A novel method for mapping the heterogeneity in blood supply to normal and malignant tissues in the mouse dorsal window chamber.

abstract：:Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...

journal_title：Microvascular research

authors： Yang J

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase. NAD(P)H oxidase subunit p22phox is reported to be related to the development of atherosclerosis...

journal_title：Microvascular research

authors： Kou B,Zhang J,Singer DR

更新日期：2009-03-01 00:00:00

abstract：:Fluorescence-mediated photoplethysmography (FM-PPG) was developed to facilitate determination of tissue microvascular (capillary) blood perfusion, requiring intra-venous injection of a small bolus (~0.33mL) of dye (25mg/mL ICG) and acquisition of high-speed angiogram images (>15images/s). The methodology is applicable...

journal_title：Microvascular research

authors： Flower RW,Kling R

更新日期：2017-11-01 00:00:00

abstract：:Circulation of blood depends, in part, on the ability of red blood cells (RBCs) to aggregate, disaggregate, and deform. The primary intrinsic disaggregating force of RBCs is derived from their electronegativity, which is largely determined by sialylated glycoproteins on the plasma membrane. Given supraphysiological sh...

journal_title：Microvascular research

authors： McNamee AP,Tansley GD,Simmonds MJ

更新日期：2018-11-01 00:00:00

abstract：:Metabolic syndrome (MetS) is a combination of clinical disorders that together increase the risk for cardiovascular disease and diabetes. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS show impaired nitric oxide-mediated relaxation in coronary and mesenteric arteries, and angiotensin II receptor type 1 blockers pr...

journal_title：Microvascular research

authors： Kagota S,Maruyama K,Tada Y,Fukushima K,Umetani K,Wakuda H,Shinozuka K

更新日期：2013-07-01 00:00:00

abstract：:A well developed capillary bed is essential for proper function of skeletal muscles. We present for the first time a triple immunofluorescent method suitable for staining capillaries and muscle fibre outlines in thick sections of human skeletal muscle, applying antibodies against collagen IV (in red) and F8 (in green)...

journal_title：Microvascular research

authors： Janáček J,Cvetko E,Kubínová L,Travnik L,Eržen I

更新日期：2011-03-01 00:00:00

abstract：:Angiogenesis, or the growth of new blood vessels, is critical to both health and disease. Several genes are implicated in the regulation of angiogenesis, such as genes encoding growth factors, cytokines, and the extracellular matrix, as well as transcription factors. Among them, Hox genes exert master regulatory effec...

journal_title：Microvascular research

authors： Mahdipour E

更新日期：2013-05-01 00:00:00

abstract：:This study was designed to determine if vascular dysfunction and enhanced norepinephrine sensitivity occurring in early experimental juvenile diabetes (S. M. Mueller, T. M. Mueller, and P. J. Ertel, 1982, Amer. J. Physiol. 243, H139-H144) persist, improve, or worsen in adulthood. Alloxan was administered to rats at 4 ...

journal_title：Microvascular research

authors： Mueller SM

更新日期：1984-07-01 00:00:00

abstract：:The fluorescence ratio imaging technique is currently applied in vitro and in vivo to measure intracellular as well as extracellular pH. To date, however, no effort has been made to assess the technique's ability to detect spatial pH gradients in vitro or in vivo, where pH gradients are known to exist, in a controlled...

journal_title：Microvascular research

authors： Martin GR,Jain RK

更新日期：1993-09-01 00:00:00

abstract：:Red blood cell (RBC)-plasma suspensions with a hematocrit of 10-12% were forced to flow through microchannels (equivalent diameter 6 microns, equivalent length 20 microns, 2600 in parallel) by applying a pressure difference of 20 cm H2O. Transit times for 100 microliters of fresh suspensions from 33 healthy male subje...

journal_title：Microvascular research

authors： Kikuchi Y,Da QW,Fujino T

更新日期：1994-03-01 00:00:00

abstract：:During diabetes in rats, the choroid of the eye shows increased permeability to albumin, basement membrane thickening, and decreased anionic charge sites on the abluminal surfaces of the choriocapillary microvessels. In other microvascular beds, permeability differences are correlated with differences in luminal membr...

journal_title：Microvascular research

authors： Caldwell RB,Fitzgerald ME

更新日期：1991-11-01 00:00:00

abstract：:Growing interest in utilizing endothelial cells (ECs) for therapeutic purposes has led to the exploration of human embryonic stem cells (hESCs) as a potential source for endothelial progenitors. In this study, ECs were induced from hESC lines and their biological characteristics were analyzed and compared with both co...

journal_title：Microvascular research

authors： Sun X,Cheng L,Duan H,Lin G,Lu G

更新日期：2012-09-01 00:00:00

abstract：:In this study cerebral capillary bed structure and the effects of chronic hypertension on these systems have been assessed in 6- to 7-month-old spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. Capillary diameter (D), profile frequency (Na), volume fraction (Vv), and surface area (Sv) were quantitated by l...

journal_title：Microvascular research

authors： Lin SZ,Sposito N,Pettersen S,Rybacki L,McKenna E,Pettigrew K,Fenstermacher J

更新日期：1990-11-01 00:00:00

abstract：:Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene expression in the vascular endothelium. Here, we applied immunofluorescence staining for different endothelial markers (PECAM-1, CD34, laminin) on paraffin sections...

journal_title：Microvascular research

authors： Aleku M,Fisch G,Möpert K,Keil O,Arnold W,Kaufmann J,Santel A

更新日期：2008-05-01 00:00:00

abstract：:The present study was conducted to compare laser speckle imaging (LSI) with sidestream dark field (SDF) imaging (i.e., capillary microscopy) so as to validate the use of LSI for assessing microvascular (re)perfusion. For this purpose, LSI and SDF measurements were performed on the human nail fold during gradual occlus...

journal_title：Microvascular research

authors： Bezemer R,Klijn E,Khalilzada M,Lima A,Heger M,van Bommel J,Ince C

更新日期：2010-03-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a disease that causes blindness due to vascular leakage or abnormal angiogenesis. Hepatocyte growth factor (HGF) is increased in the serum or vitreous fluid in proliferative diabetic retinopathy (PDR) patients, although the effect of HGF on the blood vessels remains unclear. This study foc...

journal_title：Microvascular research

authors： Yun JH

更新日期：2021-01-01 00:00:00

abstract：:The effect of mean blood velocity on thrombus formation parameters was studied using mesenteric vessels of white rats. An advanced phenomenological theory, explaining the relationship between mean blood velocity and thrombus growth rate, is presented. The qualitative analysis of theoretical and experimental data have ...

journal_title：Microvascular research

authors： Petrishchev NN,Mikhailova IA

更新日期：1995-01-01 00:00:00

abstract：:Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In thi...

journal_title：Microvascular research

authors： Mizeva I,Zharkikh E,Dremin V,Zherebtsov E,Makovik I,Potapova E,Dunaev A

更新日期：2018-11-01 00:00:00

abstract：:Homeostasis around vascular endothelium is a function of the equilibrium between the bioavailability of nitric oxide (NO) and oxidizing reactive oxygen species (ROS). Within the vascular endothelium, NO enhances vasodilatation, reduces platelet aggression and adhesion (anti-thrombotic), prevents smooth muscle prolifer...

journal_title：Microvascular research

authors： Yuyun MF,Ng LL,Ng GA

更新日期：2018-09-01 00:00:00

abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...

journal_title：Microvascular research

authors： Sugihara-Seki M,Minamiyama M,Hanai S

更新日期：1989-09-01 00:00:00

abstract：:Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse a...

journal_title：Microvascular research

authors： Sharma B,Albig AR

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Leukocytes play a key role in the early response to tissue injury/infection resulting from physical, chemical or biological stimuli. This process involves the initiation of the leukocyte adhesion cascade mediated by a series of interactions between receptors and ligands on the endothelium and the leukocytes. ...

journal_title：Microvascular research

authors： Lamberti G,Tang Y,Prabhakarpandian B,Wang Y,Pant K,Kiani MF,Wang B

更新日期：2013-09-01 00:00:00

abstract：:The effects of systemic injections of vasoactive substances were studied in the micro-circulation of the hamster skin fold window preparation, which can be observed without anesthesia, exposure, and acute surgical procedures. The effects were characterized by the continuous measurement of the diameter of the arterial ...

journal_title：Microvascular research

authors： Colantuoni A,Bertuglia S,Intaglietta M

更新日期：1984-09-01 00:00:00

abstract：:Carrier-immobilized carbohydrates are valuable tools for assessing the glycoligand-binding capacity of cell surfaces. A panel of 10 types of fluorescent neoglycoproteins has been synthesized to determine the extent of their specific binding to endothelial cells in vitro that have been obtained from porcine brain, ovar...

journal_title：Microvascular research

authors： Plendl J,Sinowatz F,Auerbach R,Gabius HJ

更新日期：1995-09-01 00:00:00

abstract：:We have developed an intensity analysis technique for fluorescence microscopy that allows us to measure, in real time, the diameter and the membrane potential or intracellular calcium ([Ca(2+)]i) of in vivo arteriolar endothelium or smooth muscle. Cheek pouch arterioles of anesthetized hamsters were luminally or ablum...

journal_title：Microvascular research

authors： Chen Y,Rivers RJ

更新日期：2001-07-01 00:00:00

abstract：:We have performed a mathematical simulation on a CYBER computer of the release, diffusion, and consumption of oxygen in the capillaries and surrounding tissue of peripheral nerve under steady-state conditions. The Krogh-Erlang equation was used to calculate oxygen tension in tissue, while numerical solution of the dif...

journal_title：Microvascular research

authors： Lagerlund TD,Low PA

更新日期：1987-09-01 00:00:00

abstract：OBJECTIVES:The advanced glycation end products (AGEs)-receptor for AGE (RAGE) axis activity are implicated in diabetic vascular complications. We measured serum AGE, sRAGE and pentosidine levels in Tunisian patients with diabetic retinopathy (DR) and examined whether these biomarkers are related to the severity of DR. ...

journal_title：Microvascular research

authors： Kerkeni M,Saïdi A,Bouzidi H,Ben Yahya S,Hammami M

更新日期：2012-11-01 00:00:00

abstract：:We tested the hypothesis that p42/44MAPK and p38MAPK (mitogen-activated protein kinases; MAPK) signaling pathways regulate endothelial cell permeability to macromolecules. Passage 2-4 human umbilical vein endothelial cells (HUVEC) were grown to confluence on fibronectin-coated Snapwell membranes. The flux of fluoresce...

journal_title：Microvascular research

authors： Varma S,Breslin JW,Lal BK,Pappas PJ,Hobson RW 2nd,Durán WN

更新日期：2002-03-01 00:00:00

abstract：:Oxygen tension was recorded with double-barreled microelectrodes in the retina of anesthetized cats and monkeys. The oxygen tension (PO2) was often observed to undergo spontaneous irregular fluctuations with peak-to-peak amplitudes of about 3 to as much as 20 mm Hg. These fluctuations were observed only in the vascula...

journal_title：Microvascular research

authors： Braun RD,Linsenmeier RA,Yancey CM

更新日期：1992-07-01 00:00:00

abstract：:Interactions between migratory endothelial cells (ECs) and surrounding extracellular matrix (ECM) are of central importance to vascular growth. Here, we present a new model of EC migration and morphogenesis within three-dimensional ECM termed "radial invasion of matrix by aggregated cells" (RIMAC). In the RIMAC model,...

journal_title：Microvascular research

authors： Vernon RB,Sage EH

更新日期：1999-03-01 00:00:00