当前位置： SCI文献检索 > JOURNAL OF BONE AND MINERAL METABOLISM期刊下所有文献 > Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.

Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice.

Abstract：

:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulating bone mass. PTH treatment of primary murine osteoblasts for 24 h reduced Dkk1 expression by 90% as quantified by real-time PCR, whereas PTH treatment in vivo reduced Dkk1 expression by 30% when given as a single daily subcutaneous dose. To directly determine whether Dkk1 modulates the anabolic response of PTH in vivo, we engineered transgenic (TG) mice expressing murine Dkk1 under the control of the 2.3-kb rat collagen alpha-1 promoter. TG mice had significantly reduced bone mass, which was accompanied by reduced histomorphometric parameters of bone formation (reduced OV/TV, ObS/OS, and NOb/TAR). Treatment of TG mice and wild-type (WT) littermates with 95 ng/g body weight of human (1-34) PTH daily for 34 days resulted in comparable increases in bone mass at all skeletal sites. Histomorphometric analyses indicated that PTH treatment increased the numbers of both osteoblasts and osteoclasts in WT mice but only increased the numbers of osteoblasts in TG mice. We conclude that overexpression of Dkk1 does not attenuate the anabolic response to PTH in vivo.

journal_name

J Bone Miner Metab

journal_title

Journal of bone and mineral metabolism

authors

Yao GQ,Wu JJ,Troiano N,Insogna K

doi

10.1007/s00774-010-0202-3

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

141-8

issue

2

eissn

0914-8779

issn

1435-5604

journal_volume

29

pub_type

杂志文章

相关文献

JOURNAL OF BONE AND MINERAL METABOLISM文献大全
  • Incidence of four major types of osteoporotic fragility fractures among elderly individuals in Sado, Japan, in 2015.

    abstract：:The aim of this study was to survey the incidence of osteoporotic fragility fractures, which include vertebral, hip, distal radius, and proximal humerus fractures, in patients ≥ 50 years of age, from 2004 to 2015, in Sado City, Japan. We examined temporal changes in the incidence of these fractures from 2010 through 2...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-018-0937-9

    authors： Imai N,Endo N,Shobugawa Y,Oinuma T,Takahashi Y,Suzuki K,Ishikawa Y,Makino T,Suzuki H,Miyasaka D,Sakuma M

    更新日期：2019-05-01 00:00:00

  • Post-surgery cholecystectomy, hepatectomy, and pancreatectomy patients increase the risk of osteoporotic vertebral fracture.

    abstract：INTRODUCTION:Data is currently lacking regarding association between the cholecystectomy/hepatectomy/pancreatectomy and the development of osteoporotic fracture. A retrospective cohort study was conducted to investigate the relationship between cholecystectomy/hepatectomy/pancreatectomy and the subsequent risk of devel...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01129-7

    authors： Cheng WZ,Lin YL,Su YC,Lin MC,Tseng CH,Lin RM,Huang ST

    更新日期：2020-08-05 00:00:00

  • Expression of osteotropic growth factors and growth hormone receptor in a canine distraction osteogenesis model.

    abstract：:Osteotropic growth factors play an important role in bone metabolism. Nevertheless, knowledge about their expression in relation to distraction osteogenesis remains limited. The aim of the present study was to determine the expression of growth hormone (GH), growth hormone receptor (GHR), insulin-like growth factor I ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-006-0683-2

    authors： Theyse LF,Oosterlaken-Dijksterhuis MA,van Doorn J,Terlou M,Mol JA,Voorhout G,Hazewinkel HA

    更新日期：2006-01-01 00:00:00

  • Progeroid syndrome as a model for impaired bone formation in senile osteoporosis.

    abstract：:Senile or age-related/dependent osteoporosis is caused by reduced bone formation, rather than increased bone resorption as in postmenopausal osteoporosis. Here we review genetically engineered mouse models with defects in osteoblastic proliferation or differentiation with focus on IGF signaling and stem cells. Model m...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,评审

    doi：10.1007/s00774-004-0517-z

    authors： Hishiya A,Watanabe K

    更新日期：2004-01-01 00:00:00

  • Prevalence and involvement patterns of radiographic hand osteoarthritis in Japanese women: the Hizen-Oshima Study.

    abstract：:The prevalence and pattern of joint involvement in radiographic hand osteoarthritis (OA) have been reported in Western populations, but similar data are lacking for Japanese. We examined this issue in 551 Japanese women aged > or = 40 years. Radiographs were obtained of both hands and graded according to the Kellgren-...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-006-0693-0

    authors： Toba N,Sakai A,Aoyagi K,Yoshida S,Honda S,Nakamura T

    更新日期：2006-01-01 00:00:00

  • Tracking of appendicular bone mineral density for 6 years including the pubertal growth spurt: Japanese Population-based Osteoporosis kids cohort study.

    abstract：:Bone development up to early adulthood plays an important role in determining the risk of osteoporosis later in life. However, bone development in children has not been fully documented by longitudinal studies in Japanese children. The purpose of this study is to determine the degree of tracking of areal bone mineral ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0213-0

    authors： Fujita Y,Iki M,Ikeda Y,Morita A,Matsukura T,Nishino H,Yamagami T,Kagamimori S,Kagawa Y,Yoneshima H

    更新日期：2011-03-01 00:00:00

  • Eldecalcitol reduces the risk of severe vertebral fractures and improves the health-related quality of life in patients with osteoporosis.

    abstract：:Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-012-0397-6

    authors： Hagino H,Takano T,Fukunaga M,Shiraki M,Nakamura T,Matsumoto T

    更新日期：2013-03-01 00:00:00

  • Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel.

    abstract：:Previously, we reported that millimeter wave promoted the chondrocyte proliferation by pushing cell cycle progression. Activation of K(+) channels plays an essential role in the stimulating of extracellular matrix (ECM) synthesis and the cell proliferation in chondrocytes. While it is unclear if millimeter wave enhanc...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0513-2

    authors： Li X,Liu C,Liang W,Ye H,Chen W,Lin R,Li Z,Liu X,Wu M

    更新日期：2014-07-01 00:00:00

  • CA repeat polymorphism of the TNFR2 gene is not associated with bone mineral density in two independent Caucasian populations.

    abstract：:Osteoporosis has a strong genetic component, but the genes involved are poorly defined. Genome-wide scans in multiple populations have identified chromosome 1p36 as one region linked to bone mineral density (BMD). The tumor necrosis factor receptor 2 (TNFR2) at 1p36 is a positional and functional candidate gene in ost...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-005-0659-7

    authors： Huang QY,Shen H,Deng HY,Conway T,Elze L,Davies KM,Recker RR,Deng HW

    更新日期：2006-01-01 00:00:00

  • Evaluation of aortic calcification using a three-dimensional volume-rendering method in patients with end-stage kidney disease.

    abstract：INTRODUCTION:Very few studies have been performed to evaluate both the severity and site of aortic calcification (AC) in both end-stage kidney disease (ESKD) and diabetes mellitus (DM). The purpose of our study was to examine the utility of a newly developed three-dimensional (3D) visualization and quantification metho...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01172-4

    authors： Fujii H,Kono K,Watanabe K,Goto S,Nishii T,Kono A,Nishi S

    更新日期：2020-11-03 00:00:00

  • Cancellous bone of aged rats maintains its capacity to respond vigorously to the anabolic effects of prostaglandin E2 by modeling-dependent bone gain.

    abstract：:The present study examined the early effects of prostaglandin (PG)E2 on proximal tibial metaphyses of 20-month-old Wistar male rats. PGE, was given to intact rats for 10 and 30 days at 3mg/kg/day. After multiple in vivo fluorochrome labeling, undecalcified longitudinal sections were subjected to analysis of bone histo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740170057

    authors： Cui L,Ma YF,Yao W,Zhou H,Setterberg RB,Liang TC,Jee WS

    更新日期：2001-01-01 00:00:00

  • Persistence with osteoporosis medication among newly-treated osteoporotic patients.

    abstract：:Low persistence with osteoporosis medication is associated with higher fracture risk. Previous studies estimated that 1-year persistence with osteoporosis medication is low. Our aim was to study persistence with osteoporosis medication among patients with long-term follow-up (to 5 years). The InterAction Database (IAD...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0440-2

    authors： van Boven JF,de Boer PT,Postma MJ,Vegter S

    更新日期：2013-09-01 00:00:00

  • Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial.

    abstract：:We have previously demonstrated the efficacy of therapeutic exercise for osteoarthritis (OA) of the knee. This study was performed to examine the additive effects of glucosamine or risedronate on the exercise therapy. In this study, 142 female patients with moderate OA of the knee, who had been recommended to undergo ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00774-007-0813-5

    authors： Kawasaki T,Kurosawa H,Ikeda H,Kim SG,Osawa A,Takazawa Y,Kubota M,Ishijima M

    更新日期：2008-01-01 00:00:00

  • Time to benefit and the long-term persistence of new users of oral bisphosphonates.

    abstract：INTRODUCTION:This study aimed to examine long-term persistence in new users of oral bisphosphonates in a population-wide cohort in Manitoba, Canada. MATERIALS AND METHODS:A longitudinal observational study was conducted using administrative health data characterizing long-term bisphosphonate persistence in those who s...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-019-01069-x

    authors： Friesen KJ,Bugden S,Falk J

    更新日期：2020-05-01 00:00:00

  • Smoking among premenopausal women is associated with increased risk of low bone status: the JPOS Study.

    abstract：:The impact of smoking on peak bone density has not been conclusively established. We examined how smoking exposure influences bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative sample of Japanese women in 1996. The effect of current an...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-009-0129-8

    authors： Tamaki J,Iki M,Sato Y,Kajita E,Kagamimori S,Kagawa Y,Yoneshima H

    更新日期：2010-05-01 00:00:00

  • Should COPD patients be routinely evaluated for bone mineral density?

    abstract：:There are many factors that increase the risk of osteoporosis, including smoking, malnutrition, vitamin D deficiency, hypogonadism, limited physical activity due to chronic disease, and corticosteroid therapy in chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate bone mineral density...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-002-0416-0

    authors： Karadag F,Cildag O,Yurekli Y,Gurgey O

    更新日期：2003-01-01 00:00:00

  • Visfatin is a positive predictor of bone mineral density in young survivors of acute lymphocytic leukemia.

    abstract：:Bone mass acquisition may be compromised in survivors of childhood acute lymphocytic leukemia due to various factors, including adiposity. Fat accumulation can affect bone through the direct effect of adipokines or indirectly through the state of chronic inflammation. The aim of this study was to evaluate the effect o...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1007/s00774-015-0728-5

    authors： Siviero-Miachon AA,Spinola-Castro AM,de Martino Lee ML,Calixto AR,Geloneze B,Lazaretti-Castro M,Guerra-Junior G

    更新日期：2017-01-01 00:00:00

  • Alendronate treatment promotes bone formation with a less anisotropic microstructure during intramembranous ossification in rats.

    abstract：:There are safety concerns regarding administration of bisphosphonates to children. Little is known about the effects of bisphosphonates on bone matrix organization during bone modeling. The present study examined the effects of alendronate (ALN) on bone matrices formed by intramembranous ossification in the appendicul...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-007-0782-8

    authors： Kashii M,Hashimoto J,Nakano T,Umakoshi Y,Yoshikawa H

    更新日期：2008-01-01 00:00:00

  • Production of IL-7 is increased in ovariectomized mice, but not RANKL mRNA expression by osteoblasts/stromal cells in bone, and IL-7 enhances generation of osteoclast precursors in vitro.

    abstract：:Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-006-0723-y

    authors： Sato T,Watanabe K,Masuhara M,Hada N,Hakeda Y

    更新日期：2007-01-01 00:00:00

  • Computational segmentation of collagen fibers in bone matrix indicates bone quality in ovariectomized rat spine.

    abstract：:Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlo...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-017-0844-5

    authors： Daghma DES,Malhan D,Simon P,Stötzel S,Kern S,Hassan F,Lips KS,Heiss C,El Khassawna T

    更新日期：2018-05-01 00:00:00

  • Evaluation of bioactivity of alkali- and heat-treated titanium using fluorescent mouse osteoblasts.

    abstract：:Stimulation of osteoblast proliferation and differentiation is important for the in vivo bone-bonding ability of biomaterials. Previous in vitro studies have used biochemical assays to analyze osteoblast-specific gene expression in cultured osteoblasts. In this study, we generated transgenic mice harboring a monomeric...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0544-8

    authors： Tsukanaka M,Yamamoto K,Fujibayashi S,Pattanayak DK,Matsushita T,Kokubo T,Matsuda S,Akiyama H

    更新日期：2014-11-01 00:00:00

  • Hypophosphatasia: is it an underdiagnosed disease even by expert physicians?

    abstract：INTRODUCTION:Hypophosphatasia (HPP) is caused by mutations in the ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (ALP). Clinical manifestations range from extreme life-threatening lethal forms to no signs or symptoms at all. MATERIALS AND METHODS:Consecutive 30,000 outpatients and inpatient...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01193-z

    authors： İnci A,Ergin FBC,Yüce BT,Çiftçi B,Demir E,Buyan N,Okur İ,Biberoğlu G,Öktem RM,Tümer L,Ezgü FS

    更新日期：2021-01-06 00:00:00

  • Executive summary of clinical practice guide on fracture risk in lifestyle diseases.

    abstract：:Accumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifesty...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-020-01149-3

    authors： Kanazawa I,Inaba M,Inoue D,Uenishi K,Saito M,Shiraki M,Suzuki A,Takeuchi Y,Hagino H,Fujiwara S,Sugimoto T,from the Japan Osteoporosis Society Lifestyle diseases-related Fracture Risk Investigation Committee.

    更新日期：2020-11-01 00:00:00

  • Absolute height reduction and percent height ratio of the vertebral body in incident fracture in Japanese women.

    abstract：:Vertebral fractures are the most common complication associated with osteoporosis. The definition of prevalent or incident vertebral fractures is important in epidemiological evaluation and in clinical trials of osteoporosis treatment. There have been few reports regarding the morphometric cutoff criteria for incident...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-003-0457-z

    authors： Fukunaga M,Nakamura T,Shiraki M,Kuroda T,Ohta H,Hosoi T,Orimo H

    更新日期：2004-01-01 00:00:00

  • Diagnostic criteria for primary osteoporosis: year 2012 revision.

    abstract：:In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, pr...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-013-0447-8

    authors： Soen S,Fukunaga M,Sugimoto T,Sone T,Fujiwara S,Endo N,Gorai I,Shiraki M,Hagino H,Hosoi T,Ohta H,Yoneda T,Tomomitsu T,Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the R

    更新日期：2013-05-01 00:00:00

  • Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures.

    abstract：:Advanced glycation end products (AGE) in collagen have been reported to decrease the mechanical property of bone. However, there are no available data on the relation between fracture risk and levels of glycoxidative (nonenzymatic) cross-links of collagen in clinical samples. A total of 432 Japanese elderly women who ...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-007-0784-6

    authors： Shiraki M,Kuroda T,Tanaka S,Saito M,Fukunaga M,Nakamura T

    更新日期：2008-01-01 00:00:00

  • Densitometric and geometric measurement of the proximal femur in elderly women with and without osteoporotic vertebral fractures by volumetric quantitative multi-slice CT.

    abstract：:There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral ne...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s00774-010-0174-3

    authors： Wu SY,Qi J,Lu Y,Lan J,Yu JC,Wen LQ,Zhang ZL

    更新日期：2010-11-01 00:00:00

  • Peripheral computed tomography (pQCT) detected short-term effect of AAACa (heated oyster shell with heated algal ingredient HAI): a double-blind comparison with CaCO3 and placebo.

    abstract：:Trabecular bone density at the distal radius and cortical bone density at the midradius were measured in four randomized groups of women before and after 4 months administration of AAACa, oyster shell heated under reduced pressure with addition of heated algal ingredient (HAI) (group A); AACa, the same preparation wit...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s007740070022

    authors： Fujita T,Fujii Y,Goto B,Miyauchi A,Takagi Y

    更新日期：2000-01-01 00:00:00

  • The role of serum osteoprotegerin and receptor-activator of nuclear factor-κB ligand in metabolic bone disease of women after obesity surgery.

    abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00774-015-0712-0

    authors： Balsa JA,Lafuente C,Gómez-Martín JM,Galindo J,Peromingo R,García-Moreno F,Rodriguez-Velasco G,Martínez-Botas J,Gómez-Coronado D,Escobar-Morreale HF,Botella-Carretero JI

    更新日期：2016-11-01 00:00:00

  • Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2).

    abstract：:We have been using hormone replacement therapy (HRT) as the treatment of choice for menopausal symptoms and osteoporosis. Estrogen increases bone mineral density (BMD) for 2 or 3 years, and only maintains BMD thereafter. In the present study, we investigated whether BMD improved with HRT in combination with vitamin K(...

    journal_title：Journal of bone and mineral metabolism

    pub_type： 杂志文章

    doi：10.1007/s007740200034

    authors： Hidaka T,Hasegawa T,Fujimura M,Sakai M,Saito S

    更新日期：2002-01-01 00:00:00