Abstract：
:We examined the influence of local cooling (-15 degrees C, 60 sec) on blood flow velocity in nailfold capillaries and on laser Doppler flux (LDF) at the fingertip in 12 patients with primary Raynaud's phenomenon (PRP) and 13 patients with secondary Raynaud's (SRP) in comparison with 10 health controls. Skin temperature at the pulp of the finger decreased significantly during local cooling in RP but not in controls. LDF before cooling was comparable between patients and controls and dropped significantly under cooling. Flux motions at the fingertip were present in all individuals with 7.9-9.1 cycles/min. Flux motions persisted throughout the cooling test and faded away in 5 patients (1 PRP, 4 SRP) with cooling. Frequency of LDF motions was little influenced by a change in skin temperature. The amplitudes were dampened in relation to the drop in LDF level during local cooling in patients with RP. We conclude that LDF does respond to local cooling of the fingertip by significant decrease of perfusion but not with regard to flux motions. The wide overlap of the single values does not allow as good a separation of patients with RP from controls as capillary microscopy.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Lütolf O,Chen D,Zehnder T,Mahler Fdoi
10.1006/mvre.1993.1060subject
Has Abstractpub_date
1993-11-01 00:00:00pages
374-82issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(83)71060-5journal_volume
46pub_type
杂志文章abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90023-x
更新日期：1989-09-01 00:00:00
abstract：OBJECTIVE:Leukocytes play a key role in the early response to tissue injury/infection resulting from physical, chemical or biological stimuli. This process involves the initiation of the leukocyte adhesion cascade mediated by a series of interactions between receptors and ligands on the endothelium and the leukocytes. ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.03.007
更新日期：2013-09-01 00:00:00
abstract：:Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arteriole...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.04.007
更新日期：2018-09-01 00:00:00
abstract：:A novel first-pass imaging method for studying blood flow in tumors and normal tissues in mouse dorsal window chamber preparations is reported in this study. A fluorescence-labeled macromolecule is administered i.v. as a bolus dose, and the signal generated by the bolus is detected as the bolus passes through the vasc...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.06.009
更新日期：2008-03-01 00:00:00
abstract：:Despite intensive study in the area of angiogenesis, relatively little is known about normal angiogenesis in adult animals. Preliminary studies using the Griffonia simplicifolia I (GSI) lectin as a microvascular marker indicated that capillary sprouting occurs in the clear "windows" of normal intact adult rat mesenter...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1994.1029
更新日期：1994-05-01 00:00:00
abstract：OBJECTIVE:High aerobic fitness may prevent age-related decrements in cutaneous vasodilation while type 2 diabetes may exacerbate this decline. The mechanisms underlying these responses remain unclear, but may be due to an excess of reactive oxygen species. We hypothesized that superoxide scavenging or NADPH oxidase inh...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103886
更新日期：2019-09-01 00:00:00
abstract：:Histone acetylation/deacetylation is a key mechanism for regulating transcription, which plays an important role in the control of gene expression, tissue growth, and development. In particular, histone deacetylase 7 (HDAC7), a member of class IIa HDACs, is crucial in maintaining vascular integrity. Endothelial progen...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.10.006
更新日期：2014-01-01 00:00:00
abstract：:Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.01.002
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:The conjunctival microcirculation is a readily-accessible vascular bed for quantitative haemodynamic assessment and has been studied previously using a digital charge-coupled device (CCD). Smartphone video imaging of the conjunctiva, and haemodynamic parameter quantification, represents a novel approach. We rep...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103907
更新日期：2019-11-01 00:00:00
abstract：:We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin...
journal_title：Microvascular research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.mvr.2010.01.002
更新日期：2010-03-01 00:00:00
abstract：:Thrombolysis treatment of acute ischemic stroke is limited by the pro-edematous and hemorrhagic effects exerted by reperfusion, which disrupts the blood-brain barrier (BBB) capillary endothelium in the infarct core. Most studies of the ischemic BBB overlook the complexity of the penumbral area, where the affected brai...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.12.002
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The relationship between NF-κB Interacting lncRNA (NKILA) and angiogenesis in breast cancer has never been studied. Our study aimed to investigate effect of NKILA on proliferation, migration, apoptosis, as well as angiogenesis in breast cancer. METHODS:NKILA was over-expressed in MDA-MB-231 cells by transfec...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103968
更新日期：2020-05-01 00:00:00
abstract：:Synthetic big endothelin-1 (ET-1), a 39-residue precursor of ET-1, has been reported to elicit potent contractile action on helical strip specimens obtained from the porcine coronary artery, but its molar potency was found to be 140-fold lower than that of ET-1 [Saito, Y., Nakao, K., Mukoyama, M., Imura, H., 1990. Inc...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.04.007
更新日期：2006-11-01 00:00:00
abstract：:Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2017.12.001
更新日期：2018-05-01 00:00:00
abstract：:The cytoskeleton is vital to the function of virtually all cell types in the organism as it is required for cell division, cell motility, endo- or exocytosis and the maintenance of cell shape. Endothelial cells, lining the inner surface of the blood vessels, exploit cytoskeletal elements to ensure the integrity of cel...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2008.06.003
更新日期：2008-11-01 00:00:00
abstract：UNLABELLED:Metabolic syndrome (MetS) increases the risk of the subsequent development of cardiovascular disease. This study aimed to determine if the harmonic indexes of finger photoplethysmography (PPG) waveforms can be used to discriminate different arterial pulse transmission conditions between MetS and healthy subj...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.04.001
更新日期：2016-07-01 00:00:00
abstract：:Leukocyte margination in the vessels of the microcirculation has been attributed to a flow-dependent interaction with red cells. To determine the extent of this effect, experiments with human blood were done in 100- to 180-micron tubes to detect changes in cell distribution as a function of hematocrit and flow rate. U...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(84)90054-2
更新日期：1984-03-01 00:00:00
abstract：PURPOSE:Subcutaneous tissue is a promising site for cell transplantation; advantages include minimally invasive procedures and easy post-transplant monitoring. However, limited vascularity is the major known challenge. To address this challenge, a prevascularized graft bed is prepared in recipients. We aimed to establi...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104070
更新日期：2020-11-01 00:00:00
abstract：:A theoretical model, appropriate for data interpretation, is presented for the transcapillary fluid exchange and associated intraluminal hydrodynamic and solute transport occurring in the microocclusion of single capillaries. This analysis describes the spatial and temporal behavior of the intraluminal flow. A compari...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90012-2
更新日期：1983-03-01 00:00:00
abstract：:The anatomic arrangement, pressure distribution, and resting vascular tone of the feed arteries located upstream from the rat cremaster microcirculation were determined to characterize the sites of the vascular resistance in this macrovessel segment of the cremaster circulation. The cremaster microcirculation and its ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(87)90009-4
更新日期：1987-01-01 00:00:00
abstract：:The kidneys of 14 female Wistar rats from 5 days to 18 months postnatally have been perfusion-fixed to study the development of glomerular capillaries using design-based stereological techniques. This report uses a topological definition of a capillary structural unit which forms the basis for the estimation of the nu...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1022
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Ischemia-reperfusion (IR) injury impairs microcirculatory function by reducing nitric oxide (NO) bioavailability and increasing sympathetic tone. This study non-invasively examined the effects of acute upper limb IR injury on local thermal hyperemia (LTH) in glabrous and non-glabrous finger skin. MATERIALS ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.02.003
更新日期：2018-07-01 00:00:00
abstract：:A hallmark of severe inflammation is reactive oxygen species (ROS) overproduction induced by increased inflammatory mediators secretion. During systemic inflammation, inflammation mediators circulating in the bloodstream interact with endothelial cells (ECs) raising intracellular oxidative stress at the endothelial mo...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.02.001
更新日期：2015-03-01 00:00:00
abstract：:An increased recognition of the role of endothelial cells in disease and the development of methods for endothelial cell culture has led to an upsurge in in vitro studies of endothelial cell function. However, the cells most often used for these studies do not reflect the in vivo heterogeneity of endothelial cells. To...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1997.2045
更新日期：1998-01-01 00:00:00
abstract：:Normal brain parenchyma has a highly complex microvascular structure that undergoes re-modelling in the presence of a tumor. A detailed understanding of the clinical and pathological aspects of neo-angiogenesis in malignant human brain tumors is essential in order to ensure the successful clinical application of anti-...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2010.09.005
更新日期：2010-12-01 00:00:00
abstract：:Patients with diabetic polyneuropathy are known to have an impaired neurovascular reflex arc compared to healthy controls. This is seen in a delayed decrease in microcirculation of the ipsilateral hand after cooling of the contralateral hand. The aim of this pilot study was to investigate whether intravenous alpha-lip...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2151
更新日期：1999-07-01 00:00:00
abstract：:The purpose of this study was to investigate reactive hyperemia in the capillary network of human skin in terms of the flow per capillary and the density of flow-active capillaries. Seventeen male subjects 20 to 40 years of age were seated with their right foot placed on the stage of a Leitz epi-ilumination microscope...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90040-8
更新日期：1985-07-01 00:00:00
abstract：:Lymphangiogenesis is thought to be essential for cancer progression, making it an important target in cancer therapy. Lymphangiogenic factors (VEGF-C and VEGF-D) are upregulated in various tumors/cancers, and play an important role in lymphangiogenesis and lymph node metastasis. Similarly, semaphorin 4D (Sema4D) is a ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.02.007
更新日期：2014-05-01 00:00:00
abstract：:Previous studies on mice have revealed that the Griffonia simplicifolia I (GSI) lectin selectively binds to capillaries in a number of microvascular beds. These observations suggest that the lectin might be a suitable microvascular marker for physiological studies of skeletal muscle, particularly when fluorescent visu...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(88)90022-2
更新日期：1988-11-01 00:00:00
abstract：:Non-freezing cold injury (NFCI) is a prevalent, but largely undiagnosed and poorly understood syndrome afflicting many who, as part of their work or leisure, expose their extremities to cold temperatures. The long term sequelae of NFCI are hyperhidrosis, cold-sensitivity and pain; these can last a lifetime. We tested ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.11.002
更新日期：2014-01-01 00:00:00
