Abstract：
:The kidneys of 14 female Wistar rats from 5 days to 18 months postnatally have been perfusion-fixed to study the development of glomerular capillaries using design-based stereological techniques. This report uses a topological definition of a capillary structural unit which forms the basis for the estimation of the number of glomerular capillaries using histological sections. The number of mature glomeruli is about 27,500 for all animals older than 5 days, whereas the 5-day-old animals have 21,100 mature glomeruli. Postnatally, the mean glomerular volume increases rapidly for the first 2 months after which it increases at a much slower rate. At first there is a rapid increase in total number, length, and surface area of glomerular capillaries with age; after 2 months the increase is rather moderate. The rapid growth of glomerular capillaries is anisomorphic, and the restrained growth is roughly isomorphic. The mean length of glomerular capillaries is nearly constant at 56 microns in mature and immature rats. The cross-sectional area rises only twofold from the most immature to the oldest rats. Using an approximation of the geometric factor in the law of Poiseuille, a decreasing resistance of glomerular capillaries with age is obtained. This is in agreement with the falling resistance of maturing renal vasculature and the increasing single-nephron glomerular filtration rate. When taking into account the constant mean capillary length and moderate increase in cross-sectional area of glomerular capillaries in growing rats, it appears that the branching of capillaries, forming a complicated network of serial and parallel connections, seems to be the structural basis for normal glomerular capillary growth.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Nyengaard JRdoi
10.1006/mvre.1993.1022subject
Has Abstractpub_date
1993-05-01 00:00:00pages
243-61issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(83)71022-8journal_volume
45pub_type
杂志文章abstract：:Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2018.12.005
更新日期：2019-05-01 00:00:00
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journal_title：Microvascular research
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更新日期：1984-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：1996-05-01 00:00:00
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更新日期：2004-11-01 00:00:00
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journal_title：Microvascular research
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pub_type： 临床试验,杂志文章
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更新日期：2008-08-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1996.0016
更新日期：1996-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2011-03-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2021-03-01 00:00:00
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更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.008
更新日期：2010-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2208
更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Microvascular research
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journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
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更新日期：2017-11-01 00:00:00
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pub_type： 杂志文章
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pub_type：
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更新日期：2002-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
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更新日期：2014-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.04.005
更新日期：2006-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.08.005
更新日期：2012-11-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.08.001
更新日期：2004-11-01 00:00:00
