Electrokinetically modulated peristaltic transport of power-law fluids.


:The electrokinetically modulated peristaltic transport of power-law fluids through a narrow confinement in the form of a deformable tube is investigated. The fluid is considered to be divided into two regions - a non-Newtonian core region (described by the power-law behavior) which is surrounded by a thin wall-adhering layer of Newtonian fluid. This division mimics the occurrence of a wall-adjacent cell-free skimming layer in blood samples typically handled in microfluidic transport. The pumping characteristics and the trapping of the fluid bolus are studied by considering the effect of fluid viscosities, power-law index and electroosmosis. It is found that the zero-flow pressure rise is strongly dependent on the relative viscosity ratio of the near-wall depleted fluid and the core fluid as well as on the power-law index. The effect of electroosmosis on the pressure rise is strongly manifested at lower occlusion values, thereby indicating its importance in transport modulation for weakly peristaltic flow. It is also established that the phenomenon of trapping may be controlled on-the-fly by tuning the magnitude of the electric field: the trapping vanishes as the magnitude of the electric field is increased. Similarly, the phenomenon of reflux is shown to disappear due to the action of the applied electric field. These findings may be applied for the modulation of pumping in bio-physical environments by means of external electric fields.


Microvasc Res


Microvascular research


Goswami P,Chakraborty J,Bandopadhyay A,Chakraborty S




Has Abstract


2016-01-01 00:00:00












  • Effect of dispersion of vessel diameters and lengths in stochastic networks. II. Modeling of microvascular hematocrit distribution.

    abstract::A microvascular network model described in the preceding paper (B. Dawant, M. Levin, and A. S. Popel, 1986, Microvasc. Res. 31, 203-222) featuring random distribution of vessel diameters and lengths, is extended to calculate the distributions of red blood cell flux and discharge hematocrit throughout the network. A re...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Levin M,Dawant B,Popel AS

    更新日期:1986-03-01 00:00:00

  • The Rho-kinase inhibitor Y-27632 inhibits cholestasis-induced platelet interactions in the hepatic microcirculation.

    abstract::Bile duct obstruction is associated with hepatic accumulation of leukocytes and liver injury. Emerging data suggest that platelets may play an important role in tissue damage and inflammation. Herein, we characterized the platelet response in cholestatic liver injury and evaluated the role of Rho-kinase signaling. For...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Laschke MW,Dold S,Menger MD,Jeppsson B,Thorlacius H

    更新日期:2009-06-01 00:00:00

  • Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy.

    abstract::We investigated the kinetics of human mesenchymal stem cells (MSCs) after intravascular administration into SCID mouse cremaster vasculature by intravital microscopy. MSCs were injected into abdominal aorta through left femoral artery at two different concentrations (1 x 10(6) or 0.2 x 10(6) cell). Arterial blood velo...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Furlani D,Ugurlucan M,Ong L,Bieback K,Pittermann E,Westien I,Wang W,Yerebakan C,Li W,Gaebel R,Li RK,Vollmar B,Steinhoff G,Ma N

    更新日期:2009-05-01 00:00:00

  • Segmental differences of microvascular permeability for FITC-dextrans measured in the hamster cheek pouch.

    abstract::An intravital microscopic method for quantitative measurement of interstitial concentrations of fluorescent tracers has been applied to the investigation of microvascular permeability in the hamster cheek pouch. Some nanoliters of FITC-dextran mean mol wt (Mw) 20,000, 3000, or sodium fluorescein (Mw 376) were injected...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Ley K,Arfors KE

    更新日期:1986-01-01 00:00:00

  • Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells.

    abstract::The main objective of this study was to identify molecular mechanisms through which angiopoietin-1 (Ang-1), a ligand for Tie-2 receptors, influences endothelial cell apoptosis. Human umbilical vein endothelial cells were cultured in a medium enriched with 2% fetal bovine serum (FBS) and growth supplements. Apoptosis w...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Harfouche R,Hasséssian HM,Guo Y,Faivre V,Srikant CB,Yancopoulos GD,Hussain SN

    更新日期:2002-07-01 00:00:00

  • Effects of big endothelin-1 in comparison with endothelin-1 on the microvascular blood flow velocity and diameter of rat mesentery in vivo.

    abstract::Synthetic big endothelin-1 (ET-1), a 39-residue precursor of ET-1, has been reported to elicit potent contractile action on helical strip specimens obtained from the porcine coronary artery, but its molar potency was found to be 140-fold lower than that of ET-1 [Saito, Y., Nakao, K., Mukoyama, M., Imura, H., 1990. Inc...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Abdelhalim MA

    更新日期:2006-11-01 00:00:00

  • Characterization and comparison of embryonic stem cell-derived KDR+ cells with endothelial cells.

    abstract::Growing interest in utilizing endothelial cells (ECs) for therapeutic purposes has led to the exploration of human embryonic stem cells (hESCs) as a potential source for endothelial progenitors. In this study, ECs were induced from hESC lines and their biological characteristics were analyzed and compared with both co...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Sun X,Cheng L,Duan H,Lin G,Lu G

    更新日期:2012-09-01 00:00:00

  • Spontaneous cyclic contractions of the capillary wall in vivo, impeding red cell flow: a quantitative analysis. Evidence for endothelial contractility.

    abstract::We have videorecorded spontaneous cyclic contractions of capillary walls which often stopped the flow of blood cells, in spleens of rat and mouse. An inverted microscope and oblique lighting were key elements in obtaining images in which the boundaries of cells composing vessel walls were clearly distinguishable. Usin...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Ragan DM,Schmidt EE,MacDonald IC,Groom AC

    更新日期:1988-07-01 00:00:00

  • Differences in skin blood flow oscillations between the plantar and dorsal foot in people with diabetes mellitus and peripheral neuropathy.

    abstract:BACKGROUND:Understanding the differences in skin blood flow (SBF) on the plantar and dorsal foot in people with diabetes mellitus (DM) may help to assess the influence of diabetes and neuropathy on microvascular dysfunction and risks of diabetic foot ulcers in this population. However, there is no study comparing SBF o...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Jan YK,Liao F,Cheing GLY,Pu F,Ren W,Choi HMC

    更新日期:2019-03-01 00:00:00

  • Lumen formation and other angiogenic activities of cultured capillary endothelial cells are inhibited by thrombospondin-1.

    abstract::The large secreted glycoprotein thrombospondin-1 is a potent inhibitor of neovascularization in vivo. In order to better understand its mechanism of action, we have determined the full range of deficits thrombospondin can impose on cultured capillary endothelial cells. Exogenously added thrombospondin-1 blocked the ab...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Tolsma SS,Stack MS,Bouck N

    更新日期:1997-07-01 00:00:00

  • Emerging from the PAC: studying zebrafish lymphatic development.

    abstract::Recently the zebrafish has emerged as a promising vertebrate model of lymphatic vasculature development. The establishment of numerous transgenic lines that label the lymphatic endothelium in the zebrafish has allowed the fine examination of the developmental timing and the anatomy of their lymphatic vasculature. Alth...

    journal_title:Microvascular research

    pub_type: 杂志文章,评审


    authors: Mulligan TS,Weinstein BM

    更新日期:2014-11-01 00:00:00

  • Isolation, culture, and characterisation of MHC class II-positive microvascular endothelial cells from the human heart.

    abstract::Immunological studies of human endothelial cells have been performed almost entirely on endothelial cells (EC) derived from foetal (umbilical vein) or adult (aorta) large vessels. Immunologically these EC have in common the fact that they are negative for major histocompatibility complex (MHC) class II antigens (HLA-D...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: McDouall RM,Yacoub M,Rose ML

    更新日期:1996-03-01 00:00:00

  • Emergent behaviors in RBCs flows in micro-channels using digital particle image velocimetry.

    abstract::The key points in the design of microfluidic Lab-On-a-Chips for blood tests are the simplicity of the microfluidic chip geometry, the portability of the monitoring system and the ease on-chip integration of the data analysis procedure. The majority of those, recently designed, have been used for blood separation, howe...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Cairone F,Ortiz D,Cabrales PJ,Intaglietta M,Bucolo M

    更新日期:2018-03-01 00:00:00

  • Real-time imaging reveals endothelium-mediated leukocyte retention in LPS-treated lung microvessels.

    abstract::Endotoxemia, a major feature of sepsis, is a common cause of acute lung injury and initiates rapid accumulation of leukocytes in the lung vasculature. Endothelial mechanisms that underlie this accumulation remain unclear, as current experimental models of endotoxemia are less suitable for targeted activation of the en...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Kandasamy K,Sahu G,Parthasarathi K

    更新日期:2012-05-01 00:00:00

  • A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation.

    abstract::Pericytes are perivascular support cells, the origin of which in tumor tissue is not clear. Recently, we identified a Tie1(+) precursor cell that differentiates into vascular smooth muscle, in a Notch-dependent manner. To understand the involvement of Notch in the ontogeny of tumor pericytes we used a novel flow immun...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Patenaude A,Woerher S,Umlandt P,Wong F,Ibrahim R,Kyle A,Unger S,Fuller M,Parker J,Minchinton A,Eaves CJ,Karsan A

    更新日期:2015-09-01 00:00:00

  • Wavelet coherence analysis of spontaneous oscillations in cerebral tissue oxyhemoglobin concentrations and arterial blood pressure in elderly subjects.

    abstract::This study aims to assess the relationship between spontaneous oscillations in changes in cerebral tissue oxyhemoglobin concentrations (Delta [HbO2]) and arterial blood pressure (ABP) signals in healthy elderly subjects during the resting state using wavelet coherence analysis. Continuous recordings of near-infrared s...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Cui R,Zhang M,Li Z,Xin Q,Lu L,Zhou W,Han Q,Gao Y

    更新日期:2014-05-01 00:00:00

  • A novel assay of angiogenesis in the quail chorioallantoic membrane: stimulation by bFGF and inhibition by angiostatin according to fractal dimension and grid intersection.

    abstract::In a novel assay of angiogenesis in the quail chorioallantoic membrane (CAM), we measured vascular pattern and angiogenic rate after homogeneous exposure of the entire vascular tree to recognized modulators of vessel growth. In comparison to phosphate-buffered saline (PBS)-treated controls, the vascular stimulator, ba...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Parsons-Wingerter P,Lwai B,Yang MC,Elliott KE,Milaninia A,Redlitz A,Clark JI,Sage EH

    更新日期:1998-05-01 00:00:00

  • Expression and regulation of tumor necrosis factor-α-induced protein-8-like 2 is associated with acute lung injury induced by myocardial ischemia reperfusion in diabetic rats.

    abstract:AIMS:The purpose of the present study was to investigate the possible role of TIPE2 on acute lung injury (ALI) induced by myocardial ischemia/reperfusion (MIR) in diabetic rats. METHODS:Sprague-Dawley (SD) rats were randomly separated into four groups: control+sham (C + sham); control+MIR (C + MIR); diabetes+sham (D +...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Kong Q,Yuan M,Ming T,Fang Q,Wu X,Song X

    更新日期:2020-07-01 00:00:00

  • Laser speckle contrast imaging for measurement of hepatic microcirculation during the sepsis: a novel tool for early detection of microcirculation dysfunction.

    abstract:BACKGROUND:Sepsis is a fatal systemic inflammatory response syndrome caused by severe infection. The aim of this study was to measure hepatic microcirculation during the sepsis with laser speckle contrast imaging (LSCI), as well as investigating the underlying mechanisms. METHODS:Sepsis was induced by cecal ligation a...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Wu Y,Ren J,Zhou B,Ding C,Chen J,Wang G,Gu G,Liu S,Li J

    更新日期:2015-01-01 00:00:00

  • Modified cell-flow microchannels in a single-crystal silicon substrate and flow behavior of blood cells.

    abstract::Previously reported cell-flow microchannels in a single-crystal silicon substrate (Microvasc. Res. 44, 226-240, 1992) have been modified, and flow behavior of blood cells is described using flow rate-time curves and video pictures. The principal structure (2600 identically sized channels in parallel) was retained to g...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Kikuchi Y,Sato K,Mizuguchi Y

    更新日期:1994-01-01 00:00:00

  • Longitudinal differences in vascular control mechanisms in isolated resistance arteries of the rat cremaster muscle.

    abstract::The purpose of this study was to determine if there are intrinsic differences in resting tone, vascular reactivity, myogenic responses, and neurogenic vasoconstriction between the large and small feeder arteries and first order arterioles (1A) of the rat cremaster muscle. The pudic-epigastric artery (PEA), external sp...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Sylvester FA,Frisbee JC,Lombard JH

    更新日期:2000-09-01 00:00:00

  • Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity.

    abstract::Hypoxia-inducible factor-1 (HIF-1) orchestrates angiogenesis under hypoxic conditions mainly due to increased expression of such target genes as vascular endothelial growth factor (VEGF). Na+/H+exchanger-1 (NHE1), a potential HIF target gene product, plays a pivotal role in proliferation, survival, migration, adhesion...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Mo XG,Chen QW,Li XS,Zheng MM,Ke DZ,Deng W,Li GQ,Jiang J,Wu ZQ,Wang L,Wang P,Yang Y,Cao GY

    更新日期:2011-03-01 00:00:00

  • Relative magnitude of vascular reactivity in the major arterioles of the retina.

    abstract::The relative magnitude of vascular reactivity to inhaled gas stimuli in the major retinal arterioles has not been systematically investigated. The purpose of this study was to compare the magnitude of retinal vascular reactivity in response to inhaled gas provocation at equivalent measurement sites in the superior-, a...

    journal_title:Microvascular research

    pub_type: 杂志文章,随机对照试验


    authors: Sehi M,Tsui E,Cheng R,Wan J,Wong T,Dorner S,Fisher J,Hudson C

    更新日期:2012-03-01 00:00:00

  • Voltage-gated potassium channels and NOS contribute to a sustained cutaneous vasodilation elicited by local heating in an interactive manner in young adults.

    abstract::Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested ...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Fujii N,Halili L,Nishiyasu T,Kenny GP

    更新日期:2018-05-01 00:00:00

  • Sublingual microvascular perfusion is altered during normobaric and hyperbaric hyperoxia.

    abstract::Hyperoxia and hyperbaric oxygen therapy can restore oxygen tensions in tissues distressed by ischemic injury and poor vascularization and is believed to also yield angiogenesis and regulate tissue perfusion. The aim of this study was to develop a model in which hyperoxia-driven microvascular changes could be quantifie...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Milstein DM,Helmers R,Hackmann S,Belterman CN,van Hulst RA,de Lange J

    更新日期:2016-05-01 00:00:00

  • The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia.

    abstract::Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...

    journal_title:Microvascular research

    pub_type: 杂志文章,评审


    authors: Yang J

    更新日期:2019-05-01 00:00:00

  • Effects of ascorbic acid and EDTA on vascular concentration-response to catecholamines.

    abstract::Concentration-response curves are often used as indicators of vascular reactivity and receptor sensitivity. Some investigators use ethylenediaminetetraacetate (EDTA) or ascorbic acid (ASC) to prevent catecholamine oxidation but many others do not. This difference may affect estimates of reactivity. We tested the effec...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Maxwell LC,Herlihy JT,Riedel GL

    更新日期:1983-07-01 00:00:00

  • Acute endothelial cell contraction in vitro: a comparison with vascular smooth muscle cells and fibroblasts.

    abstract::The contractile responses of cultured rat and calf endothelial cells (EC), vascular smooth muscle cells (VSMC), and fibroblasts (FB) to vasoactive mediators (thrombin, serotonin, bradykinin, and histamine), forskolin, and cytochalasin B were compared. Cells were grown on a pliable silicone membrane, and contraction wa...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Boswell CA,Majno G,Joris I,Ostrom KA

    更新日期:1992-03-01 00:00:00

  • Measurement of meningeal blood vessel diameter in vivo with a plug-in for ImageJ.

    abstract::Changes in blood vessel diameter can be measured manually, but this is time-consuming and often impractical. For automatic measurement commercial solutions are available, but the proprietary algorithms and their potential shortcomings are not known to the user. We present an approach with a CCD camera for image acquis...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Fischer MJ,Uchida S,Messlinger K

    更新日期:2010-09-01 00:00:00

  • Spontaneous fluctuations in oxygen tension in the cat retina.

    abstract::Oxygen tension was recorded with double-barreled microelectrodes in the retina of anesthetized cats and monkeys. The oxygen tension (PO2) was often observed to undergo spontaneous irregular fluctuations with peak-to-peak amplitudes of about 3 to as much as 20 mm Hg. These fluctuations were observed only in the vascula...

    journal_title:Microvascular research

    pub_type: 杂志文章


    authors: Braun RD,Linsenmeier RA,Yancey CM

    更新日期:1992-07-01 00:00:00