Low calcium intake is associated with decreased adrenal androgens and reduced bone age in premenarcheal girls in the last pubertal stages.

abstract：:Osteonecrosis of the jaw (ONJ) associated with bisphosphonate therapy is a rare but severe side effect in osteoporosis patients. Recently, the number of osteoporosis patients with ONJ has dramatically increased in Japan. This has contributed to an increase in the number of patients avoiding extractions. However, there...

journal_title：Journal of bone and mineral metabolism

authors： Taguchi A,Uemura Y,Imai T,Tanaka S,Ohta H,Nakamura T,Orimo H,Sugimoto T,Soen S,Shiraki M,Adequate Treatment of Osteoporosis (A-TOP) research group.

更新日期：2019-09-01 00:00:00

abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...

journal_title：Journal of bone and mineral metabolism

authors： Balsa JA,Lafuente C,Gómez-Martín JM,Galindo J,Peromingo R,García-Moreno F,Rodriguez-Velasco G,Martínez-Botas J,Gómez-Coronado D,Escobar-Morreale HF,Botella-Carretero JI

更新日期：2016-11-01 00:00:00

abstract：:Data from retrospective and prospective observational and case-control studies suggest that activity is associated with reduced fracture risk, but consistently replicated bias may be responsible for this desired endpoint. Exercise during growth is likely to build a larger and stronger skeleton. However, cessation of e...

journal_title：Journal of bone and mineral metabolism

authors： Seeman E

更新日期：2005-01-01 00:00:00

abstract：:The G171V mutation (high bone mass, HBM) is autosomal dominant and is responsible for high bone mass in humans. Transgenic HBM mice in which the human LRP5 G171V gene is inserted also show a similar phenotype with greater bone mass and biomechanical performance than wild-type mice, as determined by whole bone testing....

journal_title：Journal of bone and mineral metabolism

authors： Lopez Franco GE,Blank RD,Akhter MP

更新日期：2011-01-01 00:00:00

abstract：:Bone mineral density (BMD) and peak bone mass (PBM) are important determinants of skeletal resistance. The development of bone densitometry improved the possibility of studying BMD and the influence of genetic and environmental factors on bone. Heredity factors are important for BMD, and Runx-2 is accepted as a regula...

journal_title：Journal of bone and mineral metabolism

authors： Zanatta M,Valenti MT,Donatelli L,Zucal C,Dalle Carbonare L

更新日期：2012-11-01 00:00:00

abstract：:Vertebral fracture (VFx) is associated with various co-morbidities and increased mortality. In this paper, we have studied the detective value of height loss for VFx using two indices; historical height loss (HHL) which is the difference between the maximal height, and the current height (CH), and CH/knee height (KH) ...

journal_title：Journal of bone and mineral metabolism

authors： Yoh K,Kuwabara A,Tanaka K

更新日期：2014-09-01 00:00:00

abstract：:Bone loss varies according to disease and age and these variations affect bone cells and extracellular matrix. Osteoporosis rat models are widely investigated to assess mechanical and structural properties of bone; however, bone matrix proteins and their discrepant regulation of diseased and aged bone are often overlo...

journal_title：Journal of bone and mineral metabolism

authors： Daghma DES,Malhan D,Simon P,Stötzel S,Kern S,Hassan F,Lips KS,Heiss C,El Khassawna T

更新日期：2018-05-01 00:00:00

abstract：:The activation sequence of clasts (the designation clast was used because ultrastructurally in this tissue, it is not always possible to differentiate between chondroclasts sitting on cartilage and osteoclasts sitting on bone matrix) was studied in vivo using the healing of low-phosphate, vitamin D-deficiency rickets ...

journal_title：Journal of bone and mineral metabolism

authors： Hollberg K,Nordahl J,Hultenby K,Mengarelli-Widholm S,Andersson G,Reinholt FP

更新日期：2005-01-01 00:00:00

abstract：:Primary hyperparathyroidism is characterized by hypercalcemia with loss of bone mass. After parathyroidectomy, hypocalcemia may develop in some patients due to unregulated bone mineralization. Preoperative administration of bisphosphonates, potent inhibitors of osteoclast activity, may prevent postoperative hypocalcem...

journal_title：Journal of bone and mineral metabolism

authors： Lee IT,Sheu WH,Tu ST,Kuo SW,Pei D

更新日期：2006-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress has been reported to be linked to various diseases such as diabetes, neurodegenerative diseases, and osteogenesis imperfecta (OI). Old astrocyte specifically induced substance (OASIS), a novel type of ER stress transducer, is a basic leucine zipper transcription factor belonging to th...

journal_title：Journal of bone and mineral metabolism

authors： Sekiya H,Murakami T,Saito A,Hino S,Tsumagari K,Ochiai K,Imaizumi K

更新日期：2010-07-01 00:00:00

abstract：:Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarth...

journal_title：Journal of bone and mineral metabolism

authors： Jingsheng S,Yibing W,Jun X,Siqun W,Jianguo W,Feiyan C,Gangyong H,Jie C

更新日期：2015-01-01 00:00:00

abstract：:The MOVEMENT study was designed to assess the effectiveness of monthly intravenous ibandronate on bone mineral density (BMD) in daily clinical practice in Japanese patients with primary osteoporosis whose lumbar spine BMD did not increase despite oral bisphosphonate therapy. This study was a multicenter, prospective, ...

journal_title：Journal of bone and mineral metabolism

authors： Hagino H,Sakai A,Ikeda S,Imanishi Y,Tsurukami H,Nakajo S,Miyakoshi N

更新日期：2019-11-01 00:00:00

abstract：:We evaluated short-term changes in serum amino-terminal procollagen propeptide (P1NP) and cross-linked C-terminal telopeptide (betaCTX) of type I collagen after parathyroidectomy (PTX) in 41 postmenopausal women with primary hyperparathyroidism (PHPT). Serum levels of 25-hydroxyvitamin D, intact PTH, calcium, phosphat...

journal_title：Journal of bone and mineral metabolism

authors： Boudou P,Ibrahim F,Cormier C,Sarfati E,Souberbielle JC

更新日期：2009-01-01 00:00:00

abstract：:High serum homocysteine (HCY) and indirectly deficiency of folate and/or vitamin B(12) stimulate bone resorption and adversely affect collagen cross-linking. The aim of this study was the evaluation of serum levels of HCY, folate and vitamin B(12) in patients with Paget's disease of bone (PDB) and the effect of zoledr...

journal_title：Journal of bone and mineral metabolism

authors： Polyzos SA,Anastasilakis AD,Efstathiadou Z,Litsas I,Kita M,Panagiotou A,Papatheodorou A,Arsos G,Moralidis E,Barmpalios G,Zafeiriadou E,Triantafillidou E,Makrigiannaki E,Terpos E

更新日期：2010-05-01 00:00:00

abstract：:This study aimed to explore the effects of additional weight bearing in combination with low-magnitude high-frequency vibration (LMHFV; 45 Hz, 0.3 g) on bone quality. One hundred twenty rats were randomly divided into ten groups; namely, sedentary (SED), additional weight bearing in which the rat wears a backpack whos...

journal_title：Journal of bone and mineral metabolism

authors： Zhang T,Gao J,Fang J,Gong H

更新日期：2018-03-01 00:00:00

abstract：:Osteoporosis is a systemic and metabolic bone disease. New drugs with good curative effect, fewer side effects, and high safety need to be developed urgently. Recently, simvastatin has been used to treat osteoporosis more frequently; however, its clinical effect and treatment mechanism are still unknown. With the use ...

journal_title：Journal of bone and mineral metabolism

authors： Dai L,Xu M,Wu H,Xue L,Yuan D,Wang Y,Shen Z,Zhao H,Hu M

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to record the clinical course of osteoporosis over time in Japanese women. We hypothesized that successful control of acute pain associated with osteoporosis will allow better treatment for health-related problems. To confirm this working hypothesis, we developed the Japan Questionnaire...

journal_title：Journal of bone and mineral metabolism

authors： Doi T,Akai M,Endo N,Fujino K,Iwaya T

更新日期：2013-11-01 00:00:00

abstract：:We have been using hormone replacement therapy (HRT) as the treatment of choice for menopausal symptoms and osteoporosis. Estrogen increases bone mineral density (BMD) for 2 or 3 years, and only maintains BMD thereafter. In the present study, we investigated whether BMD improved with HRT in combination with vitamin K(...

journal_title：Journal of bone and mineral metabolism

authors： Hidaka T,Hasegawa T,Fujimura M,Sakai M,Saito S

更新日期：2002-01-01 00:00:00

abstract：:The effects of basic fibroblast growth factor (bFGF) on osteogenic differentiation in-vivo were investigated using a rat bone marrow ablation model. bFGF was infused directly into rat femora for 6 days after bone marrow ablation. The contralateral femur was infused with vehicle only and used as control. Bone formation...

journal_title：Journal of bone and mineral metabolism

authors： Tanaka H,Wakisaka A,Ogasa H,Kawai S,Liang CT

更新日期：2003-01-01 00:00:00

abstract：:Low persistence with osteoporosis medication is associated with higher fracture risk. Previous studies estimated that 1-year persistence with osteoporosis medication is low. Our aim was to study persistence with osteoporosis medication among patients with long-term follow-up (to 5 years). The InterAction Database (IAD...

journal_title：Journal of bone and mineral metabolism

authors： van Boven JF,de Boer PT,Postma MJ,Vegter S

更新日期：2013-09-01 00:00:00

abstract：:Parathyroid hormone (PTH) is a potent anabolic agent, but the cellular mechanisms by which it increases bone mass are not fully understood. Dickkopf 1 (Dkk1) is an endogenous inhibitor of Wnt signaling and suppresses bone formation in vivo. We sought to determine if Dkk1 and anabolic PTH treatment interact in regulati...

journal_title：Journal of bone and mineral metabolism

authors： Yao GQ,Wu JJ,Troiano N,Insogna K

更新日期：2011-03-01 00:00:00

abstract：:Positive associations between vitamin D levels and hand grip strength have been reported worldwide, but the results are not consistent and few studies on East Asian populations have been published. The aim of this study was to determine whether such an association is present in a community-dwelling Japanese population...

journal_title：Journal of bone and mineral metabolism

authors： Kitsu T,Kabasawa K,Ito Y,Kitamura K,Watanabe Y,Tanaka J,Nakamura K,Narita I

更新日期：2020-03-01 00:00:00

abstract：:Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density...

journal_title：Journal of bone and mineral metabolism

authors： Ishii T,Ito K,Kato S,Tsubokura M,Ochi S,Iwamoto Y,Saito Y

更新日期：2013-11-01 00:00:00

abstract：:We have retrospectively studied postmenopausal elderly Japanese women (n = 288; age range, 60-75 years, 65.8 +/- 4.5 [mean +/- SD]) for the evaluation of biochemical measurements in assessment of bone mass and vertebral fracture, comparing with several bone mineral measurements and quantitative ultrasound (QUS) measur...

journal_title：Journal of bone and mineral metabolism

authors： Matsushita R,Yamamoto I,Takada M,Hamanaka Y,Yuh I,Morita R

更新日期：2000-01-01 00:00:00

abstract：:Measurements of bone biochemical markers are increasingly being used to evaluate the state of bone turnover in the management of bone metabolic diseases, especially osteoporosis. However, changes in the bone turnover rate vary with age. The aim of this study was to establish the laboratory reference range of serum bon...

journal_title：Journal of bone and mineral metabolism

authors： Pi YZ,Wu XP,Liu SP,Luo XH,Cao XZ,Xie H,Liao EY

更新日期：2006-01-01 00:00:00

abstract：:In 1995, the Japanese Society for Bone and Mineral Metabolism (now the Japanese Society for Bone and Mineral Research) established the Osteoporosis Diagnostic Criteria Review Committee. Following discussion held at the 13th scientific meeting of the Society in 1996, the Committee, with the consensus of its members, pr...

journal_title：Journal of bone and mineral metabolism

authors： Soen S,Fukunaga M,Sugimoto T,Sone T,Fujiwara S,Endo N,Gorai I,Shiraki M,Hagino H,Hosoi T,Ohta H,Yoneda T,Tomomitsu T,Japanese Society for Bone and Mineral Research and Japan Osteoporosis Society Joint Review Committee for the R

更新日期：2013-05-01 00:00:00

abstract：:Fracture healing is a complex biological process involving the proliferation of mesenchymal progenitor cells, and chondrogenic, osteogenic, and angiogenic differentiation. The mechanisms underlying the proliferation and differentiation of mesenchymal progenitor cells remain unclear. Here, we demonstrate Dickkopf-relat...

journal_title：Journal of bone and mineral metabolism

authors： Mori Y,Adams D,Hagiwara Y,Yoshida R,Kamimura M,Itoi E,Rowe DW

更新日期：2016-11-01 00:00:00

abstract：:The exact mechanism by which focal adhesion kinase (FAK) translates mechanical signals into osteogenesis differentiation in force-subjected cells has not been elucidated. The responses to different forces differ according to the origin of cells and the type of stress applied. Therefore, the recruitment of osteoclast a...

journal_title：Journal of bone and mineral metabolism

authors： Chen YJ,Shie MY,Hung CJ,Wu BC,Liu SL,Huang TH,Kao CT

更新日期：2014-11-01 00:00:00

abstract：INTRODUCTION:Hypophosphatasia (HPP) is caused by mutations in the ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (ALP). Clinical manifestations range from extreme life-threatening lethal forms to no signs or symptoms at all. MATERIALS AND METHODS:Consecutive 30,000 outpatients and inpatient...

journal_title：Journal of bone and mineral metabolism

authors： İnci A,Ergin FBC,Yüce BT,Çiftçi B,Demir E,Buyan N,Okur İ,Biberoğlu G,Öktem RM,Tümer L,Ezgü FS

更新日期：2021-01-06 00:00:00

abstract：:Inactivating mutations and/or deletions of PHEX ( Phosphate-regulating gene with Homologies to Endopeptidase on the X chromosome) are responsible for X-linked hypophosphatemic rickets in humans. In the present study, three Drosophila PHEX homologues (dPHEX-1, -2, -3) were isolated by the screening of a Drosophila cDNA...

journal_title：Journal of bone and mineral metabolism

authors： Ito M,Akai E,Izuka M,Segawa H,Kuwahata M,Miyamoto K

更新日期：2004-01-01 00:00:00