Abstract：
:Knowledge of the microenvironment of articular cartilage in health and disease is the key to accomplishing fundamental disease-modifying treatments for osteoarthritis. The proteins comprising the CCN Family are matricellular proteins with a remarkable relevance within the context of cartilage metabolism. CCN2 displays a great capability for regenerating articular cartilage, and CCN3 has been shown to activate the expression of genes related to articular chondrocytes and to repress genes related to endochondral ossification in epiphyseal chondrocytes. Moreover, mice lacking CCN3 protein have been shown to display ostearthritic changes in their knee articular cartilage. In this study, we employed a monoiodoacetic acid (MIA)-induced osteoarthritic model to investigate whether osteoarthritic changes in the cartilage are reciprocally accompanied by CCN3 down-regulation and an inducible overexpression system to evaluate the effects of CCN3 on articular chondrocytes in vitro. Finally, we also investigated the effects of exogenous CCN3 in vivo during the early stages of MIA-induced osteoarthritis. We discovered that CCN3 is expressed by articular chondrocytes in normal rat knees, whereas it is rapidly down-regulated in osteoarthritic knees. In vitro, we also discovered that CCN3 increases the proteoglycan accumulation, the gene expression of type II collagen, tenascin-C and lubricin, as well as the protein production of tenascin-C and lubricin in articular chondrocytes. In vivo, it was discovered that exogenous CCN3 increased tidemark integrity and produced an increased production of lubricin protein. The potential utility of CCN3 as a future therapeutic agent and possible strategies to improve its therapeutic functions are also discussed.
journal_name
J Bone Miner Metabjournal_title
Journal of bone and mineral metabolismauthors
Janune D,Abd El Kader T,Aoyama E,Nishida T,Tabata Y,Kubota S,Takigawa Mdoi
10.1007/s00774-016-0793-4subject
Has Abstractpub_date
2017-11-01 00:00:00pages
582-597issue
6eissn
0914-8779issn
1435-5604pii
10.1007/s00774-016-0793-4journal_volume
35pub_type
杂志文章abstract：INTRODUCTION:Data is currently lacking regarding association between the cholecystectomy/hepatectomy/pancreatectomy and the development of osteoporotic fracture. A retrospective cohort study was conducted to investigate the relationship between cholecystectomy/hepatectomy/pancreatectomy and the subsequent risk of devel...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-020-01129-7
更新日期：2020-08-05 00:00:00
abstract：:Digital X-ray radiogrammetry (DXR) is a computer-assisted diagnosis technique for quantifying cortical hand bone mineral density (BMD) as well as the metacarpal index (MCI) in the metacarpal bones from radiographs. The objective was to compare DXR-BMD and DXR-MCI between healthy individuals and patients with rheumatoi...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-016-0741-3
更新日期：2017-03-01 00:00:00
abstract：:Metformin, an anti-hyperglycemic agent used for type 2 diabetes, has recently been found to have more effects apart from glucose regulation. We found that, in ultra-high-molecular-weight polyethylene particle-induced osteolysis mouse models, metformin had bone protect property and reduced the negative regulator of bon...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-018-0939-7
更新日期：2019-05-01 00:00:00
abstract：:Metabolic bone disease may appear as a complication of obesity surgery. Because an imbalance in the osteoprotegerin and receptor-activator of nuclear factor-κB ligand system may underlie osteoporosis, we aimed to study this system in humans in the metabolic bone disease occurring after obesity surgery. In this study w...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章
doi：10.1007/s00774-015-0712-0
更新日期：2016-11-01 00:00:00
abstract：:This study aimed to identify the osteogenesis effect of icariside II (ICSII) and icaritin (ICT) in vitro. Bone marrow mesenchymal stem cells (BMSCs) were treated with ICSII and ICT in order to detect the proliferation and differentiation of BMSCs, the expression of the osteogenesis-related proteins with or without ost...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-017-0889-5
更新日期：2018-11-01 00:00:00
abstract：:A T869-->C polymorphism of the transforming growth factor-beta1 (TGF-beta1) gene is reported to be associated with genetic susceptibility to both osteoporosis and vertebral fractures. A low serum 25-hydroxyvitamin D [25(OH)D] level is known to be associated with a higher risk for hip fracture. This study aimed to asse...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0147-6
更新日期：2010-07-01 00:00:00
abstract：:Bone mass differs according to ethnic classification, with individuals of African ancestry attaining the highest measurements across numerous skeletal sites. Elevated bone mass is even maintained in those individuals exposed to adverse environmental factors, suggesting a prominent genetic effect that may have clinical...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-013-0431-3
更新日期：2013-11-01 00:00:00
abstract：:Endoplasmic reticulum (ER) stress has been reported to be linked to various diseases such as diabetes, neurodegenerative diseases, and osteogenesis imperfecta (OI). Old astrocyte specifically induced substance (OASIS), a novel type of ER stress transducer, is a basic leucine zipper transcription factor belonging to th...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0142-y
更新日期：2010-07-01 00:00:00
abstract：:Advanced glycation end products (AGE) in collagen have been reported to decrease the mechanical property of bone. However, there are no available data on the relation between fracture risk and levels of glycoxidative (nonenzymatic) cross-links of collagen in clinical samples. A total of 432 Japanese elderly women who ...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-007-0784-6
更新日期：2008-01-01 00:00:00
abstract：:The impact of smoking on peak bone density has not been conclusively established. We examined how smoking exposure influences bone mineral density (BMD) or the risk of low bone status in premenopausal women. We conducted a baseline survey with a representative sample of Japanese women in 1996. The effect of current an...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0129-8
更新日期：2010-05-01 00:00:00
abstract：:Chronic liver disease in adults is a risk factor of osteoporosis, but little is known about risk of fractures in children with non-cholestatic liver disease. The aim of this study was to investigate associations among the severity of liver fibrosis, bone mass and low-energy fractures in children. History of fractures,...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-010-0219-7
更新日期：2011-05-01 00:00:00
abstract：:We evaluated short-term changes in serum amino-terminal procollagen propeptide (P1NP) and cross-linked C-terminal telopeptide (betaCTX) of type I collagen after parathyroidectomy (PTX) in 41 postmenopausal women with primary hyperparathyroidism (PHPT). Serum levels of 25-hydroxyvitamin D, intact PTH, calcium, phosphat...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-008-0033-7
更新日期：2009-01-01 00:00:00
abstract：:Lipid rafts are membrane platforms for signaling molecules that regulate various cellular functions. During osteoclastogenesis, lipid rafts also have been shown to play a crucial role for cell fusion upon RANK/RANKL interaction and further activation of osteoclasts, resulting in bone resorption. To investigate protein...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0150-y
更新日期：2010-07-01 00:00:00
abstract：:Osteoclastogenic cytokines produced by T and B lineage cells and interleukin (IL)-7-induced expansion of the pool size of osteoclast precursors have been suggested to play an important role in acceleration of osteoclastogenesis induced by estrogen deficiency. However, the contribution of increased RANKL produced by os...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-006-0723-y
更新日期：2007-01-01 00:00:00
abstract：:Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarth...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,评审
doi：10.1007/s00774-014-0628-0
更新日期：2015-01-01 00:00:00
abstract：:The effects of basic fibroblast growth factor (bFGF) on osteogenic differentiation in-vivo were investigated using a rat bone marrow ablation model. bFGF was infused directly into rat femora for 6 days after bone marrow ablation. The contralateral femur was infused with vehicle only and used as control. Bone formation...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740300012
更新日期：2003-01-01 00:00:00
abstract：:Recent studies have showed a significant correlation between vascular calcification and bone mineral density (BMD). Therefore, an investigation was carried out on the association between arterial stiffness, lumbar BMD and bone metabolic markers in Japanese postmenopausal women. Brachial-ankle PWV (baPWV) and BMD of th...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-008-0014-x
更新日期：2009-01-01 00:00:00
abstract：:Alendronate has recently been approved for the prevention and treatment of postmenopausal osteoporosis, and its efficacy has been demonstrated in many Western countries. Our present study was performed to evaluate the effect of alendronate on bone mineral density (BMD) and its tolerability in Thais. Eighty postmenopau...
journal_title：Journal of bone and mineral metabolism
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00774-003-0438-2
更新日期：2003-01-01 00:00:00
abstract：:Lactoferrin (Lf) expression was investigated by using a Lf monoclonal antibody in 50 formalin-fixed and paraffin-embedded human bone tumours [10 giant cell tumours (GCTs), 7 osteoid osteomas, 6 ossifying fibromas, 19 enchondromas, 2 chondroblastomas, 2 chondrosarcomas, 2 chondroblastic osteosarcomas, 1 myeloma and 1 a...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-009-0044-z
更新日期：2009-01-01 00:00:00
abstract：:The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,多中心研究
doi：10.1007/s00774-013-0529-7
更新日期：2014-09-01 00:00:00
abstract：:We designed a randomized, double-blind, controlled clinical trial to compare the effect of two regimens for administering cholecalciferol on the serum 25-hydroxycholecalciferol [25(OH)D] levels and in the reversion of secondary hyperparathyroidism in the elderly living in a low-income housing unit in the city of Porto...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00774-008-0858-0
更新日期：2008-01-01 00:00:00
abstract：:The purpose of this study was to investigate the association of the Singh index, cortical thickness index (CTI) and calcar-to-canal (CC) ratio with bone mineral density (BMD) as well as their relationship with physical parameters [age, gender, height, and body mass index (BMI)] in order to assess their potential as an...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-012-0348-2
更新日期：2012-09-01 00:00:00
abstract：:Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of immortalizing genes. The resulting cell lines had no major differences t...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-016-0753-z
更新日期：2017-03-01 00:00:00
abstract：:The effects of unilateral sciatic neurectomy (USN) on the development of the femur were studied in 15 growing Wistar-derived rats (age, 5 weeks). The rats were divided into four groups: USN-operated group (right femur), USN-nonoperated group (left femur), sham-operated group (right femur), and sham-nonoperated group (...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s007740050093
更新日期：1999-01-01 00:00:00
abstract：:The aim of this observational, non-randomized study was to clarify the unknown effects of switching oral bisphosphonates (BPs) to denosumab (DMAb) or daily teriparatide (TPTD) in patients with rheumatoid arthritis (RA). The characteristics of the 194 female patients included in the study were 183 postmenopausal, age 6...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,多中心研究
doi：10.1007/s00774-017-0861-4
更新日期：2018-07-01 00:00:00
abstract：:Osteoporosis is a growing health problem in women and in men. This cross-sectional study examined the association of anthropometric, lifestyle, and hormonal factors with bone mineral density (BMD) in 152 healthy Korean middle-aged men. Smoking habits and alcohol consumption were assessed by interview. Serum testostero...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-003-0500-0
更新日期：2004-01-01 00:00:00
abstract：:In end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femo...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-019-00988-z
更新日期：2019-09-01 00:00:00
abstract：:We aimed to clarify changes in biochemical markers of bone turnover (BTMs) over 10 years, associations with changes in bone mineral density (BMD), and birth-cohort effects in a Japanese community. We randomly selected 400 individuals (age, 40-79 years; 50 of each gender and age stratum) from a list of registered resid...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-011-0266-8
更新日期：2011-11-01 00:00:00
abstract：:Bone microarchitecture of the iliac bone is used to characterize the properties of bone tissue in osteoporosis, particularly in pharmacological studies. Trabecular bone is known to be heterogeneous media. For a few years, the analysis of three-dimensional (3-D) bone microarchitecture has been based on micro-computed t...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章
doi：10.1007/s00774-008-0856-2
更新日期：2008-01-01 00:00:00
abstract：:Eldecalcitol reduces the risk of vertebral fractures in comparison to alfacalcidol in osteoporotic patients under vitamin D repletion. The aim of this study was to evaluate the effects of eldecalcitol on the spinal location of incident vertebral fractures, the severity of the fractures, and the changes in health-relat...
journal_title：Journal of bone and mineral metabolism
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00774-012-0397-6
更新日期：2013-03-01 00:00:00
