当前位置： SCI文献检索 > MICROVASCULAR RESEARCH期刊下所有文献 > The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud's syndrome.

The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud's syndrome.

Abstract：

OBJECTIVES:Calcium channel inhibitors have beneficial impact on microcirculation, but beta-blocker effect is controversial. Clinicians still do not agree on beta-blocker combination with other treatments in the management of impaired microcirculation. The aim of the present study was to describe the effects of beta-blocker metoprolol monotherapy and combined with calcium channel inhibitor felodipin on digital microcirculation in primary Raynaud's syndrome. METHODS:We enrolled in this study 46 patients suffering from both hypertension and primary Raynaud's syndrome. Fifteen patients were treated with beta-blocker monotherapy (metoprolol), 13 received combined beta-blocker and calcium channel blocker therapy (felodipin and metoprolol), while 18 patients without any medications served as controls. Measurement of digital microcirculation was carried out with laser Doppler scanner. RESULTS AND CONCLUSIONS:Our investigation concludes that the concurrent administration of beta-blockers with calcium channel inhibitors positively reduces symptoms in patients suffering from Raynaud's syndrome.

journal_name

Microvasc Res

journal_title

Microvascular research

authors

Csiki Z,Garai I,Shemirani AH,Papp G,Zsori KS,Andras C,Zeher M

doi

10.1016/j.mvr.2011.04.004

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

84-7

issue

1

eissn

0026-2862

issn

1095-9319

pii

S0026-2862(11)00066-5

journal_volume

82

pub_type

杂志文章

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