Abstract:
:The Raynaud's phenomenon often accompanies systemic rheumatic diseases and is also known as a vascular side effect of chemotherapy. Therapy of the Raynaud's phenomenon with nitrates or calcium-channel-blockers is rarely beneficial. In contrast, the PDE-V-inhibitor sildenafil seems to be effective in these patients. For the first time we report on a patient with Raynaud's phenomenon due to chemotherapy not responding to sildenafil but to the new PDE-V-inhibitor tadalafil in an equivalent dosage. Measurement with a laser Doppler revealed an increased blood flow and a reduction of symptoms. Therefore, therapy of Raynaud's phenomenon with the new PDE-V-inhibitor tadalafil seems to be an effective treatment option in patients not responding to sildenafil.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Baumhaekel M,Scheffler P,Boehm Mdoi
10.1016/j.mvr.2005.03.001keywords:
subject
Has Abstractpub_date
2005-05-01 00:00:00pages
178-9issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(05)00023-3journal_volume
69pub_type
杂志文章abstract::Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle prolifer...
journal_title:Microvascular research
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Microvascular research
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更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.06.008
更新日期:2013-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.12.001
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journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.12.006
更新日期:2016-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1999.2151
更新日期:1999-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(83)90057-2
更新日期:1983-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.03.010
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:Angiogenin levels are increased in children and adolescent patients with type 1 diabetes, regardless of the extent of diabetic microangiopathy. However, little is known about the angiogenin concentrations in adults with type 1 diabetes. Thus we studied its level in middle aged subjects with the presence of d...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.08.005
更新日期:2012-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.04.001
更新日期:2013-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.04.006
更新日期:2006-07-01 00:00:00
abstract::Controversy exists concerning whether activation of N-methyl-D-aspartate (NMDA) receptors exerts direct dilator effects on cerebral arteries. The purpose of this study was to examine the responses of isolated piglet arteries to NMDA to determine whether isolated arteries, apart from surrounding neuronal tissue, are ca...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2005.04.007
更新日期:2005-07-01 00:00:00
abstract::A large loss of blood during hemorrhage can result in profound shock, a state of hypotension associated with hemodynamic abnormalities. One of the hypotheses to account for this collapse of homeostasis is that the production of nitric oxide (NO), a gas molecule that dilates blood vessels, is significantly impaired dur...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.02.009
更新日期:2009-06-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,评审
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更新日期:2009-06-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.03.004
更新日期:2004-07-01 00:00:00
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journal_title:Microvascular research
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doi:10.1016/j.mvr.2015.11.007
更新日期:2016-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2001.2315
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abstract::We investigated the role of nitric oxide synthase (NOS) on regional cutaneous vascular function at rest (thermoneutral conditions) and during the vasodilator response to increased local skin temperature (Tloc). Dorsal forearm and lateral leg sites were instrumented with microdialysis fibers, local heaters, and laser-D...
journal_title:Microvascular research
pub_type: 杂志文章
doi:
更新日期:2013-11-01 00:00:00
abstract::The kidneys of 14 female Wistar rats from 5 days to 18 months postnatally have been perfusion-fixed to study the development of glomerular capillaries using design-based stereological techniques. This report uses a topological definition of a capillary structural unit which forms the basis for the estimation of the nu...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1993.1022
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.10.006
更新日期:2015-01-01 00:00:00
abstract::Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1998.2105
更新日期:1998-11-01 00:00:00
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journal_title:Microvascular research
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doi:10.1016/j.mvr.2013.10.006
更新日期:2014-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1994.1029
更新日期:1994-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.mvr.2010.01.002
更新日期:2010-03-01 00:00:00