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Frequency-dependent enhancement of bone formation in murine tibiae and femora with knee loading.

Abstract：

:Knee loading is a relatively new loading modality in which dynamic loads are laterally applied to the knee to induce bone formation in the tibia and the femur. The specific aim of the current study was to evaluate the effects of loading frequencies (in Hz) on bone formation at the site away from the loading site on the knee. The left knee of C57/BL/6 mice was loaded with 0.5 N force at 5, 10, or 15 Hz for 3 min/day for 3 consecutive days, and bone histomorphometry was conducted at the site 75% away from the loading site along the length of tibiae and femora. The results revealed frequency-dependent induction of bone formation, in which the dependence was different in the tibia and the femur. Compared with the sham-loading control, for instance, the cross-sectional cortical area was elevated maximally at 5 Hz in the tibia, whereas the most significant increase was observed at 15 Hz in the femur. Furthermore, mineralizing surface, mineral apposition rate, and bone formation rate were the highest at 5 Hz in the tibia (2.0-, 1.4-, and 2.7 fold, respectively) and 15 Hz in the femur (1.5-, 1.2-, and 1.8 fold, respectively). We observed that the tibia had a lower bone mineral density with more porous microstructures than the femur. Those differences may contribute to the observed differential dependence on loading frequencies.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Zhang P,Tanaka SM,Sun Q,Turner CH,Yokota H

doi

10.1007/s00774-007-0774-8

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

383-91

issue

6

eissn

0914-8779

issn

1435-5604

journal_volume

25

pub_type

杂志文章

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