Abstract:
:Expression of the genes encoding bone morphogenetic proteins (BMPs), BMP type IA receptor (BMPR-1A), and rat distal-less homolog (rDlx) was studied in bone, callus, and the surrounding soft tissue following rat femoral closed fracture, using RT-PCR-based techniques. Before fracture, the genes encoding BMP-5, BMP-6, and BMPR-1A were found to be expressed in both bone and the surrounding soft tissue, whereas the BMP-2 gene was expressed only in bone and BMP-7 was not expressed in either tissue. Expression of these genes was unaffected by fracture. The gene encoding BMP-4 was also expressed in both bone and the surrounding soft tissue before fracture. Moreover, although unchanged in bone, 6 h after fracture BMP-4 expression was increased tenfold in the surrounding soft tissue. The increased BMP-4 expression was transient and returned to prefracture levels within 72 h. Expression of rDlx was also increased in bone after fracture, but at later times than were observed with BMP-4: elevated rDlx expression was detected after 48 h and persisted for 30 days or more. No expression of rDlx was observed in the surrounding soft tissue before or after fracture. These findings indicate that BMP-4 and rDlx are selectively expressed following femoral fracture in the rat, and also suggest that they are involved in the formation of the callus at an early point during the postfracture healing of bone.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Yaoita H,Orimo H,Shirai Y,Shimada Tdoi
10.1007/s007740050013subject
Has Abstractpub_date
2000-01-01 00:00:00pages
63-70issue
2eissn
0914-8779issn
1435-5604journal_volume
18pub_type
杂志文章abstract::Metformin, an anti-hyperglycemic agent used for type 2 diabetes, has recently been found to have more effects apart from glucose regulation. We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bon...
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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更新日期:2003-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0216-x
更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00774-014-0566-x
更新日期:2015-01-01 00:00:00
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更新日期:2013-11-01 00:00:00
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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