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Loading and bone fragility.

Abstract：

:Data from retrospective and prospective observational and case-control studies suggest that activity is associated with reduced fracture risk, but consistently replicated bias may be responsible for this desired endpoint. Exercise during growth is likely to build a larger and stronger skeleton. However, cessation of exercise may erode the benefits. Modeling changes produced by exercise during growth may be permanent; remodeling changes may not be. Exercise during adulthood produces small increments in BMD or may prevent bone loss. Absence of evidence is not evidence of absence of effect, but the null hypothesis that exercise has no effect on fracture rates in old age cannot be rejected by any published data. Proof requires demonstration of a reduction in spine and hip fractures in well-designed and well-executed prospective randomized studies; none exists. Blinded studies cannot be done, but open trials can and should be done.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Seeman E

doi

10.1007/BF03026319

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

23-9

eissn

0914-8779

issn

1435-5604

journal_volume

23 Suppl

pub_type

杂志文章,评审

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