Abstract:
:Despite intensive study in the area of angiogenesis, relatively little is known about normal angiogenesis in adult animals. Preliminary studies using the Griffonia simplicifolia I (GSI) lectin as a microvascular marker indicated that capillary sprouting occurs in the clear "windows" of normal intact adult rat mesentery. The purpose of this study was to determine whether angiogenesis occurs uniformly within the mesenteric windows and whether maturational age affects the extent of angiogenesis in the absence of any experimental or pathological perturbation. Four groups of female Sprague-Dawley rats were used, "weanling" (4-5 weeks), "juvenile" (6-8 weeks), "young adult" (10-13 weeks), and "adult" (16-20 weeks). Microvessels sprouting into proximal and distal windows were delineated in whole mounts by use of fluorescent derivative of the GSI lectin. Microvascular sprouting, indicating angiogenesis, was found in all age groups, but was most frequent in the windows sampled from the distal region of the small intestine when compared with those from the proximal region. The mean number of microvessels per sample site was significantly higher in the distal windows of adults than in the weanling or juvenile rats. Angiogenesis was found to occur asymmetrically within the individual windows in the two adult groups, with significantly more angiogenesis on the intestinal side compared to that along the portal vessels. We conclude that there is an age-related increase in angiogenesis into the mesenteric windows, and that the intestinal side is more prone to spontaneous angiogenesis than is the portal side.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Hansen-Smith FM,Joswiak GR,Baustert JLdoi
10.1006/mvre.1994.1029subject
Has Abstractpub_date
1994-05-01 00:00:00pages
369-76issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(84)71029-6journal_volume
47pub_type
杂志文章abstract:BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.10.006
更新日期:2015-01-01 00:00:00
abstract::Rho-associated kinases are involved in regulation of actin-myosin contractility and the organization of the actin cytoskeleton in both endothelial and smooth muscle cells. By influencing the contraction of the intraendothelial filaments, Rho kinases may affect the size of the interendothelial gaps and thereby influenc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/s0026-2862(03)00041-4
更新日期:2003-09-01 00:00:00
abstract::The stereomorphological arrangement of skeletal muscle capillaries depends on many factors. Genetic biochemical composition of muscle fibers, age, and training can interfere with the growth of the capillary network. This study is focused on the age effect of chronic reduction of blood flow, as in arterial stenosis, in...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(84)90060-8
更新日期:1984-05-01 00:00:00
abstract::IL-20 is an arteriogenic cytokine that remodels collateral networks in vivo, and plays a role in cellular organization. Here, we investigate its role in lymphangiogenesis using a lymphatic endothelial cell line, hTERT-HDLEC, which expresses the lymphatic markers LYVE-1 and podoplanin. Upon stimulation of hTERT-HDLEC w...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2009.02.007
更新日期:2009-06-01 00:00:00
abstract::In diabetic patients small fiber neuropathy has been associated with impairment of 0.1 Hz microvascular vasomotion. The aim of this study was (1) to investigate whether vasoconstriction-induced microvascular oscillations in the skin are reduced in diabetic patients with peripheral and/or autonomic neuropathy, and (2) ...
journal_title:Microvascular research
pub_type: 临床试验,杂志文章
doi:10.1016/j.mvr.2008.04.004
更新日期:2008-08-01 00:00:00
abstract::Vessel size index (R(v), μm) has been proposed as a quantitative magnetic resonance imaging (MRI) derived imaging biomarker in oncology, for the non-invasive assessment of tumour blood vessel architecture and vascular targeted therapies. Appropriate pre-clinical evaluation of R(v) in animal tumour models will improve ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2012.08.001
更新日期:2012-11-01 00:00:00
abstract::Developing tissue engineering approaches to generate functional vascular networks is important for improving treatments of peripheral and cardiovascular disease. Endothelial colony forming cells (ECFCs) are an endothelial progenitor cell (EPC) population defined by high proliferative potential and an ability to vascul...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2010.03.001
更新日期:2010-07-01 00:00:00
abstract::To investigate the effect of vascular endothelial growth factor (VEGF) on solute permeability of mammalian microvessels, we measured the apparent permeability (P) of various-sized solutes on the postcapillary venules of rat mesentery in vivo. Exposure to 1 nM VEGF transiently increased P from a mean of 1.4 (+/-0.11 SE...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2004.03.004
更新日期:2004-07-01 00:00:00
abstract::Previous studies on mice have revealed that the Griffonia simplicifolia I (GSI) lectin selectively binds to capillaries in a number of microvascular beds. These observations suggest that the lectin might be a suitable microvascular marker for physiological studies of skeletal muscle, particularly when fluorescent visu...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(88)90022-2
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Endothelial cells are suggested regulators of tumor response to radiation. Anti-vascular targeting agents can enhance tumor response by targeting endothelial cells. Here, we have conducted experiments in vitro to discern the effects of radiation combined with the anti-angiogenic Sunitinib on endothelial (HUV...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2013.10.008
更新日期:2014-03-01 00:00:00
abstract::The aim of this study is to develop a novel non-contrast 4-dimensional MR arterial spin labeling (4D-ASL) technique (3D acquisition and time) and to investigate myocardial perfusion on healthy volunteers without administration of contrast materials. A non-contrast 4D-ASL technique was developed using the time-spatial ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.01.007
更新日期:2015-03-01 00:00:00
abstract::A hallmark of severe inflammation is reactive oxygen species (ROS) overproduction induced by increased inflammatory mediators secretion. During systemic inflammation, inflammation mediators circulating in the bloodstream interact with endothelial cells (ECs) raising intracellular oxidative stress at the endothelial mo...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2014.02.001
更新日期:2015-03-01 00:00:00
abstract::Diabetic retinopathy (DR) is a disease that causes blindness due to vascular leakage or abnormal angiogenesis. Hepatocyte growth factor (HGF) is increased in the serum or vitreous fluid in proliferative diabetic retinopathy (PDR) patients, although the effect of HGF on the blood vessels remains unclear. This study foc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104103
更新日期:2021-01-01 00:00:00
abstract::The contribution of the pleural mesothelium to pleural liquid and protein transport is still vigorously debated. Recent in vitro studies of stripped pleural membrane and free-standing pericardium have demonstrated active ion solute coupled transport of liquid and transcytosis of protein. However, the relative contribu...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2005.10.003
更新日期:2005-11-01 00:00:00
abstract::The kidneys of 14 female Wistar rats from 5 days to 18 months postnatally have been perfusion-fixed to study the development of glomerular capillaries using design-based stereological techniques. This report uses a topological definition of a capillary structural unit which forms the basis for the estimation of the nu...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1993.1022
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels. MATERIALS AND METHODS:8 lower extremities in 4 consecutive patients with secondary unilateral lymphedema of the lower extremities were examined by MR lympha...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2008.03.003
更新日期:2008-05-01 00:00:00
abstract::Polymorphonuclear leukocytes are thought to play a pivotal role in the generation of ischemia-reperfusion-induced mucosal injury; however, their behavior in the intestinal microvasculature following this injury has not been directly examined. In this study intravital microscopy was used to investigate the dynamics of ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1994.1028
更新日期:1994-05-01 00:00:00
abstract::The aim of our study was to evaluate the feasibility of laser Doppler flowmetry (LDF) coupled with iontophoresis in exploring the skin vasodilator activity of exogenous calcitonin gene-related peptide (CGRP) in healthy subjects and to investigate the mechanisms involved in the skin vasodilator activity of this peptide...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.10.006
更新日期:2007-03-01 00:00:00
abstract::Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1998.2105
更新日期:1998-11-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic neuro-degenerative disease that adversely affect many people on a global scale. Despite different diagnostic and therapeutic treatment, there is no cure for AD. The brain is one of the most complex organ and researchers are still trying to understand so as to find a cure. OBJECTI...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2019.103928
更新日期:2020-03-01 00:00:00
abstract::Synthetic big endothelin-1 (ET-1), a 39-residue precursor of ET-1, has been reported to elicit potent contractile action on helical strip specimens obtained from the porcine coronary artery, but its molar potency was found to be 140-fold lower than that of ET-1 [Saito, Y., Nakao, K., Mukoyama, M., Imura, H., 1990. Inc...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2006.04.007
更新日期:2006-11-01 00:00:00
abstract::The microfibrils of anchoring filaments, a typical ultrastructural feature of initial lymphatic vessels, consist mainly of fibrillin and are similar to the microfibrils of elastic fibers. As we previously demonstrated, they radiate from focal adhesions of lymphatic endothelium to the perivascular elastic network. Alth...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.2002.2397
更新日期:2002-07-01 00:00:00
abstract::The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, howe...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2017.09.003
更新日期:2018-03-01 00:00:00
abstract::Since the internal carotid artery supplies blood to both the eye and the brain, ocular microvascular hemodynamics can be altered due to ischemic stroke. The purpose of the current study was to establish the feasibility of conjunctival microcirculation imaging for detection of inter-ocular differences in microvascular ...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2015.04.007
更新日期:2015-07-01 00:00:00
abstract::The relative magnitude of vascular reactivity to inhaled gas stimuli in the major retinal arterioles has not been systematically investigated. The purpose of this study was to compare the magnitude of retinal vascular reactivity in response to inhaled gas provocation at equivalent measurement sites in the superior-, a...
journal_title:Microvascular research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mvr.2011.11.002
更新日期:2012-03-01 00:00:00
abstract::Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated in various models of pulmonary arterial hypertension (PAH). We addressed the relationship between P...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2010.04.008
更新日期:2010-09-01 00:00:00
abstract::Oxygen tension was recorded with double-barreled microelectrodes in the retina of anesthetized cats and monkeys. The oxygen tension (PO2) was often observed to undergo spontaneous irregular fluctuations with peak-to-peak amplitudes of about 3 to as much as 20 mm Hg. These fluctuations were observed only in the vascula...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/0026-2862(92)90103-v
更新日期:1992-07-01 00:00:00
abstract::The steatotic liver is characterized by deranged intrahepatic microvasculature that is believed to predispose it to ischemia-reperfusion injury. The aim of this study was to investigate the distorted hepatic hemodynamics and its impact on the redox status of the steatotic liver. Hepatic hemodynamic parameters, hepatic...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/s0026-2862(03)00021-9
更新日期:2003-07-01 00:00:00
abstract::Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene expression in the vascular endothelium. Here, we applied immunofluorescence staining for different endothelial markers (PECAM-1, CD34, laminin) on paraffin sections...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2008.02.004
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate the correlation between the expression of miR-210 in peripheral blood and the number of peripheral endothelial progenitor cells (EPCs) in patients with type 2 diabetes mellitus (T2DM). We also determined the effect of miR-210 on EPC proliferation, adhesion, migration, tube forma...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2020.104032
更新日期:2020-09-01 00:00:00