Abstract:
:The object of the present study was to employ specific pharmacological agents and the chemical sympatholytic drug 6-hydroxydopamine (6-OHDA) to characterize the neural and adrenergic control of vascular smooth muscle tone in arterioles of the hamster cheek pouch. Arteriolar diameters were measured in the superfused cheek pouch of anesthetized male golden hamsters. All orders of arterioles constricted in response to norepinephrine (10(-7) g/ml) and increased superfusion solution PO2, and dilated in response to isoproterenol (10(-7) g/ml) and adenosine (10(-4) M). Tetrodotoxin (10(-6) g/ml), phentolamine (10(-6) g/ml), and propranolol (10(-6) g/ml) had no effect upon arteriolar diameters under resting conditions. However, phentolamine and propranolol completely blocked vessel responses to norepinephrine and isoproterenol, respectively. Arterioles dilated during superfusion with either 6-OHDA (300 micrograms/ml) or its acidic vehicle. However, vessel diameters returned toward control values during the subsequent 2-hr washout period and exhibited no net dilation following recovery from 6-OHDA or its vehicle. This study suggests that neural and adrenergic mechanisms are not the primary determinants of arteriolar tone in the hamster cheek pouch.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Lombard JH,Chenoweth JL,Stekiel WJdoi
10.1016/0026-2862(85)90008-1subject
Has Abstractpub_date
1985-01-01 00:00:00pages
81-8issue
1eissn
0026-2862issn
1095-9319journal_volume
29pub_type
杂志文章abstract::Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathop...
journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
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journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
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更新日期:2013-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
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更新日期:2001-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2002.2432
更新日期:2002-09-01 00:00:00
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journal_title:Microvascular research
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更新日期:2016-09-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/s0026-2862(03)00041-4
更新日期:2003-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1996.2006
更新日期:1997-03-01 00:00:00
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journal_title:Microvascular research
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journal_title:Microvascular research
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journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1997.2067
更新日期:1998-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1998.2086
更新日期:1998-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
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journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00