Abstract:
:Bone is a specialized connective tissue that functions as the load-bearing structure of the body. Free radicals may affect bone remodeling by regulating osteoclast activity in either the physiological or pathological condition. Vitamin E, a lipid-soluble antioxidant, has been demonstrated to offer protection against osteoporosis and to improve the bone material and structure of animal models. The aim of this study was to observe and compare the effects of alpha-tocopherol (alpha-tocopherol), delta-tocotrienol (delta-tocotrienol), and gamma-tocotrienol (gamma-tocotrienol) on the static and dynamic bone histomorphometric parameters in normal male rats. Thirty-two normal Sprague-Dawley male rats aged 3 months and weighing 200-250 g were randomly divided into four groups. The control group was supplemented with oral gavages of olive oil (vehicle), whereas the alpha-tocopherol, delta-tocotrienol, and gamma-tocotrienol groups were given oral gavages of 60 mg/kg alpha-tocopherol, delta-tocotrienol, and gamma-tocotrienol, respectively. The rats were injected twice with calcein to fluorochrome-label the bones. After 4 months of treatment, the rats were killed, and the left femurs were dissected out and prepared for bone histomorphometry. Both the static and dynamic parameters of the vitamin E-treated groups were better than those of the normal control group. Among the vitamin E-treated groups, the tocotrienol groups showed better histomorphometry results compared to the α-tocopherol group, with the γ-tocotrienol group demonstrating the best effects on both sets of parameters. We concluded that vitamin E can promote bone formation in normal rats, with gamma-tocotrienol being the most potent form of vitamin E.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Mehat MZ,Shuid AN,Mohamed N,Muhammad N,Soelaiman INdoi
10.1007/s00774-010-0159-2subject
Has Abstractpub_date
2010-09-01 00:00:00pages
503-9issue
5eissn
0914-8779issn
1435-5604journal_volume
28pub_type
杂志文章abstract::Knee loading is a relatively new loading modality in which dynamic loads are laterally applied to the knee to induce bone formation in the tibia and the femur. The specific aim of the current study was to evaluate the effects of loading frequencies (in Hz) on bone formation at the site away from the loading site on th...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740170004
更新日期:2001-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-005-0680-x
更新日期:2006-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,多中心研究
doi:10.1007/s00774-013-0529-7
更新日期:2014-09-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0216-x
更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0693-0
更新日期:2006-01-01 00:00:00
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doi:10.1007/s00774-019-01060-6
更新日期:2020-05-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-007-0808-2
更新日期:2008-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 临床试验,杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-005-0626-3
更新日期:2005-01-01 00:00:00
abstract::Twenty elderly osteoporotic women with vertebral fracture(s) were randomly allocated to two groups; women in the MK(4) group received calcium with menaquinone 4 (MK(4)) at a dose of 45 mg/day for 2 weeks, and women in the control group received calcium alone for the same period. Serum intact osteocalcin (OC) and under...
journal_title:Journal of bone and mineral metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
abstract::Measurements of bone biochemical markers are increasingly being used to evaluate the state of bone turnover in the management of bone metabolic diseases, especially osteoporosis. However, changes in the bone turnover rate vary with age. The aim of this study was to establish the laboratory reference range of serum bon...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0703-2
更新日期:2006-01-01 00:00:00
abstract::There is no well-established treatment for osteoporosis in male patients with leprosy, because no clinical trials have examined the efficacy of treatment on bone mineral density (BMD) or fracture incidence in patients with leprosy. In this study, we report a case of osteoporosis in a man with leprosy, treated by oral ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-004-0546-7
更新日期:2005-01-01 00:00:00
abstract::Variation in drug response to hormone replacement therapy (HRT) may reflect genetic heterogeneity in the estrogen-related genes, possibly including estrogen receptor alpha (ERalpha) gene. However, only a few association studies of the drug response to HRT have been reported, focusing mainly on the intronic polymorphis...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-005-0619-2
更新日期:2005-01-01 00:00:00
abstract::Osteoporosis is a serious public health problem, and dietary interventions may potentially be helpful in preventing this disorder. The purpose of this study was to determine the effects of a low sodium diet on bone metabolism in postmenopausal women. This was a longitudinal study to determine the effects of a low sodi...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-005-0621-8
更新日期:2005-01-01 00:00:00
abstract::The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...
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pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740300004
更新日期:2003-01-01 00:00:00
abstract::Various animal experiments and human studies have shown that intermittent injections of parathyroid hormone (PTH) exert anabolic effects on bone, whereas continuous PTH treatment decreases the bone mass and causes hypercalcemia in animals. However, limited data are available with regard to the effects of a repetitive ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0181-4
更新日期:2010-11-01 00:00:00
abstract::Hyperhomocysteinemia has been shown to increase the incidence of osteoporosis and osteoporotic fractures. Endoplasmic reticulum (ER) stress was recently shown to be associated with apoptosis in several types of cells. In this study, we determined the effect of homocysteine (Hcy) on the apoptosis of osteoblastic cells ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-011-0346-9
更新日期:2012-07-01 00:00:00
abstract::Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0213-0
更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-009-0051-0
更新日期:2009-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-008-0856-2
更新日期:2008-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00774-009-0112-4
更新日期:2010-03-01 00:00:00
abstract::We evaluated adherence with raloxifene therapy compared with daily bisphosphonate in Asian postmenopausal women at increased risk of osteoporotic fractures. In this 12-month observational study conducted in Asia (Hong Kong, Malaysia, Pakistan, Philippines, Singapore, Taiwan), 984 postmenopausal women (aged 55 years or...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0735-7
更新日期:2007-01-01 00:00:00
abstract::Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 6...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-004-0593-0
更新日期:2005-01-01 00:00:00