Abstract：
:Secondary hyperparathyroidism (SHPT) develops as a compensatory mechanism when the body is in calcium deficit. SHPT may be harmful and has been associated with elevated blood pressure. The cause of SHPT could be low calcium intake, reduced intestinal calcium absorption, or increased excretion. However, the relative importance of these factors for the development of SHPT is not known. During the 5th Tromsø study, serum PTH and calcium were measured in 7954 subjects. Then 96 subjects with SHPT (defined as serum PTH above 6.4 pmol/l together with serum calcium below 2.40 mmol/l) and 106 control subjects were examined at follow-up with a food frequency questionnaire, calcium absorption test, measurement of 24-h urinary calcium excretion, and serum vitamin D status. The statistical analyses showed several interactions necessitating subgroup analysis. It was found that the calcium intake was significantly lower in the SHPT group, but only in nonsmoking males; the calcium absorption was nonsignificantly higher in the SHPT group; the serum 25-hydroxyvitamin D levels were significantly lower in the SHPT group but only in nonsmokers; and the 24-h urinary calcium excretion was significantly lower in the SHPT group but only in those not on blood pressure medication. The most frequent cause of SHPT appeared to be low calcium intake (18%) and a low serum 25-hydroxyvitamin D level (18%). However, in most subjects with SHPT all tests were within the normal range, and the cause is therefore probably a combination of several factors.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Saleh F,Jorde R,Sundsfjord J,Haug E,Figenschau Ydoi
10.1007/s00774-005-0647-ysubject
Has Abstractpub_date
2006-01-01 00:00:00pages
58-64issue
1eissn
0914-8779issn
1435-5604journal_volume
24pub_type
杂志文章abstract：:To screen a potential risk factor for femoral neck fracture, we characterized lumbar vertebral fractures in 120 patients with femoral neck fractures (19 men, 101 women; mean age, 78.7 years) by investigating the frequency of patients with lumbar vertebral fracture, the number of vertebral fractures per patient, and th...
journal_title：Journal of bone and mineral metabolism
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journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,评审
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journal_title：Journal of bone and mineral metabolism
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journal_title：Journal of bone and mineral metabolism
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更新日期：2007-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-05-01 00:00:00
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journal_title：Journal of bone and mineral metabolism
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journal_title：Journal of bone and mineral metabolism
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journal_title：Journal of bone and mineral metabolism
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journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
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journal_title：Journal of bone and mineral metabolism
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