Abstract:
:Vertebral fractures are the most common complication associated with osteoporosis. The definition of prevalent or incident vertebral fractures is important in epidemiological evaluation and in clinical trials of osteoporosis treatment. There have been few reports regarding the morphometric cutoff criteria for incident fractures in Asians, and only a few reports of their occurrence in Caucasians. The aim of this study was to establish a definition for incident fractures in Japanese women. A total of 279 women, aged 64.8 +/- 9.9 (mean +/- SD) years, were recruited, and repeated thoracolumbar spinal radiographs were performed at a mean of 1.45 +/- 0.44 years after the baseline film. Vertebral fractures were graded from 0 to 3 in both baseline and follow-up films using a semiquantitative assessment by the consensus of three readers. Incident fractures were defined as an increase of grade, except grade 3, and a vertebral body height of less than 12 mm on the baseline film. As morphometric criteria, both absolute height reduction (AHr) and the percent height ratio (PHr) were calculated. Prevalent fractures were observed in 207 vertebrae (6.2%) and 85 cases (30.5%), and incident fractures in 42 vertebrae (1.3%) and 29 cases (10.4%). As morphometric criteria for incident fracture, both a PHr > or =15% and an AHr > or =3 mm or > or =4 mm indicated sensitivity of 49.17% and 50.83% and specificity of 99.92% and 99.90%, respectively. In conclusion, the morphometric criteria of incident fracture combined with a semiquantitative assessment will provide useful information in the study of clinical osteoporosis, especially for international comparisons.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Fukunaga M,Nakamura T,Shiraki M,Kuroda T,Ohta H,Hosoi T,Orimo Hdoi
10.1007/s00774-003-0457-zsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
104-10issue
2eissn
0914-8779issn
1435-5604journal_volume
22pub_type
杂志文章abstract::Stimulation of osteoblast proliferation and differentiation is important for the in vivo bone-bonding ability of biomaterials. Previous in vitro studies have used biochemical assays to analyze osteoblast-specific gene expression in cultured osteoblasts. In this study, we generated transgenic mice harboring a monomeric...
journal_title:Journal of bone and mineral metabolism
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journal_title:Journal of bone and mineral metabolism
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journal_title:Journal of bone and mineral metabolism
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-004-0550-y
更新日期:2005-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
abstract::Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhanc...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-013-0513-2
更新日期:2014-07-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
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更新日期:2008-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-020-01129-7
更新日期:2020-08-05 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,评审
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
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更新日期:2013-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-015-0659-1
更新日期:2016-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0703-2
更新日期:2006-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0723-y
更新日期:2007-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,多中心研究
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更新日期:2014-09-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-003-0440-8
更新日期:2004-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
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更新日期:2019-11-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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更新日期:2016-11-01 00:00:00
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更新日期:2012-11-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
abstract::Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-020-01172-4
更新日期:2020-11-03 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-016-0741-3
更新日期:2017-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-009-0150-y
更新日期:2010-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-009-0147-6
更新日期:2010-07-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00774-009-0112-4
更新日期:2010-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-014-0562-1
更新日期:2015-01-01 00:00:00