Abstract：
:An ex vivo perfused solid tumor preparation provides control over the physiological, biochemical, and pharmacological composition of the arterial input and easy access to the venous output. This is advantageous for studies of transport and metabolism in solid tumors. Here we present a tissue-isolated tumor preparation adapted to the nude mouse, allowing ex vivo perfusion of human tumor xenografts. Previously, such preparations have only been developed in rats, to study primarily rodent tumors. In the present study this new tumor preparation is physiologically characterized in comparison with subcutaneously transplanted tumors in nude mice using the human colon adenocarcinoma LS174T.
journal_name
Microvasc Resjournal_title
Microvascular researchauthors
Kristjansen PE,Roberge S,Lee I,Jain RKdoi
10.1006/mvre.1994.1063subject
Has Abstractpub_date
1994-11-01 00:00:00pages
389-402issue
3eissn
0026-2862issn
1095-9319pii
S0026-2862(84)71063-6journal_volume
48pub_type
杂志文章abstract：:The steatotic liver is characterized by deranged intrahepatic microvasculature that is believed to predispose it to ischemia-reperfusion injury. The aim of this study was to investigate the distorted hepatic hemodynamics and its impact on the redox status of the steatotic liver. Hepatic hemodynamic parameters, hepatic...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/s0026-2862(03)00021-9
更新日期：2003-07-01 00:00:00
abstract：:During diabetes in rats, the choroid of the eye shows increased permeability to albumin, basement membrane thickening, and decreased anionic charge sites on the abluminal surfaces of the choriocapillary microvessels. In other microvascular beds, permeability differences are correlated with differences in luminal membr...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90058-j
更新日期：1991-11-01 00:00:00
abstract：:Capillary diameters in sartorius muscle of frogs were measured in vivo by means of a new computer video method, based on the passage of red blood cells (RBCs) through the capillary (C. Ellis, R. Sanfranyos, and A. Groom (1983), Microvasc. Res. 26, 139-150). The distribution of capillary diameters from 21 frogs was rep...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(83)90066-3
更新日期：1983-09-01 00:00:00
abstract：:IL-20 is an arteriogenic cytokine that remodels collateral networks in vivo, and plays a role in cellular organization. Here, we investigate its role in lymphangiogenesis using a lymphatic endothelial cell line, hTERT-HDLEC, which expresses the lymphatic markers LYVE-1 and podoplanin. Upon stimulation of hTERT-HDLEC w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.02.007
更新日期：2009-06-01 00:00:00
abstract：:The multiple pore model of T. R. Harris and R. J. Roselli (1981, J. Appl. Physiol: Respir. Environ. Exercise Physiol. 50, 1-14), was used to simulate lung lymph flow and protein transport at various levels of microvascular pressure. Response of the three-pore structure determined in that study was found to be in excel...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(85)90022-6
更新日期：1985-05-01 00:00:00
abstract：:The retina provides a window to study the pathophysiology of cerebrovascular diseases. Pathological retinal microvascular changes may reflect microangiopathic processes in the brain. Recent advances in optical imaging techniques have enabled the imaging of the retinal microvasculature at the capillary level, and the g...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.06.008
更新日期：2013-09-01 00:00:00
abstract：:Recent studies indicate that the human choroid has a considerable capacity to keep blood flow constant despite exercise-induced increases in perfusion pressure. The mechanisms underlying this vasoconstrictor response remain unclear. We hypothesized that pharmacological modulation of the autonomic nervous system may al...
journal_title：Microvascular research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0026-2862(02)00010-9
更新日期：2003-01-01 00:00:00
abstract：:In previous studies, the flow of albumin solution through hydrated lung interstitial segments was higher than a prior flow of Ringer solution (A. Tajaddinni et al., 1994, J. Appl. Physiol. 76, 578-583). We wondered whether this effect was caused by an increased pore size. We measured the flow of albumin solutions thro...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.2001.2363
更新日期：2002-01-01 00:00:00
abstract：:There is evidence that vascular beds distal to the ophthalmic artery (OA) show vasoconstriction in response to a step decrease in systemic blood pressure (BP). The mediators of this response are mostly unidentified. The aim of the current study was to test the hypothesis that α2-adrenoreceptors may contribute to the r...
journal_title：Microvascular research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mvr.2010.10.001
更新日期：2011-01-01 00:00:00
abstract：:Ischemia/Reperfusion injury and hemolysis are characterized by erythrocyte lysis and release of free heme into the microcirculation. Following substantial erythrocyte lysis, heme overwhelms circulatory heme-binding protein networks rapidly forming hemin, the oxidized form of iron protoporphyrin IX. Hemin's role in mod...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2007.01.002
更新日期：2007-05-01 00:00:00
abstract：:H2O2 mediates autocrine and paracrine signaling in the vasculature and can propagate endothelial dysfunction. However, it is not clear how endothelial cells withstand H2O2 exposure and promote H2O2-induced vascular remodeling. To understand the innate ability of endothelial cells for sustaining excess H2O2 exposure, w...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2015.09.003
更新日期：2016-01-01 00:00:00
abstract：:The purpose of the present study was to investigate the nervous control of gingival blood flow in cats. Gingival blood flow was measured by laser Doppler flowmeter in 75 cats during electrical stimulation and cutting or ligation of the inferior alveolar nerve and cervical sympathetic nerve without sympathectomy or pre...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(90)90061-u
更新日期：1990-01-01 00:00:00
abstract：:Reperfusion of the ischemic lung is associated with increased pulmonary vascular resistance and reduced alveolar perfusion in conjunction with an inflammatory response. To determine the contribution of platelet-endothelial interactions, we examined effects of pulmonary ischemia-reperfusion (IR) on platelet adhesion an...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2003.09.003
更新日期：2004-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is a chronic neuro-degenerative disease that adversely affect many people on a global scale. Despite different diagnostic and therapeutic treatment, there is no cure for AD. The brain is one of the most complex organ and researchers are still trying to understand so as to find a cure. OBJECTI...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2019.103928
更新日期：2020-03-01 00:00:00
abstract：:Particle tracking velocimetry provides a Lagrangian description of flow properties in the microcirculation. To determine the utility of fluorescent nanoparticles to provide Lagrangian coordinates, we tracked these particles both in vitro and in vivo. The particles had a neutral charge and fluorescence intensity greate...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2006.04.006
更新日期：2006-07-01 00:00:00
abstract：:Lipopolysaccharide released during bacterial sepsis causes acute lung injury and ARDS. Pulmonary microvascular injury is a feature of ARDS, and vascular remodeling develops, leading to pulmonary hypertension. Pericytes in the lung circulation proliferate and contribute to the remodeling seen in experimental sepsis. It...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1998.2085
更新日期：1998-09-01 00:00:00
abstract：OBJECTIVE:This study aims to investigate the correlation between the expression of miR-210 in peripheral blood and the number of peripheral endothelial progenitor cells (EPCs) in patients with type 2 diabetes mellitus (T2DM). We also determined the effect of miR-210 on EPC proliferation, adhesion, migration, tube forma...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2020.104032
更新日期：2020-09-01 00:00:00
abstract：:A large loss of blood during hemorrhage can result in profound shock, a state of hypotension associated with hemodynamic abnormalities. One of the hypotheses to account for this collapse of homeostasis is that the production of nitric oxide (NO), a gas molecule that dilates blood vessels, is significantly impaired dur...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.02.009
更新日期：2009-06-01 00:00:00
abstract：:Most forms of tissue healing depend critically on revascularisation. In soft tissues and in vitro, mechanical stimuli have been shown to promote vessel-forming activity. However, in bone defects, increased interfragmentary motion impairs vascular regeneration. Because these effects seem contradictory, we aimed to dete...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2009.08.002
更新日期：2009-12-01 00:00:00
abstract：:The maturational changes in tissue water spaces and in the fractional exclusion of albumin from the interstitial gel were studied in the developing rabbit using multiple radioactive tracers. Total tissue water and extracellular water decrease with age in all organs studied. Intracellular water decreases in the heart a...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(86)90021-x
更新日期：1986-05-01 00:00:00
abstract：:Previous studies on mice have revealed that the Griffonia simplicifolia I (GSI) lectin selectively binds to capillaries in a number of microvascular beds. These observations suggest that the lectin might be a suitable microvascular marker for physiological studies of skeletal muscle, particularly when fluorescent visu...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(88)90022-2
更新日期：1988-11-01 00:00:00
abstract：:Spontaneous contractions and those elicited by electrical stimulation were studied in isolated segments of bovine mesenteric lymphatic vessels. The effects of three general anesthetics, pentobarbitone, halothane, and ether, on these spontaneous and evoked contractions were studied. Pentobarbitone and halothane inhibit...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(89)90073-3
更新日期：1989-01-01 00:00:00
abstract：:Visualization of the lymphatic system is clinically necessary during diagnosis or treatment of many conditions and diseases; it is used for identifying and monitoring lymphedema, for detecting metastatic lesions during cancer staging and for locating lymphatic structures so they can be spared during surgical procedure...
journal_title：Microvascular research
pub_type： 杂志文章,评审
doi：10.1016/j.mvr.2014.06.006
更新日期：2014-11-01 00:00:00
abstract：:Immunological studies of human endothelial cells have been performed almost entirely on endothelial cells (EC) derived from foetal (umbilical vein) or adult (aorta) large vessels. Immunologically these EC have in common the fact that they are negative for major histocompatibility complex (MHC) class II antigens (HLA-D...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1996.0016
更新日期：1996-03-01 00:00:00
abstract：:The mechanism by which macromolecular contents are concentrated during lymph transport was investigated in the collecting lymphatics of the mesentery of the rat. To examine changes in the concentration of lymph macromolecular tracer (fluorescein isothiocyanate-tagged dextran, MW 148,900) in the rhythmically contractil...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1997.2043
更新日期：1997-11-01 00:00:00
abstract：:Tetrahydroxystilbene glucoside (TSG) is the main water-soluble component in Polygonum multiflorum Thunb, and it has many cardioprotective effects. Although TSG is able to relax blood vessels, its relaxation of rat superior mesenteric arteries and the underlying mechanism of this process are not clearly understood. The...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.10.007
更新日期：2019-05-01 00:00:00
abstract：:A mathematical model of nonsteady-state fluid movement in the lung interstitium during hydrodynamic loading is evaluated. The model is based on experimental results obtained in isolated perfused canine lungs. The interstitium is treated as a porous phase with an elastic framework, able to relax; all resistance to flux...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/0026-2862(91)90071-i
更新日期：1991-07-01 00:00:00
abstract：:Non-freezing cold injury (NFCI) is a prevalent, but largely undiagnosed and poorly understood syndrome afflicting many who, as part of their work or leisure, expose their extremities to cold temperatures. The long term sequelae of NFCI are hyperhidrosis, cold-sensitivity and pain; these can last a lifetime. We tested ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2013.11.002
更新日期：2014-01-01 00:00:00
abstract：:Failure of the glomerular barrier causing proteinuria has been modeled chiefly by Chang, Deen, and Brenner. They have refined models from an isoporous filter to a mostly isoporous membrane, which during proteinuric disease opens up nondiscriminating shunts. This report extends these concepts by measuring a larger dist...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1006/mvre.1999.2146
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Ischemia-reperfusion (IR) injury impairs microcirculatory function by reducing nitric oxide (NO) bioavailability and increasing sympathetic tone. This study non-invasively examined the effects of acute upper limb IR injury on local thermal hyperemia (LTH) in glabrous and non-glabrous finger skin. MATERIALS ...
journal_title：Microvascular research
pub_type： 杂志文章
doi：10.1016/j.mvr.2018.02.003
更新日期：2018-07-01 00:00:00
