V,Remmel L,Tamm AL,Purge P,Gruodyte-Raciene R,Kamandulis S,Maasalu K,Gracia-Marco L,Tillmann V

    更新日期:2020-09-02 00:00:00

  • Executive summary of clinical practice guide on fracture risk in lifestyle diseases.

    abstract::Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifesty...

    journal_title:Journal of bone and mineral metabolism

    pub_type: 杂志文章


    authors: Kanazawa I,Inaba M,Inoue D,Uenishi K,Saito M,Shiraki M,Suzuki A,Takeuchi Y,Hagino H,Fujiwara S,Sugimoto T,from the Japan Osteoporosis Society Lifestyle diseases-related Fracture Risk Investigation Committee.

    更新日期:2020-11-01 00:00:00