Progeroid syndrome as a model for impaired bone formation in senile osteoporosis.

abstract：:The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2...

journal_title：Journal of bone and mineral metabolism

authors： Imai N,Endo N,Shobugawa Y,Oinuma T,Takahashi Y,Suzuki K,Ishikawa Y,Makino T,Suzuki H,Miyasaka D,Sakuma M

更新日期：2019-05-01 00:00:00

abstract：:Syndecans are single-pass integral membrane components that serve as co-receptors for growth factors and cytokines and can elicit signal transduction via their cytoplasmic tails. We review here previous studies from our groups on syndecan-3 biology and function in the growth plates of developing long bones in chick an...

journal_title：Journal of bone and mineral metabolism

authors： Pacifici M,Shimo T,Gentili C,Kirsch T,Freeman TA,Enomoto-Iwamoto M,Iwamoto M,Koyama E

更新日期：2005-01-01 00:00:00

abstract：:Although the influence of weight-bearing activity on bone mass has been widely investigated in white women, few studies have been conducted in black, African populations. We investigated bone mineral density (BMD) in black South African women, with and without a history of load-carrying on the head. We also investigat...

journal_title：Journal of bone and mineral metabolism

authors： Lloyd R,Hind K,Micklesfield LK,Carroll S,Truscott JG,Parr B,Davies S,Cooke C

更新日期：2010-03-01 00:00:00

abstract：:The objective of this study was to record the clinical course of osteoporosis over time in Japanese women. We hypothesized that successful control of acute pain associated with osteoporosis will allow better treatment for health-related problems. To confirm this working hypothesis, we developed the Japan Questionnaire...

journal_title：Journal of bone and mineral metabolism

authors： Doi T,Akai M,Endo N,Fujino K,Iwaya T

更新日期：2013-11-01 00:00:00

abstract：INTRODUCTION:Hypophosphatasia (HPP) is caused by mutations in the ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (ALP). Clinical manifestations range from extreme life-threatening lethal forms to no signs or symptoms at all. MATERIALS AND METHODS:Consecutive 30,000 outpatients and inpatient...

journal_title：Journal of bone and mineral metabolism

authors： İnci A,Ergin FBC,Yüce BT,Çiftçi B,Demir E,Buyan N,Okur İ,Biberoğlu G,Öktem RM,Tümer L,Ezgü FS

更新日期：2021-01-06 00:00:00

abstract：:The dietary reference intake (DRI) of vitamin D for Korean children was reduced from 400 IU/day in 2005 to 200 IU/day in 2010. We evaluated the risk factors for low 25-hydroxyvitamin D [25(OH)D] status and its relationships with bone health in peripubertal nonobese children living in Seoul or Gyeonggi-do. One hundred ...

journal_title：Journal of bone and mineral metabolism

authors： Lee YA,Kim JY,Kang MJ,Chung SJ,Shin CH,Yang SW

更新日期：2013-05-01 00:00:00

abstract：:This study was carried out to evaluate the clinical validity and usefulness of serum tartrate-resistant fluoride-sensitive acid phosphatase (TrFsACP) activity using 2,6-dichloro-4-acetylphenyl phosphate as substrate at pH 6.2 in metabolic bone diseases. The mean Z-scores of TrFsACP activity in patients on hemodialysis...

journal_title：Journal of bone and mineral metabolism

authors： Nakanishi M,Yoh K,Uchida K,Maruo S,Rai SK,Matsuoka A

更新日期：1999-01-01 00:00:00

abstract：:Bone mass differs according to ethnic classification, with individuals of African ancestry attaining the highest measurements across numerous skeletal sites. Elevated bone mass is even maintained in those individuals exposed to adverse environmental factors, suggesting a prominent genetic effect that may have clinical...

journal_title：Journal of bone and mineral metabolism

authors： May A,Pettifor JM,Norris SA,Ramsay M,Lombard Z

更新日期：2013-11-01 00:00:00

abstract：:Data from retrospective and prospective observational and case-control studies suggest that activity is associated with reduced fracture risk, but consistently replicated bias may be responsible for this desired endpoint. Exercise during growth is likely to build a larger and stronger skeleton. However, cessation of e...

journal_title：Journal of bone and mineral metabolism

authors： Seeman E

更新日期：2005-01-01 00:00:00

abstract：:Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...

journal_title：Journal of bone and mineral metabolism

authors： Hagino H,Takano T,Fukunaga M,Shiraki M,Nakamura T,Matsumoto T

更新日期：2013-03-01 00:00:00

abstract：:Bone mineral density (BMD) seems not to be decreased in young patients given long-term suppressive doses of levothyroxine (LT4), but information regarding the bone microstructure in these patients is lacking. The aim of this study was to determine whether supraphysiologic doses of LT4, initiated during childhood or ad...

journal_title：Journal of bone and mineral metabolism

authors： Mendonça Monteiro de Barros G,Madeira M,Vieira Neto L,de Paula Paranhos Neto F,Carvalho Mendonça LM,Corrêa Barbosa Lima I,Corbo R,Fleiuss Farias ML

更新日期：2016-07-01 00:00:00

abstract：:In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femo...

journal_title：Journal of bone and mineral metabolism

authors： Shimamura M,Iwata K,Mashiba T,Miki T,Yamamoto T

更新日期：2019-09-01 00:00:00

abstract：:Metformin, an anti-hyperglycemic agent used for type 2 diabetes, has recently been found to have more effects apart from glucose regulation. We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bon...

journal_title：Journal of bone and mineral metabolism

authors： Yan Z,Zhu S,Tian X,Ye Z,Zhai D,Zhu Z,Wei D,Zhu Q,Lu Z,Cao X

更新日期：2019-05-01 00:00:00

abstract：:We have retrospectively studied postmenopausal elderly Japanese women (n = 288; age range, 60-75 years, 65.8 +/- 4.5 [mean +/- SD]) for the evaluation of biochemical measurements in assessment of bone mass and vertebral fracture, comparing with several bone mineral measurements and quantitative ultrasound (QUS) measur...

journal_title：Journal of bone and mineral metabolism

authors： Matsushita R,Yamamoto I,Takada M,Hamanaka Y,Yuh I,Morita R

更新日期：2000-01-01 00:00:00

abstract：:The aim of the study was to assess body composition in subjects with phenylketonuria (PKU). Forty-five patients aged 13.8 ± 5.2 years were evaluated. Among them, 15 patients had not reached sexual maturity, showing normal serum values of phenylalanine (Phe) (subgroup 1), and 30 subjects were sexually mature (Tanner 5 ...

journal_title：Journal of bone and mineral metabolism

authors： Adamczyk P,Morawiec-Knysak A,Płudowski P,Banaszak B,Karpe J,Pluskiewicz W

更新日期：2011-03-01 00:00:00

abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...

journal_title：Journal of bone and mineral metabolism

authors： Zanatta M,Valenti MT,Donatelli L,Zucal C,Dalle Carbonare L

更新日期：2012-11-01 00:00:00

abstract：:We aimed to assess the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) and its association with lumbar spondylosis (LS) and knee osteoarthritis (KOA) using a population-based cohort study entitled Research on Osteoarthritis/osteoporosis Against Disability (ROAD). In the baseline ROAD study, which was per...

journal_title：Journal of bone and mineral metabolism

authors： Kagotani R,Yoshida M,Muraki S,Oka H,Hashizume H,Yamada H,Enyo Y,Nagata K,Ishimoto Y,Teraguchi M,Tanaka S,Nakamura K,Kawaguchi H,Akune T,Yoshimura N

更新日期：2015-03-01 00:00:00

abstract：:Secondary hyperparathyroidism (SHPT) develops as a compensatory mechanism when the body is in calcium deficit. SHPT may be harmful and has been associated with elevated blood pressure. The cause of SHPT could be low calcium intake, reduced intestinal calcium absorption, or increased excretion. However, the relative im...

journal_title：Journal of bone and mineral metabolism

authors： Saleh F,Jorde R,Sundsfjord J,Haug E,Figenschau Y

更新日期：2006-01-01 00:00:00

abstract：:Histomorphometry is commonly applied to study bone remodeling. Histological definitions of cortical bone boundaries have not been consistent. In this study, new criteria for specific definition of the transitional zone between the cortical and cancellous bone in the femoral neck were developed. The intra- and inter-ob...

journal_title：Journal of bone and mineral metabolism

authors： Tong XY,Malo M,Tamminen IS,Isaksson H,Jurvelin JS,Kröger H

更新日期：2015-01-01 00:00:00

abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....

journal_title：Journal of bone and mineral metabolism

authors： Lopez Franco GE,Blank RD,Akhter MP

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Previous studies have reported that the peak in lean body mass (LBM) precedes the peak in bone mineral content (BMC). However, it is unknown whether the trunk region growth is similar. MATERIALS AND METHODS:We investigated the difference between pubertal peak age in the increase of LBM in the trunk (trunk...

journal_title：Journal of bone and mineral metabolism

authors： Takei S,Taketomi S,Tanaka S,Torii S

更新日期：2020-05-01 00:00:00

abstract：:Inactivating mutations and/or deletions of PHEX ( Phosphate-regulating gene with Homologies to Endopeptidase on the X chromosome) are responsible for X-linked hypophosphatemic rickets in humans. In the present study, three Drosophila PHEX homologues (dPHEX-1, -2, -3) were isolated by the screening of a Drosophila cDNA...

journal_title：Journal of bone and mineral metabolism

authors： Ito M,Akai E,Izuka M,Segawa H,Kuwahata M,Miyamoto K

更新日期：2004-01-01 00:00:00

abstract：:Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous stu...

journal_title：Journal of bone and mineral metabolism

authors： Cassella JP,Barrie PJ,Garrington N,Ali SY

更新日期：2000-01-01 00:00:00

abstract：:Gastrectomy-evoked osteopenia in the femoral metaphysis of rats can be prevented by the consumption of fructooligosaccharides (FOS). We examined the effect of FOS on the femoral neck. Twenty-eight 5-week-old male Sprague-Dawley rats were divided into two groups, sham-operated (SH) and gastrectomized (GX). One week aft...

journal_title：Journal of bone and mineral metabolism

authors： Hirama Y,Morohashi T,Sano T,Maki K,Ohta A,Sakai N,Yamada S,Sasa R

更新日期：2003-01-01 00:00:00

abstract：:McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia. However, it remains unclear whether a humoral factor is associated with the cause of hypophosphatemia. We isolated cells with mutations of the Gsalpha gene from fibrous bone dysplasia tissues of two MAS patients (MAS cells). Severe combined i...

journal_title：Journal of bone and mineral metabolism

authors： Yamamoto T,Miyamoto KI,Ozono K,Taketani Y,Katai K,Miyauchi A,Shima M,Yoshikawa H,Yoh K,Takeda E,Okada S

更新日期：2001-01-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a cytokine implicated in the promotion of osteoclastogenesis. Its effect has been believed not to be directly exerted on osteoclast precursors, but rather indirectly carried out via an induction of receptor activator of NF-κB ligand (RANKL), the osteoclast differentiation factor, on osteoclas...

journal_title：Journal of bone and mineral metabolism

authors： Ota M,Yanagisawa M,Tachibana H,Yokota K,Araki Y,Sato K,Mimura T

更新日期：2015-01-01 00:00:00

abstract：:This study was designed to investigate whether biochemical markers of bone resorption and formation could be determined in the serum and urine of marmosets (Callithrix jacchus), using standard laboratory chemistry methods and commercially available human kits. Consequently, the findings from this study will indicate w...

journal_title：Journal of bone and mineral metabolism

authors： Angeliewa A,Budde M,Schlachter M,Hoyle NR,Bauss F

更新日期：2004-01-01 00:00:00

abstract：:This study aimed to identify the osteogenesis effect of icariside II (ICSII) and icaritin (ICT) in vitro. Bone marrow mesenchymal stem cells (BMSCs) were treated with ICSII and ICT in order to detect the proliferation and differentiation of BMSCs, the expression of the osteogenesis-related proteins with or without ost...

journal_title：Journal of bone and mineral metabolism

authors： Luo G,Xu B,Wang W,Wu Y,Li M

更新日期：2018-11-01 00:00:00

abstract：:The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role...

journal_title：Journal of bone and mineral metabolism

authors： Vasic J,Petranova T,Povoroznyuk V,Barbu CG,Karadzic M,Gojkovic F,Elez J,Winzenrieth R,Hans D,CulaficVojinovic V,Poiana C,Dzerovych N,Rashkov R,Dimic A

更新日期：2014-09-01 00:00:00

abstract：:Vertebral fractures are the most common complication associated with osteoporosis. The definition of prevalent or incident vertebral fractures is important in epidemiological evaluation and in clinical trials of osteoporosis treatment. There have been few reports regarding the morphometric cutoff criteria for incident...

journal_title：Journal of bone and mineral metabolism

authors： Fukunaga M,Nakamura T,Shiraki M,Kuroda T,Ohta H,Hosoi T,Orimo H

更新日期：2004-01-01 00:00:00