Abstract：
:Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedures. Imaging lymphatic anatomy and function also plays an important role in experimental studies of lymphatic development and function, where spatial resolution and accessibility are better. Here, we review technologies for visualizing and imaging the lymphatic system for clinical applications. We then describe the use of lymphatic imaging in experimental systems as well as some of the emerging technologies for improving these methodologies.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Munn LL,Padera TPdoi
10.1016/j.mvr.2014.06.006subject
Has Abstractpub_date
2014-11-01 00:00:00pages
55-63eissn
0026-2862issn
1095-9319pii
S0026-2862(14)00092-2journal_volume
96pub_type
杂志文章,评审abstract：OBJECTIVE:Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase. NAD(P)H oxidase subunit p22phox is reported to be related to the development of atherosclerosis...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2008.08.001
更新日期：2009-03-01 00:00:00
abstract：:Sanguinate, a polyethylene glycol-conjugated carboxyhemoglobin, was investigated for cerebral vasoactivity in healthy male Sprague-Dawley rats (Study 1) and for its ability to increase brain tissue oxygen pressure (PbtO2) after controlled cortical impact (CCI) - traumatic brain injury (TBI) (Study 2). In both studies ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2016.06.001
更新日期：2016-09-01 00:00:00
abstract：:Post occlusive skin reactive hyperemia (PORH) is a tool used to assess microcirculation. Endothelial nitric oxide synthase (eNOS) mediates nitric oxide (NO) production; polymorphism of the eNOS gene may affect response to the PORH process. This study aims to determine whether eNOS G894T gene polymorphism affects respo...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.05.005
更新日期：2009-09-01 00:00:00
abstract：:There is evidence that vascular beds distal to the ophthalmic artery (OA) show vasoconstriction in response to a step decrease in systemic blood pressure (BP). The mediators of this response are mostly unidentified. The aim of the current study was to test the hypothesis that α2-adrenoreceptors may contribute to the r...
journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mvr.2010.10.001
更新日期：2011-01-01 00:00:00
abstract：:In this paper we quantitatively investigate the hypothesis proposed by Michel (Exp. Physiol. 82, 1-30, 1997) and Weinbaum (Ann. Biomed. Eng. 26, 1-17, 1998) that the Starling forces are determined by the local difference in the hydrostatic and colloid osmotic pressure across the endothelial surface glycocalyx, which w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2177
更新日期：1999-11-01 00:00:00
abstract：:An ex vivo perfused solid tumor preparation provides control over the physiological, biochemical, and pharmacological composition of the arterial input and easy access to the venous output. This is advantageous for studies of transport and metabolism in solid tumors. Here we present a tissue-isolated tumor preparation...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1994.1063
更新日期：1994-11-01 00:00:00
abstract：:The contribution of the pleural mesothelium to pleural liquid and protein transport is still vigorously debated. Recent in vitro studies of stripped pleural membrane and free-standing pericardium have demonstrated active ion solute coupled transport of liquid and transcytosis of protein. However, the relative contribu...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2005.10.003
更新日期：2005-11-01 00:00:00
abstract：:Pulmonary arterial hypertension is a common complication of congenital heart defects with left-to-right shunts. Current preclinical models do not reproduce clinical characteristics of shunt-related pulmonary hypertension. Aorto-caval shunt was firstly described as a model of right ventricle volume overload. The pathop...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.005
更新日期：2014-07-01 00:00:00
abstract：:The main objective of this study was to identify molecular mechanisms through which angiopoietin-1 (Ang-1), a ligand for Tie-2 receptors, influences endothelial cell apoptosis. Human umbilical vein endothelial cells were cultured in a medium enriched with 2% fetal bovine serum (FBS) and growth supplements. Apoptosis w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2002.2421
更新日期：2002-07-01 00:00:00
abstract：:The study deals with the adhesion and proliferation of bovine retina pericytes onto surfaces of poly(hydroxymethylsiloxane) (PHMS) modified either by cold plasma or by low-energy ion beams. The surface treatment was able to convert the original polymer matrix into SiO2-like phases for O2-plasma or ion-mixed SiCxOy(Hz)...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2004.08.003
更新日期：2004-11-01 00:00:00
abstract：:We have used ruthenium red, a cationic dye, to detect at the electron microscopic level the presence of anionic sites in various murine basement membranes, with particular emphasis on those of the microvasculature. We have observed anionic sites in all continuous and fenestrated capillaries examined. Terminal lymphati...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90018-3
更新日期：1983-05-01 00:00:00
abstract：:An intravital microscopic method for quantitative measurement of interstitial concentrations of fluorescent tracers has been applied to the investigation of microvascular permeability in the hamster cheek pouch. Some nanoliters of FITC-dextran mean mol wt (Mw) 20,000, 3000, or sodium fluorescein (Mw 376) were injected...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(86)90009-9
更新日期：1986-01-01 00:00:00
abstract：:Spontaneous contractions and those elicited by electrical stimulation were studied in isolated segments of bovine mesenteric lymphatic vessels. The effects of three general anesthetics, pentobarbitone, halothane, and ether, on these spontaneous and evoked contractions were studied. Pentobarbitone and halothane inhibit...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90073-3
更新日期：1989-01-01 00:00:00
abstract：:Age-related macular degeneration (AMD) is a common cause of blindness worldwide. While recent studies have revealed that the loss of choroidal endothelial cells (ChECs) is critical to the disease pathogenesis of dry AMD, in vitro studies are needed to fully elucidate the disease mechanism. However, these studies remai...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.12.002
更新日期：2019-05-01 00:00:00
abstract：:The anatomic arrangement, pressure distribution, and resting vascular tone of the feed arteries located upstream from the rat cremaster microcirculation were determined to characterize the sites of the vascular resistance in this macrovessel segment of the cremaster circulation. The cremaster microcirculation and its ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(87)90009-4
更新日期：1987-01-01 00:00:00
abstract：:This study was designed to determine if vascular dysfunction and enhanced norepinephrine sensitivity occurring in early experimental juvenile diabetes (S. M. Mueller, T. M. Mueller, and P. J. Ertel, 1982, Amer. J. Physiol. 243, H139-H144) persist, improve, or worsen in adulthood. Alloxan was administered to rats at 4 ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(84)90030-x
更新日期：1984-07-01 00:00:00
abstract：:In preeclampsia, invasion of intrauterine decidual blood vessels by placental cytotrophoblasts is significantly reduced. This study examined the secretion of matrix metalloproteinases (MMP) by cultured human decidual endothelial cells from normal (NDEC) and preeclamptic (PEDEC) pregnancies. MMPs secreted into the cult...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2142
更新日期：1999-05-01 00:00:00
abstract：:Living mesenteric capillaries with either an intact or disrupted glycocalyx were challenged with ramp change in shear stress (Deltatau). Animals (Rana pipiens) were divided randomly into two experimental groups, and two true capillaries (TC) per animal were investigated. The modified Landis technique was combined with...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.12.001
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate whether region-dependent endothelial heterogeneity is present within the porcine vortex vein system. METHODS:The superior temporal vortex vein in young adult pig eyes were dissected out and cannulated. The intact vortex vein system down to the choroidal veins was then p...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.06.004
更新日期：2013-09-01 00:00:00
abstract：:Carrier-immobilized carbohydrates are valuable tools for assessing the glycoligand-binding capacity of cell surfaces. A panel of 10 types of fluorescent neoglycoproteins has been synthesized to determine the extent of their specific binding to endothelial cells in vitro that have been obtained from porcine brain, ovar...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1053
更新日期：1995-09-01 00:00:00
abstract：:The effect of mean blood velocity on thrombus formation parameters was studied using mesenteric vessels of white rats. An advanced phenomenological theory, explaining the relationship between mean blood velocity and thrombus growth rate, is presented. The qualitative analysis of theoretical and experimental data have ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1002
更新日期：1995-01-01 00:00:00
abstract：:The microcirculation in normal and arthritic juxtaarticular bone was studied in 16 young dogs with carragheenan-induced arthritis of one knee. The regional blood flow was determined by the tissue uptake of intracardially injected 15-microns 141Ce-labeled microspheres, and the microvascular plasma volume was determined...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(90)90020-r
更新日期：1990-09-01 00:00:00
abstract：:Oxidative stress, which is defined as an imbalance between proxidant and antioxidant systems, is the essential mechanism involving in the ischemic process. During the early stage of brain ischemia, reactive oxygen species (ROS) are increased. Increased ROS are thought of a consequence of brain ischemia and exacerbatin...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2018.12.005
更新日期：2019-05-01 00:00:00
abstract：:The electrokinetically modulated peristaltic transport of power-law fluids through a narrow confinement in the form of a deformable tube is investigated. The fluid is considered to be divided into two regions - a non-Newtonian core region (described by the power-law behavior) which is surrounded by a thin wall-adherin...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.10.004
更新日期：2016-01-01 00:00:00
abstract：:Oxygen pressure histograms were determined with the multiwire surface electrode from the gastrocnemius muscle in patients with arterial occlusive disease and compared with those of healthy volunteers. Seven out of 22 patients had normally distributed histograms like volunteers, but the mean PO2 values were lower than ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90024-x
更新日期：1985-05-01 00:00:00
abstract：BACKGROUND:Angiogenin levels are increased in children and adolescent patients with type 1 diabetes, regardless of the extent of diabetic microangiopathy. However, little is known about the angiogenin concentrations in adults with type 1 diabetes. Thus we studied its level in middle aged subjects with the presence of d...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2012.08.005
更新日期：2012-11-01 00:00:00
abstract：:Current tissue engineering techniques have failed to provide an established microvasculature in skin substitutes, a requisite for the maintenance of graft viability and rapid revascularization subsequent to graft transplantation in vivo. To improve outcomes for both conventional skin grafts and skin substitutes, the e...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.04.012
更新日期：2008-01-01 00:00:00
abstract：:A mathematical model of nonsteady-state fluid movement in the lung interstitium during hydrodynamic loading is evaluated. The model is based on experimental results obtained in isolated perfused canine lungs. The interstitium is treated as a porous phase with an elastic framework, able to relax; all resistance to flux...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90071-i
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:In this study we aimed to evaluate effects of liver resection on hepatic microcirculation. In addition we wanted to study if histological liver damage could be detected intra-operatively. PATIENTS AND METHODS:40 patients undergoing hepatic resection were included and grouped according to if they were operat...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2014.05.002
更新日期：2014-07-01 00:00:00
abstract：:We tested the hypothesis that cationic peptides (polyarginine; poly-argn) and eosinophil-derived major basic protein (MaBP) increase permeability by stimulating the release of histamine and/or nitric oxide. We used intravital microscopy, clearance, and integrated optical intensity (IOI), using FITC-dextran 150 (FITC-d...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1995.1038
更新日期：1995-07-01 00:00:00
