Abstract：
:There is evidence that vascular beds distal to the ophthalmic artery (OA) show vasoconstriction in response to a step decrease in systemic blood pressure (BP). The mediators of this response are mostly unidentified. The aim of the current study was to test the hypothesis that α2-adrenoreceptors may contribute to the regulatory process in response to a decrease in BP. In this randomized, double-masked, placebo-controlled study 14 healthy male volunteers received either 22mg yohimbine hydrochloride or placebo. Beat-to-beat BP was measured by analysis of arterial pressure waveform; blood flow velocities in the middle cerebral artery (MCA) and the OA were measured with Doppler ultrasound. Measurements were done before, during and after a step decrease in BP. The step decrease in BP was induced by bilateral thigh cuffs at a suprasystolic pressure followed by a rapid cuff deflation. After cuff deflation, BP returned to baseline after 7-8 pulse cycles (PC). Blood velocities in the MCA returned to baseline earlier (4 PC) than BP indicating peripheral vasodilatation. Blood velocities in the OA returned to baseline later (15-20 PC) indicating peripheral vasoconstriction. Yohimbine did not affect the blood velocity response in the MCA, but significantly shortened the time of OA blood velocities to return to baseline values (6-7 PC, p<0.05). In conclusion, our results indicate that yohimbine did not alter the regulatory response in the MCA, but modified the response of vascular beds distal to the OA. This suggests that α2-adrenoceptors play a role in the vasoconstrictor response of the vasculatures distal to the OA.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Kaya S,Kolodjaschna J,Berisha F,Polska E,Pemp B,Garhöfer G,Schmetterer Ldoi
10.1016/j.mvr.2010.10.001subject
Has Abstractpub_date
2011-01-01 00:00:00pages
117-22issue
1eissn
0026-2862issn
1095-9319pii
S0026-2862(10)00188-3journal_volume
81pub_type
杂志文章,随机对照试验abstract：:The electrokinetically modulated peristaltic transport of power-law fluids through a narrow confinement in the form of a deformable tube is investigated. The fluid is considered to be divided into two regions - a non-Newtonian core region (described by the power-law behavior) which is surrounded by a thin wall-adherin...
journal_title：Microvascular research
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journal_title：Microvascular research
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更新日期：2008-01-01 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2086
更新日期：1998-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0026-2862(84)90060-8
更新日期：1984-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(87)90054-9
更新日期：1987-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2014.06.006
更新日期：2014-11-01 00:00:00
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doi：10.1016/j.mvr.2015.01.007
更新日期：2015-03-01 00:00:00
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更新日期：2014-01-01 00:00:00
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doi：10.1006/mvre.1995.1038
更新日期：1995-07-01 00:00:00
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更新日期：2005-05-01 00:00:00
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更新日期：1985-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0026-2862(83)90066-3
更新日期：1983-09-01 00:00:00
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doi：10.1016/j.mvr.2013.06.004
更新日期：2013-09-01 00:00:00
