A fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta.

Abstract:

:Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.

journal_name

J Bone Miner Metab

authors

Cassella JP,Barrie PJ,Garrington N,Ali SY

doi

10.1007/pl00010645

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

291-6

issue

5

eissn

0914-8779

issn

1435-5604

journal_volume

18

pub_type

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