Abstract:
:Angiotensin II is considered to have angiogenic properties. Nevertheless, several authors reported an increase in coronary capillary density after treatment with ACE inhibitors. The aim of the present study was to evaluate the effect of treatment with low doses of ACE inhibitor perindopril, low doses of the diuretic indapamide, or a combination of the two on microvascular structure in hearts from stroke-prone spontaneously hypertensive rats (SHR-sp). Young adult male SHR treated with indapamide (0.24 mg/kg/day), perindopril (0.76 mg/kg/day), or both were compared with untreated animals after 8 or 14 weeks of treatment. Survival of SHR-sp was significantly increased after treatment. Only perindopril alone or in combination with indapamide significantly decreased blood pressure and cardiac mass. Treatment also significantly increased capillary and myocyte densities but arteriolar density tended to decrease. External and internal diameters significantly increased in treated animals while arteriolar thickness remained the same. Thus, thickness in vessels of the same size was the greatest in untreated animals, followed by indapamide- and perindopril-treated rats with the thinnest walls in rats with combined treatment, and the treatment resulted in a significant increase in the lumen to wall ratio. Capillary and arteriolar growth responses in treated animals seem to indicate that the two are independently regulated processes. Treatment with indapamide alone at this dosage did not significantly influence most responses but in combination with perindopril it strengthened the effect of perindopril.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Rakusan K,Cicutti N,Maurin A,Guez D,Schiavi Pdoi
10.1006/mvre.1999.2224keywords:
subject
Has Abstractpub_date
2000-03-01 00:00:00pages
243-54issue
2eissn
0026-2862issn
1095-9319pii
S0026-2862(99)92224-0journal_volume
59pub_type
杂志文章abstract:OBJECTIVE:This study aims to investigate the correlation between the expression of miR-210 in peripheral blood and the number of peripheral endothelial progenitor cells (EPCs) in patients with type 2 diabetes mellitus (T2DM). We also determined the effect of miR-210 on EPC proliferation, adhesion, migration, tube forma...
journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:Microvascular research
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更新日期:2018-11-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1995.1025
更新日期:1995-05-01 00:00:00
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journal_title:Microvascular research
pub_type: 临床试验,杂志文章,随机对照试验
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abstract::The aim of this study was to analyze the development of vascular architecture as well as vascular morphometry and morphology of anastomosed microvascular free flaps. Free pectoral skin flaps were raised in 25 rats and anastomosed to the femoral vessels in the groin region. CD31 immunohistology was performed after 3, 7...
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journal_title:Microvascular research
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.11.003
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Microvascular research
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更新日期:2016-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.mvr.2011.11.002
更新日期:2012-03-01 00:00:00
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journal_title:Microvascular research
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更新日期:2001-11-01 00:00:00
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更新日期:1992-01-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:Microvascular research
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doi:10.1016/j.mvr.2019.04.002
更新日期:2019-07-01 00:00:00
abstract::The mechanism by which macromolecular contents are concentrated during lymph transport was investigated in the collecting lymphatics of the mesentery of the rat. To examine changes in the concentration of lymph macromolecular tracer (fluorescein isothiocyanate-tagged dextran, MW 148,900) in the rhythmically contractil...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1997.2043
更新日期:1997-11-01 00:00:00
abstract::Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In thi...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1016/j.mvr.2018.05.005
更新日期:2018-11-01 00:00:00
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journal_title:Microvascular research
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doi:10.1016/j.mvr.2012.08.005
更新日期:2012-11-01 00:00:00
abstract::Neutrophil-derived hydrogen peroxide (H2O2) is believed to play an important role in inflammatory lung injury. We investigated the influence of pharmacological agents that increase intracellular c-AMP levels on endothelial and epithelial leakage in response to intravascular H2O2 challenge in buffer-perfused rabbit lun...
journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1995.1033
更新日期:1995-07-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章,评审
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abstract:PURPOSE:To investigate conjunctival microvascular responses in patients with mild diabetic retinopathy (MDR) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms (D + PM) after administration of Ocufolin™, a medical food containing 900 μg l-methylfolate (levomefolate calcium or [6S]-5-methyltetrahydrofolic aci...
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pub_type: 杂志文章
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更新日期:2015-03-01 00:00:00
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更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0026-2862(90)90070-8
更新日期:1990-03-01 00:00:00
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journal_title:Microvascular research
pub_type: 杂志文章
doi:10.1006/mvre.1995.1038
更新日期:1995-07-01 00:00:00
abstract::The retina provides a window to study the pathophysiology of cerebrovascular diseases. Pathological retinal microvascular changes may reflect microangiopathic processes in the brain. Recent advances in optical imaging techniques have enabled the imaging of the retinal microvasculature at the capillary level, and the g...
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更新日期:2013-09-01 00:00:00
abstract::Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantifie...
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pub_type: 杂志文章
doi:10.1016/j.mvr.2016.02.001
更新日期:2016-05-01 00:00:00