Acute VEGF effect on solute permeability of mammalian microvessels in vivo.

abstract：:The purpose of this study was to elucidate the mechanism by which bradykinin (BK) enhances prostacyclin (PGI(2)) production in human umbilical vein endothelial cells (HUVEC). BK-induced enhancement of PGI(2) synthesis was observed in a dose- and time-dependent manner, and it also increased [Ca(2+)](i) followed by enha...

journal_title：Microvascular research

authors： Higaki T,Sawada S,Kono Y,Imamura H,Tada Y,Yamasaki S,Toratani A,Sato T,Komatsu S,Akamatsu N,Tamagaki T,Tsuda Y,Tsuji H,Nakagawa M

更新日期：1999-09-01 00:00:00

abstract：:Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and...

journal_title：Microvascular research

authors： Nowroozpoor A,Gutterman D,Safdar B

更新日期：2021-03-01 00:00:00

abstract：:The aim of our study was to evaluate the feasibility of laser Doppler flowmetry (LDF) coupled with iontophoresis in exploring the skin vasodilator activity of exogenous calcitonin gene-related peptide (CGRP) in healthy subjects and to investigate the mechanisms involved in the skin vasodilator activity of this peptide...

journal_title：Microvascular research

authors： Rossi M,Carpi A,Di Maria C,Galetta F,Santoro G

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase. NAD(P)H oxidase subunit p22phox is reported to be related to the development of atherosclerosis...

journal_title：Microvascular research

authors： Kou B,Zhang J,Singer DR

更新日期：2009-03-01 00:00:00

abstract：:Estrogen induces endothelial progenitor cells (EPCs) migration and proliferation, which may serve as a potential target for coronary artery disease, but the mechanisms are unclear. We hypothesized that estrogen receptors (ERs) and phosphatidylinositol 3-kinase (PI3K) signaling pathway, which represent particularly imp...

journal_title：Microvascular research

authors： Zhao X,Huang L,Yin Y,Fang Y,Zhao J,Chen J

更新日期：2008-01-01 00:00:00

abstract：:A large loss of blood during hemorrhage can result in profound shock, a state of hypotension associated with hemodynamic abnormalities. One of the hypotheses to account for this collapse of homeostasis is that the production of nitric oxide (NO), a gas molecule that dilates blood vessels, is significantly impaired dur...

journal_title：Microvascular research

authors： Chen K,Pittman RN,Popel AS

更新日期：2009-06-01 00:00:00

abstract：:Microalbuminuria is a primary manifestation of diabetic nephropathy. Endothelial cell-selective adhesion molecule (ESAM) is a new member of the immunoglobulin superfamily which is selectively expressed by vascular endothelial cells. Although ESAM mediates homophilic interaction between endothelial cells, the role of E...

journal_title：Microvascular research

authors： Hara T,Ishida T,Cangara HM,Hirata K

更新日期：2009-05-01 00:00:00

abstract：:The dynamics of the microvasculature of the blood-perfused canine gastrocnemius-plantaris muscle in situ at rest and during contraction were determined using multiple-indicator dilution analysis. Permeability-surface area product (PS) was estimated using a bolus indicator dilution of 86Rb, with 125I-albumin serving as...

journal_title：Microvascular research

authors： Frisbee JC,Barclay JK

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:The proepicardium (PE), a transient embryonic structure crucial for the development of the epicardium and heart, contains its own population of endothelial cells (ECs). The aim of our study was to determine the pattern, anatomical orientation and phenotypic marker expression of the endothelial cell network w...

journal_title：Microvascular research

authors： Niderla-Bielińska J,Gula G,Flaht-Zabost A,Jankowska-Steifer E,Czarnowska E,Radomska-Leśniewska DM,Ciszek B,Ratajska A

更新日期：2015-11-01 00:00:00

abstract：:It is generally assumed that when a muscle is shortened or extended the total length of capillaries does not change, implying that capillaries are nondistensible, longitudinally. On the basis of stereological estimates of capillary anisotropy versus sarcomere length, we propose that as long as capillaries are in a tor...

journal_title：Microvascular research

authors： Ellis CG,Mathieu-Costello O,Potter RF,MacDonald IC,Groom AC

更新日期：1990-07-01 00:00:00

abstract：:Fluorescence-mediated photoplethysmography (FM-PPG) was developed to facilitate determination of tissue microvascular (capillary) blood perfusion, requiring intra-venous injection of a small bolus (~0.33mL) of dye (25mg/mL ICG) and acquisition of high-speed angiogram images (>15images/s). The methodology is applicable...

journal_title：Microvascular research

authors： Flower RW,Kling R

更新日期：2017-11-01 00:00:00

abstract：:The extravascular uptake for labeled albumin and IgG and the extravascular masses for endogenous albumin and IgG were measured in skin and skeletal muscle from anesthetized rabbits following 24 hr of intermittent plasmapheresis. An amount of protein equivalent to the total intravascular protein mass was removed. There...

journal_title：Microvascular research

authors： Wallace JR,Powers MR,Bell DR

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to evaluate whether streptokinase (SK) may produce beneficial effects at the level of microvascular circulation in addition to coronary recanalization. Twenty mongrel dogs weighing 28.4 +/- 4.6 kg were randomized to receive SK (16,000-72,000 U/kg) or 20 ml saline (control) in an open-chest an...

journal_title：Microvascular research

authors： Woo KS,Armiger LC,White HD,Norris RM

更新日期：2000-07-01 00:00:00

abstract：:We examined the influence of local cooling (-15 degrees C, 60 sec) on blood flow velocity in nailfold capillaries and on laser Doppler flux (LDF) at the fingertip in 12 patients with primary Raynaud's phenomenon (PRP) and 13 patients with secondary Raynaud's (SRP) in comparison with 10 health controls. Skin temperatur...

journal_title：Microvascular research

authors： Lütolf O,Chen D,Zehnder T,Mahler F

更新日期：1993-11-01 00:00:00

abstract：:The steatotic liver is characterized by deranged intrahepatic microvasculature that is believed to predispose it to ischemia-reperfusion injury. The aim of this study was to investigate the distorted hepatic hemodynamics and its impact on the redox status of the steatotic liver. Hepatic hemodynamic parameters, hepatic...

journal_title：Microvascular research

authors： Sun CK,Zhang XY,Wheatley AM

更新日期：2003-07-01 00:00:00

abstract：:The purpose of this study was to determine if there are intrinsic differences in resting tone, vascular reactivity, myogenic responses, and neurogenic vasoconstriction between the large and small feeder arteries and first order arterioles (1A) of the rat cremaster muscle. The pudic-epigastric artery (PEA), external sp...

journal_title：Microvascular research

authors： Sylvester FA,Frisbee JC,Lombard JH

更新日期：2000-09-01 00:00:00

abstract：:Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...

journal_title：Microvascular research

authors： Frisbee JC,Lombard JH

更新日期：1998-11-01 00:00:00

abstract：:Vessel size index (R(v), μm) has been proposed as a quantitative magnetic resonance imaging (MRI) derived imaging biomarker in oncology, for the non-invasive assessment of tumour blood vessel architecture and vascular targeted therapies. Appropriate pre-clinical evaluation of R(v) in animal tumour models will improve ...

journal_title：Microvascular research

authors： Burrell JS,Bradley RS,Walker-Samuel S,Jamin Y,Baker LC,Boult JK,Withers PJ,Halliday J,Waterton JC,Robinson SP

更新日期：2012-11-01 00:00:00

abstract：:An increased recognition of the role of endothelial cells in disease and the development of methods for endothelial cell culture has led to an upsurge in in vitro studies of endothelial cell function. However, the cells most often used for these studies do not reflect the in vivo heterogeneity of endothelial cells. To...

journal_title：Microvascular research

authors： Craig LE,Spelman JP,Strandberg JD,Zink MC

更新日期：1998-01-01 00:00:00

abstract：:A mathematical model of nonsteady-state fluid movement in the lung interstitium during hydrodynamic loading is evaluated. The model is based on experimental results obtained in isolated perfused canine lungs. The interstitium is treated as a porous phase with an elastic framework, able to relax; all resistance to flux...

journal_title：Microvascular research

authors： Serikov VB

更新日期：1991-07-01 00:00:00

abstract：:We tested the hypothesis that p42/44MAPK and p38MAPK (mitogen-activated protein kinases; MAPK) signaling pathways regulate endothelial cell permeability to macromolecules. Passage 2-4 human umbilical vein endothelial cells (HUVEC) were grown to confluence on fibronectin-coated Snapwell membranes. The flux of fluoresce...

journal_title：Microvascular research

authors： Varma S,Breslin JW,Lal BK,Pappas PJ,Hobson RW 2nd,Durán WN

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg l-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic aci...

journal_title：Microvascular research

authors： Liu Z,Jiang H,Townsend JH,Wang J

更新日期：2020-11-01 00:00:00

abstract：:The angiopoietin/Tie2 system is a predominant regulator of vascular development. This vascular development appears to be controlled and completed by the coordinated actions of two vascular cells, endothelial cells and their surrounding supporting cells, smooth muscle cells, or pericytes. The role of the angiopoietin/T...

journal_title：Microvascular research

authors： Park YS,Kim NH,Jo I

更新日期：2003-03-01 00:00:00

abstract：:P120 catenin (p120ctn) belongs to the family of Armadillo repeat-containing proteins, which are believed to have dual functions of cell-cell adhesion and transcriptional regulation. In vascular endothelium, p120ctn is mostly recognized for its cell-cell adhesion function through its ability to regulate VE-cadherin. Th...

journal_title：Microvascular research

authors： Zhang J,O'Donnell JJ 3rd,Holian O,Vincent PA,Kim KS,Lum H

更新日期：2010-09-01 00:00:00

abstract：:An intravital microscopic method for quantitative measurement of interstitial concentrations of fluorescent tracers has been applied to the investigation of microvascular permeability in the hamster cheek pouch. Some nanoliters of FITC-dextran mean mol wt (Mw) 20,000, 3000, or sodium fluorescein (Mw 376) were injected...

journal_title：Microvascular research

authors： Ley K,Arfors KE

更新日期：1986-01-01 00:00:00

abstract：:The steroid hormone estradiol is suggested to play a protective role in intestinal injury during systemic inflammation (sepsis). Our aim was to determine the effects of specific estradiol receptor (ER-α and ER-ß) agonists on the intestinal microcirculation during experimental sepsis. Male and sham ovariectomized femal...

journal_title：Microvascular research

authors： Sharawy N,Ribback S,Al-Banna N,Lehmann C,Kern H,Wendt M,Cerny V,Dombrowski F,Pavlovic D

更新日期：2013-01-01 00:00:00

abstract：:Non-freezing cold injury (NFCI) is a prevalent, but largely undiagnosed and poorly understood syndrome afflicting many who, as part of their work or leisure, expose their extremities to cold temperatures. The long term sequelae of NFCI are hyperhidrosis, cold-sensitivity and pain; these can last a lifetime. We tested ...

journal_title：Microvascular research

authors： Hope K,Eglin C,Golden F,Tipton M

更新日期：2014-01-01 00:00:00

abstract：:Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...

journal_title：Microvascular research

authors： Buerk DG,Riva CE

更新日期：2002-09-01 00:00:00

abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...

journal_title：Microvascular research

authors： Sugihara-Seki M,Minamiyama M,Hanai S

更新日期：1989-09-01 00:00:00

abstract：:The concept of anti-angiogenesis therapy was introduced by Judah Folkman in 1971 and since then, a plethora of pro- and anti-angiogenic factors have been identified. In the recent years, it has become clear that angiogenesis, the formation of new capillaries from a pre-existing capillary network, is highly regulated b...

journal_title：Microvascular research

authors： Mundel TM,Kalluri R

更新日期：2007-09-01 00:00:00