Abstract:
:In this study, we focused on collagen metabolism as a factor involved in menatetrenone (MK-4)-related improvement in bone quality. Using rats with a congenital ascorbic acid (AA) deficiency, osteogenic disorder Shionogi (ODS) rats, we established a model in which abnormal collagen metabolism reduced bone mechanical properties, and investigated the effects of MK-4. We divided 13-week-old ODS rats into four groups: Pre, AA sufficiency (AA(+)), AA deficiency-control (AA(-)control), and AA deficiency+ MK-4-treated (AA(-)MK-4). MK-4 was given as a dietary supplement (30 mg/kg). At the beginning (pre) and after two, three, and four weeks, seven rats in each group were killed to measure plasma bone metabolism and femoral bone mass data and bone mechanical properties. In the rats killed after four weeks, histomorphometric data of the tibiae, the total amino acid level in bone collagen, and rates of proline and lysine hydroxylation were determined. In the AA(+)group, both the cortical bone mass data and bone mechanical properties were serially increased. However, in the AA(-)control group, the cortical bone mass data were similar for four weeks and the bone mechanical properties decreased after three to four weeks. After four weeks, the total level of amino acids in bone collagen and rates of proline and lysine hydroxylation were significantly lower in the AA(-)control group than in the AA(+)group. MK-4 increased bone mechanical properties after four weeks without influencing cortical bone mass. Simultaneously, it inhibited decreases in the total level of amino acids in collagen (P = 0.017). The rates of proline and lysine hydroxylation were higher in the AA(-)MK-4 group than in the AA(-)control group, but not significantly. These results suggest the level of collagen and abnormalities of hydroxylation are involved in the AA deficiency-related reduction in bone mechanical properties, and that MK-4 improves bone mechanical properties by restoring collagen metabolism.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Hara K,Akiyama Ydoi
10.1007/s00774-009-0069-3subject
Has Abstractpub_date
2009-01-01 00:00:00pages
324-32issue
3eissn
0914-8779issn
1435-5604journal_volume
27pub_type
杂志文章abstract::Bone microarchitecture of the iliac bone is used to characterize the properties of bone tissue in osteoporosis, particularly in pharmacological studies. Trabecular bone is known to be heterogeneous media. For a few years, the analysis of three-dimensional (3-D) bone microarchitecture has been based on micro-computed t...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-008-0856-2
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0174-3
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-004-0536-9
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-006-0715-y
更新日期:2006-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00774-007-0813-5
更新日期:2008-01-01 00:00:00
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更新日期:2010-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-07-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00774-015-0717-8
更新日期:2016-11-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740300004
更新日期:2003-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s007740200012
更新日期:2002-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-020-01086-1
更新日期:2020-07-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00774-013-0439-8
更新日期:2013-09-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-03-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-004-0607-y
更新日期:2005-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-004-0550-y
更新日期:2005-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章,评审
doi:10.1007/BF03026319
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00774-014-0566-x
更新日期:2015-01-01 00:00:00
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journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-017-0881-0
更新日期:2018-11-01 00:00:00
abstract::Various animal experiments and human studies have shown that intermittent injections of parathyroid hormone (PTH) exert anabolic effects on bone, whereas continuous PTH treatment decreases the bone mass and causes hypercalcemia in animals. However, limited data are available with regard to the effects of a repetitive ...
journal_title:Journal of bone and mineral metabolism
pub_type: 杂志文章
doi:10.1007/s00774-010-0181-4
更新日期:2010-11-01 00:00:00