Abstract:
:Fluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. As far as we know, none of those models consider a physiological description for the lymphatic drainage-interstitial pressure relation. We develop a computational model that consists of a network of straight cylindrical vessels and an isotropic porous media with a uniformly distributed sink term acting as the lymphatic system. In order to describe the lymphatic flow rate, a non-linear function of the interstitial pressure is defined, based on literature data on the lymphatic system. The proposed model of lymphatic drainage is compared to a linear one, as is typically used in computational models. To evaluate the response of the model, the two are compared with reference to both physiological and pathological conditions. Differences in the local fluid dynamic description have been observed using the non-linear model. In particular, the distribution of interstitial pressure is heterogeneous in all the cases analyzed. The resulting averaged values of the interstitial pressure are also different, and they agree with literature data when using the non-linear model. This work highlights the key role of lymphatic drainage and its modeling when studying the fluid balance in microcirculation for both to physiological and pathological conditions, e.g. uremia.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Possenti L,Casagrande G,Di Gregorio S,Zunino P,Costantino MLdoi
10.1016/j.mvr.2018.11.003subject
Has Abstractpub_date
2019-03-01 00:00:00pages
101-110eissn
0026-2862issn
1095-9319pii
S0026-2862(18)30038-4journal_volume
122pub_type
杂志文章abstract:PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103907
更新日期:2019-11-01 00:00:00
abstract::Cerebral ischemia and post-ischemic reperfusion commonly result in significant brain damage. Brain microvessel endothelial cells, the key target cells and regulating sites, can secrete adenosine which plays an important neuroprotective role in the ischemic brain. A primary determinant of localized production of adenos...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.04.005
更新日期:2006-07-01 00:00:00
abstract::The multiple pore model of T. R. Harris and R. J. Roselli (1981, J. Appl. Physiol: Respir. Environ. Exercise Physiol. 50, 1-14), was used to simulate lung lymph flow and protein transport at various levels of microvascular pressure. Response of the three-pore structure determined in that study was found to be in excel...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(85)90022-6
更新日期:1985-05-01 00:00:00
abstract::This study further investigates the mechanisms responsible for the effects of acute and severe hypoxia, and subsequent reoxygenation, on the contractility of isolated rat mesenteric arteries. In noradrenaline (NA)-contracted arteries, hypoxia caused a relaxation to near baseline levels. Reoxygenation resulted in an im...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.08.001
更新日期:2004-11-01 00:00:00
abstract::The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cel...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2008.06.003
更新日期:2008-11-01 00:00:00
abstract::Spontaneous contractions and those elicited by electrical stimulation were studied in isolated segments of bovine mesenteric lymphatic vessels. The effects of three general anesthetics, pentobarbitone, halothane, and ether, on these spontaneous and evoked contractions were studied. Pentobarbitone and halothane inhibit...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(89)90073-3
更新日期:1989-01-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) and their receptors play important roles in cellular processes such as proliferation, differentiation, migration and cell survival. It was also demonstrated that BMPs are involved in vasculogenesis and angiogenesis. In this study, we investigated the expression profile of BMP recepto...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.03.010
更新日期:2012-07-01 00:00:00
abstract::The most universal angiogenic cytokines (VEGF, bFGF, HGF) are all heparin-binding proteins, the function of which is dependent on cell surface heparan sulfate proteoglycans (HSPG). Several proteoglycans have been demonstrated in endothelial cells, but only glypican-1 from the cell surface HSPG subfamily was documented...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.05.001
更新日期:2004-09-01 00:00:00
abstract::Pericytes are perivascular support cells, the origin of which in tumor tissue is not clear. Recently, we identified a Tie1(+) precursor cell that differentiates into vascular smooth muscle, in a Notch-dependent manner. To understand the involvement of Notch in the ontogeny of tumor pericytes we used a novel flow immun...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.05.004
更新日期:2015-09-01 00:00:00
abstract::Angiogenesis is widely accepted to play a central role in tumor growth and spreading. Therefore, anti-angiogenic agents appear as promising tools in cancer therapy, and great efforts have been devoted to their identification in recent years. Despite fast progress in this area, a quantitative and objective system for r...
journal_title:Microvascular research
pub_type:
doi:10.1006/mvre.2001.2389
更新日期:2002-05-01 00:00:00
abstract::Developing tissue engineering approaches to generate functional vascular networks is important for improving treatments of peripheral and cardiovascular disease. Endothelial colony forming cells (ECFCs) are an endothelial progenitor cell (EPC) population defined by high proliferative potential and an ability to vascul...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2010.03.001
更新日期:2010-07-01 00:00:00
abstract::It has generally been assumed that movement of fluid between the pulmonary microvasculature and surrounding tissues is governed by a "Starling" balance of hydrostatic and protein osmotic forces similar to that which prevails in the extremities. However, both recent and older observations suggest that the lungs are mor...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2009.03.004
更新日期:2009-06-01 00:00:00
abstract::Studies of microvascular geometry made from microscope observations of tissues in vivo or after perfusion with a silastic elastomer or india ink are restricted to a two-dimensional field of view. Microvascular corrosion casts, however, if of sufficient rigidity and structural integrity, can yield three-dimensional inf...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(83)90044-4
更新日期:1983-01-01 00:00:00
abstract::Failure of the glomerular barrier causing proteinuria has been modeled chiefly by Chang, Deen, and Brenner. They have refined models from an isoporous filter to a mostly isoporous membrane, which during proteinuric disease opens up nondiscriminating shunts. This report extends these concepts by measuring a larger dist...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2146
更新日期:1999-05-01 00:00:00
abstract::The contractile responses of cultured rat and calf endothelial cells (EC), vascular smooth muscle cells (VSMC), and fibroblasts (FB) to vasoactive mediators (thrombin, serotonin, bradykinin, and histamine), forskolin, and cytochalasin B were compared. Cells were grown on a pliable silicone membrane, and contraction wa...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(92)90015-h
更新日期:1992-03-01 00:00:00
abstract::Excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), by activated neutrophils and endothelial cells, has been implicated in the pathophysiology of endothelial barrier dysfunction. Disruption of the integrity of this barrier markedly increases permeability to fluids, solutes and in...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2008.10.005
更新日期:2009-01-01 00:00:00
abstract::Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2193
更新日期:2000-01-01 00:00:00
abstract::We have videorecorded spontaneous cyclic contractions of capillary walls which often stopped the flow of blood cells, in spleens of rat and mouse. An inverted microscope and oblique lighting were key elements in obtaining images in which the boundaries of cells composing vessel walls were clearly distinguishable. Usin...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(88)90035-0
更新日期:1988-07-01 00:00:00
abstract::Endoneurial capillaries in nerve biopsies from 12 adult diabetic cats with varying degrees of neurological dysfunction were examined for evidence of microvascular pathology and compared to nerves obtained at necropsy from 7 adult non-diabetic cats without clinical evidence of neurological dysfunction. As reported prev...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2007.12.002
更新日期:2008-04-01 00:00:00
abstract::We tested the hypothesis that the endothelial nitric oxide (NO)-soluble guanylyl cyclase system is involved in atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) mediated regulation of coronary and peripheral vascular resistance. Rat hearts were perfused via the aorta at constant flow and the effect...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2000.2289
更新日期:2001-01-01 00:00:00
abstract::Despite intensive study in the area of angiogenesis, relatively little is known about normal angiogenesis in adult animals. Preliminary studies using the Griffonia simplicifolia I (GSI) lectin as a microvascular marker indicated that capillary sprouting occurs in the clear "windows" of normal intact adult rat mesenter...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1994.1029
更新日期:1994-05-01 00:00:00
abstract::Oxygen tension was recorded with double-barreled microelectrodes in the retina of anesthetized cats and monkeys. The oxygen tension (PO2) was often observed to undergo spontaneous irregular fluctuations with peak-to-peak amplitudes of about 3 to as much as 20 mm Hg. These fluctuations were observed only in the vascula...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(92)90103-v
更新日期:1992-07-01 00:00:00
abstract::The dynamics of the microvasculature of the blood-perfused canine gastrocnemius-plantaris muscle in situ at rest and during contraction were determined using multiple-indicator dilution analysis. Permeability-surface area product (PS) was estimated using a bolus indicator dilution of 86Rb, with 125I-albumin serving as...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1997.2067
更新日期:1998-03-01 00:00:00
abstract::Strychnine is known to possess anti-inflammatory and antitumour activity, but its roles in tumour angiogenesis, the key step involved in tumour growth and metastasis, and the involved molecular mechanism are still unknown. We aimed to investigate the effects of strychnine on key components of inflammatory angiogenesis...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.01.003
更新日期:2013-05-01 00:00:00
abstract::In a novel assay of angiogenesis in the quail chorioallantoic membrane (CAM), we measured vascular pattern and angiogenic rate after homogeneous exposure of the entire vascular tree to recognized modulators of vessel growth. In comparison to phosphate-buffered saline (PBS)-treated controls, the vascular stimulator, ba...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1998.2073
更新日期:1998-05-01 00:00:00
abstract::In the present study, human myometrial microvascular endothelial cells (HMMEC) were cocultured with human vascular smooth muscle cells (VSMC) labeled with fluorescent dyes to examine their morphological interaction using confocal laser fluorescent microscopy. HMMEC and VSMC labeled with fluorescent green and red dyes,...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2005.04.008
更新日期:2005-07-01 00:00:00
abstract::Neovascularization is crucial for fracture healing and plays an important role in long-time graft survival in tissue engineering applications. Endothelial progenitor cells (EPCs) can be isolated from peripheral blood avoiding donor site morbidity, which makes them attractive for autologous cell-based engineering of ne...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.12.001
更新日期:2015-03-01 00:00:00
abstract::Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse a...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.10.005
更新日期:2013-01-01 00:00:00
abstract::Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicate...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.08.003
更新日期:2012-11-01 00:00:00
abstract::Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedure...
journal_title:Microvascular research
pub_type: 杂志文章,评审
doi:10.1016/j.mvr.2014.06.006
更新日期:2014-11-01 00:00:00