Role of stromal cells in osteoclast differentiation in bone marrow.

abstract：:Low levels of vitamin D nutrition (i.e., vitamin D insufficiency), which potentially cause osteoporosis, have been recognized as a common health problem for elderly people in European and North American countries, but there have been no studies on the prevalence of vitamin D insufficiency in Japan until recently. The ...

journal_title：Journal of bone and mineral metabolism

authors： Nakamura K

更新日期：2006-01-01 00:00:00

abstract：:This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...

journal_title：Journal of bone and mineral metabolism

authors： Zhang T,Gao J,Fang J,Gong H

更新日期：2018-03-01 00:00:00

abstract：:Patients with MRI-proved acute painful vertebral fractures in whom conservative pain management fails are frequently referred for vertebroplasty. This study investigated the effects of treating osteoporosis on the mortality rate of patients with MRI-proved acute osteoporosis-related vertebral fractures who had undergo...

journal_title：Journal of bone and mineral metabolism

authors： Chen YC,Su FM,Cheng TT,Lin WC,Lui CC

更新日期：2016-05-01 00:00:00

abstract：:Apolipoprotein E (Apo E) polymorphism has been implicated in many chronic diseases, including Alzheimer disease and osteoporosis. Significant association of the Apo E4 allele to low bone mineral density (BMD) has been repeatedly reported. We here examined the Apo E genotype frequencies in the Chinese population (n = 6...

journal_title：Journal of bone and mineral metabolism

authors： Wong SY,Lau EM,Li M,Chung T,Sham A,Woo J

更新日期：2005-01-01 00:00:00

abstract：:The prevalence and pattern of joint involvement in radiographic hand osteoarthritis (OA) have been reported in Western populations, but similar data are lacking for Japanese. We examined this issue in 551 Japanese women aged > or = 40 years. Radiographs were obtained of both hands and graded according to the Kellgren-...

journal_title：Journal of bone and mineral metabolism

authors： Toba N,Sakai A,Aoyagi K,Yoshida S,Honda S,Nakamura T

更新日期：2006-01-01 00:00:00

abstract：:We performed this study to clarify whether celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, prevents trabecular bone mass reduction by suppressing arthritis-related increase of bone resorption, and to discriminate differences in actions on bone among celecoxib, SC-58560 (a selective COX-1 inhibitor), and ind...

journal_title：Journal of bone and mineral metabolism

authors： Taketa T,Sakai A,Tanaka S,Nakai K,Menuki K,Yamane H,Tanaka K,Nakamura T

更新日期：2008-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

journal_title：Journal of bone and mineral metabolism

authors： Yao GQ,Wu JJ,Troiano N,Insogna K

更新日期：2011-03-01 00:00:00

abstract：:This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged ≥ 60 yea...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Iidaka T,Oka H,Horii C,Kawaguchi H,Akune T,Nakamura K,Tanaka S

更新日期：2019-11-01 00:00:00

abstract：:The present study aimed to evaluate the prevalence and clinical presentation of Paget's disease of bone (PDB) in Japan. As PDB is a very rare disease in Japan, a nationwide mail survey was conducted targeting doctors in the specialty most frequently diagnosing and treating PDB patients in Japan. First, the literature ...

journal_title：Journal of bone and mineral metabolism

authors： Hashimoto J,Ohno I,Nakatsuka K,Yoshimura N,Takata S,Zamma M,Yabe H,Abe S,Terada M,Yoh K,Fukunaga M,Cooper C,Morii H,Yoshikawa H,Japanese Committee on Clinical Guidelines of Diagnosis and Treatment of Paget's Disease of Bone o

更新日期：2006-01-01 00:00:00

abstract：:Alendronate has recently been approved for the prevention and treatment of postmenopausal osteoporosis, and its efficacy has been demonstrated in many Western countries. Our present study was performed to evaluate the effect of alendronate on bone mineral density (BMD) and its tolerability in Thais. Eighty postmenopau...

journal_title：Journal of bone and mineral metabolism

authors： Chailurkit LO,Jongjaroenprasert W,Rungbunnapun S,Ongphiphadhanakul B,Sae-tung S,Rajatanavin R

更新日期：2003-01-01 00:00:00

abstract：:There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral ne...

journal_title：Journal of bone and mineral metabolism

authors： Wu SY,Qi J,Lu Y,Lan J,Yu JC,Wen LQ,Zhang ZL

更新日期：2010-11-01 00:00:00

abstract：:The activation sequence of clasts (the designation clast was used because ultrastructurally in this tissue, it is not always possible to differentiate between chondroclasts sitting on cartilage and osteoclasts sitting on bone matrix) was studied in vivo using the healing of low-phosphate, vitamin D-deficiency rickets ...

journal_title：Journal of bone and mineral metabolism

authors： Hollberg K,Nordahl J,Hultenby K,Mengarelli-Widholm S,Andersson G,Reinholt FP

更新日期：2005-01-01 00:00:00

abstract：:Studies examining the effects of hypoxia upon osteoclast biology have consistently revealed a stimulatory effect; both osteoclast differentiation and resorption activity have been shown to be enhanced in the presence of hypoxia. In the present study we examined the effects of the hypoxia mimetics dimethyloxallyl glyci...

journal_title：Journal of bone and mineral metabolism

authors： Leger AJ,Altobelli A,Mosquea LM,Belanger AJ,Song A,Cheng SH,Jiang C,Yew NS

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Previous studies have reported that the peak in lean body mass (LBM) precedes the peak in bone mineral content (BMC). However, it is unknown whether the trunk region growth is similar. MATERIALS AND METHODS:We investigated the difference between pubertal peak age in the increase of LBM in the trunk (trunk...

journal_title：Journal of bone and mineral metabolism

authors： Takei S,Taketomi S,Tanaka S,Torii S

更新日期：2020-05-01 00:00:00

abstract：:To screen a potential risk factor for femoral neck fracture, we characterized lumbar vertebral fractures in 120 patients with femoral neck fractures (19 men, 101 women; mean age, 78.7 years) by investigating the frequency of patients with lumbar vertebral fracture, the number of vertebral fractures per patient, and th...

journal_title：Journal of bone and mineral metabolism

authors： Kinoshita T,Ebara S,Kamimura M,Tateiwa Y,Itoh H,Yuzawa Y,Takahashi J,Takaoka K

更新日期：1999-01-01 00:00:00

abstract：:Osteopathic changes sometimes occur in patients with complex regional pain syndrome (reflex sympathetic dystrophy and causalgia). We aimed to investigate whether such osteopathic changes occurred in rats with chronic constriction injury (CCI) of the sciatic nerve. A CCI of the sciatic nerve was established in a unilat...

journal_title：Journal of bone and mineral metabolism

authors： Suyama H,Moriwaki K,Niida S,Maehara Y,Kawamoto M,Yuge O

更新日期：2002-01-01 00:00:00

abstract：:The aim of our study was to investigate the occurrence of osteonecrosis of the jaw (ONJ) after implementation of dental preventive measures before starting bisphosphonates (BPs) therapy and during treatment. All consecutive patients with bone lesions eligible for BPs treatment were prospectively evaluated. Before star...

journal_title：Journal of bone and mineral metabolism

authors： Bramati A,Girelli S,Farina G,Dazzani MC,Torri V,Moretti A,Piva S,Dimaiuta M,La Verde N

更新日期：2015-01-01 00:00:00

abstract：:Quantitative analysis of the orientational distribution of biological apatite (BAp) crystals is proposed as a new index of bone quality. This study aimed to analyze BAp c-axis orientation in ovariectomized (OVX) monkeys treated with amino-bisphosphonates minodronic acid and alendronate as reference. Sixty female monke...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka M,Matsugaki A,Ishimoto T,Nakano T

更新日期：2016-03-01 00:00:00

abstract：:To effectively treat degenerative joint diseases including osteoarthritis (OA), small chemical compounds need to be developed that can potently induce chondrogenic differentiation without promoting terminal differentiation. For this purpose, we screened natural and synthetic compound libraries using a Col2GFP-ATDC5 sy...

journal_title：Journal of bone and mineral metabolism

authors： Hojo H,Yano F,Ohba S,Igawa K,Nakajima K,Komiyama Y,Kan A,Ikeda T,Yonezawa T,Woo JT,Takato T,Nakamura K,Kawaguchi H,Chung UI

更新日期：2010-11-01 00:00:00

abstract：:Osteoporosis is a growing health problem in women and in men. This cross-sectional study examined the association of anthropometric, lifestyle, and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men. Smoking habits and alcohol consumption were assessed by interview. Serum testostero...

journal_title：Journal of bone and mineral metabolism

authors： Rhee EJ,Oh KW,Lee WY,Kim SW,Oh ES,Baek KH,Kang MI,Park CY,Choi MG,Yoo HJ,Park SW

更新日期：2004-01-01 00:00:00

abstract：:Hypophosphatasia is a rare inherited disorder characterized by a low serum alkaline phosphatase (ALP) activity and defective bone mineralization. Adult hypophosphatasia typically manifests in middle-age as a result of osteomalacia with recurrent stress fractures of the lower limb. However, considerable variation occur...

journal_title：Journal of bone and mineral metabolism

authors： Iida K,Fukushi J,Fujiwara T,Oda Y,Iwamoto Y

更新日期：2012-11-01 00:00:00

abstract：:Aromatase inhibitors (AIs) are the gold standard therapy for breast cancer in postmenopausal women. AI suppresses the conversion of androgens to estrogens; however, this results in osteopenia, osteoporosis, and bone fracture, thus reducing the patient's quality of life. The use of adjuvant denosumab reduces the risk o...

journal_title：Journal of bone and mineral metabolism

authors： Nakatsukasa K,Koyama H,Ouchi Y,Sakaguchi K,Fujita Y,Matsuda T,Kato M,Konishi E,Taguchi T

更新日期：2019-09-01 00:00:00

abstract：:We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered resid...

journal_title：Journal of bone and mineral metabolism

authors： Yoshimura N,Muraki S,Oka H,Kawaguchi H,Nakamura K,Akune T

更新日期：2011-11-01 00:00:00

abstract：:Simvastatin has been shown to stimulate osteogenesis both in vitro and in vivo. However, the mechanism by which simvastatin exerts its effects is still unclear. We previously reported that simvastatin promotes bone morphogenetic protein 2 (BMP-2) expression, induces osteoblastic differentiation, and inhibits adipocyti...

journal_title：Journal of bone and mineral metabolism

authors： Song C,Wang J,Song Q,Li X,Chen Z,Ma Q,Liu Z,Jia H,Dang G

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2...

journal_title：Journal of bone and mineral metabolism

authors： Imai N,Endo N,Shobugawa Y,Oinuma T,Takahashi Y,Suzuki K,Ishikawa Y,Makino T,Suzuki H,Miyasaka D,Sakuma M

更新日期：2019-05-01 00:00:00

abstract：:Menin, a product of the MEN1 gene, is related to the ontogeny of several cancers such as MEN1 and sporadic endocrine tumors, although it is considered to be a tumor suppressor. Many proteins interact with menin, and it is involved in various biological functions in several tissues. Menin plays some physiological and p...

journal_title：Journal of bone and mineral metabolism

authors： Kaji H

更新日期：2012-07-01 00:00:00

abstract：:This study was carried out to evaluate the clinical validity and usefulness of serum tartrate-resistant fluoride-sensitive acid phosphatase (TrFsACP) activity using 2,6-dichloro-4-acetylphenyl phosphate as substrate at pH 6.2 in metabolic bone diseases. The mean Z-scores of TrFsACP activity in patients on hemodialysis...

journal_title：Journal of bone and mineral metabolism

authors： Nakanishi M,Yoh K,Uchida K,Maruo S,Rai SK,Matsuoka A

更新日期：1999-01-01 00:00:00

abstract：:In this study, we tested the interleukin-6 (IL-6) gene as an important candidate gene for its linkage and association with the variation of bone phenotypes (bone mineral density [BMD] and bone size) in young Chinese female subjects. We genotyped the IL-6 gene at the -634C/G restriction fragment length polymorphism (RF...

journal_title：Journal of bone and mineral metabolism

authors： Lei SF,Liu YZ,Deng FY,Li YM,Li MX,Deng HW

更新日期：2005-01-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a cytokine implicated in the promotion of osteoclastogenesis. Its effect has been believed not to be directly exerted on osteoclast precursors, but rather indirectly carried out via an induction of receptor activator of NF-κB ligand (RANKL), the osteoclast differentiation factor, on osteoclas...

journal_title：Journal of bone and mineral metabolism

authors： Ota M,Yanagisawa M,Tachibana H,Yokota K,Araki Y,Sato K,Mimura T

更新日期：2015-01-01 00:00:00

abstract：:Based on the relationship between bone strength, trabecular skeletal structure, and bone mineral density (BMD), structure parameters for assessing vertebral bone strength were studied using 18 cancellous bone blocks from the third lumbar vertebra of elderly persons. The trabecular bone pattern of each bone block was b...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka T,Sakurai T,Kashima I

更新日期：2001-01-01 00:00:00