Abstract：
:Capillaries are often assumed to be indistensible. Only recently has the error caused by capillary distensibility in the measurement of hydraulic conductance been considered. An oil-drop method was used to measure simultaneously distensibility and hydraulic conductance (Lp) of mesenteric capillaries of 40 cranially pithed Rana pipiens. All vessels studied were distensible in the range 5-80 mm Hg, with a mean equilibrium time, teq, of 12.4 +/- 0.5 sec (SEM, n = 7). Capillary distensibility decreased with increasing pressure. Mean capillary distensibilities at 10, 30, and 60 mm Hg were 18.9 +/- 4.9 X 10(-4) (mm Hg)-1, 13.5 +/- 1.2 X 10(-4) (mm Hg)-1 (mean +/- SEM, n = 9), and 7.6 +/- 2.7 X 10(-4) (mm Hg)-1 (mean +/- SEM, n = 7), respectively. Mean values of capillary Lp, uncorrected and corrected for distensibility, were 0.0113 +/- 0.0017 microns(sec.mm Hg)-1 and 0.0083 +/- 0.0016 microns(sec.mm Hg)-1 (SEM, n = 8 capillaries), respectively. A paired t test demonstrated that uncorrected and corrected values of Lp were statistically different from one another (P less than 0.005). Both distensibility and Lp varied widely between capillaries indicating the necessity of measuring and correcting for distensibility in each individual capillary when estimating Lp. The finding of a slow component of vessel distensibility demonstrates that previous filtration data taken not only from single vessels, but also from whole organs, should be reinterpreted.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Baldwin AL,Gore RWdoi
10.1016/0026-2862(89)90013-7subject
Has Abstractpub_date
1989-07-01 00:00:00pages
1-22issue
1eissn
0026-2862issn
1095-9319pii
0026-2862(89)90013-7journal_volume
38pub_type
杂志文章abstract：:Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, in part, by equilibrative nucleoside transporter subtype 1 (ENT1; SLC29A1) and by equilibrative nucleobase transporter ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.06.008
更新日期：2014-09-01 00:00:00
abstract：:Lymphangiogenesis is thought to be essential for cancer progression, making it an important target in cancer therapy. Lymphangiogenic factors (VEGF-C and VEGF-D) are upregulated in various tumors/cancers, and play an important role in lymphangiogenesis and lymph node metastasis. Similarly, semaphorin 4D (Sema4D) is a ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.02.007
更新日期：2014-05-01 00:00:00
abstract：:The extravascular uptake for labeled albumin and IgG and the extravascular masses for endogenous albumin and IgG were measured in skin and skeletal muscle from anesthetized rabbits following 24 hr of intermittent plasmapheresis. An amount of protein equivalent to the total intravascular protein mass was removed. There...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(92)90089-8
更新日期：1992-11-01 00:00:00
abstract：:Strychnine is known to possess anti-inflammatory and antitumour activity, but its roles in tumour angiogenesis, the key step involved in tumour growth and metastasis, and the involved molecular mechanism are still unknown. We aimed to investigate the effects of strychnine on key components of inflammatory angiogenesis...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.01.003
更新日期：2013-05-01 00:00:00
abstract：:The relative magnitude of vascular reactivity to inhaled gas stimuli in the major retinal arterioles has not been systematically investigated. The purpose of this study was to compare the magnitude of retinal vascular reactivity in response to inhaled gas provocation at equivalent measurement sites in the superior-, a...
journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mvr.2011.11.002
更新日期：2012-03-01 00:00:00
abstract：:Overexpression of EGFR plays a key-role in head and neck squamous cell carcinoma (HNSCC) and justifies the extensive use of cetuximab, a monoclonal anti-EGFR antibody, as well as EGFR-tyrosine kinase inhibitors (EGFR-TKI), which have been reported to inhibit tumor cell growth and the secretion of pro-angiogenic factor...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2011.07.008
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVE:Studies on the acute effects of coffee on the microcirculation have shown contradicting results. This study aimed to investigate if intake of caffeine-containing coffee changes blood flow and microvascular reactivity in the skin. METHODS:We measured acute changes in cutaneous vascular conductance (CVC) in th...
journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mvr.2017.06.006
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate whether region-dependent endothelial heterogeneity is present within the porcine vortex vein system. METHODS:The superior temporal vortex vein in young adult pig eyes were dissected out and cannulated. The intact vortex vein system down to the choroidal veins was then p...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.06.004
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Tissue ischemia and reperfusion (I/R) affects blood flow restoration and oxygen delivery to the damaged tissues contributing to tissue morbidity and microcirculatory compromise. Pulsed acoustic cellular expression (PACE) technology is known to support tissue neovascularization. The aim of this study was to t...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2011.11.005
更新日期：2012-03-01 00:00:00
abstract：:Using the laser-Doppler method we measured blood flow on the nailfold skin to compare the reactivity of cutaneous microcirculation in three groups of normotensive subjects: 11 subjects with a familial predisposition to hypertension without a previous record of high blood pressure, 6 predisposed subjects with a previou...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2279
更新日期：2000-11-01 00:00:00
abstract：:We examined the influence of local cooling (-15 degrees C, 60 sec) on blood flow velocity in nailfold capillaries and on laser Doppler flux (LDF) at the fingertip in 12 patients with primary Raynaud's phenomenon (PRP) and 13 patients with secondary Raynaud's (SRP) in comparison with 10 health controls. Skin temperatur...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1060
更新日期：1993-11-01 00:00:00
abstract：:Studies of blood flow in mesentery, cremaster muscle, and small bore glass tubes were performed to obtain a relationship between mean velocity (Vmean) and red cell velocity using the two-slit method under epifluorescence (Vepi) and transillumination (Vtrans) microscopy. The velocities Vepi and Vtrans obtained in vivo ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90020-4
更新日期：1989-07-01 00:00:00
abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90023-x
更新日期：1989-09-01 00:00:00
abstract：:Changes in blood vessel diameter can be measured manually, but this is time-consuming and often impractical. For automatic measurement commercial solutions are available, but the proprietary algorithms and their potential shortcomings are not known to the user. We present an approach with a CCD camera for image acquis...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.04.004
更新日期：2010-09-01 00:00:00
abstract：:Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2193
更新日期：2000-01-01 00:00:00
abstract：:Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathop...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.005
更新日期：2014-07-01 00:00:00
abstract：:To compute two parameters of capillary protein transport of reflection coefficient (sigma) and permeability--surface area product (PS), two major methods have been employed. The first, or crosspoint method, uses two sets of lymph flow (Jv) and lymph/plasma protein concentration ratios (R) and solves the irreversible t...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90051-2
更新日期：1985-09-01 00:00:00
abstract：:Vascular dysfunction is an important pathophysiologic manifestation of sickle cell disease (SCD), a condition that increases risk of pulmonary hypertension and stroke. We hypothesized that infrared (IR) imaging would detect changes in cutaneous bloodflow reflective of vascular function. We performed IR imaging and con...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.06.011
更新日期：2012-11-01 00:00:00
abstract：:The retina provides a window to study the pathophysiology of cerebrovascular diseases. Pathological retinal microvascular changes may reflect microangiopathic processes in the brain. Recent advances in optical imaging techniques have enabled the imaging of the retinal microvasculature at the capillary level, and the g...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.06.008
更新日期：2013-09-01 00:00:00
abstract：:This study was undertaken to determine if coronary vascular permeability (CVP) increases and if myocardial edema develops in the canine heart after local exposure to histamine. Histamine (50 or 15 micrograms/min) or compound 48/80 (0.1-0.2 mg/kg) was infused into the left anterior descending coronary artery (LAD) of o...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90034-9
更新日期：1991-05-01 00:00:00
abstract：:Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.04.007
更新日期：2015-07-01 00:00:00
abstract：:Endotoxemia, a major feature of sepsis, is a common cause of acute lung injury and initiates rapid accumulation of leukocytes in the lung vasculature. Endothelial mechanisms that underlie this accumulation remain unclear, as current experimental models of endotoxemia are less suitable for targeted activation of the en...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.01.006
更新日期：2012-05-01 00:00:00
abstract：:Thermal injuries of more than 20% body surface area (BSA) result in systemic capillary leakage with subsequent edema. This can similarly be induced by burn plasma transfer (BPT) from burned individuals to healthy rats. We evaluated if cerium nitrate (CN) bathing can prevent edema after BPT. Therefore, donor rats (DR) ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.07.006
更新日期：2009-12-01 00:00:00
abstract：:In preeclampsia, invasion of intrauterine decidual blood vessels by placental cytotrophoblasts is significantly reduced. This study examined the secretion of matrix metalloproteinases (MMP) by cultured human decidual endothelial cells from normal (NDEC) and preeclamptic (PEDEC) pregnancies. MMPs secreted into the cult...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2142
更新日期：1999-05-01 00:00:00
abstract：:Recent studies indicate that the human choroid has a considerable capacity to keep blood flow constant despite exercise-induced increases in perfusion pressure. The mechanisms underlying this vasoconstrictor response remain unclear. We hypothesized that pharmacological modulation of the autonomic nervous system may al...
journal_title：Microvascular research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0026-2862(02)00010-9
更新日期：2003-01-01 00:00:00
abstract：:The microcirculation in normal and arthritic juxtaarticular bone was studied in 16 young dogs with carragheenan-induced arthritis of one knee. The regional blood flow was determined by the tissue uptake of intracardially injected 15-microns 141Ce-labeled microspheres, and the microvascular plasma volume was determined...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(90)90020-r
更新日期：1990-09-01 00:00:00
abstract：BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.10.006
更新日期：2015-01-01 00:00:00
abstract：:We have performed a mathematical simulation on a CYBER computer of the release, diffusion, and consumption of oxygen in the capillaries and surrounding tissue of peripheral nerve under steady-state conditions. The Krogh-Erlang equation was used to calculate oxygen tension in tissue, while numerical solution of the dif...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(87)90054-9
更新日期：1987-09-01 00:00:00
abstract：:Skeletal muscle arterioles are known to constrict upon elevation of ambient PO2. While several studies have shown that the endothelium plays an important role in this response, it is not clear how this response is mediated. We examined the oxygen-induced constriction of arterioles in the rat spinotrapezius muscle. Ele...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1025
更新日期：1995-05-01 00:00:00
abstract：:We tested the hypothesis that the endothelial nitric oxide (NO)-soluble guanylyl cyclase system is involved in atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) mediated regulation of coronary and peripheral vascular resistance. Rat hearts were perfused via the aorta at constant flow and the effect...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2289
更新日期：2001-01-01 00:00:00
