Pigment epithelium-derived factor inhibits leptin-induced angiogenesis by suppressing vascular endothelial growth factor gene expression through anti-oxidative properties.

abstract：:Oxygen pressure histograms were determined with the multiwire surface electrode from the gastrocnemius muscle in patients with arterial occlusive disease and compared with those of healthy volunteers. Seven out of 22 patients had normally distributed histograms like volunteers, but the mean PO2 values were lower than ...

journal_title：Microvascular research

authors： Creutzig A,Wrabetz W,Lux M,Alexander K

更新日期：1985-05-01 00:00:00

abstract：:During diabetes in rats, the choroid of the eye shows increased permeability to albumin, basement membrane thickening, and decreased anionic charge sites on the abluminal surfaces of the choriocapillary microvessels. In other microvascular beds, permeability differences are correlated with differences in luminal membr...

journal_title：Microvascular research

authors： Caldwell RB,Fitzgerald ME

更新日期：1991-11-01 00:00:00

abstract：:We describe a sensitive, reliable, and convenient procedure to assay cell adhesion based on flow cytometry which allows quantitative studies of all major peripheral blood leukocytes adhering to microvascular endothelial cells. Using this assay, we show that adhesion of mononuclear cells is significantly increased in t...

journal_title：Microvascular research

authors： Heckmann M,Pirthauer M

更新日期：1996-09-01 00:00:00

abstract：:An ex vivo perfused solid tumor preparation provides control over the physiological, biochemical, and pharmacological composition of the arterial input and easy access to the venous output. This is advantageous for studies of transport and metabolism in solid tumors. Here we present a tissue-isolated tumor preparation...

journal_title：Microvascular research

authors： Kristjansen PE,Roberge S,Lee I,Jain RK

更新日期：1994-11-01 00:00:00

abstract：:Non-freezing cold injury (NFCI) is a prevalent, but largely undiagnosed and poorly understood syndrome afflicting many who, as part of their work or leisure, expose their extremities to cold temperatures. The long term sequelae of NFCI are hyperhidrosis, cold-sensitivity and pain; these can last a lifetime. We tested ...

journal_title：Microvascular research

authors： Hope K,Eglin C,Golden F,Tipton M

更新日期：2014-01-01 00:00:00

abstract：:Rho-associated kinases are involved in regulation of actin-myosin contractility and the organization of the actin cytoskeleton in both endothelial and smooth muscle cells. By influencing the contraction of the intraendothelial filaments, Rho kinases may affect the size of the interendothelial gaps and thereby influenc...

journal_title：Microvascular research

authors： Lundblad C,Bentzer P,Grände PO

更新日期：2003-09-01 00:00:00

abstract：:Red blood cell (RBC)-plasma suspensions with a hematocrit of 10-12% were forced to flow through microchannels (equivalent diameter 6 microns, equivalent length 20 microns, 2600 in parallel) by applying a pressure difference of 20 cm H2O. Transit times for 100 microliters of fresh suspensions from 33 healthy male subje...

journal_title：Microvascular research

authors： Kikuchi Y,Da QW,Fujino T

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Subcutaneous tissue is a promising site for cell transplantation; advantages include minimally invasive procedures and easy post-transplant monitoring. However, limited vascularity is the major known challenge. To address this challenge, a prevascularized graft bed is prepared in recipients. We aimed to establi...

journal_title：Microvascular research

authors： Komatsu H,Gonzalez N,Kandeel F,Mullen Y

更新日期：2020-11-01 00:00:00

abstract：:Particle adhesion in vivo is highly dependent on the microvascular environment comprising of unique anatomical, geometrical, physiological fluid flow conditions and cell-particle and cell-cell interactions. Hence, proper design of vascular-targeted drug carriers that efficiently deliver therapeutics to the targeted ce...

journal_title：Microvascular research

authors： Lamberti G,Soroush F,Smith A,Kiani MF,Prabhakarpandian B,Pant K

更新日期：2015-05-01 00:00:00

abstract：:The first description of endothelial progenitor cells (EPC) in 1997 led rapidly to substantial changes in our understanding of angiogenesis, and within 5 years to the first clinical studies in humans using bone marrow derived EPC to enhance coronary neovascularisation and cardiac function after myocardial ischemia. Ho...

journal_title：Microvascular research

authors： Pearson JD

更新日期：2010-05-01 00:00:00

abstract：:Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested ...

journal_title：Microvascular research

authors： Fujii N,Halili L,Nishiyasu T,Kenny GP

更新日期：2018-05-01 00:00:00

abstract：:Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter ...

journal_title：Microvascular research

authors： Bone DB,Antic M,Vilas G,Hammond JR

更新日期：2014-09-01 00:00:00

abstract：:Innate immunity is characterized by the coordinated activity of multiple leukocytes mobilizing at or near the site of tissue injury. Slow rolling and/or adherent leukocytes have been shown to hydrodynamically recruit free-stream leukocytes to a model of inflamed tissue. In this paper, we numerically investigate the hy...

journal_title：Microvascular research

authors： Subramaniam DR,Gee DJ

更新日期：2018-01-01 00:00:00

abstract：:The large secreted glycoprotein thrombospondin-1 is a potent inhibitor of neovascularization in vivo. In order to better understand its mechanism of action, we have determined the full range of deficits thrombospondin can impose on cultured capillary endothelial cells. Exogenously added thrombospondin-1 blocked the ab...

journal_title：Microvascular research

authors： Tolsma SS,Stack MS,Bouck N

更新日期：1997-07-01 00:00:00

abstract：:The effect of hemodilution on oxygen delivery to the tissue was investigated analytically by taking into consideration the oxygen loss that occurs along the arterial microvasculature due to diffusion into the tissue and shunting to parallel running venules. The theoretical findings were related to experimental data on...

journal_title：Microvascular research

authors： Mirhashemi S,Ertefai S,Messmer K,Intaglietta M

更新日期：1987-11-01 00:00:00

abstract：:There is evidence that vascular beds distal to the ophthalmic artery (OA) show vasoconstriction in response to a step decrease in systemic blood pressure (BP). The mediators of this response are mostly unidentified. The aim of the current study was to test the hypothesis that α2-adrenoreceptors may contribute to the r...

journal_title：Microvascular research

authors： Kaya S,Kolodjaschna J,Berisha F,Polska E,Pemp B,Garhöfer G,Schmetterer L

更新日期：2011-01-01 00:00:00

abstract：:Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response to intravascular H2O2 challenge in buffer-perfused rabbit lun...

journal_title：Microvascular research

authors： Seeger W,Hansen T,Rössig R,Schmehl T,Schütte H,Krämer HJ,Walmrath D,Weissmann N,Grimminger F,Suttorp N

更新日期：1995-07-01 00:00:00

abstract：:The size of hyaluronan in lymph and gastrocnemius muscle was measured to test the hypothesis that reperfusion of ischemic skeletal muscle leads to hyaluronan depolymerization. Prenodal lymph was collected from the gastrocnemius muscle in anesthetized rabbits. Hyaluronan size was measured using a combination of agarose...

journal_title：Microvascular research

authors： Armstrong SE,Bell DR

更新日期：2002-09-01 00:00:00

abstract：:The dynamics of the microvasculature of the blood-perfused canine gastrocnemius-plantaris muscle in situ at rest and during contraction were determined using multiple-indicator dilution analysis. Permeability-surface area product (PS) was estimated using a bolus indicator dilution of 86Rb, with 125I-albumin serving as...

journal_title：Microvascular research

authors： Frisbee JC,Barclay JK

更新日期：1998-03-01 00:00:00

abstract：:Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...

journal_title：Microvascular research

authors： Buerk DG,Riva CE

更新日期：2002-09-01 00:00:00

abstract：:It is generally assumed that when a muscle is shortened or extended the total length of capillaries does not change, implying that capillaries are nondistensible, longitudinally. On the basis of stereological estimates of capillary anisotropy versus sarcomere length, we propose that as long as capillaries are in a tor...

journal_title：Microvascular research

authors： Ellis CG,Mathieu-Costello O,Potter RF,MacDonald IC,Groom AC

更新日期：1990-07-01 00:00:00

abstract：:Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantifie...

journal_title：Microvascular research

authors： Milstein DM,Helmers R,Hackmann S,Belterman CN,van Hulst RA,de Lange J

更新日期：2016-05-01 00:00:00

abstract：:We investigated the expression of cell adhesion molecules on the surface of glomerular endothelial cells (GEC), dermal microvascular endothelial cells (MvE), and umbilical vein endothelial cells (HUVEC) that had or had not been stimulated by cytokines. PECAM-1 was constitutively expressed at a high level on HUVEC but ...

journal_title：Microvascular research

authors： Murakami S,Morioka T,Nakagawa Y,Suzuki Y,Arakawa M,Oite T

更新日期：2001-11-01 00:00:00

abstract：:The concept of anti-angiogenesis therapy was introduced by Judah Folkman in 1971 and since then, a plethora of pro- and anti-angiogenic factors have been identified. In the recent years, it has become clear that angiogenesis, the formation of new capillaries from a pre-existing capillary network, is highly regulated b...

journal_title：Microvascular research

authors： Mundel TM,Kalluri R

更新日期：2007-09-01 00:00:00

abstract：:Cerebral ischemia and post-ischemic reperfusion commonly result in significant brain damage. Brain microvessel endothelial cells, the key target cells and regulating sites, can secrete adenosine which plays an important neuroprotective role in the ischemic brain. A primary determinant of localized production of adenos...

journal_title：Microvascular research

authors： Li X,Zhou T,Zhi X,Zhao F,Yin L,Zhou P

更新日期：2006-07-01 00:00:00

abstract：:Endothelial cells represent one of the critical cellular elements in tumor microenvironment playing a crucial role in the growth and progression of cancer through controlling angiogenesis. Vascular endothelial growth factor (VEGF) produced from tumor cells is essential for the expansion of breast cancer and may functi...

journal_title：Microvascular research

authors： Alvarez-García V,González A,Alonso-González C,Martínez-Campa C,Cos S

更新日期：2013-05-01 00:00:00

abstract：:The present study was conducted to compare laser speckle imaging (LSI) with sidestream dark field (SDF) imaging (i.e., capillary microscopy) so as to validate the use of LSI for assessing microvascular (re)perfusion. For this purpose, LSI and SDF measurements were performed on the human nail fold during gradual occlus...

journal_title：Microvascular research

authors： Bezemer R,Klijn E,Khalilzada M,Lima A,Heger M,van Bommel J,Ince C

更新日期：2010-03-01 00:00:00

abstract：:Studies of blood flow in mesentery, cremaster muscle, and small bore glass tubes were performed to obtain a relationship between mean velocity (Vmean) and red cell velocity using the two-slit method under epifluorescence (Vepi) and transillumination (Vtrans) microscopy. The velocities Vepi and Vtrans obtained in vivo ...

journal_title：Microvascular research

authors： Seki J,Lipowsky HH

更新日期：1989-07-01 00:00:00

abstract：:Endotoxemia, a major feature of sepsis, is a common cause of acute lung injury and initiates rapid accumulation of leukocytes in the lung vasculature. Endothelial mechanisms that underlie this accumulation remain unclear, as current experimental models of endotoxemia are less suitable for targeted activation of the en...

journal_title：Microvascular research

authors： Kandasamy K,Sahu G,Parthasarathi K

更新日期：2012-05-01 00:00:00

abstract：:We observed the retinal capillary pericytes of the rat in situ. Whole retinae were mounted, immediately post vivo, in a special tissue chamber for electronic light microscopy at high magnifications. Under electronic light microscopy the pericytes could be clearly distinguished from the endothelial cells. In addition, ...

journal_title：Microvascular research

authors： Schönfelder U,Hofer A,Paul M,Funk RH

更新日期：1998-07-01 00:00:00