Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel.

abstract：:Concentration-response curves are often used as indicators of vascular reactivity and receptor sensitivity. Some investigators use ethylenediaminetetraacetate (EDTA) or ascorbic acid (ASC) to prevent catecholamine oxidation but many others do not. This difference may affect estimates of reactivity. We tested the effec...

journal_title：Microvascular research

authors： Maxwell LC,Herlihy JT,Riedel GL

更新日期：1983-07-01 00:00:00

abstract：:Skeletal muscle arterioles are known to constrict upon elevation of ambient PO2. While several studies have shown that the endothelium plays an important role in this response, it is not clear how this response is mediated. We examined the oxygen-induced constriction of arterioles in the rat spinotrapezius muscle. Ele...

journal_title：Microvascular research

authors： Pries AR,Heide J,Ley K,Klotz KF,Gaehtgens P

更新日期：1995-05-01 00:00:00

abstract：:We observed the retinal capillary pericytes of the rat in situ. Whole retinae were mounted, immediately post vivo, in a special tissue chamber for electronic light microscopy at high magnifications. Under electronic light microscopy the pericytes could be clearly distinguished from the endothelial cells. In addition, ...

journal_title：Microvascular research

authors： Schönfelder U,Hofer A,Paul M,Funk RH

更新日期：1998-07-01 00:00:00

abstract：:Alterations in the reactivity of arterioles to vasodilator agonists were assessed in the skeletal muscle microcirculation of age-matched, normotensive male Sprague-Dawley rats fed either a high salt (4% NaCl, HS) or a low salt (0.4% NaCl, LS) diet and in reduced renal mass hypertensive rats on a high salt diet (HSRRM)...

journal_title：Microvascular research

authors： Frisbee JC,Lombard JH

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:To assess the morphology of the lymphatic system pre- and postoperatively in patients undergoing microsurgical reconstructions of the lymphatic vessels. MATERIALS AND METHODS:8 lower extremities in 4 consecutive patients with secondary unilateral lymphedema of the lower extremities were examined by MR lympha...

journal_title：Microvascular research

authors： Lohrmann C,Felmerer G,Foeldi E,Bartholomä JP,Langer M

更新日期：2008-05-01 00:00:00

abstract：:Arterioles in various vascular beds have been often observed to have nonuniform diameters along the vessel axis. The effect of nonuniformity of arteriolar diameter on vascular resistance was investigated using a theoretical model of blood flow in arterioles. Viscous flow of a Newtonian fluid in tubes with periodically...

journal_title：Microvascular research

authors： Sugihara-Seki M,Minamiyama M,Hanai S

更新日期：1989-09-01 00:00:00

abstract：:Reduced lung capillary expression of angiotensin I-converting enzyme (ACE), a key enzyme in cardiovascular pathophysiology, and of caveolin-1, an important regulator of endothelial cell signalling, has been demonstrated in various models of pulmonary arterial hypertension (PAH). We addressed the relationship between P...

journal_title：Microvascular research

authors： Maniatis NA,Balyasnikova IV,Metzger R,Castellon M,Visintine DJ,Schwartz DE,Minshall RD,Danilov SM

更新日期：2010-09-01 00:00:00

abstract：:The mechanism by which macromolecular contents are concentrated during lymph transport was investigated in the collecting lymphatics of the mesentery of the rat. To examine changes in the concentration of lymph macromolecular tracer (fluorescein isothiocyanate-tagged dextran, MW 148,900) in the rhythmically contractil...

journal_title：Microvascular research

authors： Takahashi T,Shibata M,Kamiya A

更新日期：1997-11-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) and their receptors play important roles in cellular processes such as proliferation, differentiation, migration and cell survival. It was also demonstrated that BMPs are involved in vasculogenesis and angiogenesis. In this study, we investigated the expression profile of BMP recepto...

journal_title：Microvascular research

authors： Finkenzeller G,Hager S,Stark GB

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:The present study was examined whether fluvastatin, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, can increase the production of interstitial adenosine via activation of ecto-5'-nucleotidase in the ventricular myocardium, with use of microdialysis techniques in in situ rat hearts. METH...

journal_title：Microvascular research

authors： Obata T,Nakashima M

更新日期：2016-09-01 00:00:00

abstract：:Endometriosis, the presence of endometrium-like tissue outside of the uterine cavity, is a common disease among women of reproductive age. Typical symptoms include abdominal pain and painful menstruation. In addition, endometriosis is associated with reduced fertility. Current treatment modalities, the surgical remova...

journal_title：Microvascular research

authors： Becker CM,D'Amato RJ

更新日期：2007-09-01 00:00:00

abstract：:To investigate the relevance of *NO and oxyradicals in the blood-brain barrier (BBB), differentiated and well-proliferating brain capillary endothelial cells (BCEC) are required. Therefore, rat BCEC (rBCEC) were transfected with immortalizing genes. The resulting lines exhibited endothelial characteristics (factor VII...

journal_title：Microvascular research

authors： Blasig IE,Giese H,Schroeter ML,Sporbert A,Utepbergenov DI,Buchwalow IB,Neubert K,Schönfelder G,Freyer D,Schimke I,Siems WE,Paul M,Haseloff RF,Blasig R

更新日期：2001-09-01 00:00:00

abstract：:Fluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. As far as we know, none of those models consider a physiological d...

journal_title：Microvascular research

authors： Possenti L,Casagrande G,Di Gregorio S,Zunino P,Costantino ML

更新日期：2019-03-01 00:00:00

abstract：:HPMECs were successfully isolated by differential trypsinization from peripheral lung lobes. The cells proliferated rapidly in EGM-MV with 10% FBS and were serially cultivated for more than 20 passages (1:4 split ratio) in vitro. Cells were characterized as endothelial based upon their cobblestone morphology, the pres...

journal_title：Microvascular research

authors： Shen J,Ham RG,Karmiol S

更新日期：1995-11-01 00:00:00

abstract：:Sanguinate, a polyethylene glycol-conjugated carboxyhemoglobin, was investigated for cerebral vasoactivity in healthy male Sprague-Dawley rats (Study 1) and for its ability to increase brain tissue oxygen pressure (PbtO2) after controlled cortical impact (CCI) - traumatic brain injury (TBI) (Study 2). In both studies ...

journal_title：Microvascular research

authors： Mullah SH,Abutarboush R,Moon-Massat PF,Saha BK,Haque A,Walker PB,Auker CR,Arnaud FG,McCarron RM,Scultetus AH

更新日期：2016-09-01 00:00:00

abstract：:Routine pulmonary ultrasound for diagnosis of disease or injury relies on interpretation of image features, such as comet-tail artifacts, which can also be indicative of the poorly understood phenomenon of ultrasound-induced pulmonary capillary hemorrhage (PCH). Evans blue extraction and bronchoalveolar lavage (BAL) w...

journal_title：Microvascular research

authors： Miller DL,Suresh MV,Dou C,Yu B,Raghavendran K

更新日期：2014-05-01 00:00:00

abstract：:H2O2 mediates autocrine and paracrine signaling in the vasculature and can propagate endothelial dysfunction. However, it is not clear how endothelial cells withstand H2O2 exposure and promote H2O2-induced vascular remodeling. To understand the innate ability of endothelial cells for sustaining excess H2O2 exposure, w...

journal_title：Microvascular research

authors： Patel H,Chen J,Kavdia M

更新日期：2016-01-01 00:00:00

abstract：:Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenic lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Alth...

journal_title：Microvascular research

authors： Mulligan TS,Weinstein BM

更新日期：2014-11-01 00:00:00

abstract：:Although vasodilation is conventionally held to be the predominant microvascular response to a wound, there has been no previous attempt to actually quantitate skin blood flow within and in the neighborhood of wounds. In particular, there has been no differentiation between sites with primarily nutritive (NUTR) blood ...

journal_title：Microvascular research

authors： Rendell MS,Milliken BK,Finnegan MF,Finney DA,Healy JC

更新日期：1997-05-01 00:00:00

abstract：:We describe a sensitive, reliable, and convenient procedure to assay cell adhesion based on flow cytometry which allows quantitative studies of all major peripheral blood leukocytes adhering to microvascular endothelial cells. Using this assay, we show that adhesion of mononuclear cells is significantly increased in t...

journal_title：Microvascular research

authors： Heckmann M,Pirthauer M

更新日期：1996-09-01 00:00:00

abstract：:Living mesenteric capillaries with either an intact or disrupted glycocalyx were challenged with ramp change in shear stress (Deltatau). Animals (Rana pipiens) were divided randomly into two experimental groups, and two true capillaries (TC) per animal were investigated. The modified Landis technique was combined with...

journal_title：Microvascular research

authors： Williams DA

更新日期：2010-03-01 00:00:00

abstract：:Innate immunity is characterized by the coordinated activity of multiple leukocytes mobilizing at or near the site of tissue injury. Slow rolling and/or adherent leukocytes have been shown to hydrodynamically recruit free-stream leukocytes to a model of inflamed tissue. In this paper, we numerically investigate the hy...

journal_title：Microvascular research

authors： Subramaniam DR,Gee DJ

更新日期：2018-01-01 00:00:00

abstract：:Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantifie...

journal_title：Microvascular research

authors： Milstein DM,Helmers R,Hackmann S,Belterman CN,van Hulst RA,de Lange J

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate whether region-dependent endothelial heterogeneity is present within the porcine vortex vein system. METHODS:The superior temporal vortex vein in young adult pig eyes were dissected out and cannulated. The intact vortex vein system down to the choroidal veins was then p...

journal_title：Microvascular research

authors： Tan PE,Yu PK,Cringle SJ,Morgan WH,Yu DY

更新日期：2013-09-01 00:00:00

abstract：:Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicate...

journal_title：Microvascular research

authors： Woolnough C,Wang Y,Kan CY,Morris JM,Tasevski V,Ashton AW

更新日期：2012-11-01 00:00:00

abstract：:The size of hyaluronan in lymph and gastrocnemius muscle was measured to test the hypothesis that reperfusion of ischemic skeletal muscle leads to hyaluronan depolymerization. Prenodal lymph was collected from the gastrocnemius muscle in anesthetized rabbits. Hyaluronan size was measured using a combination of agarose...

journal_title：Microvascular research

authors： Armstrong SE,Bell DR

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVE:High aerobic fitness may prevent age-related decrements in cutaneous vasodilation while type 2 diabetes may exacerbate this decline. The mechanisms underlying these responses remain unclear, but may be due to an excess of reactive oxygen species. We hypothesized that superoxide scavenging or NADPH oxidase inh...

journal_title：Microvascular research

authors： McGarr GW,Fujii N,McNeely BD,Hatam K,Nishiyasu T,Sigal RJ,Boulay P,Kenny GP

更新日期：2019-09-01 00:00:00

abstract：:The distribution of anionic sites in the basal laminae of the blood capillaries of the murine pancreas was studied in specimens fixed in ruthenium red (RR)-glutaraldehyde mixtures. The sites appeared as discrete, small (6 to 18 nm) particles distributed throughout the three laminae but concentrated primarily in the la...

journal_title：Microvascular research

authors： Simionescu M,Simionescu N,Palade GE

更新日期：1984-11-01 00:00:00

abstract：:Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...

journal_title：Microvascular research

authors： Natarajan R,Fisher BJ,Fowler AA 3rd

更新日期：2007-05-01 00:00:00

abstract：:The fluidity (the inverse of viscosity) of red blood cell (RBC) suspensions in vivo was estimated by means of microcirculatory measurements such as RBC flow velocity, micropressure in arterioles and venules, and vessel geometry, and by means of simultaneous macrocirculatory measurements such as volume flow and perfusi...

journal_title：Microvascular research

authors： Driessen G,Scheidt H,Inhoffen W,Sobota A,Malotta H,Schmid-Schönbein H

更新日期：1988-01-01 00:00:00