Abstract：
:Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supplying frontoparietal white matter (WM) tracts and cortex and compared to normal pregnant (Preg) and nonpregnant (Nonpreg) Sprague Dawley rats (n = 8/group). Myogenic reactivity and tone were similar between groups; however, constriction to intermediate-conductance calcium-activated potassium (IK) channel inhibition was diminished and dilation to inward-rectifying K+ (KIR) channel activation was impaired in PAs from ePE rats, suggesting altered ion channel function. Conducted vasodilation was significantly delayed in response to 12 mM KCl, but not 10 μM adenosine, in PAs from ePE rats versus Preg and Nonpreg rats (940 ± 300 ms vs. 70 ± 50 ms and 370 ± 90 ms; p < 0.05). Overall, dysfunction of PAs supplying frontoparietal WM and gray matter was present in ePE. If persistent these changes could potentiate neuronal injury that over time could contribute to WM lesions and early-onset cognitive decline.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Johnson AC,Cipolla MJdoi
10.1016/j.mvr.2018.04.007subject
Has Abstractpub_date
2018-09-01 00:00:00pages
64-72eissn
0026-2862issn
1095-9319pii
S0026-2862(17)30232-7journal_volume
119pub_type
杂志文章abstract：:The effect of isoprenaline infusion (1 gamma/min) on blood flow in the extremities was studied in 15 Raynaud's disease (RD) patients and 9 healthy controls. A highly significant (P less than 0.0005) decrease in blood flow was seen in the RD subjects. It is suggested that an increased presynaptic beta receptor response...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(84)90045-1
更新日期：1984-01-01 00:00:00
abstract：:Leptin, a circulating hormone secreted mainly from adipose tissues, is involved in the control of body weight. Recently, leptin was found to be an angiogenic factor, and its vitreous levels are associated with angiogenic eye diseases such as proliferative diabetic retinopathy. However, the molecular mechanism for lept...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/s0026-2862(03)00005-0
更新日期：2003-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90051-2
更新日期：1985-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.12.004
更新日期：2011-03-01 00:00:00
abstract：:The distribution of anionic sites in the basal laminae of the blood capillaries of the murine pancreas was studied in specimens fixed in ruthenium red (RR)-glutaraldehyde mixtures. The sites appeared as discrete, small (6 to 18 nm) particles distributed throughout the three laminae but concentrated primarily in the la...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(84)90006-2
更新日期：1984-11-01 00:00:00
abstract：PURPOSE:Diabetic retinopathy (DR) is characterized by pro-inflammatory, pro-angiogenic and pro-fibrotic environment during the various stages of the disease progression. Basement membrane changes in the retina and formation of fibrovascular membrane are characteristically seen in DR. In the present study the effect of ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.09.001
更新日期：2019-01-01 00:00:00
abstract：:This paper presents the results of a circulation analysis using an image based network model of a murine retinal vasculature, which closely represents the 3D vascular distribution of the retina. The uneven distribution of the red blood cells at vascular network bifurcations (i.e., plasma skimming effect), the microvas...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.02.005
更新日期：2010-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(86)90021-x
更新日期：1986-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90058-j
更新日期：1991-11-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2011.11.005
更新日期：2012-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0026-2862(02)00010-9
更新日期：2003-01-01 00:00:00
abstract：:Angiogenesis is widely accepted to play a central role in tumor growth and spreading. Therefore, anti-angiogenic agents appear as promising tools in cancer therapy, and great efforts have been devoted to their identification in recent years. Despite fast progress in this area, a quantitative and objective system for r...
journal_title：Microvascular research
pub_type：
doi：10.1006/mvre.2001.2389
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood. OBJECTIVES:To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA. MET...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.01.005
更新日期：2018-05-01 00:00:00
abstract：:Changes in blood vessel diameter can be measured manually, but this is time-consuming and often impractical. For automatic measurement commercial solutions are available, but the proprietary algorithms and their potential shortcomings are not known to the user. We present an approach with a CCD camera for image acquis...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.004
更新日期：2010-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104032
更新日期：2020-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2005.04.008
更新日期：2005-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.005
更新日期：2014-07-01 00:00:00
abstract：:The purpose of this study was to determine whether bidirectional flow exists in the sciatic vasa nervorum. Images obtained using high-frequency color Doppler ultrasound in duplex imaging mode (Vevo 2100) were studied retroactively. In Fig. 1 (left panel; rat 1), the color Doppler signal and flow-velocity waveforms are...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.008
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:Calcium channel inhibitors have beneficial impact on microcirculation, but beta-blocker effect is controversial. Clinicians still do not agree on beta-blocker combination with other treatments in the management of impaired microcirculation. The aim of the present study was to describe the effects of beta-blo...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2011.04.004
更新日期：2011-07-01 00:00:00
abstract：:We examined the influence of local cooling (-15 degrees C, 60 sec) on blood flow velocity in nailfold capillaries and on laser Doppler flux (LDF) at the fingertip in 12 patients with primary Raynaud's phenomenon (PRP) and 13 patients with secondary Raynaud's (SRP) in comparison with 10 health controls. Skin temperatur...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1060
更新日期：1993-11-01 00:00:00
abstract：:Alveolar epithelial and endothelial cell death caused by mechanical over-distension is likely to contribute to ventilator-induced lung injury (VILI). Consequently, the search for cytoprotective interventions is of interest. We investigated the effect of the mTOR inhibitor rapamycin on human pulmonary microvascular end...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.01.012
更新日期：2009-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.mvr.2010.01.002
更新日期：2010-03-01 00:00:00
abstract：:Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2193
更新日期：2000-01-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.08.001
更新日期：2004-11-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(90)90008-f
更新日期：1990-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2017.04.003
更新日期：2017-09-01 00:00:00
abstract：:Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated in various models of pulmonary arterial hypertension (PAH). We addressed the relationship between P...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.008
更新日期：2010-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2003.09.003
更新日期：2004-01-01 00:00:00
abstract：:Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenic lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Alth...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2014.06.001
更新日期：2014-11-01 00:00:00
abstract：:Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response to intravascular H2O2 challenge in buffer-perfused rabbit lun...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1033
更新日期：1995-07-01 00:00:00
