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Modification of vascular and inflammation biomarkers after OGTT in overweight healthy and diabetic subjects.

Abstract：

:We evaluated the effect of an oral glucose tolerance test (OGTT) on the level of biomarkers of vascular remodelling. We enrolled 256 Caucasian overweight healthy subjects (H) and 274 overweight type 2 diabetic patients (D). All patients underwent basal measurements of blood glucose (BG), nitrites/nitrates, adiponectin (ADP), matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-9 (MMP-9) before and after OGTT. Nitrites/nitrates decrease was present after 60, 90, 120, and 180 min in both groups. Nitrite/nitrate levels were decreased at baseline, after 30 and 60 min in D group compared to H group. ADP decrease was present after 90, 120, and 180 min, in both groups. ADP levels were lower in D group than in H group during OGTT. MMP-2 increase was present after 60, 90, and 120 min in H group, while MMP-2 increase was observed after 90, 120, and 180 min in D group. MMP-2 levels were higher in D group than in H group during OGTT. MMP-9 increase was present in H group after 60, 90, 120, and 180 min, while MMP-9 increase was observed after 90, 120, and 180 min in D group. MMP-9 levels were higher in D group than in H group during OGTT. Postprandial glycemia induces an acute increase in biomarkers of vascular remodelling.

journal_name

Microvasc Res

journal_title

Microvascular research

authors

Derosa G,D'Angelo A,Salvadeo SA,Ferrari I,Fogari E,Gravina A,Mereu R,Palumbo I,Maffioli P,Randazzo S,Cicero AF

doi

10.1016/j.mvr.2010.01.002

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

144-9

issue

2

eissn

0026-2862

issn

1095-9319

pii

S0026-2862(10)00003-8

journal_volume

79

pub_type

杂志文章,多中心研究

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