Regulatory crosstalk between Hox genes and miRNAs during angiogenesis.

abstract：:The aim of this study was to evaluate whether streptokinase (SK) may produce beneficial effects at the level of microvascular circulation in addition to coronary recanalization. Twenty mongrel dogs weighing 28.4 +/- 4.6 kg were randomized to receive SK (16,000-72,000 U/kg) or 20 ml saline (control) in an open-chest an...

journal_title：Microvascular research

authors： Woo KS,Armiger LC,White HD,Norris RM

更新日期：2000-07-01 00:00:00

abstract：:Previous findings have shown that pulmonary fibroblasts are associated with preexisting holes in the endothelial and epithelial basal laminae through which neutrophils appear to enter and leave the interstitium as they migrate from capillaries to alveoli. To determine their role in neutrophil migration, fibroblast org...

journal_title：Microvascular research

authors： Behzad AR,Chu F,Walker DC

更新日期：1996-05-01 00:00:00

abstract：:This study further investigates the mechanisms responsible for the effects of acute and severe hypoxia, and subsequent reoxygenation, on the contractility of isolated rat mesenteric arteries. In noradrenaline (NA)-contracted arteries, hypoxia caused a relaxation to near baseline levels. Reoxygenation resulted in an im...

journal_title：Microvascular research

authors： Bruce J,Taggart M,Austin C

更新日期：2004-11-01 00:00:00

abstract：:Skeletal muscle arterioles are known to constrict upon elevation of ambient PO2. While several studies have shown that the endothelium plays an important role in this response, it is not clear how this response is mediated. We examined the oxygen-induced constriction of arterioles in the rat spinotrapezius muscle. Ele...

journal_title：Microvascular research

authors： Pries AR,Heide J,Ley K,Klotz KF,Gaehtgens P

更新日期：1995-05-01 00:00:00

abstract：:The therapeutic efficacy of various genetically engineered macromolecules is determined by their delivery and distribution in tumors. We have recently developed mathematical models which describe the interstitial velocity, pressure, and concentration profiles of macromolecules over the length scale of a solid tumor (B...

journal_title：Microvascular research

authors： Baxter LT,Jain RK

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Endothelial cells are suggested regulators of tumor response to radiation. Anti-vascular targeting agents can enhance tumor response by targeting endothelial cells. Here, we have conducted experiments in vitro to discern the effects of radiation combined with the anti-angiogenic Sunitinib on endothelial (HUV...

journal_title：Microvascular research

authors： El Kaffas A,Al-Mahrouki A,Tran WT,Giles A,Czarnota GJ

更新日期：2014-03-01 00:00:00

abstract：:Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In thi...

journal_title：Microvascular research

authors： Mizeva I,Zharkikh E,Dremin V,Zherebtsov E,Makovik I,Potapova E,Dunaev A

更新日期：2018-11-01 00:00:00

abstract：:The stereomorphological arrangement of skeletal muscle capillaries depends on many factors. Genetic biochemical composition of muscle fibers, age, and training can interfere with the growth of the capillary network. This study is focused on the age effect of chronic reduction of blood flow, as in arterial stenosis, in...

journal_title：Microvascular research

authors： Brotzu G,Carta M,D'Alia G,Diaz G,Montisci R,Savona G

更新日期：1984-05-01 00:00:00

abstract：:Growing interest in utilizing endothelial cells (ECs) for therapeutic purposes has led to the exploration of human embryonic stem cells (hESCs) as a potential source for endothelial progenitors. In this study, ECs were induced from hESC lines and their biological characteristics were analyzed and compared with both co...

journal_title：Microvascular research

authors： Sun X,Cheng L,Duan H,Lin G,Lu G

更新日期：2012-09-01 00:00:00

abstract：:Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response to intravascular H2O2 challenge in buffer-perfused rabbit lun...

journal_title：Microvascular research

authors： Seeger W,Hansen T,Rössig R,Schmehl T,Schütte H,Krämer HJ,Walmrath D,Weissmann N,Grimminger F,Suttorp N

更新日期：1995-07-01 00:00:00

abstract：:The microfibrils of anchoring filaments, a typical ultrastructural feature of initial lymphatic vessels, consist mainly of fibrillin and are similar to the microfibrils of elastic fibers. As we previously demonstrated, they radiate from focal adhesions of lymphatic endothelium to the perivascular elastic network. Alth...

journal_title：Microvascular research

authors： Weber E,Rossi A,Solito R,Sacchi G,Agliano' M,Gerli R

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase. NAD(P)H oxidase subunit p22phox is reported to be related to the development of atherosclerosis...

journal_title：Microvascular research

authors： Kou B,Zhang J,Singer DR

更新日期：2009-03-01 00:00:00

abstract：:We present a simple method for isolation and long-term cultivation of porcine and murine cerebral capillary endothelial cells (cEC). Two major points are made. First, that the "characteristic" morphology of the endothelial cells depends mainly on the presence of endothelial cell growth factors in the culture medium an...

journal_title：Microvascular research

authors： Tontsch U,Bauer HC

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Angiogenin levels are increased in children and adolescent patients with type 1 diabetes, regardless of the extent of diabetic microangiopathy. However, little is known about the angiogenin concentrations in adults with type 1 diabetes. Thus we studied its level in middle aged subjects with the presence of d...

journal_title：Microvascular research

authors： Neubauer-Geryk J,Kozera GM,Wolnik B,Szczyrba S,Nyka WM,Bieniaszewski L

更新日期：2012-11-01 00:00:00

abstract：:Recent studies indicate that the human choroid has a considerable capacity to keep blood flow constant despite exercise-induced increases in perfusion pressure. The mechanisms underlying this vasoconstrictor response remain unclear. We hypothesized that pharmacological modulation of the autonomic nervous system may al...

journal_title：Microvascular research

authors： Polska E,Luksch A,Schering J,Frank B,Imhof A,Fuchsjäger-Mayrl G,Wolzt M,Schmetterer L

更新日期：2003-01-01 00:00:00

abstract：:Developing tissue engineering approaches to generate functional vascular networks is important for improving treatments of peripheral and cardiovascular disease. Endothelial colony forming cells (ECFCs) are an endothelial progenitor cell (EPC) population defined by high proliferative potential and an ability to vascul...

journal_title：Microvascular research

authors： Critser PJ,Kreger ST,Voytik-Harbin SL,Yoder MC

更新日期：2010-07-01 00:00:00

abstract：:The steatotic liver is characterized by deranged intrahepatic microvasculature that is believed to predispose it to ischemia-reperfusion injury. The aim of this study was to investigate the distorted hepatic hemodynamics and its impact on the redox status of the steatotic liver. Hepatic hemodynamic parameters, hepatic...

journal_title：Microvascular research

authors： Sun CK,Zhang XY,Wheatley AM

更新日期：2003-07-01 00:00:00

abstract：:The fluidity (the inverse of viscosity) of red blood cell (RBC) suspensions in vivo was estimated by means of microcirculatory measurements such as RBC flow velocity, micropressure in arterioles and venules, and vessel geometry, and by means of simultaneous macrocirculatory measurements such as volume flow and perfusi...

journal_title：Microvascular research

authors： Driessen G,Scheidt H,Inhoffen W,Sobota A,Malotta H,Schmid-Schönbein H

更新日期：1988-01-01 00:00:00

abstract：:A well developed capillary bed is essential for proper function of skeletal muscles. We present for the first time a triple immunofluorescent method suitable for staining capillaries and muscle fibre outlines in thick sections of human skeletal muscle, applying antibodies against collagen IV (in red) and F8 (in green)...

journal_title：Microvascular research

authors： Janáček J,Cvetko E,Kubínová L,Travnik L,Eržen I

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. METHODS:Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospe...

journal_title：Microvascular research

authors： Ingegnoli F,Boracchi P,Gualtierotti R,Smith V,Cutolo M,Foeldvari I,EUSTAR co-authors.

更新日期：2015-11-01 00:00:00

abstract：:In the present study, human myometrial microvascular endothelial cells (HMMEC) were cocultured with human vascular smooth muscle cells (VSMC) labeled with fluorescent dyes to examine their morphological interaction using confocal laser fluorescent microscopy. HMMEC and VSMC labeled with fluorescent green and red dyes,...

journal_title：Microvascular research

authors： Burch MG,Pepe GJ,Dobrian AD,Lattanzio FA Jr,Albrecht ED

更新日期：2005-07-01 00:00:00

abstract：:We have applied theories of mass transfer, in laminar and turbulent flow, to red cells in the stopped-flow apparatus in order to estimate the effect of extracellular diffusion boundary layers on the initial rate of O2 uptake. We compared the theoretical predictions with the results of our previous stopped-flow experim...

journal_title：Microvascular research

authors： Huxley VH,Kutchai H

更新日期：1983-07-01 00:00:00

abstract：PURPOSE:To examine the possible role of Klotho (Kl) in human microvasculature. METHODS:The expression level of Kl in primary human dermal microvascular endothelial cells (HDMECs) and primary human dermal fibroblasts (HFb) was detected by real-time polymerase chain reaction amplification (qRT-PCR), Western blot analyse...

journal_title：Microvascular research

authors： Markiewicz M,Panneerselvam K,Marks N

更新日期：2016-09-01 00:00:00

abstract：:Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle prolifer...

journal_title：Microvascular research

authors： Yuyun MF,Ng LL,Ng GA

更新日期：2018-09-01 00:00:00

abstract：:We describe a sensitive, reliable, and convenient procedure to assay cell adhesion based on flow cytometry which allows quantitative studies of all major peripheral blood leukocytes adhering to microvascular endothelial cells. Using this assay, we show that adhesion of mononuclear cells is significantly increased in t...

journal_title：Microvascular research

authors： Heckmann M,Pirthauer M

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether region-dependent endothelial heterogeneity is present within the porcine vortex vein system. METHODS:The superior temporal vortex vein in young adult pig eyes were dissected out and cannulated. The intact vortex vein system down to the choroidal veins was then p...

journal_title：Microvascular research

authors： Tan PE,Yu PK,Cringle SJ,Morgan WH,Yu DY

更新日期：2013-09-01 00:00:00

abstract：:The purpose of this study was to determine if there are intrinsic differences in resting tone, vascular reactivity, myogenic responses, and neurogenic vasoconstriction between the large and small feeder arteries and first order arterioles (1A) of the rat cremaster muscle. The pudic-epigastric artery (PEA), external sp...

journal_title：Microvascular research

authors： Sylvester FA,Frisbee JC,Lombard JH

更新日期：2000-09-01 00:00:00

abstract：:Previous studies on mice have revealed that the Griffonia simplicifolia I (GSI) lectin selectively binds to capillaries in a number of microvascular beds. These observations suggest that the lectin might be a suitable microvascular marker for physiological studies of skeletal muscle, particularly when fluorescent visu...

journal_title：Microvascular research

authors： Hansen-Smith FM,Watson L,Lu DY,Goldstein I

更新日期：1988-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a chronic neuro-degenerative disease that adversely affect many people on a global scale. Despite different diagnostic and therapeutic treatment, there is no cure for AD. The brain is one of the most complex organ and researchers are still trying to understand so as to find a cure. OBJECTI...

journal_title：Microvascular research

authors： Bukenya F,Nerissa C,Serres S,Pardon MC,Bai L

更新日期：2020-03-01 00:00:00

abstract：:Despite intensive study in the area of angiogenesis, relatively little is known about normal angiogenesis in adult animals. Preliminary studies using the Griffonia simplicifolia I (GSI) lectin as a microvascular marker indicated that capillary sprouting occurs in the clear "windows" of normal intact adult rat mesenter...

journal_title：Microvascular research

authors： Hansen-Smith FM,Joswiak GR,Baustert JL

更新日期：1994-05-01 00:00:00