Effects of sciatic neurectomy on the femur in growing rats: application of peripheral quantitative computed tomography and Fourier transform infrared spectroscopy.

abstract：:The effects of basic fibroblast growth factor (bFGF) on osteogenic differentiation in-vivo were investigated using a rat bone marrow ablation model. bFGF was infused directly into rat femora for 6 days after bone marrow ablation. The contralateral femur was infused with vehicle only and used as control. Bone formation...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka H,Wakisaka A,Ogasa H,Kawai S,Liang CT

更新日期：2003-01-01 00:00:00

abstract：:Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or ad...

journal_title：Journal of bone and mineral metabolism

authors： Mendonça Monteiro de Barros G,Madeira M,Vieira Neto L,de Paula Paranhos Neto F,Carvalho Mendonça LM,Corrêa Barbosa Lima I,Corbo R,Fleiuss Farias ML

更新日期：2016-07-01 00:00:00

abstract：:It has been reported that alfacalcidol had an anticatabolic and anabolic effect on bone in ovariectomized and aged male rat models, but this has not been tested on intact female rats. The current study was to determine the effects of alfacalcidol on cancellous and cortical bone in intact female rats with or without ex...

journal_title：Journal of bone and mineral metabolism

authors： Liu XQ,Chen HY,Tian XY,Setterberg RB,Li M,Jee WS

更新日期：2008-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress has been reported to be linked to various diseases such as diabetes, neurodegenerative diseases, and osteogenesis imperfecta (OI). Old astrocyte specifically induced substance (OASIS), a novel type of ER stress transducer, is a basic leucine zipper transcription factor belonging to th...

journal_title：Journal of bone and mineral metabolism

authors： Sekiya H,Murakami T,Saito A,Hino S,Tsumagari K,Ochiai K,Imaizumi K

更新日期：2010-07-01 00:00:00

abstract：:Sarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the stren...

journal_title：Journal of bone and mineral metabolism

authors： Yakabe M,Hosoi T,Akishita M,Ogawa S

更新日期：2020-01-01 00:00:00

abstract：:Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use ...

journal_title：Journal of bone and mineral metabolism

authors： Dai L,Xu M,Wu H,Xue L,Yuan D,Wang Y,Shen Z,Zhao H,Hu M

更新日期：2016-01-01 00:00:00

abstract：:Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodi...

journal_title：Journal of bone and mineral metabolism

authors： Carbone LD,Barrow KD,Bush AJ,Boatright MD,Michelson JA,Pitts KA,Pintea VN,Kang AH,Watsky MA

更新日期：2005-01-01 00:00:00

abstract：:Disturbed zinc (Zn) homeostasis in mammals is mainly characterized by impaired bone generation accompanied with growth retardation. However, the underlying mechanisms that determine how Zn controls bone homeostasis remain to be defined. Zn homeostasis is tightly controlled by Zn transporter families. Recent studies ha...

journal_title：Journal of bone and mineral metabolism

authors： Fukada T,Hojyo S,Furuichi T

更新日期：2013-03-01 00:00:00

abstract：:In the course of complex regional pain syndrome (CRPS), local osteopenia in the subchondral/subcortical areas of the affected limb represents a central manifestation. Mechanistic aspects of CRPS-associated pathologies remain unclear, and knowledge about bone morphology in CRPS-affected areas is rare. The aim of this s...

journal_title：Journal of bone and mineral metabolism

authors： Oehler N,Rolvien T,Schmidt T,Butscheidt S,Oheim R,Barvencik F,Mussawy H

更新日期：2019-07-01 00:00:00

abstract：:Interleukin-11 (IL-11) is a bone marrow stromal fibroblast-derived cytokine with a wide spectrum of activities in different biological systems. IL-11 and IL-6 are two cytokines known to rely on osteoblast-osteoclast communication for their effects on osteoclast differentiation. Bone sialoprotein (BSP) is a mineralized...

journal_title：Journal of bone and mineral metabolism

authors： Matsumura H,Nakayama Y,Takai H,Ogata Y

更新日期：2015-03-01 00:00:00

abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

journal_title：Journal of bone and mineral metabolism

authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

更新日期：2006-01-01 00:00:00

abstract：:Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference. Sixty female monke...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka M,Matsugaki A,Ishimoto T,Nakano T

更新日期：2016-03-01 00:00:00

abstract：:Bone is a specialized connective tissue that functions as the load-bearing structure of the body. Free radicals may affect bone remodeling by regulating osteoclast activity in either the physiological or pathological condition. Vitamin E, a lipid-soluble antioxidant, has been demonstrated to offer protection against o...

journal_title：Journal of bone and mineral metabolism

authors： Mehat MZ,Shuid AN,Mohamed N,Muhammad N,Soelaiman IN

更新日期：2010-09-01 00:00:00

abstract：:To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 sy...

journal_title：Journal of bone and mineral metabolism

authors： Hojo H,Yano F,Ohba S,Igawa K,Nakajima K,Komiyama Y,Kan A,Ikeda T,Yonezawa T,Woo JT,Takato T,Nakamura K,Kawaguchi H,Chung UI

更新日期：2010-11-01 00:00:00

abstract：:In 50 premenarcheal girls selected from the lowest and highest end of the calcium-intake distribution of a large population sample, we evaluated bone mineral density (BMD), together with the following hormonal-metabolic parameters: androstenedione (ASD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (D...

journal_title：Journal of bone and mineral metabolism

authors： Bonofiglio D,Garofalo C,Catalano S,Marsico S,Aquila S,Andò S

更新日期：2004-01-01 00:00:00

abstract：:Bone microarchitecture of the iliac bone is used to characterize the properties of bone tissue in osteoporosis, particularly in pharmacological studies. Trabecular bone is known to be heterogeneous media. For a few years, the analysis of three-dimensional (3-D) bone microarchitecture has been based on micro-computed t...

journal_title：Journal of bone and mineral metabolism

authors： Chappard C,Marchadier A,Benhamou L

更新日期：2008-01-01 00:00:00

abstract：:Low levels of vitamin D nutrition (i.e., vitamin D insufficiency), which potentially cause osteoporosis, have been recognized as a common health problem for elderly people in European and North American countries, but there have been no studies on the prevalence of vitamin D insufficiency in Japan until recently. The ...

journal_title：Journal of bone and mineral metabolism

authors： Nakamura K

更新日期：2006-01-01 00:00:00

abstract：:Bone marrow stromal cells have been considered to play an important role in osteoclast differentiation. However, the interaction of these cells in vivo has not been clearly demonstrated. To clarify this, we examined the distribution of alkaline phosphatase (ALPase) and tartrate-resistant acid phosphatase (TRAPase) act...

journal_title：Journal of bone and mineral metabolism

authors： Kondo Y,Irie K,Ikegame M,Ejiri S,Hanada K,Ozawa H

更新日期：2001-01-01 00:00:00

abstract：:It has been suggested that there are several possible linkages between vascular calcification and osteoporosis. In addition, the processes of vascular calcification may have a common etiology with bone formation. Thus, we hypothesized that the serum levels of bone metabolic markers would be different between osteoporo...

journal_title：Journal of bone and mineral metabolism

authors： Iba K,Takada J,Yamashita T

更新日期：2004-01-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a cytokine implicated in the promotion of osteoclastogenesis. Its effect has been believed not to be directly exerted on osteoclast precursors, but rather indirectly carried out via an induction of receptor activator of NF-κB ligand (RANKL), the osteoclast differentiation factor, on osteoclas...

journal_title：Journal of bone and mineral metabolism

authors： Ota M,Yanagisawa M,Tachibana H,Yokota K,Araki Y,Sato K,Mimura T

更新日期：2015-01-01 00:00:00

abstract：:Serum 25-hydroxyvitamin D (25-OHD) concentrations are thought to accurately reflect vitamin D stores, and vitamin D deficiency causes secondary hyperparathyroidism, irreversible bone loss, and increased risk of fracture. Recent studies suggest that decrease of serum 25-OHD level in mothers could increase the risk of p...

journal_title：Journal of bone and mineral metabolism

authors： Shibata M,Suzuki A,Sekiya T,Sekiguchi S,Asano S,Udagawa Y,Itoh M

更新日期：2011-09-01 00:00:00

abstract：:Notch is a transmembrane protein involved in cell fate determination. In the present study, we observed temporally and spatially restricted expression of Notch1 in developing cartilage. Notch1 was localized starting from the mesenchymal condensation stage of embryonic mouse forelimbs. Interestingly, although localizat...

journal_title：Journal of bone and mineral metabolism

authors： Watanabe N,Tezuka Y,Matsuno K,Miyatani S,Morimura N,Yasuda M,Fujimaki R,Kuroda K,Hiraki Y,Hozumi N,Tezuka K

更新日期：2003-01-01 00:00:00

abstract：:The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

journal_title：Journal of bone and mineral metabolism

authors： Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

更新日期：2011-03-01 00:00:00

abstract：:Hypophosphatasia is a rare inherited disorder characterized by a low serum alkaline phosphatase (ALP) activity and defective bone mineralization. Adult hypophosphatasia typically manifests in middle-age as a result of osteomalacia with recurrent stress fractures of the lower limb. However, considerable variation occur...

journal_title：Journal of bone and mineral metabolism

authors： Iida K,Fukushi J,Fujiwara T,Oda Y,Iwamoto Y

更新日期：2012-11-01 00:00:00

abstract：:Here we report the identification of two different mutations in chloride channel 7 gene in two unrelated patients with autosomal dominant osteopetrosis type II. We determined that one patient (a 32-year-old woman) carried a heterozygous gene for a R767W mutation in exon 24, and another patient (a 17-year-old boy) carr...

journal_title：Journal of bone and mineral metabolism

authors： Zhang ZL,He JW,Zhang H,Hu WW,Fu WZ,Gu JM,Yu JB,Gao G,Hu YQ,Li M,Liu YJ

更新日期：2009-01-01 00:00:00

abstract：:The aim of this study was to explore the effects of α-zearalanol (α-ZAL) on the proliferation of mouse bone-marrow-derived mesenchymal stem cells (BMSCs) and their differentiation into osteoblasts. Six- to eight-week-old BALB/C mice were used either as recipients or as bone marrow donors. BMSCs were isolated and colle...

journal_title：Journal of bone and mineral metabolism

authors： Zong S,Zeng G,Fang Y,Peng J,Zou B,Gao T,Zhao J

更新日期：2016-03-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk o...

journal_title：Journal of bone and mineral metabolism

authors： Nakatsukasa K,Koyama H,Ouchi Y,Sakaguchi K,Fujita Y,Matsuda T,Kato M,Konishi E,Taguchi T

更新日期：2019-09-01 00:00:00

abstract：:Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated under reduced pressure with addition of heated algal ingredient (HAI) (group A); AACa, the same preparation wit...

journal_title：Journal of bone and mineral metabolism

authors： Fujita T,Fujii Y,Goto B,Miyauchi A,Takagi Y

更新日期：2000-01-01 00:00:00

abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...

journal_title：Journal of bone and mineral metabolism

authors： Zanatta M,Valenti MT,Donatelli L,Zucal C,Dalle Carbonare L

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was to investigate the association of the Singh index, cortical thickness index (CTI) and calcar-to-canal (CC) ratio with bone mineral density (BMD) as well as their relationship with physical parameters [age, gender, height, and body mass index (BMI)] in order to assess their potential as an...

journal_title：Journal of bone and mineral metabolism

authors： Im GI,Park PG,Moon SW

更新日期：2012-09-01 00:00:00