Abstract：
:Routine pulmonary ultrasound for diagnosis of disease or injury relies on interpretation of image features, such as comet-tail artifacts, which can also be indicative of the poorly understood phenomenon of ultrasound-induced pulmonary capillary hemorrhage (PCH). Evans blue extraction and bronchoalveolar lavage (BAL) were evaluated for assessment of PCH induced by ultrasound scanning. Rats anesthetized with ketamine with or without xylazine received sham or scanning for 5 min with a 7.6 MHz linear array. Evans blue extraction and BAL albumin measurements failed to demonstrate significant increases for scanning, even though the induction of comet-tail artifacts was significant. BAL cell counts had an insignificant increase relative to shams at a near-threshold mechanical index (MI) of 0.52 (P=0.07), but a highly significant increase at MI=0.9 (P=0.001). The possibility of xylazine-induced elevated albumin was tested, but no significant decrease was found for sham or scanned rats with ketamine-only anesthesia. Interestingly, without xylazine, the widths of comet-tail artifacts in the ultrasound images were significantly smaller (P=0.001) and cell counts in BAL fluid also were reduced (P=0.014). The BAL cell-count method provides a valuable additional means of PCH quantification.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Miller DL,Suresh MV,Dou C,Yu B,Raghavendran Kdoi
10.1016/j.mvr.2014.02.006subject
Has Abstractpub_date
2014-05-01 00:00:00pages
42-5eissn
0026-2862issn
1095-9319pii
S0026-2862(14)00037-5journal_volume
93pub_type
杂志文章abstract：:We observed the retinal capillary pericytes of the rat in situ. Whole retinae were mounted, immediately post vivo, in a special tissue chamber for electronic light microscopy at high magnifications. Under electronic light microscopy the pericytes could be clearly distinguished from the endothelial cells. In addition, ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2086
更新日期：1998-07-01 00:00:00
abstract：:Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedure...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2014.06.006
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abstract：:We tested the hypothesis that p42/44MAPK and p38MAPK (mitogen-activated protein kinases; MAPK) signaling pathways regulate endothelial cell permeability to macromolecules. Passage 2-4 human umbilical vein endothelial cells (HUVEC) were grown to confluence on fibronectin-coated Snapwell membranes. The flux of fluoresce...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2001.2381
更新日期：2002-03-01 00:00:00
abstract：:Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantifie...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.02.001
更新日期：2016-05-01 00:00:00
abstract：:Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. Emerging data suggest that platelets may play an important role in tissue damage and inflammation. Herein, we characterized the platelet response in cholestatic liver injury and evaluated the role of Rho-kinase signaling. For...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.04.003
更新日期：2009-06-01 00:00:00
abstract：:Pericytes are perivascular support cells, the origin of which in tumor tissue is not clear. Recently, we identified a Tie1(+) precursor cell that differentiates into vascular smooth muscle, in a Notch-dependent manner. To understand the involvement of Notch in the ontogeny of tumor pericytes we used a novel flow immun...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.05.004
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Angiogenin levels are increased in children and adolescent patients with type 1 diabetes, regardless of the extent of diabetic microangiopathy. However, little is known about the angiogenin concentrations in adults with type 1 diabetes. Thus we studied its level in middle aged subjects with the presence of d...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.08.005
更新日期：2012-11-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2000.2289
更新日期：2001-01-01 00:00:00
abstract：:Particle adhesion in vivo is highly dependent on the microvascular environment comprising of unique anatomical, geometrical, physiological fluid flow conditions and cell-particle and cell-cell interactions. Hence, proper design of vascular-targeted drug carriers that efficiently deliver therapeutics to the targeted ce...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.02.004
更新日期：2015-05-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
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更新日期：2011-01-01 00:00:00
abstract：:We investigated the expression of cell adhesion molecules on the surface of glomerular endothelial cells (GEC), dermal microvascular endothelial cells (MvE), and umbilical vein endothelial cells (HUVEC) that had or had not been stimulated by cytokines. PECAM-1 was constitutively expressed at a high level on HUVEC but ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2001.2356
更新日期：2001-11-01 00:00:00
abstract：:Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2020.104123
更新日期：2021-03-01 00:00:00
abstract：BACKGROUND:Ischemia-reperfusion (IR) injury impairs microcirculatory function by reducing nitric oxide (NO) bioavailability and increasing sympathetic tone. This study non-invasively examined the effects of acute upper limb IR injury on local thermal hyperemia (LTH) in glabrous and non-glabrous finger skin. MATERIALS ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.02.003
更新日期：2018-07-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90012-2
更新日期：1983-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90051-2
更新日期：1985-09-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(92)90015-h
更新日期：1992-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/s0026-2862(03)00005-0
更新日期：2003-05-01 00:00:00
abstract：:Hypoxia-inducible factor-1 (HIF-1) orchestrates angiogenesis under hypoxic conditions mainly due to increased expression of such target genes as vascular endothelial growth factor (VEGF). Na+/H+exchanger-1 (NHE1), a potential HIF target gene product, plays a pivotal role in proliferation, survival, migration, adhesion...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2010.12.004
更新日期：2011-03-01 00:00:00
abstract：:Shear stress causes release of nitric oxide (NO) from microvascular endothelial cells in vivo and stimulates their growth in vitro. After chronic electrical stimulation of lower hind limb skeletal muscles in the rat, measurements of capillary diameters and red blood cell velocity indicated that shear stress is increas...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2193
更新日期：2000-01-01 00:00:00
abstract：:Thrombolysis treatment of acute ischemic stroke is limited by the pro-edematous and hemorrhagic effects exerted by reperfusion, which disrupts the blood-brain barrier (BBB) capillary endothelium in the infarct core. Most studies of the ischemic BBB overlook the complexity of the penumbral area, where the affected brai...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.12.002
更新日期：2014-01-01 00:00:00
abstract：:Angiotensin II is considered to have angiogenic properties. Nevertheless, several authors reported an increase in coronary capillary density after treatment with ACE inhibitors. The aim of the present study was to evaluate the effect of treatment with low doses of ACE inhibitor perindopril, low doses of the diuretic i...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2224
更新日期：2000-03-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1993.1016
更新日期：1993-03-01 00:00:00
abstract：:Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathop...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.005
更新日期：2014-07-01 00:00:00
abstract：:The fluidity (the inverse of viscosity) of red blood cell (RBC) suspensions in vivo was estimated by means of microcirculatory measurements such as RBC flow velocity, micropressure in arterioles and venules, and vessel geometry, and by means of simultaneous macrocirculatory measurements such as volume flow and perfusi...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(88)90051-9
更新日期：1988-01-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.11.003
更新日期：2007-05-01 00:00:00
abstract：:Skeletal muscle arterioles are known to constrict upon elevation of ambient PO2. While several studies have shown that the endothelium plays an important role in this response, it is not clear how this response is mediated. We examined the oxygen-induced constriction of arterioles in the rat spinotrapezius muscle. Ele...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1025
更新日期：1995-05-01 00:00:00
abstract：:Post occlusive skin reactive hyperemia (PORH) is a tool used to assess microcirculation. Endothelial nitric oxide synthase (eNOS) mediates nitric oxide (NO) production; polymorphism of the eNOS gene may affect response to the PORH process. This study aims to determine whether eNOS G894T gene polymorphism affects respo...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.05.005
更新日期：2009-09-01 00:00:00
abstract：:IL-20 is an arteriogenic cytokine that remodels collateral networks in vivo, and plays a role in cellular organization. Here, we investigate its role in lymphangiogenesis using a lymphatic endothelial cell line, hTERT-HDLEC, which expresses the lymphatic markers LYVE-1 and podoplanin. Upon stimulation of hTERT-HDLEC w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.02.007
更新日期：2009-06-01 00:00:00
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journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(90)90070-8
更新日期：1990-03-01 00:00:00
abstract：:Alveolar epithelial and endothelial cell death caused by mechanical over-distension is likely to contribute to ventilator-induced lung injury (VILI). Consequently, the search for cytoprotective interventions is of interest. We investigated the effect of the mTOR inhibitor rapamycin on human pulmonary microvascular end...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.01.012
更新日期：2009-05-01 00:00:00
