Abstract：
:Recent studies have suggested that a high level of recent physical activity increases the risk of a wrist fracture in postmenopausal women. The relationship of more distant past physical activity to wrist fracture is less clear, and most studies have relied on recall of physical activity much earlier in life. The aim of this study was to assess the risk of wrist fracture in a subset of women who had completed a recent questionnaire and also had participated in a cohort study 25 years earlier, 1865 women who were perimenopausal and postmenopausal in 1976 and had completed the 1976 and 2002 Adventist Health Study lifestyle questionnaires. Data on risk factors including physical activity were collected from the 1976 survey. Subjects reported wrist fractures occurring since baseline, and the approximate time of fracture, in the 2002 questionnaire. Incidence of wrist fracture was 3.7/1000 person-years of follow up. There was a dose-response inverse relationship between level of physical activity and wrist fracture with a 37% reduction of risk for the highest level of physical activity with respect to the lowest level (HR, 0.63; 95% CI, 0.45, 0.89). The effect of physical activity changed little in the final multivariable model (HR, 0.61; 95% CI, 0.43, 0.87). In this cohort of women with a relatively low incidence of wrist fracture, higher levels of physical activity at baseline were protective against risk of fracture during 25 years of follow-up.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Thorpe DL,Knutsen SF,Beeson WL,Fraser GEdoi
10.1007/s00774-006-0715-ysubject
Has Abstractpub_date
2006-01-01 00:00:00pages
476-83issue
6eissn
0914-8779issn
1435-5604journal_volume
24pub_type
杂志文章abstract：:The objective of this study was to record the clinical course of osteoporosis over time in Japanese women. We hypothesized that successful control of acute pain associated with osteoporosis will allow better treatment for health-related problems. To confirm this working hypothesis, we developed the Japan Questionnaire...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-013-0458-5
更新日期：2013-11-01 00:00:00
abstract：:The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 6...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,多中心研究
doi：10.1007/s00774-017-0861-4
更新日期：2018-07-01 00:00:00
abstract：:In this study, we focused on collagen metabolism as a factor involved in menatetrenone (MK-4)-related improvement in bone quality. Using rats with a congenital ascorbic acid (AA) deficiency, osteogenic disorder Shionogi (ODS) rats, we established a model in which abnormal collagen metabolism reduced bone mechanical pr...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0069-3
更新日期：2009-01-01 00:00:00
abstract：:Chronic liver disease in adults is a risk factor of osteoporosis, but little is known about risk of fractures in children with non-cholestatic liver disease. The aim of this study was to investigate associations among the severity of liver fibrosis, bone mass and low-energy fractures in children. History of fractures,...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0219-7
更新日期：2011-05-01 00:00:00
abstract：:Inactivating mutations and/or deletions of PHEX ( Phosphate-regulating gene with Homologies to Endopeptidase on the X chromosome) are responsible for X-linked hypophosphatemic rickets in humans. In the present study, three Drosophila PHEX homologues (dPHEX-1, -2, -3) were isolated by the screening of a Drosophila cDNA...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-003-0440-8
更新日期：2004-01-01 00:00:00
abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,评审
doi：10.1007/s00774-004-0517-z
更新日期：2004-01-01 00:00:00
abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-012-0373-1
更新日期：2012-11-01 00:00:00
abstract：:This study was carried out to evaluate the clinical validity and usefulness of serum tartrate-resistant fluoride-sensitive acid phosphatase (TrFsACP) activity using 2,6-dichloro-4-acetylphenyl phosphate as substrate at pH 6.2 in metabolic bone diseases. The mean Z-scores of TrFsACP activity in patients on hemodialysis...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740050075
更新日期：1999-01-01 00:00:00
abstract：INTRODUCTION:Aromatase inhibitors are known to accelerate bone loss in patients with breast cancer. However, how much AIs affect the efficacy of antiresorptive agents has not been studied. The study aimed to compare the effect of alendronate on bone mineral density (BMD) between patients with and without AI treatment. ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-020-01111-3
更新日期：2020-09-01 00:00:00
abstract：:This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-017-0827-6
更新日期：2018-03-01 00:00:00
abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0202-3
更新日期：2011-03-01 00:00:00
abstract：:In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this s...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-018-0976-2
更新日期：2019-07-01 00:00:00
abstract：:Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s007740300025
更新日期：2003-01-01 00:00:00
abstract：:Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 6...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-004-0593-0
更新日期：2005-01-01 00:00:00
abstract：:We evaluated adherence with raloxifene therapy compared with daily bisphosphonate in Asian postmenopausal women at increased risk of osteoporotic fractures. In this 12-month observational study conducted in Asia (Hong Kong, Malaysia, Pakistan, Philippines, Singapore, Taiwan), 984 postmenopausal women (aged 55 years or...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-006-0735-7
更新日期：2007-01-01 00:00:00
abstract：:The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before star...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-014-0566-x
更新日期：2015-01-01 00:00:00
abstract：:Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhanc...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-013-0513-2
更新日期：2014-07-01 00:00:00
abstract：:The purpose of this study was to investigate the relationship between intervertebral disk degeneration and bone mass. Magnetic resonance imaging was performed to evaluate lumbar disk degeneration according to Thompson's classification (grades 1 and 2, normal disk; grades 3, 4, and 5, degenerated disk), and bone minera...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740300004
更新日期：2003-01-01 00:00:00
abstract：:The effects of catecholamine excess due to pheochromocytoma on body composition, including skeletal muscle mass, are unknown. Here, we investigated the effects of catecholamine metabolites on body composition in subjects with pheochromocytoma. After body compositions using bioelectrical impedance analysis, urinary met...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00774-018-0959-3
更新日期：2019-07-01 00:00:00
abstract：:Osteocytes form a three-dimensional (3D) cellular network within the mineralized bone matrix. The cellular network has important roles in mechanosensation and mechanotransduction related to bone homeostasis. We visualized the embedded osteocyte network in chick calvariae and observed the flow-induced Ca2+ signaling in...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-017-0868-x
更新日期：2018-09-01 00:00:00
abstract：:Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated under reduced pressure with addition of heated algal ingredient (HAI) (group A); AACa, the same preparation wit...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s007740070022
更新日期：2000-01-01 00:00:00
abstract：:A link between vascular calcification and bone anomalies has been suggested in chronic kidney disease (CKD) patients with low bone turnover disease. We investigated the vascular expression of osteocyte markers in relation to bone microarchitecture and mineralization defects in a model of low bone turnover CKD rats wit...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-018-0919-y
更新日期：2019-03-01 00:00:00
abstract：:In order to explore the effects of calcitonin gene-related peptide (CGRP) on bone mesenchymal stem cells (BMSCs) from ovariectomized (OVX) rats, an OVX rat model was used. An ELISA was performed to examine the changes in CGRP level in the plasma and skeleton. The BMSCs from the sham rats were designated group A. The B...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-016-0780-9
更新日期：2017-09-01 00:00:00
abstract：:Lipid rafts are membrane platforms for signaling molecules that regulate various cellular functions. During osteoclastogenesis, lipid rafts also have been shown to play a crucial role for cell fusion upon RANK/RANKL interaction and further activation of osteoclasts, resulting in bone resorption. To investigate protein...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0150-y
更新日期：2010-07-01 00:00:00
abstract：:Variation in drug response to hormone replacement therapy (HRT) may reflect genetic heterogeneity in the estrogen-related genes, possibly including estrogen receptor alpha (ERalpha) gene. However, only a few association studies of the drug response to HRT have been reported, focusing mainly on the intronic polymorphis...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-005-0619-2
更新日期：2005-01-01 00:00:00
abstract：:A cell line of murine osteogenic progenitor cells, Kusa, was established from femoral bone marrow stromal cells with other types of mesenchymal progenitor cells. We characterized two sublines of Kusa (Kusa-A1 and Kusa-O) from several aspects, including the use of an expression profiling system, a cDNA microarray. The ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-004-0550-y
更新日期：2005-01-01 00:00:00
abstract：:Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic, and angiogenic differentiation. The mechanisms underlying the proliferation and differentiation of mesenchymal progenitor cells remain unclear. Here, we demonstrate Dickkopf-relat...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-015-0711-1
更新日期：2016-11-01 00:00:00
abstract：:Menin, a product of the MEN1 gene, is related to the ontogeny of several cancers such as MEN1 and sporadic endocrine tumors, although it is considered to be a tumor suppressor. Many proteins interact with menin, and it is involved in various biological functions in several tissues. Menin plays some physiological and p...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,评审
doi：10.1007/s00774-012-0355-3
更新日期：2012-07-01 00:00:00
abstract：:Leptin has been proposed to be a key molecule involved in energy regulation. Based on the generally acknowledged concept that a heavier person has a higher bone density, leptin is thought to be potentially involved in bone metabolism. Serum leptin, various bone markers, and bone mineral density (BMD) were studied in 5...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740170050
更新日期：2001-01-01 00:00:00
abstract：:There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-004-0546-7
更新日期：2005-01-01 00:00:00
