Abstract：
:The dynamics of the microvasculature of the blood-perfused canine gastrocnemius-plantaris muscle in situ at rest and during contraction were determined using multiple-indicator dilution analysis. Permeability-surface area product (PS) was estimated using a bolus indicator dilution of 86Rb, with 125I-albumin serving as the reference tracer, while microvascular hematocrit (Hmv) was estimated using the relationship between plasma (125I-albumin) and erythrocyte (51Cr) tracer washout curves. The muscle was stimulated to contract, under self-perfusion, for 3-min periods with either isometric twitch (1.5, 3, or 5 Hz; 4 ms) or tetanic (20, 40, or 60 trains/min, 200 ms, 100 Hz) contractions, separated by 25 min of rest, randomized to prevent ordering effects. At all stimulation frequencies, Hmv increased significantly from rest value of 36.5 +/- 1.6% to 3 min of either isometric twitch or tetanic contractions. PS rose significantly from 0.08 +/- 0.002 ml/g min at rest to a maximum of 0. 40 +/- 0.01 ml/g min at 60 isometric tetanic contractions per minute and 0.38 +/- 0.01 at 5 Hz. Changes in PS appeared related to stimulation frequency in both twitch and tetanic contractions. The change in Hmv with muscle contraction appeared to depend on contraction frequency during twitch contractions only, but was independent of stimulus frequency during tetanic contractions.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Frisbee JC,Barclay JKdoi
10.1006/mvre.1997.2067subject
Has Abstractpub_date
1998-03-01 00:00:00pages
153-64issue
2eissn
0026-2862issn
1095-9319pii
S0026-2862(97)92067-7journal_volume
55pub_type
杂志文章abstract：:The purpose of this study was to determine whether bidirectional flow exists in the sciatic vasa nervorum. Images obtained using high-frequency color Doppler ultrasound in duplex imaging mode (Vevo 2100) were studied retroactively. In Fig. 1 (left panel; rat 1), the color Doppler signal and flow-velocity waveforms are...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.008
更新日期：2014-07-01 00:00:00
abstract：:Estrogen induces endothelial progenitor cells (EPCs) migration and proliferation, which may serve as a potential target for coronary artery disease, but the mechanisms are unclear. We hypothesized that estrogen receptors (ERs) and phosphatidylinositol 3-kinase (PI3K) signaling pathway, which represent particularly imp...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.02.009
更新日期：2008-01-01 00:00:00
abstract：:Capillaries are often assumed to be indistensible. Only recently has the error caused by capillary distensibility in the measurement of hydraulic conductance been considered. An oil-drop method was used to measure simultaneously distensibility and hydraulic conductance (Lp) of mesenteric capillaries of 40 cranially pi...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90013-7
更新日期：1989-07-01 00:00:00
abstract：:We present a simple method for isolation and long-term cultivation of porcine and murine cerebral capillary endothelial cells (cEC). Two major points are made. First, that the "characteristic" morphology of the endothelial cells depends mainly on the presence of endothelial cell growth factors in the culture medium an...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90034-4
更新日期：1989-03-01 00:00:00
abstract：:The purpose of this study was to examine the distribution and extent of autoregulatory behavior among arterioles in the arcade network of the cat mesentery. We found that 71% of 169 arterioles studied dilated and 63% showed blood flow autoregulation with arterial pressure reduction to 55-60 mm Hg. There appeared to be...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90050-x
更新日期：1983-07-01 00:00:00
abstract：:The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, howe...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2017.09.003
更新日期：2018-03-01 00:00:00
abstract：:We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin...
journal_title：Microvascular research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.mvr.2010.01.002
更新日期：2010-03-01 00:00:00
abstract：:Excessive generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS), by activated neutrophils and endothelial cells, has been implicated in the pathophysiology of endothelial barrier dysfunction. Disruption of the integrity of this barrier markedly increases permeability to fluids, solutes and in...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2008.10.005
更新日期：2009-01-01 00:00:00
abstract：:The Raynaud's phenomenon often accompanies systemic rheumatic diseases and is also known as a vascular side effect of chemotherapy. Therapy of the Raynaud's phenomenon with nitrates or calcium-channel-blockers is rarely beneficial. In contrast, the PDE-V-inhibitor sildenafil seems to be effective in these patients. Fo...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2005.03.001
更新日期：2005-05-01 00:00:00
abstract：:Using the laser-Doppler method we measured blood flow on the nailfold skin to compare the reactivity of cutaneous microcirculation in three groups of normotensive subjects: 11 subjects with a familial predisposition to hypertension without a previous record of high blood pressure, 6 predisposed subjects with a previou...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2279
更新日期：2000-11-01 00:00:00
abstract：:Blood flow studies in the brain, heart, and other organs suggest that there could be interaction between nitric oxide (NO) and adenosine. This possibility was investigated in the optic nerve head (ONH) during photic stimulation of the dark-adapted cat eye. Functional activation of ONH blood flow was measured by laser ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2002.2432
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate whether region-dependent endothelial heterogeneity is present within the porcine vortex vein system. METHODS:The superior temporal vortex vein in young adult pig eyes were dissected out and cannulated. The intact vortex vein system down to the choroidal veins was then p...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.06.004
更新日期：2013-09-01 00:00:00
abstract：:Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. We tested the hypothesis that nitrate supplementation would augment the NO co...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.12.002
更新日期：2015-03-01 00:00:00
abstract：AIMS:The purpose of the present study was to investigate the possible role of TIPE2 on acute lung injury (ALI) induced by myocardial ischemia/reperfusion (MIR) in diabetic rats. METHODS:Sprague-Dawley (SD) rats were randomly separated into four groups: control+sham (C + sham); control+MIR (C + MIR); diabetes+sham (D +...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104009
更新日期：2020-07-01 00:00:00
abstract：:We observed the retinal capillary pericytes of the rat in situ. Whole retinae were mounted, immediately post vivo, in a special tissue chamber for electronic light microscopy at high magnifications. Under electronic light microscopy the pericytes could be clearly distinguished from the endothelial cells. In addition, ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2086
更新日期：1998-07-01 00:00:00
abstract：:Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenic lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Alth...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2014.06.001
更新日期：2014-11-01 00:00:00
abstract：:Lipopolysaccharide released during bacterial sepsis causes acute lung injury and ARDS. Pulmonary microvascular injury is a feature of ARDS, and vascular remodeling develops, leading to pulmonary hypertension. Pericytes in the lung circulation proliferate and contribute to the remodeling seen in experimental sepsis. It...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2085
更新日期：1998-09-01 00:00:00
abstract：:Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle prolifer...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2018.03.012
更新日期：2018-09-01 00:00:00
abstract：:Microvascular dysfunction contributes to the development of cardiovascular and metabolic disease. This study tested the hypothesis that young obese (BMI>30 kg m(-2)), otherwise healthy, adults (N=15) have impaired microvascular function relative to age and sex matched, lean (BMI<25 kg m(-2)) individuals (N=14). Partic...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.11.007
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Endothelial cells are suggested regulators of tumor response to radiation. Anti-vascular targeting agents can enhance tumor response by targeting endothelial cells. Here, we have conducted experiments in vitro to discern the effects of radiation combined with the anti-angiogenic Sunitinib on endothelial (HUV...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.10.008
更新日期：2014-03-01 00:00:00
abstract：:Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis in the mammalian eye, suggesting that loss of PEDF is implicated in the pathogenesis of proliferative diabetic retinopathy. However, a role for PEDF in early diabetic retinopathy remains to be elucidated. Since oxidative stress is thought t...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.11.001
更新日期：2005-01-01 00:00:00
abstract：:Innate immunity is characterized by the coordinated activity of multiple leukocytes mobilizing at or near the site of tissue injury. Slow rolling and/or adherent leukocytes have been shown to hydrodynamically recruit free-stream leukocytes to a model of inflamed tissue. In this paper, we numerically investigate the hy...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2017.09.002
更新日期：2018-01-01 00:00:00
abstract：:Injection of labeled microspheres is an established method in animal models to analyze the capillary organ blood flow at different time points. However, the microspheres can lead to stenoses of the capillary lumen, which might affect tissue oxygen supply. Our study aimed to investigate the influence of repeated inject...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2011.04.001
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVE:Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS:Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospe...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.07.007
更新日期：2015-11-01 00:00:00
abstract：:Patients with diabetic polyneuropathy are known to have an impaired neurovascular reflex arc compared to healthy controls. This is seen in a delayed decrease in microcirculation of the ipsilateral hand after cooling of the contralateral hand. The aim of this pilot study was to investigate whether intravenous alpha-lip...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2151
更新日期：1999-07-01 00:00:00
abstract：:Skeletal muscle arterioles are known to constrict upon elevation of ambient PO2. While several studies have shown that the endothelium plays an important role in this response, it is not clear how this response is mediated. We examined the oxygen-induced constriction of arterioles in the rat spinotrapezius muscle. Ele...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1025
更新日期：1995-05-01 00:00:00
abstract：:The study of angiogenesis as a therapeutic target requires reliable in vivo assays that can provide physiologically relevant data. A murine in vivo Matrigel-based angiogenesis assay is presented here which includes the quantitative assessment of vascular-specific indicators of neovascularization. Matrigel containing 1...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.01.002
更新日期：2006-03-01 00:00:00
abstract：:This study aims to assess the relationship between spontaneous oscillations in changes in cerebral tissue oxyhemoglobin concentrations (Delta [HbO2]) and arterial blood pressure (ABP) signals in healthy elderly subjects during the resting state using wavelet coherence analysis. Continuous recordings of near-infrared s...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Impairments at the microvascular level might lead to more overt cardiovascular complications, therefore, being able to early detect microvascular dysfunction would be beneficial. Thus, the present study investigated whether near-infrared spectroscopy (NIRS) assessment of microvascular responsiveness (reoxyge...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.04.009
更新日期：2019-09-01 00:00:00
abstract：:The objective of this study was to provide the first quantitative measurements of the process of vascular growth in the rat peritoneal disseminated tumor model in both arteriolar and venular systems. Male Fischer 344 rats were injected intraperitoneally with 1 x 10(7) cells of colon carcinoma cell line (RCN-9). Three ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1996.0003
更新日期：1996-01-01 00:00:00
